World Journal of Diabetes,
Journal Year:
2024,
Volume and Issue:
15(11), P. 2177 - 2181
Published: Oct. 16, 2024
In
this
editorial,
we
discuss
the
article
by
Wen
et
al
published.
Diabetic
foot
ulcers
are
prevalent
and
serious
complications
of
diabetes,
significantly
impacting
patients’
quality
life
often
leading
to
disability
or
death,
thereby
placing
a
heavy
burden
on
society.
Effective
diabetic
wound
healing
is
hindered
an
imbalance
in
macrophage
polarization;
many
macrophages
fail
transition
from
pro-inflammatory
M1
phenotype
anti-inflammatory
M2
phenotype,
which
crucial
for
tissue
remodelling
repair.
The
process
both
dynamic
complex.
Healthy
macrophages,
have
strong
phagocytic
abilities,
vital
during
inflammatory
phase
healing.
However,
failure
proliferative
hinders
We
anticipate
development
new
therapies
that
can
repair
damaged
promote
polarization
phase,
enhancing
overall
process.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 14, 2024
Macrophages
play
a
pivotal
role
in
the
healing
of
diabetic
ulcers.
The
sustained
elevation
glucose
levels
damages
insulin
signaling
pathway
macrophages,
leading
to
dysfunctional
macrophages
that
struggle
transition
from
pro-inflammatory
(M1)
reparative
(M2)
states.
Therefore,
modulating
macrophage
inflammatory
responses
via
holds
promise
for
ulcer
treatment.
Additionally,
presence
biofilm
impedes
drug
penetration,
and
resulting
immunosuppressive
microenvironment
exacerbates
persistent
infiltration
M1
macrophages.
we
designed
an
array
dissolvable
microneedle
(denoted
as
NPF@MN)
loaded
with
self-assembled
nanoparticles
could
deliver
NPF
nanoparticles,
acid-sensitive
NPF-releasing
Protocatechualdehyde
(PA)
hypoglycemic
insulin-like
effects,
regulating
polarization
anti-inflammatory
M2
phenotype.
this
study
extensively
examined
mechanism
by
which
NPF@MN
accelerates
ulcers
through
activation
pathway.
Through
RNA-seq
GSEA
analysis,
identified
reduction
expression
pathway-related
factors
such
IR,
IRS-1,
IRS-2,
SHC.
Our
work
presents
innovative
therapeutic
approach
targeting
underscores
its
translational
potential
clinical
management.
Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 9, 2024
Since
wound
healing
is
one
of
the
most
important
medical
challenges
and
common
dressings
have
not
been
able
to
manage
this
challenge
well
today,
efforts
increased
achieve
an
advanced
dressing.
Mesenchymal
stem
cells
exosomes
derived
from
them
shown
high
potential
in
regenerating
wounds
due
their
immunomodulatory,
anti-inflammatory,
immunosuppressive,
regenerative
capacities.
However,
such
as
short
life
these
cells,
low
durability
area,
stability
resulted
limitations
use
for
healing.
Nowadays,
different
scaffolds
are
considered
suitable
biomaterials
These
made
natural
or
synthetic
polymers
promising
ideal
dressing
that
does
disadvantages
dressings.
One
strategies
has
attracted
much
attention
today
using
seeding
delivering
MSCs
exosomes.
This
combined
strategy
a
enhancing
shelf
increasing
In
review,
combination
with
comprehensively
discussed.
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
Hydrogels,
composed
of
three-dimensional
polymer
networks,
are
excellent
delivery
carriers
and
have
been
extensively
employed
in
the
biomedical
field.
Inflammation
acts
as
a
protective
mechanism
to
prevent
harmful
substances
from
entering
living
organisms,
but
chronic,
long-lasting
inflammation
can
cause
oxidative
stress,
which
damages
tissue
organs
adversely
affects
patients’
quality
life.
The
aberrant
expression
microRNAs
(miRNAs)
has
found
play
significant
part
etiology
progression
inflammatory
diseases,
suggested
by
growing
evidence.
Numerous
hydrogels
that
act
gene
for
intracellular
miRNA
described
during
ongoing
research
into
innovative
hydrogel
materials.
MiRNA
systems,
loaded
with
exogenous
inhibitors
or
mimics,
enable
targeted
intervention
diseases
effectively
environmental
stressors
degrading
inactivating
miRNA.
In
this
review,
we
summarize
classification
basic
strategies
mechanisms
loading
miRNAs
hydrogels,
highlight
applications
systems
share
our
viewpoints
on
potential
opportunities
challenges
promising
region
systems.
These
findings
may
provide
new
theoretical
basis
prevention
treatment
inflammation-related
lay
foundation
clinical
translation.
