Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 2, 2024
Abstract
The
elimination
of
localized
cancer
pain
remains
a
globally
neglected
challenge.
A
potential
solution
lies
in
combining
gas
therapy
with
targeted
interventional
ablation
therapy.
In
this
study,
HA‐As
2
S
3
nanoparticles
controlled
sizes
are
synthesized
using
different
molecular
weights
sodium
hyaluronate
(HA)
as
supramolecular
scaffold.
Initially,
HA
co‐assembles
arsenic
ions
(As
3+
)
via
coordinate
bonds,
forming
scaffold
intermediates.
These
intermediates,
varying
size,
then
react
sulfur
to
produce
size‐controlled
particles.
This
approach
demonstrates
that
enable
precise
control
over
the
particle
size
sulfide,
offering
straightforward
and
environmentally
friendly
method
for
synthesizing
metal
sulfide
an
acidic
environment,
release
hydrogen
sulfide(H
S)
As
.
released
directly
damage
tumor
mitochondria,
leading
substantial
reactive
oxygen
species
(ROS)
production
from
mitochondria.
Concurrently,
H
inhibits
activity
catalase
(CAT)
complex
IV,
preventing
beneficial
decomposition
ROS
disrupting
electron
transfer
mitochondrial
respiratory
chain.
Consequently,
it
is
found
significantly
enhances
induced
by
nanodrugs,
effectively
killing
local
tumors
ultimately
eliminating
mice.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Sept. 28, 2024
Excessive
accumulation
of
reactive
oxygen
and
nitrogen
species
(RONS)
dysbiosis
intestinal
microbiota
are
pivotal
symptoms
for
inflammatory
bowel
disease
(IBD)
its
associated
complications,
such
as
fibrosis.
This
research
introduces
a
probiotic
inulin
hydrogel
loaded
with
polypyrrole
(PPy)
nanozymes
antifibrotic
drug
pirfenidone
(PFD)
(PPy/PFD@Inulin
gel)
designed
the
concurrent
amelioration
IBD
fibrotic
complication.
Upon
oral
administration,
gel
matrix
could
extend
gastrointestinal
residence
time
PPy
PFD,
facilitating
efficient
reduction
pro-inflammatory
cytokine
levels
enhancement
epithelial
barrier
repair
well
suppression
fibrosis
through
sustained
RONS
scavenging,
modulation
gut
attenuation
TGF-β/Smad
signaling
pathway
to
inhibit
fibroblast
proliferation.
Notably,
PPy/PFD@Inulin
demonstrated
significant
prophylactic
therapeutic
efficacy
in
acute
chronic
colitis
induced
by
dextran
sodium
sulfate
(DSS)
mouse
models.
Thus,
engineered
ternary
offered
pioneered
paradigm
simultaneous
reversal
fibrosis,
single
regimen.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Natural
plant‐derived
polysaccharides
exhibit
substantial
potential
for
treating
ulcerative
colitis
(UC)
owing
to
their
anti‐inflammatory
and
antioxidant
properties
favorable
safety
profiles.
However,
practical
application
faces
several
challenges,
including
structural
instability
in
gastric
acid,
imprecise
targeting
of
inflamed
regions,
limited
intestinal
retention
times.
To
address
these
limitations,
pH‐responsive,
colon‐targeting
microspheres
(pWGPAC
MSs)
are
developed
delivering
phosphorylated
wild
ginseng
(pWGP)
alleviate
UC.
These
pWGPAC
MSs
fabricated
by
incorporating
pWGP
into
calcium‐crosslinked
alginate
with
subsequent
chitosan
surface
modification
enhance
mucosal
adhesion.
demonstrated
exceptional
stability
under
acidic
conditions
while
enabling
targeted
release
the
colon.
In
a
mouse
model
UC,
effectively
mitigated
injury,
attenuated
inflammation,
restored
barrier
function.
