Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: March 2, 2023

Abstract Macrophages are highly heterogeneous and exhibit a diversity of functions phenotypes. They can be divided into pro‐inflammatory macrophages (M1) anti‐inflammatory (M2). Diabetic wounds characterized by prolonged inflammatory phase difficulty in healing due to the accumulation wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise promoting diabetic wound clinical applications. However, precise conversion M1 M2 simple biosafe approaches is still challenge. Here, an all‐natural ability regulate developed promote angiogenesis healing. The protocatechuic aldehyde hybridized collagen‐based exhibits good bioadhesive antibacterial properties as well reactive oxygen species scavenging ability. More importantly, able convert without need for any additional ingredients or external intervention. This safe immunomodulatory approach shows application potential shortening repair accelerating

Language: Английский

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Biofilm Microenvironment‐Responsive Self‐Assembly Nanoreactors for All‐Stage Biofilm Associated Infection through Bacterial Cuproptosis‐like Death and Macrophage Re‐Rousing

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(36)

Published: June 1, 2023

Bacterial biofilm-associated infections (BAIs) are the leading cause of prosthetic implant failure. The dense biofilm structure prevents antibiotic penetration, while highly acidic and H2 O2 -rich microenvironment (BME) dampens immunological response antimicrobial macrophages. Conventional treatments that fail to consistently suppress escaping planktonic bacteria from result in refractory recolonization, allowing BAIs persist. Herein, a BME-responsive copper-doped polyoxometalate clusters (Cu-POM) combination with mild photothermal therapy (PTT) macrophage immune re-rousing for BAI eradication at all stages is proposed. self-assembly Cu-POM BME converts endogenous toxic ·OH through chemodynamic (CDT) generates PTT effect induce bacterial metabolic exuberance, resulting loosening membrane bacteria, enhancing copper transporter activity increasing intracellular flux. Metabolomics reveals overload restricts TCA cycle peroxide accumulation, promoting cuproptosis-like death. CDT macrophages scavenge disintegration enhanced chemotaxis phagocytosis. Overall, promotes death via interference, also further elimination, all-stage clearance providing new reference future clinical application.

Language: Английский

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Engineered Bio‐Heterojunction Confers Extra‐ and Intracellular Bacterial Ferroptosis and Hunger‐Triggered Cell Protection for Diabetic Wound Repair

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(9)

Published: Aug. 1, 2023

Abstract Nanomaterial‐mediated ferroptosis has garnered considerable interest in the antibacterial field, as it invokes disequilibrium of ion homeostasis and boosts lipid peroxidation extra‐ intracellular bacteria. However, current ferroptosis‐associated strategies indiscriminately pose damage to healthy cells, ultimately compromising their biocompatibility. To address this daunting issue, work designed a precise bio‐heterojunction (F‐bio‐HJ) consisting Fe 2 O 3 , Ti C ‐MXene, glucose oxidase (GOx) induce extra‐intracellular bacteria‐targeted for infected diabetic cutaneous regeneration. /Ti ‐MXene@GOx (FMG) catalytically generates amount ROS which assaults membrane extracellular bacteria, facilitating permeation synchronously generated 2+ /Fe 3+ into bacteria under near‐infrared (NIR) irradiation, causing planktonic bacterial death via ferroptosis, overload, peroxidation. Additionally, FMG facilitates by transporting inward ferroportin (FPN). With GOx consuming glucose, creates hunger protection helps macrophages escape cell activating adenosine 5’‐monophosphate (AMP) activated protein kinase (AMPK) pathway. In vivo results authenticate that infectious regeneration without triggering normal cells. As envisaged, proposed tactic provides promising approach combat intractable infections precisely terminating infection steerable thereby markedly elevating biocompatibility therapeutic ferroptosis‐mediated strategies.

