Photon-Powered Ceramics: New Frontiers in Material Science and Applications DOI
Pablo Serna-Gallén,

Robinson Cadena,

Samuel Porcar

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

This chapter provides a comprehensive review of light-mediated processes in advanced ceramics, emphasizing their role developing new materials with enhanced properties. The discussion covers photocatalysis for environmental remediation and energy production, ceramic photovoltaic cells sustainable energy, the ceramics photonic devices, such as waveguides, lasers, optical fibers. analysis also includes applications laser technology, focusing on properties, biocompatible bioactive biotechnology drug delivery, sensors, theragnosis. Additionally, examines how contribute to sustainability circular economy by enhancing material properties at nanoscale promoting energy-efficient production recycling methods. aim is highlight transformative potential light interactions driving advancements efficiency, protection, medical inspiring future research these areas.

Language: Английский

MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings DOI Creative Commons
Ashkan Bigham,

Negar Islami,

Arezoo Khosravi

et al.

Small, Journal Year: 2024, Volume and Issue: 20(30)

Published: March 7, 2024

Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials

Language: Английский

Citations

36

Black Titania Janus Mesoporous Nanomotor for Enhanced Tumor Penetration and Near-Infrared Light-Triggered Photodynamic Therapy DOI

Kexin Lv,

Mengmeng Hou, Yufang Kou

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(21), P. 13910 - 13923

Published: May 16, 2024

Thanks to their excellent photoelectric characteristics generate cytotoxic reactive oxygen species (ROS) under the light-activation process, TiO2 nanomaterials have shown significant potential in photodynamic therapy (PDT) for solid tumors. Nevertheless, limited penetration depth of TiO2-based photosensitizers and excitation sources (UV/visible light) PDT remains a formidable challenge when confronted with complex tumor microenvironments (TMEs). Here, we present H2O2-driven black mesoporous nanomotor near-infrared (NIR) light absorption capability autonomous navigation ability, which effectively enhances NIR light-triggered PDT. The was rationally designed fabricated based on Janus nanostructure, consists light-responsive nanosphere an enzyme-modified periodic organosilica (PMO) nanorod that wraps around nanosphere. overexpressed H2O2 can drive TME catalysis catalase PMO domain. By precisely controlling ratio compartments TiO2&PMO nanomotors achieve optimal self-propulsive directionality velocity, enhancing cellular uptake facilitating deep penetration. Additionally, by decomposition endogenous within tumors, these continuously supply enable highly efficient ROS production photocatalysis TiO2, leading intensified effects effective inhibition.

Language: Английский

Citations

26

Development of an antibacterial and antioxidative nanofibrous membrane using curcumin-loaded halloysite nanotubes for smart wound healing: In vitro and in vivo studies DOI
Mohamadreza Shakiba, Mehdi Sheikhi,

Zohreh Pahnavar

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 642, P. 123207 - 123207

Published: July 1, 2023

Language: Английский

Citations

35

A theragenerative bio-nanocomposite consisting of black phosphorus quantum dots for bone cancer therapy and regeneration DOI Creative Commons
Ashkan Bigham, Ines Fasolino, Silvia Borsacchi

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 99 - 121

Published: Jan. 24, 2024

Recently, the term theragenerative has been proposed for biomaterials capable of inducing therapeutic approaches followed by repairing/regenerating tissue/organ. This study is focused on design a new nanocomposite composed an amphiphilic non-ionic surfactant (Pluronic F127), bioactive glass (BG), and black phosphorus (BP). The was prepared through two-step synthetic strategy, including microwave treatment that turned BP nanosheets (BPNS) into quantum dots (BPQDs) with 5 ± 2 nm dimensions in situ. effects were assessed vitro: distributes ions homogenously throughout composite chemically stabilizes composite. presence enhanced bioactivity promoted calcium phosphate formation simulated body fluid. inherent anticancer activity BP-containing nanocomposites tested against osteosarcoma cells vitro, finding 150 μg mL−1 lowest concentration which prevented proliferation SAOS-2 cells, while counterpart without did not affect cell growth rate. Moreover, apoptosis pathways evaluated mechanism action proposed. NIR irradiation applied to induce further suppression hyperthermia. inhibitory bare nanomaterials migration invasion bone cancer, breast prostate cancer vitro determine potential primary secondary cancers. regenerative behavior healthy osteoblasts human mesenchymal stem cells; BPQDs-incorporated significantly osteoblast induced osteogenic differentiation cells. introduces multifunctional platform promising simultaneous therapy regeneration.

