Nanozymes: a new approach for leukemia therapy DOI
Wei Wang,

Jingyi An,

Runze Zhao

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(10), P. 2459 - 2470

Published: Jan. 1, 2024

Leukemia is a type of clonal disorder hematopoietic stem and progenitor cells characterized by bone marrow failure, differentiation arrest, lineage skewing. Despite leukemia being complex disease it difficult to identify single driving force, redox homeostasis, the balance between reactive oxygen species (ROS) producers cellular antioxidant systems, normally impaired during leukemogenesis. In this context, modulation ROS in can be harnessed for therapeutic purposes. Nanozymes are functional nanomaterials with enzyme-like characteristics, which address intrinsic limitations natural enzymes exhibit great potential synergistic antitumor therapy. possess catalytic activities (e.g., peroxidase-like activity, catalase-like superoxide dismutase-like oxidase-like activity) regulate levels vitro vivo, making them promising On account rapid development nanozymes recently, their application potentials therapy gradually explored. To highlight achievements field, review summarizes recent studies anti-leukemia efficacy underlying mechanism. addition, challenges prospects nanozyme research discussed.

Language: Английский

Precise Tuning of the D-Band Center of Dual-Atomic Enzymes for Catalytic Therapy DOI

Ruijin Zeng,

Qian Gao,

Limei Xiao

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(14), P. 10023 - 10031

Published: March 30, 2024

Single-atom nanozyme-based catalytic therapy is of great interest in the field tumor therapy; however, their development suffers from low affinity nanozymes to substrates (H2O2 or O2), leading deficient activity microenvironment. Herein, we report a new strategy for precisely tuning d-band center dual-atomic sites enhance metal atomic and on class edge-rich N-doped porous carbon Fe–Mn (Fe1Mn1–NCe) greatly boosting multiple-enzyme-like activities. The as-made Fe1Mn1–NCe achieved much higher efficiency (Kcat/Km = 4.01 × 105 S–1·M–1) than Fe1–NCe 2.41 104 with an outstanding stability over 90% retention after 1 year, which best among reported dual-atom nanozymes. Theoretical calculations reveal that synergetic effect Mn upshifts Fe −1.113 −0.564 eV enhances adsorption capacity substrate, thus accelerating dissociation H2O2 weakening O–O bond O2. We further demonstrated superior enzyme-like combined photothermal could effectively inhibit growth vivo, inhibition rate up 95.74%, highest value artificial enzyme therapies so far.

Language: Английский

Citations

56
Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment DOI
Qinrui Fu,

Chuang Wei,

Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

Citations

53
Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy DOI Creative Commons
H.-B. Zhang, Yitong Zhang, Y. Zhang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 8, 2024

Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze production of reactive oxygen species (ROS) without requiring external stimuli catalytic substrates confirmed to be (O2) hydrogen peroxide (H2O2) through computational simulation experiments. Considering short O2 H2O2 at site, we utilize calcium (CaO2) supply for VPQDs construct nanoparticles together with them, named VPCaNPs. VPCaNPs induce oxidative stress cells, particularly characterized by a significant increase hydroxyl radicals superoxide radicals, which cause substantial damage structure function ultimately leading cell apoptosis. Intriguingly, provided CaO2 degrade slowly, degradation product, phosphate, as well CaO2-generated ions, promote calcification. Antitumor immune activation less metastasis also observed administrated animals. In conclusion, our study unveils anti-tumor activity catalysts generating cytotoxic ROS products calcification, providing promising strategy treating tumors.

Language: Английский

Citations

21
Engineering metal-organic frameworks-based nanozymes for enhanced biomimetic catalytic sensing DOI
Zhong Wei Jiang, Xue Gong, Yi Wang

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 178, P. 117862 - 117862

Published: July 10, 2024

Language: Английский

Citations

19
Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy DOI

Xiuna Jia,

Erkang Wang, Jin Wang

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

Citations

3
Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells DOI Creative Commons
Lianying Zhang, Xiaotong Chen,

Rong-Tian Li

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 6, 2025

Breast cancer (BC) is a significant cause of cancer-related deaths among women worldwide. Hypoxia, common feature solid tumor, associated with drug resistance and poor prognosis in BC. In this study, we present strategy to overcome hypoxia-induced chemotherapy tolerance Specifically, synthesized hollow gold (Au)-platinum (Pt) bimetallic nanoshell for the first time, which acted as delivery system (DDS) doxorubicin (DOX). The photothermal effect, induced by surface plasmon resonance (SPR) from Au-Pt shell under near infrared-II (NIR-II) laser irradiation, not only directly causes tumor cell death through therapy (PTT), but also significantly enhances catalase-like activity between Pt nanoparticles endogenous H2O2. This, subsequently, results heightened yield O2, further facilitates release DOX. This process alleviates hypoxia down-regulating hypoxia-inducible factor-1α (HIF-1α), multidrug gene 1 (MDR1), P-glycoprotein (P-gp), can reverse achieve more effective DOX effects. Significantly, increased availability oxygen re-polarizes immunosuppressive M2 macrophages into antitumor M1 macrophages. study presents novel tackle proliferation enhance response chemotherapy, offering hope reversing cancerous lesions.

