De novo strategy of organic semiconducting polymer brushes for NIR-II light-triggered carbon monoxide release to boost deep-tissue cancer phototheranostics DOI Creative Commons

Caijun Zhu,

Mingdian Yu,

Jingqi Lv

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 14, 2024

The integration of photoacoustic imaging (PAI) and photothermal therapy (PTT) within the second near-infrared (NIR-II) window, offering a combination high-resolution precise non-invasive thermal ablation, presents an attractive opportunity for cancer treatment. Despite significant promise, development this noninvasive phototheranostic nanomedicines encounters challenges that stem from tumor thermotolerance limited therapeutic efficacy. In contribution, we designed amphiphilic semiconducting polymer brush (SPB) featuring thermosensitive carbon monoxide (CO) donor (TDF-CO) NIR-II PAI-assisted gas-augmented deep-tissue PTT. TDF-CO nanoparticles (NPs) exhibited powerful conversion efficiency (43.1%) capacity to trigger CO release after photoirradiation. Notably, liberated not only acts on mitochondria, leading mitochondrial dysfunction promoting cellular apoptosis but also hinders overexpression heat shock proteins (HSPs), enhancing tumor's thermosensitivity This dual action accelerates achieving synergistic effect in Intravenous administration NPs 4T1 tumor-bearing mice demonstrated bright PAI signals remarkable ablation under 1064 nm laser irradiation, underscoring potential CO-mediated photothermal/gas therapy. We envision tailor-made multifunctional light-triggered SPB provides feasible approach amplify performance PTT advancing future phototheranostics.

Language: Английский

Supramolecular H-Aggregates of Squaraines with Enhanced Type I Photosensitization for Combined Photodynamic and Photothermal Therapy DOI

Weiguo Qiao,

Teng Ma,

Ge Xie

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(37), P. 25671 - 25684

Published: Sept. 3, 2024

Combined photodynamic and photothermal therapy (PDT PTT) can achieve more superior therapeutic effects than the sole mode by maximizing photon utilization, but there remains a significant challenge in development of related single-molecule photosensitizers (PSs), particularly those with type I photosensitization. In this study, self-assembly squaraine dyes (SQs) is shown to be promising strategy for designing PSs combined PDT PTT, supramolecular PS (TPE-SQ7) has been successfully developed through subtle molecular design an indolenine SQ, which self-assemble into highly ordered H-aggregates aqueous solution as well nanoparticles (NPs). contrast typical quenching effect on reactive oxygen species (ROS) generation, our results encouragingly manifest that enhance ROS (

Language: Английский

Citations

23
Construction of Through‐Space Charge‐Transfer Nanoparticles for Facilely Realizing High‐Performance NIR‐II Cancer Phototheranostics DOI Creative Commons
Ka‐Wai Lee,

Yijian Gao,

Shu‐Hua Chou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Phototheranostics with second near‐infrared (NIR‐II) emissions show great potential for disease diagnosis and imaging‐guided phototherapy owing to deep tissue penetration, high imaging resolution, excellent tumor eradication. Recently, molecular conjugation engineering J‐aggregation have been used construct organic NIR‐II materials. However, these molecules generally extensive large weight in the range of 700–1700 g mol −1 , requiring complicated design synthesis. Herein, a emissive through‐space charge‐transfer (TSCT) nanoparticle (NP) using short‐conjugated donor‐acceptor (D‐A) (TTP) is reported high‐performance bioimaging cancer phototheranostics. Owing short TTP molecule small only 518 monomer possesses visible absorption first (NIR‐I) emission. Upon forming NPs water, efficient TSCT between monomers leads significantly red‐shifted NIR‐I emission region tail that extends 1400 nm. are employed vivo blood‐vessel phototheranostics successfully. This work introduces facile strategy based on D‐A biomedical applications.

