Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)

Published: Jan. 11, 2024

Cancer poses a significant challenge to global public health, seriously threatening human health and life. Although various therapeutic strategies, such as chemotherapy (CT), radiotherapy, phototherapy, starvation therapy, are applied cancer treatment, their limited effect, severe side effects, unsatisfactory drug release behavior need be carefully considered. Thus, there is an urgent develop efficient delivery strategies for improving treatment efficacy realizing on-demand delivery. Notably, pillararenes, emerging class of supramolecular macrocycles, possess unique properties highly tunable structures, superior host-guest chemistry, facile modification, good biocompatibility, which widely used in therapy achieve controllable reduce the toxic effects on normal tissues under internal/external stimuli conditions. This review summarizes recent advance stimuli-responsive systems (SDSs) based pillararenes tumor from perspectives different assembly methods hybrid materials, including molecular-scale SDSs, nano self-assembly systems, nanohybrid SDSs. Moreover, prospects critical challenges SDSs also discussed.

Language: Английский

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Separation of benzene and toluene associated with vapochromic behaviors by hybrid[4]arene-based co-crystals

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 10, 2024

Abstract The combination of macrocyclic chemistry with co-crystal engineering has promoted the development materials vapochromic behaviors in supramolecular science. Herein, we develop a macrocycle based on hybrid[4]arene and 1,2,4,5-tetracyanobenzene that is able to construct materials. After capture benzene toluene vapors, activated hybrid[4]arene-based forms new structures, accompanied by color changes from brown yellow. However, when captures cyclohexane pyridine, neither structures nor colors change. Interestingly, can separate benzene/cyclohexane equal-volume mixture allow be removed toluene/ pyridine purities reaching 100%. In addition, process adsorptive separation visually monitored. selectivity attributed different charge-transfer interaction between vapors. Moreover, reused without losing performance. This work constructs material for hydrocarbon separation.

Language: Английский

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Immunoadjuvant-Functionalized Metal-Organic Frameworks：Synthesis and Applications in Tumor Immune Modulation

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.

Language: Английский

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Supramolecular systems for bioapplications: recent research progress in China

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441

Published: March 22, 2024

Language: Английский

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Selenium electrophilic center shuttles active electrons to boost mitochondrial electron leakage

Published: Feb. 1, 2025

Language: Английский

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Host-guest-induced electronic state triggers two-electron oxygen reduction electrocatalysis

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 25, 2024

Supramolecular polymers possess great potential in catalysis owing to their distinctive molecular recognition and dynamic crosslinking features. However, investigating supramolecular electrocatalysts with high efficiency oxygen reduction reaction hydrogen peroxide (ORHP) remains an unexplored frontier. Herein, we present organic for ORHP by introducing cyclodextrin-containing noncovalent building blocks, affording these supramolecules abundant bonds. The electronic states kinetics are further well-modulated via a host-guest strategy, resulting appropriate regional electron binding force controllable chemical activity. Notably, integrating units into phenyl group-containing model covalent polymer achieves production rate of 9.14 mol g

Language: Английский

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A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16967 - 16981

Published: June 18, 2024

Selective generation of sufficient pyroptosis inducers at the tumor site without external stimulation holds immense significance for a longer duration immunotherapy. Here, we report cascade-amplified inducer CSCCPT/SNAP that utilizes reactive nitrogen species (RNS), self-supplied from diffusion-controlled reaction between oxygen (ROS) and nitric oxide (NO) to potentiate immunotherapy, while both endogenous mitochondrial ROS stimulated by released camptothecin NO initiate pyroptosis. Mechanistically, cascade amplification antitumor immune response is prompted cooperation enhanced RNS with long lifetime, which could be used as trigger effectively compensate inherent drawbacks ROS, resulting in long-lasting favoring Tumor growth efficiently inhibited mouse melanoma tumors through facilitation oxygen/nitrogen (RONS)-NO synergy. In summary, our therapeutic approach supramolecular engineering nanotechnology integrate producers donors tumor-specific stimulus responses into system guarantees synchronous these two elicit pyroptosis-evoked response, using amplifier. RONS-NO synergy achieves sustained robust cancer

Language: Английский

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Selectivity Separation of Ortho-Chlorotoluene Using Nonporous Adaptive Crystals of Hybrid[3]arene

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1631 - 1638

Published: Jan. 18, 2024

Ortho-chlorotoluene serves as a vital raw material in the petrochemical industries. However, due to alkylation and chlorination, ortho-chlorotoluene is often mixed with meta-chlorotoluene para-chlorotoluene. The selective separation of from chlorotoluene isomers crucial step industrial production. owing close boiling points isomers, traditional methods demand large amount energy. Therefore, there an urgent need develop new achieve efficient isomers. Herein, we developed adsorptive strategy using nonporous adaptive crystals hybrid[3]arene H (Hα). Hα was proved be highly effective binary or ternary mixture Single-crystal structure analysis electrostatic potential maps indicated that selectivity derived stable host–guest between H. Besides, exhibited high recyclability reversible transformation guest-free guest-contained structures.

Language: Английский

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Development of a versatile biomaterial of chitosan polymer/ginger (Zingiber officinale Roscoe) extract/ZnO bionanocomposite: physicochemical properties, antioxidant activity, and breast cancer therapy

Research on Chemical Intermediates, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

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The Expression Kinetics and Immunogenicity of Lipid Nanoparticles Delivering Plasmid DNA and mRNA in Mice

Vaccines, Journal Year: 2023, Volume and Issue: 11(10), P. 1580 - 1580

Published: Oct. 11, 2023

In recent years, lipid nanoparticles (LNPs) have emerged as a revolutionary technology for vaccine delivery. LNPs serve an integral component of mRNA vaccines by protecting and transporting the payload into host cells. Despite their prominence in vaccines, there remains notable gap our understanding potential application delivery DNA vaccines. this study, we sought to investigate suitability leading LNP formulations plasmid (pDNA). addition, aimed explore key differences properties popular when delivering either or DNA. To address these questions, compared three encapsulating mRNA- pDNA-encoding firefly luciferase based on potency, expression kinetics, biodistribution, immunogenicity. Following intramuscular injection mice, determined that RNA-LNPs formulated with SM-102 ALC-0315 lipids were most potent (all p-values < 0.01) immunogenic 0.05), while DNA-LNPs demonstrated longest duration signal. Additionally, all found induce liver was proportional signal at site (SM102: r = 0.8787, p 0.0001; ALC0315: 0.9012, KC2: 0.9343, 0.0001). Overall, study provides important insights between applicability DNA- RNA-based vaccinations.

Language: Английский

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