Response and Regulation of the Microenvironment Based on Hollow Structured Drug Delivery Systems DOI

Decai Zhao,

Yanze Wei,

Jing Xiong

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(31)

Published: April 14, 2023

Abstract Hollow structured materials with easily modifiable surfaces and enclosed interior spaces have emerged as the most promising candidates in drug delivery systems (DDS). With various functional components inspiring cavities for creative reinvention, response regulation of external internal microenvironment hollow structures enable their ideal capabilities by improving aggregation targeted sites maintaining plasma concentrations at optimal therapeutic ranges. This review begins an in‐depth explanation interactions release mechanisms structure‐based DDS, including diffusion, assembly, solvent activation, chemical control, all which are great significance design smart carriers. Next, recent advances microenvironment‐responsive introduced, based on signals field assists. Focusing unique view intra‐carrier variability, strategies regulating environment then highlighted, pH regulation, temperature mechanical force regulation. Finally, this discusses possible challenges prospects structure‐based, particularly multishelled intelligence‐responsive platforms, providing valuable development next generation responsive DDS.

Language: Английский

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy DOI Creative Commons
Qiang Lü,

Dongquan Kou,

Shenghan Lou

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

Citations

135
Tumor-Generated Reactive Oxygen Species Storm for High-Performance Ferroptosis Therapy DOI
Lin Huang,

Jiaoyang Zhu,

Wei Xiong

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11492 - 11506

Published: June 7, 2023

Ferroptosis therapy (FT) efficacy of tumors suffers from a relatively low concentration Fenton agents, limited hydrogen peroxide (H2O2) content, and insufficient acidity in the tumor environment (TME), which are unfavorable for reactive oxygen species (ROS) generation based on or Fenton-like reactions. The glutathione (GSH) overexpression TME can scavenge ROS abate FT performance. In this study, strategy storm specifically initiated by our developed nanoplatforms (TAF-HMON-CuP@PPDG) is proposed high-performance tumors. GSH initiates HMON degradation, resulting tamoxifen (TAF) copper (CuP) release TAF3-HMON-CuP3@PPDG. released TAF leads to enhanced acidification within cells, reacts with CuP producing Cu2+ H2O2. reaction between H2O2 generates Cu+, that Cu+ Cu2+, forming cyclic catalysis effect. generate GSSG. increased accelerate consumption decreases peroxidase 4 (GPX4) expression. All above reactions cells FT, demonstrated cancer tumor-bearing mice.

Language: Английский

Citations

118
Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions DOI
Miaomiao Yan,

Sha Wu,

Yuhao Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(21)

Published: July 21, 2023

Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward

Language: Английский

Citations

96
Activity Regulating Strategies of Nanozymes for Biomedical Applications DOI
Xiaoteng Ding, Zhen Zhao, Yanfang Zhang

et al.

Small, Journal Year: 2023, Volume and Issue: 19(11)

Published: Jan. 17, 2023

Abstract On accounts of the advantages inherent high stability, ease preparation and superior catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical applications as alternatives to natural enzymes. Optimizing activity is significant for widening boosting into practical level. As research regulation strategies boosting, it essential timely review, summarize, analyze advances structure–activity relationships further inspiring ingenious this prosperous area. Herein, methods recent 5 years are systematically summarized, including size morphology, doping, vacancy, surface modification, hybridization, followed by a discussion latest consisting biosensing, antibacterial, tumor therapy. Finally, challenges opportunities rapidly developing field presented more infant yet promising

Language: Английский

Citations

55
Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition DOI Creative Commons
Huizhen Ma, Xiaoning Zhang, Ling Liu

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(31)

Published: Aug. 2, 2023

Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting a lack of bioactivity most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au22 clusters with strong NIR-II ranging from 950 1300 nm exhibiting potent enzyme-mimetic through atomic engineering create active Cu single-atom sites. The Au21Cu1 show 18-fold higher antioxidant, 90-fold catalase-like, 3-fold superoxide dismutase-like than clusters, negligible loss. Doping single atoms decreases the bandgap 1.33 1.28 eV by predominant contributions d states, lost states effectuates activities. renal clearable can monitor cisplatin-induced injury 20- 120-minute window visualize it three dimensions using light-sheet microscopy. Furthermore, inhibit oxidative stress inflammation cisplatin-treated mouse model, particularly kidneys brain.