Language: Английский

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Fabrication and characterization of PVA@PLA electrospinning nanofibers embedded with Bletilla striata polysaccharide and Rosmarinic acid to promote wound healing

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 234, P. 123693 - 123693

Published: Feb. 17, 2023

Language: Английский

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Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives

The Innovation, Journal Year: 2023, Volume and Issue: 4(6), P. 100503 - 100503

Published: Aug. 29, 2023

•Insights into the intricate facets of immune microenvironment hold key to pioneering clinical strategies in combatting bacterial infections.•The design principles for antimicrobial biomaterials vary depending on at different stages infection.•Immunomodulatory display robust efficacy and vaccine attributes animals trials, promising intractable infections. Bacterial infectious diseases are one leading causes death worldwide. Even with use multiple antibiotic treatment strategies, 4.95 million people died from drug-resistant infections 2019. By 2050, number deaths will reach 10 annually. The increasing mortality may be partly due heterogeneity infection microenvironment, such as bacteria, biofilms, persister cells, intracellular small colony variants. In addition, complexity makes direct activity unsatisfactory long-term chronic attributed failing modulate active action cells. Therefore, there is an urgent need effective alternatives treat Accordingly, development immunomodulatory has recently received considerable interest; however, a comprehensive review their research progress lacking. this review, we focus mainly future perspectives used infection. First, describe characteristics acute phases Then, highlight corresponding advantages disadvantages. Moreover, discuss biomaterial-mediated vaccines' potential applications challenges activating innate adaptive memory. This serve reference studies develop next-generation accelerate translation practice.

Language: Английский

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Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Journal Year: 2023, Volume and Issue: 4(2)

Published: Oct. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Language: Английский

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M2 macrophage-derived exosome-encapsulated microneedles with mild photothermal therapy for accelerated diabetic wound healing

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100649 - 100649

Published: April 30, 2023

Due to local overactive inflammatory response and impaired angiogenesis, current treatments for diabetic wounds remain unsatisfactory. M2 macrophage-derived exosomes (MEs) have shown considerable potential in biomedical applications, especially since they anti-inflammatory properties that modulate macrophage phenotypes. However, exosome-based strategies still limitations, such as short half-lives instability. Herein, we develop a double-layer microneedle-based wound dressing system (MEs@PMN) by encapsulating MEs the needle tips polydopamine (PDA) nanoparticles backing layer simultaneously suppress inflammation improve angiogenesis at site.

Language: Английский

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Architecture of Vanadium‐Based MXene Dysregulating Tumor Redox Homeostasis for Amplified Nanozyme Catalytic/Photothermal Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Sept. 21, 2023

Abstract Taking the significance of special microenvironment for tumor cell survival into account, disrupting redox homeostasis is highly prospective improving therapeutic efficacy. Herein, a multifunctional 2D vanadium‐based MXene nanoplatform, V 4 C 3 /atovaquone@bovine albumin (V /ATO@BSA, abbreviated as VAB) has been elaborately constructed ATO‐enhanced nanozyme catalytic/photothermal therapy. The within cells eventually disrupted, showing remarkable anti‐tumor effect. VAB nanoplatform with mixed vanadium valence states can induce cascade catalyzed reactions in microenvironment, generating plenty reactive oxygen species (ROS) effective glutathione consumption to amplify oxidative stress. Meanwhile, stable and strong photothermal effect under near‐infrared irradiation not only causes necrosis cells, but also improves its peroxidase‐like activity. In addition, release ATO effectively alleviate endogenous limit triphosadenine formation inhibit mitochondrial respiration. As result, expression heat shock proteins suppressed overcome thermoresistance production ROS be further promoted due injury. Moreover, presents high photoacoustic imaging performances. brief, provide therapy broadening biomedical applications MXene.

Language: Английский

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Designing Single‐Atom Active Sites on sp²‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: Feb. 27, 2023

With the threat posed by drug-resistant pathogenic bacteria, developing non-antibiotic strategies for eradicating clinically prevalent superbugs remains challenging. Ferroptosis is a newly discovered form of regulated cell death that can overcome drug resistance. Emerging evidence shows potential triggering ferroptosis-like antibacterial therapy, but direct delivery iron species inefficient and may cause detrimental effects. Herein, an effective strategy to induce bacterial nonferrous coordinating single-atom metal sites (e.g., Ir Ru) into sp

Language: Английский

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