Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(47)
Published: Oct. 3, 2024
Abstract
Acute
lung
injury
(ALI)
is
a
severe
complication
in
clinical
settings.
Alert
diagnosis
and
severity
assessment
of
ALI
pivotal
to
ensure
curative
treatment
increase
survival
rates.
However,
the
development
precise
diagnostic
strategy
remains
pending
task.
Here,
leveraging
neutrophil's
inflammation‐homing
physiological
barrier‐navigating
capability,
facile
proposed
for
achieving
targeted
19
F‐MRI
detection
based
on
nanoengineered
neutrophil
internalized
with
perfluorocarbon
nanoemulsion
(Neu@PFC).
The
remodeling
process
poses
negligible
impact
inherent
activation
transmigration
functions.
migratory
behavior
Neu@PFC
toward
pneumonia
confirmed
vivo
using
an
LPS‐induced
murine
model.
Direct
intratracheal
(
i.t
.)
administration
contributes
vast
deposition
within
lung,
allowing
real‐time
visualization
potential
predict
progressive
pneumonia.
Furthermore,
intravenous
i.v
enables
quantitative
extent
due
chemokine‐guided
migration.
This
study
not
only
provides
pathway
diagnose
ALI,
but
also
sheds
light
recruitment
cues
different
tissues
inflammatory
conditions,
which
prerequisite
developing
therapeutic
approaches.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Abstract
Osteoarthritis
(OA)
is
recognized
as
a
highly
friction‐related
joint
disease
primarily
associated
with
increased
friction
and
inflammation
due
to
pro‐inflammatory
M1‐type
macrophage
infiltration
in
the
articular
cavity.
Therefore,
strategies
simultaneously
increase
lubrication
relieve
remodel
damaged
microenvironment
are
of
great
significance
for
enhancing
its
treatment.
Herein,
multifunctional
core‐brush
nanoplatform
composed
ROS‐scavenging
polydopamine‐coated
SiO
2
core
lubrication‐enhancing
zwitterionic
poly(2‐methacryloyloxyethyl
phosphorylcholine)
(PMPC)
brush
loaded
anti‐inflammatory
drug
curcumin
by
reactive
oxygen
species
(ROS)‐liable
conjugation
(named
@PP‐Cur)
rationally
designed.
Benefiting
from
grafted
PMPC
brush,
tenacious
hydration
layer
enhanced
lubricity
reducing
abrasions
developed.
More
importantly,
based
on
mono‐iodoacetic
acid‐induced
arthritis
(MIA)
rat
model,
intra‐articular
injection
@PP‐Cur
can
effectively
alleviate
via
promoting
polarization
M1
M2
state
activating
nuclear
factor
erythroid
2‐related
(Nrf2)
signaling
pathway
attenuating
degradation
cartilage
matrix,
resulting
remodeling
into
pro‐regenerative
microenvironment.
As
result,
considerably
inhibit
OA
progression.
work
may
provide
novel
strategy
development
an
advanced
therapy.
Advanced NanoBiomed Research,
Journal Year:
2023,
Volume and Issue:
3(12)
Published: Nov. 21, 2023
Despite
remarkable
advances
in
understanding
the
mechanisms
underlying
inflammation,
currently
available
anti‐inflammatory
therapies
have
many
limitations,
such
as
poor
efficacies,
low
selectivity,
and
severe
adverse
effects.
Bioactive
materials
with
intrinsically
activities
emerged
promising
drug
candidates
for
treatment
of
inflammatory
disorders.
Among
them,
nanotherapies
based
on
bioactive
cyclodextrin
(CD)
attracted
much
attention,
owing
to
their
multiple
advantages,
including
broad
availability,
well‐controlled
structures,
easy
functionalization,
good
processibility,
high
cost‐effectiveness,
excellent
biocompatibility.
This
review
provides
a
comprehensive
overview
recent
advancements
development
applications
nanoparticles
(NPs)
CD
materials,
special
focus
reactive
oxygen
species‐scavenging
NPs
capable
regulating
cell
recruitment
activation.
In
addition,
these
different
acute/chronic
diseases
are
highlighted.
Furthermore,
major
challenges
clinical
translation
new
generation
derived
from
discussed.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
27, P. 101119 - 101119
Published: June 11, 2024
Cancer
represents
a
significant
threat
to
human
health,
with
the
use
of
traditional
chemotherapy
drugs
being
limited
by
their
harsh
side
effects.
Tumor-targeted
nanocarriers
have
emerged
as
promising
solution
this
problem,
they
can
deliver
directly
tumor
site,
improving
drug
effectiveness
and
reducing
adverse
However,
efficacy
most
nanomedicines
is
hindered
poor
penetration
into
solid
tumors.
Nanomotors,
capable
converting
various
forms
energy
mechanical
for
self-propelled
movement,
offer
potential
enhancing
delivery
deep
regions.
External
force-driven
nanomotors,
such
those
powered
magnetic
fields
or
ultrasound,
provide
precise
control
but
often
necessitate
bulky
costly
external
equipment.
Bio-driven
propelled
sperm,
macrophages,
bacteria,
utilize
biological
molecules
self-propulsion
are
well-suited
physiological
environment.
constrained
lifespan,
inadequate
speed,
immune
responses.
To
address
these
issues,
nanomotors
been
engineered
propel
themselves
forward
catalyzing
intrinsic
"fuel"
in
microenvironment.
This
mechanism
facilitates
through
barriers,
allowing
them
reach
regions
targeted
delivery.
In
regard,
article
provides
review
microenvironment-activatable
(fueled
hydrogen
peroxide,
urea,
arginine),
discusses
prospects
challenges
clinical
translation,
aiming
new
insights
safe,
efficient,
treatment
cancer
therapy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(47)
Published: Oct. 3, 2024
Abstract
Acute
lung
injury
(ALI)
is
a
severe
complication
in
clinical
settings.
Alert
diagnosis
and
severity
assessment
of
ALI
pivotal
to
ensure
curative
treatment
increase
survival
rates.
However,
the
development
precise
diagnostic
strategy
remains
pending
task.
Here,
leveraging
neutrophil's
inflammation‐homing
physiological
barrier‐navigating
capability,
facile
proposed
for
achieving
targeted
19
F‐MRI
detection
based
on
nanoengineered
neutrophil
internalized
with
perfluorocarbon
nanoemulsion
(Neu@PFC).
The
remodeling
process
poses
negligible
impact
inherent
activation
transmigration
functions.
migratory
behavior
Neu@PFC
toward
pneumonia
confirmed
vivo
using
an
LPS‐induced
murine
model.
Direct
intratracheal
(
i.t
.)
administration
contributes
vast
deposition
within
lung,
allowing
real‐time
visualization
potential
predict
progressive
pneumonia.
Furthermore,
intravenous
i.v
enables
quantitative
extent
due
chemokine‐guided
migration.
This
study
not
only
provides
pathway
diagnose
ALI,
but
also
sheds
light
recruitment
cues
different
tissues
inflammatory
conditions,
which
prerequisite
developing
therapeutic
approaches.