Language: Английский

Citations

7
A NIR‐II Organic Dendrimer with Superb Photothermal Performance Based on Electron‐Donor Iteration for Photothermal Immunotherapy DOI

Xiangwei Kong,

Jie Liang,

Minfeng Lü

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Organic photothermal materials have attracted extensive attention due to their designable molecular structure, tunable excited‐state properties, and excellent biocompatibility, however, the development of near‐infrared II (NIR‐II) absorbing organic with high conversion efficiency (PTCE) molar extinction coefficient ( ɛ ) remains challenging. Herein, a novel “electron‐donor iteration” strategy is proposed construct dendrimers (CR‐DPA‐T, CR‐(DPA) 2 ‐T 3 ‐T) donor‐ π ‐acceptor‐ ‐donor (D ‐π‐ A‐ ‐D) features diradical characteristics. Owing enhanced D–A effect intramolecular motions, absorption capacity increase as generation grows. Surprisingly, an performance 1064 × PTCE superb value 2.85 10 4 in NIR‐II region achieved for nanoparticles (CR‐(DPA) NPs) compared most reported counterparts. Besides, NPs exhibit superior antitumor efficacy by synergistic therapy (PTT) immunotherapy, efficiently inhibiting growth both primary distant tumors. To best knowledge, dendrimer first time reported, universal donor engineering offered develop NIR‐II‐absorbing immunotherapy.

Language: Английский

Citations

7
Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy DOI Creative Commons

Haiqiao Huang,

Yingnan Wu,

Xin He

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging efficient therapeutic capabilities. In this work, a supramolecular strategy is employed construct molecular pair agent via the direct self‐assembly two cyanines, C5TNa (anionic) Cy‐Et (cationic). The Coulombic interactions between facilitate formation complementary cyanine (C5T‐ET) creation CT‐J‐type aggregates in water. This results completely quenched fluorescence significantly enhances nonradiative deactivation (≈22 ps), leading 3.3‐fold increase photothermal conversion efficiency 7.1‐fold enhancement response compared indocyanine green (ICG). As result, J‐type aggregate demonstrates high capability remarkable antitumor efficacy vivo, highlighting its potential clinical applications. work provides strong experimental evidence superior performance enhancing photosensitization response. It believed will propel advancement controllable dye J‐aggregates contribute practical implementation phototherapy vivo.

Language: Английский

Citations

1
Dimerized Pentamethine Cyanines for Synergistically Boosting Photodynamic/Photothermal Therapy DOI Creative Commons

Haiqiao Huang,

Qiang Liu, Jinghui Zhu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Photodynamic therapy (PDT) and photothermal (PTT) have emerged promising applications in both fundamental research clinical trials. However, it remains challenging to develop ideal photosensitizers (PSs) that concurrently integrate high photostability, large near‐infrared absorptivity, efficient therapeutic capabilities. Herein, we reported a sample engineering strategy afford benzene‐fused Cy5 dimer ( Cy‐D‐5 ) for synergistically boosting PDT/PTT applications. Intriguingly, exhibits tendency form J ‐aggregates H phosphate‐buffered saline, which show long‐wavelength absorption band bathochromically shifted 810 nm short‐wavelength hypsochromically 745 nm, respectively, when compared its behavior ethanol (778 nm). Density‐functional theory calculations combined with time‐resolved transient optical spectroscopy analysis reveal the fused low Δ E ST (0.51 eV) non‐radiative transition rates (12.6 times greater than of clinically approved PS‐indocyanine green [PS‐ ICG ]). Furthermore, demonstrates higher photosensitizing ability produce 1 O 2 , stronger conversion efficiency η = 64.4%), photostability . These properties enable achieve complete tumor ablation upon 808 laser irradiation, highlighting potential as powerful dual‐function phototherapeutic agent. This work may offer practical other existing dyes red‐shifted spectral range various phototherapy

Language: Английский

Citations

5
NIR‐II Cyazulene Fluorophores with Adjustable Cycloalkenes and Spectroscopic Properties for Imaging Applications DOI Open Access
Wenjie Gao,