Language: Английский

Citations

3
Self-stablized monodispersing nano-MOFs for controlled enzyme delivery DOI
Peiwei Gong,

Huiying Cui,

Cheng Li

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 489, P. 150941 - 150941

Published: April 16, 2024

Language: Английский

Citations

14
Plasmonic Supramolecular Nanozyme‐Based Bio‐Cockleburs for Synergistic Therapy of Infected Diabetic Wounds DOI Open Access
Xin Wang,

Xudong Qin,

Yi Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract Diabetic wounds are a major devastating complication of diabetes due to hyperglycemia, bacterial invasion, and persistent inflammation, the current antibiotic treatments can lead emergence multidrug‐resistant bacteria. Herein, bimetallic nanozyme‐based biomimetic bio‐cocklebur (GNR@CeO 2 @GNPs) is designed synthesized for diabetic wound management by depositing spiky ceria (CeO ) shells gold nanoparticles (GNPs) on nanorod (GNR) nanoantenna. The plasmonic‐enhanced nanozyme catalysis self‐cascade reaction properties simultaneously boost two‐step enzyme‐mimicking catalytic activity GNR@CeO @GNPs, leading significant improvement in overall therapeutic efficacy rather than mere additive effects. Under glucose activation 808 nm laser irradiation, @GNPs material captures photons promotes transfer hot electrons from GNR GNPs into CeO , realizing “butterfly effect” consuming local glucose, overcoming limited antibacterial efficiency an individual PTT modality, providing substantial reactive oxygen species. In vitro vivo experiments demonstrate material's exceptional antibiofilm against Gram‐negative Gram‐positive bacteria, which reduce promote collagen deposition, facilitate angiogenesis, thereby accelerating healing. This study provides promising new strategy develop nanozymes with cascade mode antibiotic‐free synergistic treatment infected wounds.

Language: Английский

Citations

14
Phase Engineered CuxS–Ag2S with Photothermoelectric Activity for Enhanced Multienzyme Activity and Dynamic Therapy DOI

Pengyu Zang,

Chenghao Yu, Rui Zhang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: Feb. 28, 2024

Abstract The insufficient exposure sites and active site competition of multienzyme are the two main factors to hinder its therapeutic effect. Here, a phase‐junction nanomaterial (amorphous‐crystalline Cu x S–Ag 2 S) is designed prepared through simple room temperature ion‐exchange process. A small amount Ag + added into 7 S 4 nanocrystals, which transforms amorphous phased produces crystalline simultaneously. In this structure, overhanging bonds on surface provide abundant for optimizing activity. Meanwhile, state enhances photothermal effect non‐radiative relaxation, due low thermal resistance, forms significant gradient unlock optimized thermo‐electrodynamic therapy. Furthermore, benefiting from high asymmetry state, material spin‐polarized that can effectively inhibit electron–hole recombination. way, thermoelectric facilitate enzyme‐catalyzed cycle by providing electrons holes, enabling an enhanced coupling therapy with activity, induces excellent anti‐tumor performance. More importantly, catalytic process simulated density‐functional theory proves alleviates burden favorable adsorption O prevents competition.

Language: Английский

Citations

13
PdMoPtCoNi High Entropy Nanoalloy with d Electron Self‐Complementation‐Induced Multisite Synergistic Effect for Efficient Nanozyme Catalysis DOI Creative Commons
Xuewei Yang,

Jianxing Feng,

Yuechun Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

Engineering multimetallic nanocatalysts with the entropy-mediated strategy to reduce reaction activation energy is regarded as an innovative and effective approach facilitate efficient heterogeneous catalysis. Accordingly, conformational entropy-driven high-entropy alloys (HEAs) are emerging a promising candidate settle catalytic efficiency limitations of nanozymes, attributed their versatile active site compositions synergistic effects. As proof nanozymes (HEzymes) concept, elaborate PdMoPtCoNi HEA nanowires (NWs) abundant sites tuned electronic structures, exhibiting peroxidase-mimicking activity comparable that natural horseradish peroxidase reported. Density functional theory calculations demonstrate enhanced electron abundance NWs near Fermi level (E

Language: Английский

Citations

12