Bioconjugate Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Spinal
cord
injury
(SCI)
with
increasing
incidence
can
lead
to
severe
disability.
The
pathological
process
involves
complex
mechanisms
such
as
oxidative
stress,
inflammation,
and
neuron
apoptosis.
Current
treatment
strategies
focusing
on
the
relief
of
stress
inflammation
have
achieved
good
effects,
while
many
problems
challenges
remain
side
effect
short
half-life
therapeutic
agents.
Nanozymes
exhibiting
biocatalytic
activities
sustainably
scavenge
free
radicals,
inhibit
neuroinflammation,
protect
neurons.
With
high
stability
in
physiological
conditions
cost-effectiveness,
nanozymes
provide
a
new
strategy
for
SCI
treatment.
In
this
Review,
we
outline
advances
their
enzyme-mimicking
highlight
progress
intervention
SCI-adopting
nanozymes.
We
also
propose
future
directions
clinical
translation
nanozyme
against
SCI.
Science,
Journal Year:
2024,
Volume and Issue:
383(6680), P. 326 - 330
Published: Jan. 18, 2024
Metal
nanoclusters
have
emerged
as
promising
near-infrared
(NIR)-emissive
materials,
but
their
room-temperature
photoluminescence
quantum
yield
(PLQY),
especially
in
solution,
is
often
low
(<10%).
We
studied
the
photophysics
of
Au
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(8)
Published: Nov. 3, 2023
Abstract
Atomically
precise
gold
nanoclusters
(NCs)
have
emerged
as
a
new
class
of
precision
materials
and
attracted
wide
interest
in
recent
years.
One
the
unique
properties
such
pertains
to
their
photoluminescence
(PL),
for
it
can
widely
span
visible
near‐infrared–I
–II
wavelengths
(NIR‐I/II),
even
beyond
1700
nm
by
manipulating
size,
structure,
composition.
The
current
research
efforts
focus
on
structure–PL
correlation
development
strategies
raising
PL
quantum
yields,
which
is
nontrivial
when
moving
from
near‐infrared
wavelengths,
especially
NIR–II
regions.
This
review
summarizes
progress
field,
including
i)
types
observed
NCs
fluorescence,
phosphorescence,
thermally
activated
delayed
well
dual
emission;
ii)
some
effective
that
are
devised
improve
yield
(QY)
NCs,
heterometal
doping,
surface
rigidification,
core
phonon
engineering,
with
double‐digit
QYs
NIR
horizons;
iii)
applications
luminescent
bioimaging,
photosensitization,
optoelectronics.
Finally,
remaining
challenges
opportunities
future
highlighted.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Optical
imaging
in
the
second
near-infrared
window
(NIR-II,
1000-1700
nm)
holds
great
promise
for
biomedical
detection
due
to
reduced
tissue
scattering
and
autofluorescence.
However,
rational
design
of
NIR-II
probes
with
superior
excitation
wavelengths
balance
effects
water
absorption
remains
a
challenge.
To
address
this
issue,
here
we
developed
series
Ho
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(17), P. 8196 - 8215
Published: Jan. 1, 2024
This
review
delves
into
enzyme-mimic
catalysis
of
metal
nanoclusters
based
on
a
hierarchical
structure
scheme
reminiscent
proteins.
Biomedical
applications
established
by
the
clusters
have
also
been
outlined.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(24), P. 7321 - 7331
Published: May 24, 2024
While
oral
probiotics
show
promise
in
treating
inflammatory
bowel
disease,
the
primary
challenge
lies
sustaining
their
activity
and
retention
within
inflamed
gastrointestinal
environment.
In
this
work,
we
develop
an
engineered
probiotic
platform
that
is
armed
with
biocatalytic
colon-targeting
nanocoatings
for
multipronged
management
of
IBD.
Notably,
achieve
situ
growth
artificial
nanocatalysts
on
through
a
bioinspired
mineralization
strategy.
The
resulting
ferrihydrite
nanostructures
anchored
bacteria
exhibit
robust
catalase-like
across
broad
pH
range,
effectively
scavenging
ROS
to
alleviate
inflammation.
further
envelopment
fucoidan-based
shields
confers
additional
functions.
Upon
administration,
display
markedly
improved
viability
colonization
intestine,
they
elicit
boosted
prophylactic
therapeutic
efficacy
against
colitis
synergistic
interplay
nanocatalysis-based
immunomodulation
probiotics-mediated
microbiota
reshaping.
multifunctional
platforms
offer
great
potential
comprehensive
disorders.
