Hydrogen-Peroxide-Independent Chemodynamic Therapy via Docosahexaenoic-Acid-Hydroperoxide-Rich-Cytomembrane-Coated Magnetic Nanoparticles DOI
Wen‐Long Liu, Amin Cao, Haoran Li

et al.

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 27, 2023

In tumor therapy, tactics for producing reactive oxygen species (ROS) are already being employed to disrupt the balance of redox equilibrium in cells and cause cell death. Among these, chemodynamic therapy (CDT) is an ingenious means produce ROS via Fenton reaction. The insufficiency site or lability vivo administration hydrogen peroxide has posed significant obstacles applications CDT. Herein, we report docosahexaenoic acid hydroperoxide (D-OOH)-rich-cytomembrane-coated magnetic nanoparticles (MNP@D-OOH) hydrogen-peroxide-independent D-OOH facile incorporate into cytomembrane efficient with little risk leakage alteration. microenvironment, MNPs decompose Fe2+, which can react just like This study offers beneficial insights clinical transformation

Language: Английский

Chitosan-based hydrogel dressings for diabetic wound healing via promoting M2 macrophage-polarization DOI

Xuelian Wei,

Caikun Liu,

Zhiqian Li

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 331, P. 121873 - 121873

Published: Jan. 30, 2024

Language: Английский

Citations

41
Nitric Oxide-Producing Multiple Functional Nanoparticle Remodeling Tumor Microenvironment for Synergistic Photodynamic Immunotherapy against Hypoxic Tumor DOI
Shuyu Xu, Xinxin Xie, Ping He

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

The treatment of pancreatic cancer faces significant challenges due to connective tissue hyperplasia and severe hypoxia. Unlike oxygen-dependent Type II photosensitizers, I photosensitizers can produce a substantial amount reactive oxygen species, even under hypoxic conditions, making them more suitable for photodynamic therapy cancer. However, the dense extracellular matrix limits penetration efficiency presence immunosuppressive cells in tumor microenvironment reduces therapeutic effect. To address these challenges, we designed photoimmunotherapeutic M1@PAP nanoparticles composed photosensitizer anti-PD-L1 siRNA (siPD-L1), which was encapsulated into M1 macrophage membrane vesicles. In this system, pyropheophorbide-a (PPA) covalently conjugated poly-l-arginine (Arg9). Notably, it capable generating sufficient superoxide anions thereby functioning as photosensitizer. Furthermore, Arg9 acted nitric oxide (NO) donor, enhancing nanophotosensitizer by inhibiting cancer-associated fibroblast (CAF) activation decomposing matrix. Additionally, vesicles provided active targeting capabilities reeducated immunosuppressed M2 macrophages. reversal further promoted efficacy immunotherapy, showing great potential synergistic immunotherapy against tumor.

Language: Английский

Citations

1
Magnetic Control of Multiscale Ligand Nanoarchitecture Regulates Stem Cell Fate DOI Open Access
Ramar Thangam, Hyunsik Hong, Nayeon Kang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Native tissues exhibit hierarchical structures of anisotropically arranged extracellular matrix that dynamically regulate stem cells and tissue function. However, neither multiscale nano‐anisotropy nor dynamic anisotropy control have been reported. In this study, spherical or rod‐shaped gold small‐nanomaterials (at integrin receptor‐scale; tens nanometers) are coupled to the surface magnetic large‐nanomaterials focal adhesion complex‐scale; hundreds nanometers), with both showing constant areas at each respective scale. Each nanocomposite is flexibly conjugated substrate material densities, resulting in dual‐scale liganded nano‐anisotropies. Increasing aspect ratio nanomaterials nanometer‐scale dominantly promotes recruitment, adhesion, mechanotransduction, differentiation over nanometer‐scale. Such scale‐specific effects on cell regulation temporally regulated vitro vivo by physically raising lowering nanocomposites respectively inhibit stimulate curved surfaces modulating membrane bending. unprecedented “dynamic ligand anisotropy” can be independently engineered regarding scales, anisotropies, ligands elucidate cell‐material interactions allow for multimodal enhance tissue‐regenerative therapy.