Language: Английский

Citations

54
Nanozyme‐Based Regulation of Cellular Metabolism and Their Applications DOI Open Access
Yue Wang,

Xiaodan Jia,

Shangjie An

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: April 5, 2023

Metabolism is the sum of enzyme-dependent chemical reactions, which produces energy in catabolic process and synthesizes biomass anabolic process, exhibiting high similarity mammalian cell, microbial plant cell. Consequently, loss or gain metabolic enzyme activity greatly affects cellular metabolism. Nanozymes, as emerging mimics with diverse functions adjustable catalytic activities, have shown attractive potential for regulation. Although basic tasks are highly similar cells from different species, concrete pathway varies intracellular structure species. Here, metabolism living organisms described similarities differences pathways among mammalian, microbial, regulation mechanism discussed. The recent progress on mainly including nutrient uptake utilization, production, accompanied redox reactions by kinds oxidoreductases their applications field disease therapy, antimicrobial sustainable agriculture systematically reviewed. Furthermore, prospects challenges nanozymes regulating cell also discussed, broaden application scenarios.

Language: Английский

Citations

47
Confining Prepared Ultrasmall Nanozymes Loading ATO for Lung Cancer Catalytic Therapy/Immunotherapy DOI Open Access
Amin Zhang, Ang Gao, Cheng Zhou

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(45)

Published: Sept. 25, 2023

Nanozymes with inherent enzyme-mimicking catalytic properties combat malignant tumor progression via therapy, while the therapeutic efficacy still needs to be improved. In this work, ultrasmall platinum nanozymes (nPt) in a confined domain of wormlike pore channel gold nanobipyramidal-mesoporous silica dioxide nanocomposites, producing nanozyme carriers AP-mSi photoenhanced peroxidase ability, are innovatively synthesized. Afterward, based on prepared AP-mSi, lung-cancer probe (AP-HAI) is ingeniously produced by removing SiO2 template, modifying human serum albumin, and loading atovaquone molecules (ATO) as well IR780. Under NIR light irradiation, inner AuP IR780 collaborate for photothermal process, thus facilitating peroxidase-like process H2 O2 . Additionally, loaded ATO, cell respiration inhibitor, can impair metabolism cause oxygen retention, hence enhancing IR780's photodynamic therapy (PDT) effectiveness. As result, PDT nPt nanozymes' ability endow probes high ROS productivity, eliciting antitumor immune responses destroy tissue. Systematic studies reveal that obvious reactive species (ROS) generation obtained strategy using reducing consumption which turn enables synergetic therapy/immunogenic-cell-death-based immunotherapy. The results work would provide theoretical justification practical use probes.

Language: Английский

Citations

45
Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents DOI
Dandan Ma, Hui Bian,

Mingrui Gu

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215677 - 215677

Published: Jan. 31, 2024

Language: Английский

Citations

43
Design and regulation of defective electrocatalysts DOI
Yiqiong Zhang, Jingjing Liu, Yangfan Xu

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review focuses on the synthesis and characterization of defective electrocatalysts, internal correlation between defects catalytic activity, development application electrocatalysts in various fields.

Language: Английский

Citations

27
Spatial-Potential-Color-Resolved Bipolar Electrode Electrochemiluminescence Biosensor Using a CuMoOx Electrocatalyst for the Simultaneous Detection and Imaging of Tetracycline and Lincomycin DOI
Hongkun Li, Qianqian Cai, Yuehui Wang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(18), P. 7073 - 7081

Published: April 25, 2024

A spatial-potential-color-resolved bipolar electrode electrochemiluminescence biosensor (BPE-ECL) using a CuMoOx electrocatalyst was constructed for the simultaneous detection and imaging of tetracycline (TET) lincomycin (LIN). HOF-101 emitted peacock blue light under positive potential scanning, CdSe quantum dots (QDs) green negative scanning. could catalyze electrochemical reduction H2O2 to greatly increase Faradic current BPE realize ECL signal amplification. In channel 1, CuMoOx-Aptamer II probes were introduced into hole (left groove A) by dual aptamer sandwich method TET. During polarity negative, resulting in catalyzed CuMoOx, enhanced detecting 2, (LIN) adsorbed on MXene driving (DVE) B) hydrogen-bonding metal-chelating interactions. LIN bound with its aptamers, causing fall off. DVE decreased. The QDs reduced LIN. Furthermore, portable mobile phone platform built colorimetric (CL) TET Thus, multiple mode-resolved be realized simultaneously only one scan, which improved accuracy efficiency. This study opened new technology BPE-ECL sensor application is expected shine microchips point-of-care testing (POCT).

Language: Английский

Citations

22