Food Chemistry, Journal Year: 2024, Volume and Issue: 462, P. 141027 - 141027
Published: Aug. 28, 2024
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215245 - 215245
Published: May 22, 2023
Language: Английский
Citations
90
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 481, P. 148270 - 148270
Published: Dec. 23, 2023
Language: Английский
Citations
80
ACS Nano, Journal Year: 2024, Volume and Issue: 18(24), P. 15845 - 15863
Published: June 4, 2024
Nanozyme-driven catalytic therapy provides a promising treatment strategy for bacterial biofilm-infected wounds. However, the single functionality and limited efficiency of nanozyme-based materials often restrict effectiveness wound infection treatment. In this study, CuCo2O4 nanoflowers with multiple enzymatic activities were prepared antibacterial/antibiofilm by cuproptosis-like death. exhibited peroxidase-like (POD-like) oxidase-like (OXD-like) dual enzyme that generated large amounts •OH O2•–. Moreover, glutathione (GSH-Px-like) activity was able to reduce overexpression GSH in microenvironment, enhancing therapeutic effects reactive oxygen species (ROS). The morphology modified using hydrothermal method PEG4000 as solvent, resulting exposure more active center sites significant improvement activity. vitro results demonstrated pronounced disruption effect on biofilms formed bacteria. vivo, significantly promoted angiogenesis, collagen deposition, cell proliferation. Transcriptome sequencing revealed elevated ROS levels bacteria led membrane damage metabolic disruption. addition, Cu2+ overload induces lipid peroxidation accumulation disrupts respiratory chain tricarboxylic acid (TCA) cycle, ultimately leading This strategy, which combines synergistic enzyme-like death, an approach treating biofilm infections.
Language: Английский
Citations
79
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(44)
Published: July 17, 2023
Abstract Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are limited to unilateral efforts in lubrication, inhibition of inflammation, free radicals scavenging, and cartilage regeneration. Herein, by modifying molybdenum disulfide (MoS 2 ) with Mg 2+ ‐doped polydopamine coating polysulfobetaines, a dual‐bionic photothermal nanozyme (MPMP) constructed mimic antioxidases/hyaluronan synthase OA therapy. Photothermally enhanced lubrication lowers the coefficient friction (0.028) early stage treatment. The antioxidases‐mimicking properties MPMP contribute eliminating reactive oxygen nitrogen species (ROS/RNS) (over 90% scavenging ratio H O /·OH/O · – /DPPH/ABTS + supplying . With NIR irradiation, triggers thermogenesis (upregulating HSP70 expression) release, which promotes chondrogenesis inflammatory conditions deactivating NF‐κB/IL‐17 signaling pathways enhancing MAPK pathway. Benefiting from , MPMP‐NIR shows HAS‐mimicking activity increase intracellular (twofold) extracellular (3.12‐fold) HA production. Therefore, demonstrates superior spatiotemporally therapeutic effect on mice model, terms osteophytes (83.41% reduction), OARSI scores (88.57% ACAN expression (2.70‐fold increment). Hence, insights into nanozymes can be promising strategy therapy or other inflammation‐related diseases.
Language: Английский
Citations
69
Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(10), P. 849 - 868
Published: July 18, 2024
Language: Английский
Citations
65
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(33), P. 13663 - 13671
Published: Aug. 10, 2024
Rapid and accurate detection of human epidermal growth factor receptor 2 (HER2) is crucial for the early diagnosis prognosis breast cancer. In this study, we reported an iron-manganese ion N-doped carbon single-atom catalyst (FeMn-NC
Language: Английский
Citations
63
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150612 - 150612
Published: March 21, 2024
Language: Английский
Citations
60
ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095
Published: May 2, 2024
Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.
Language: Английский
Citations
59
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113767 - 113767
Published: Jan. 24, 2024
Language: Английский
Citations
57
Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(3), P. 766 - 796
Published: Jan. 1, 2024
Here we made a critical review on nanozyme-involved detection and degradation of environmental pollutants, the research progress achieved in last five years was emphatically concluded.
Language: Английский
Citations
54