Language: Английский

Citations

1
Degradable and Piezoelectric Hollow ZnO Heterostructures for Sonodynamic Therapy and Pro-Death Autophagy DOI
Lihan Cai, Tao Sun,

Fuping Han

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 24, 2024

Piezoelectric materials can generate charges and reactive oxygen species (ROS) under external force stimulation for ultrasound-induced sonodynamic therapy (SDT). However, their poor piezoelectricity, fast electron–hole pair recombination rate, biological toxicity of piezoelectric limit the therapeutic effects SDT. In this study, hollow ZnO (HZnO) nanospheres were synthesized by using a one-step method. The structure facilitated deformation HZnO ultrasound mechanical increased constant. Subsequently, black phosphorus quantum dots (BPQDs) arginine-glycine-aspartic acid peptide (RGD)-poly(ethylene glycol) (PEG) combined with to further enhance effect constructing heterojunctions enable tumor-targeting ability. During treatment, HZnO-BPQDs-PEG could degrade in an acidic tumor microenvironment release Zn2+ PO43– ions induce pro-death autophagy. ROS produced SDT also accelerated autophagy promoted ferroptosis cancer cells. This study demonstrates that has strong effectively cells, providing new idea design application therapy.

Language: Английский

Citations

8
Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy DOI Creative Commons
Xuancheng Fu, Xiaoran Hu

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 2, 2024

Ultrasound has gained prominence in biomedical applications due to its noninvasive nature and ability penetrate deep tissue with spatial temporal resolution. The burgeoning field of ultrasound-responsive prodrug systems exploits the mechanical chemical effects ultrasonication for controlled activation prodrugs. In polymer mechanochemistry, materials scientists exploit sonomechanical effect acoustic cavitation mechanochemically activate force-sensitive On other hand, researchers sonodynamic therapy adopt fundamentally distinct methodologies, utilizing sonochemical (e.g., generation reactive oxygen species) ultrasound presence sonosensitizers induce transformations that This cross-disciplinary review comprehensively examines these two divergent yet interrelated approaches, both which originated from cavitation. It highlights molecular design strategies potential diverse therapeutic contexts, chemotherapy immunotherapy gene methods, discusses future directions this rapidly advancing domain.

Language: Английский

Citations

7
Semiconducting polymer nanoprodrugs enable tumor-specific therapy via sono-activatable ferroptosis DOI

Fengshuo Wang,

Zhiting Wu,

Yijing Zhang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122722 - 122722

Published: July 29, 2024

Language: Английский

Citations

6
Ultrasound-activated mechanochemical reactions for controllable biomedical applications DOI Creative Commons

Maocheng Zuo,

Rong Xiao,

Fangxue Du

et al.

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

5
FeNC nanozyme-based electrochemical immunoassay for sensitive detection of human epidermal growth factor receptor 2 DOI

Minghao Qiu,

Yuqing Ren,

Lumin Huang

et al.

Microchimica Acta, Journal Year: 2023, Volume and Issue: 190(10)

Published: Sept. 6, 2023

Language: Английский

Citations

10
Challenging and new opportunities for prodrug technology DOI
Helin Li,

Xuelian Shen,

Yu Chu

et al.

Investigational New Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

0
l-Cysteine-Triggered Regulation of the Mitochondrial Energy Metabolism To Enhance Chemotherapy of Triple-Negative Breast Cancer DOI

Haoying Ge,

Jianjun Du,

Jiazhu Zheng

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(3), P. 1050 - 1058

Published: Feb. 20, 2024

Although cisplatin has widely been used for treating triple-negative breast cancer (TNBC), its anticancer effect remains unsatisfactory, due to the heavy resistance. In this study, oxidative phosphorylation (OxPhos) was proposed effectively regulate intracellular energy metabolism of heat and adenosine-triphosphate (ATP) improve efficacy in treatment TNBC. Crylic acid-caged 2,4-dinitrophenol (DNPA) developed as a novel pro-uncoupler OxPhos. By depletion cysteine, is released promote oxidation inhibit phosphorylation, which results generation rather than ATP. Importantly, generated can increase cross-linking between DNA, while reduction ATP downregulate DNA repair enzymes. Furthermore, both cysteine inhibits glutathione (GSH) synthesis TNBC cells, alleviates GSH-mediated inactivation disrupts redox microenvironment, thereby promoting ferroptosis apoptosis.

Language: Английский

Citations

3