Language: Английский

Citations

15

Inspired by nature: Bioinspired and biomimetic photocatalysts for biomedical applications DOI Creative Commons
Ashkan Bigham, Atefeh Zarepour, Moein Safarkhani

et al.

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

The field of photocatalysis has witnessed a significant advancement in the development bioinspired and biomimetic photocatalysts for various biomedical applications, including drug delivery, tissue engineering, cancer therapy, bioimaging. Nature evolved efficient light-harvesting systems energy conversion mechanisms, which serve as benchmark researchers. However, reproducing such complexity harnessing it applications is daunting task. It requires comprehensive understanding underlying biological processes ability to replicate them synthetically. By utilizing light energy, these can trigger specific chemical reactions, leading targeted release, enhanced regeneration, precise imaging structures. In this context, addressing stability, long-term performance, scalability, cost-effectiveness materials crucial their widespread implementation applications. While challenges stability persist, advantages delivery personalized medicine make fascinating area research. purpose review provide analysis evaluation existing research, highlighting advancements, current challenges, advantages, limitations, future prospects biomedicine.

Language: Английский

Citations

14

Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties DOI

Nahal Abie,

Ceyda Ünlü,

Ana Rita Pinho

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Biomaterial-mediated bone tissue engineering (BTE) offers an alternative, interesting approach for the restoration of damaged tissues in postsurgery osteosarcoma treatment. This study focused on synthesizing innovative composite inks, integrating self-assembled silk fibroin (SF), tannic acids (TA), and electrospun bioactive glass nanofibers 70SiO2-25CaO-5P2O5 (BGNF). By synergistically combining unique characteristics these three components through self-assembly microextrusion-based three-dimensional (3D) printing, our goal was to produce durable versatile aerogel-based 3D scaffolds. These scaffolds were designed exhibit hierarchical porosity along with antibacterial, antiosteosarcoma, regeneration properties. Taking inspiration from mussel foot protein attachment chemistry involving coordination dihydroxyphenylalanine (DOPA) amino ferric ions (Fe3+), we synthesized a tris-complex catecholate-iron gel. gel formation occurred oxidized SF (SFO) TA polydopamine-modified BGNF (BGNF-PDA). The dynamic nature ligand–metal bonds within SFO matrix provided excellent shear-thinning properties, allowing SFO-TA-BGNF complex be extruded nozzle, facilitating printing into outstanding shape fidelity. Moreover, developed aerogels exhibited multifaceted features, including NIR-triggered photothermal antibacterial vitro antiosteosarcoma In studies showcased their biocompatibility osteogenic features as seeded cells successfully differentiated osteoblasts, promoting 21 days. Through comprehensive characterizations biological validations, scaffold demonstrated promise exceptional platform concurrent cancer therapy, setting stage potential clinical application.

Language: Английский

Citations

10

Heterojunction‐Mediated Co‐Adjustment of Band Structure and Valence State for Achieving Selective Regulation of Semiconductor Nanozymes DOI
Jiahao Huang,

Xiaodan Jia,

Yue Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 12, 2024

Improving reaction selectivity is the next target for nanozymes to mimic natural enzymes. Currently, majority of strategies in this field are exclusively applicable metal-organic-based or organic-based nanozymes, while limited regulating metal oxide-based semiconductor nanozymes. Herein, taking Co

Language: Английский

Citations

8

Recent advances in plant-derived polysaccharide scaffolds in tissue engineering: A review DOI
Lijun Shang, Shan Wang, Yingji Mao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 133830 - 133830

Published: July 11, 2024

Language: Английский

Citations

6

Black phosphorus-based nanoplatforms for cancer therapy: chemistry, design, biological and therapeutic behaviors DOI Creative Commons
Ashkan Bigham, Manuel Serrano‐Ruiz, Maria Caporali

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Black phosphorus nanomaterials have opened new doors to cancer therapy. They can induce anticancer activities intrinsically (selectively) and/or with external stimuli (PTT, PDT, SDT, etc. ) and are highly suitable for drug/gene delivery.

Language: Английский

Citations

6

Sustainable nanomaterials for precision medicine in cancer therapy DOI
Ashkan Bigham, Atefeh Zarepour, Arezoo Khosravi

et al.

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 27, P. 100865 - 100865

Published: May 27, 2024

Language: Английский

Citations

4