Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 21, 2024
Abstract
Macrophage
dysfunction
is
one
of
the
primary
factors
leading
to
delayed
healing
diabetic
wounds.
Hypoxic
bone
marrow
mesenchymal
stem
cells‐derived
exosomes
(hyBMSC‐Exos)
have
been
shown
play
an
active
role
in
regulating
cellular
function
through
carried
microRNAs.
However,
administration
hyBMSC‐Exos
alone
wounds
usually
brings
little
effect,
because
are
inherently
unstable
and
a
short
retention
time
at
In
this
study,
multifunctional
hydrogel
based
on
gallic
acid
(GA)
conjugated
chitosan
(Chi‐GA)
partially
oxidized
hyaluronic
(OHA)
prepared
for
sustained
release
hyBMSC‐Exos.
The
not
only
exhibits
needs‐satisfying
physicochemical
properties,
but
also
displays
outstanding
biological
performances
such
as
low
hemolysis
rate,
strong
antibacterial
capacity,
great
antioxidant
ability,
excellent
biocompatibility.
It
has
ability
boost
stability
hyBMSC‐Exos,
continuous
gradual
wound
locations,
ultimately
enhancing
exosomes’
uptake
efficiency
by
target
cells.
Most
importantly,
loaded
shows
promote
macrophage
polarization
toward
M2
phenotype.
This
may
be
exosomal
miR‐4645‐5p
property
synergistically
inhibit
SREBP2
activity
macrophages.
study
presents
productive
approach
managing
International Journal of Oral Science,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Jan. 15, 2024
Abstract
Oral
diseases,
such
as
periodontitis,
salivary
gland
and
oral
cancers,
significantly
challenge
health
conditions
due
to
their
detrimental
effects
on
patient’s
digestive
functions,
pronunciation,
esthetic
demands.
Delayed
diagnosis
non-targeted
treatment
profoundly
influence
patients’
prognosis
quality
of
life.
The
exploration
innovative
approaches
for
early
detection
precise
represents
a
promising
frontier
in
medicine.
Exosomes,
which
are
characterized
nanometer-sized
extracellular
vesicles,
secreted
by
virtually
all
types
cells.
As
the
research
continues,
complex
roles
these
intracellular-derived
vesicles
biological
processes
have
gradually
unfolded.
Exosomes
attracted
attention
valuable
diagnostic
therapeutic
tools
ability
transfer
abundant
cargos
intricate
involvement
multiple
cellular
functions.
In
this
review,
we
provide
an
overview
recent
applications
exosomes
within
field
focusing
inflammation-related
bone
diseases
squamous
cell
carcinomas.
We
characterize
exosome
alterations
demonstrate
potential
biomarkers
diagnosis,
highlighting
indicators
diseases.
also
summarize
targeted
therapy
proposed
future
directions
use
clinical
treatment.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(15)
Published: April 12, 2024
Aging
skin,
vulnerable
to
age-related
defects,
is
poor
in
wound
repair.
Metabolic
regulation
accumulated
senescent
cells
(SnCs)
with
aging
essential
for
tissue
homeostasis,
and
adequate
ATP
important
cell
activation
aged
Strategies
metabolism
intervention
hold
prospects
therapeutic
advances.
Here,
we
found
energy
metabolic
changes
skin
from
patients
mice.
Our
data
show
that
metformin
engineered
EV
(Met-EV)
can
enhance
mouse
repair,
as
well
ameliorate
cellular
senescence
restore
dysfunctions.
Notably,
was
remodeled
reduced
glycolysis
enhanced
OXPHOS
after
Met-EV
treatment.
We
rescue
senescence-induced
mitochondria
dysfunctions
mitophagy
suppressions,
indicating
the
role
of
remodeling
mitochondrial
functions
via
production
results
reveal
mechanism
SnCs
rejuvenation
by
suggest
disturbed
metabolism,
be
a
potential
target
facilitating
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 12, 2025
Senescent
mandibular
bone
repair
poses
a
formidable
challenge
without
completely
satisfactory
strategy.
Endogenous
cell
recruitment
and
osteogenic
differentiation
are
two
sequential
stages
in
regeneration,
disruptions
these
processes
present
significant
obstacles
to
senescent
repair.
To
address
issues,
engineered
extracellular
vesicles
(EV)
with
stem
functions
were
developed.
This
study
demonstrated
that
Apt19s-engineered
(Apt19s-EV)
recognize
recruit
marrow
mesenchymal
cells
derived
from
old
rats
(O-BMSCs)
specifically
effectively.
MiR-376b-5p,
identified
by
RNA
sequencing
transfection,
was
significantly
decreased
O-BMSCs,
it
selected
construct
miR-376b-5p-engineered
(376b-EV).
376b-EV
could
promote
osteogenesis
alleviate
senescence
of
O-BMSCs
targeting
Camsap1.
combine
the
advantages
Apt19s
miR-376b-5p,
dual
(Apt-376b-EV)
comprising
both
miR-376b-5p
modifications
constructed.
further
validate
its
function,
Gelatin
methacryloyl
(GelMA)
hydrogel
used
as
carrier
Apt-376b-EV@GelMA
delivery
system.
The
vitro
results
have
sequentially.
Notably,
vivo
also
showed
sequentially
endogenous
enhance
new
formation
fracture
critical-sized
defect
models.
In
summary,
vesicles,
Apt-376b-EV,
offer
an
appealing
solution
for
recruiting
promoting
microenvironment,
which
may
broaden
clinical
applications
EV
provide
valuable
strategies
treating
bone-related
diseases
future
work.
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
1(3)
Published: July 1, 2023
Abstract
Osteoporosis
is
a
systemic
and
degenerative
disease
characterized
by
low
bone
mass
fragile
microarchitecture,
which
predispose
patients
to
fragility
fractures,
also
known
as
osteoporotic
fractures
(OPF).
OPF
have
become
major
social
problem
that
threaten
the
health
of
elderly.
Over
past
decade,
organoids
extracellular
vesicles
(OEVs)
play
significant
role
in
repair.
Organoids
been
widely
used
for
treatment.
Moreover,
EVs
are
promising
nanocarriers
due
their
cell‐free
system,
stable
drug
loading
capacity,
nanometer
size,
good
biocompatibility.
Importanly,
compared
with
traditional
EVs,
OEVs
more
quantity,
better
physiological
effects,
therapeutic
effects.
Therefore,
development
organoid
treatment
great
significance.
Here,
we
summarize
current
status
future
perspectives
OEVs,
will
provide
innovative
solutions