Diankai Liu,

Mai‐He Li

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Abstract NIR‐II fluorescence imaging has shown broad application prospects in life science because of its deeper tissue penetration and higher spatiotemporal resolution. Developing fluorophores with special spectroscopic properties analytical functions become a cutting‐edge but challenging topic this field. Herein, series azulene‐based (called cyazulenes) adjustable cycloalkenes for applications is reported. Cyazulenes (CA965, CA985, CA1025) are constructed via the convenient coupling azulene derivatives. They exhibit different H‐aggregation J‐aggregation. Particularly noteworthy that CA985 can form significant J‐aggregates strong sharp emission biological media, be used vivo blood vessels fine structures collecting lymphatics mice. Moreover, displays passive bone‐targeted capacity, thereby enabling bone imaging. This study demonstrates chemical impact varying on aggregate formation spectral cyazulenes, which will advance fluorophores.

Language: Английский

Citations

0
Reprogrammed glycolysis-induced augmentation of NIR-II excited photodynamic/photothermal therapy DOI
Chunbai Xiang, Qihang Ding, Ting Jiang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123235 - 123235

Published: March 4, 2025

Language: Английский

Citations

0
Exceptional Near-Infrared II Organic Small Molecule Nanoagent for Photoacoustic/Photothermal Imaging-Guided Highly Efficient Therapy in Cancer DOI

Yidong Bin,

Lixian Huang, Jiang‐Ke Qin

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Near-infrared II (NIR-II) photoacoustic (PA)/photothermal imaging-guided tumor therapy holds great promise in precision medicine for cancer treatment. This work reports on the synthesis and application of an organic small molecule nanoagent that has exceptional PA photothermal properties near-infrared region. BCy-TPE was constructed by linking NIR-II absorbing cyanine dye BCy-Cl with a twisted tetraphenylethene unit. The synthesized exhibited intense absorption peak at 1032 nm. After encapsulation into water-dispersible nanoparticles (NPs), NPs two peaks 880 1046 Notably, under 1064 nm laser excitation, deliver remarkable conversion efficiency 92%, together superior biocompatibility, photostability, PA/photothermal imaging capability. Moreover, after intravenous administration 4T1 tumor-bearing mice treatment safe-intensity (1.0 W cm-2 nm) irradiation, temperature increased rapidly to 52 °C within 1 min tumors are completely ablated single Overall, this offers novel strategy develop superb agents highly efficient cancer.

Language: Английский

Citations

0
6-(4-Pyridyl)Azulene Derivatives as Hole Transport Materials for Perovskite Solar Cells DOI Open Access
Yuanqing Sun, Zhangyan Wang, Tianyu Geng

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(7), P. 1400 - 1400

Published: March 21, 2025

Azulene has been attracting much attention as a charge transfer material in organic electronics due to its inherent large dipole moment and small band gap, but application perovskite solar cells (PSCs) is very limited. Herein, azulene was applied the core acceptor for hole transport materials (HTMs), two molecules named Azu-Py-DF Azu-Py-OMeTPA were designed synthesized, which 4-pyridyl introduced on 6-position of 1,3-substituted adjust energy levels. The different spatial orientations pyridine improve solubility reduce crystallinity material, conducive creating thin film morphology. exhibited good electron mobility compared with standard Spiro-OMeTAD. Applied an HTM PSCs, Azu-Py-OMeTPA-based device achieved power conversion efficiency (PCE) 18.10%, higher than that unsubstituted counterpart. Nevertheless, anticipated passivation effect group diminished electron-deficient nature azulene’s seven-membered ring. These results demonstrate optimizing structure azulene-based HTMs can significantly alter molecular structure, formation properties, delocalization characteristics transport, lead improved performance, providing insights future design novel HTMs.

Language: Английский

Citations

0
Design, Synthesis, and Properties of 1,3-Di-tert-butylazulene Derivatives DOI
YuLong Xie,

Junjun Xiang,

Xian‐Jiang Song

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(4), P. 1297 - 1297

Published: Jan. 1, 2025

Language: Английский

Citations

0