Further
mechanistic
investigations
revealed
that
modulated
TLR4/MYD88
signaling
pathway
promoted
M2
macrophage
polarization.
Integrated
microbiome
metabolome
analyses
regulated
gut
microbiota
composition
decreased
pro‐inflammatory
metabolite
levels.
addition,
promising
Collectively,
findings
establish
as
therapeutic
strategy
treatment
UC
provide
solid
foundation
future
clinical
applications.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: May 22, 2024
Recent
years
have
witnessed
a
surge
in
the
application
of
microrobots
within
medical
sector,
with
hydrogel
standing
out
due
to
their
distinctive
advantages.
These
microrobots,
characterized
by
exceptional
biocompatibility,
adjustable
physico-mechanical
attributes,
and
acute
sensitivity
biological
environments,
emerged
as
pivotal
tools
advancing
applications
such
targeted
drug
delivery,
wound
healing
enhancement,
bio-imaging,
precise
surgical
interventions.
The
capability
navigate
perform
tasks
complex
systems
significantly
enhances
precision,
efficiency,
safety
therapeutic
procedures.
Firstly,
this
paper
delves
into
material
classification
properties
compares
advantages
different
materials.
Furthermore,
it
offers
comprehensive
review
principal
categories
recent
innovations
synthesis,
actuation
mechanisms,
biomedical
hydrogel-based
microrobots.
Finally,
manuscript
identifies
prevailing
obstacles
future
directions
microrobot
research,
aiming
furnish
insights
that
could
propel
advancements
field.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 1, 2024
Orally
administered
nanocarriers
play
an
important
role
in
improving
druggability,
promoting
intestinal
absorption,
and
enhancing
therapeutic
applications
for
the
treatment
of
local
systemic
diseases.
However,
delivering
efficiency
cell
response
mucosa
to
orally
is
affected
by
physiological
environment
barriers
gastrointestinal
tract,
physicochemical
properties
nanocarriers,
their
bidirectional
interactions.
Goblet
cells
secrete
form
extracellular
mucus,
which
hinders
movement
nanoparticles.
Meanwhile,
epithelial
may
absorb
NPs,
allowing
transcytosis
or
degradation.
Conversely,
nanoparticle-induced
toxicity
occur
as
a
biological
nanoparticle
exposure.
Additionally,
immune
functions
secretions
such
mucin,
peptide,
cytokines
also
be
altered.
In
this
review,
we
discuss
interactions
between
nanoparticles
focusing
on
enterocytes
goblet
cells,
M
according
essential
crosstalk
with
cells.
Furthermore,
recent
advances
how
physiochemical
influence
interplay,
delivery,
fate
mucosa.
Understanding
different
from
perspective
interaction
provides
support
development,
rational
design,
potency
maximation,
application
advanced
oral
nanocarrier
delivery
systems.
APL Materials,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Jan. 1, 2025
Ulcerative
colitis
(UC)
is
an
intestinal
condition,
involving
inflammatory
response,
apoptosis,
and
associated
processes.
As
one
of
the
traditional
Chinese
medicine
treatments
for
UC,
quercetin
has
received
attention
because
it
can
attenuate
inflammation.
However,
oral
administration
does
not
perform
well
in
therapy.
In
this
study,
reactive
oxygen
species
(ROS)-sensitive
nanoparticles
(Que@Gel-DA
NPs)
prepared
by
self-assembly
polymerization
were
proposed
treatment
UC.
Quercetin
was
encapsulated
within
a
shell
layer
gelatin,
followed
dopamine
on
gelatin
surface.
Relative
to
free
form
quercetin,
dual-layer
encapsulation
enhanced
solubility
bioavailability
achieved
intragastric
protection,
extended
resident
time
gastrointestinal
tract.
Upon
reaching
colon
lesion,
underwent
degradation
response
ROS,
served
enhance
biocompatibility
mitigate
burst
release.
This
resulted
controlled
release
which
enabled
precise
therapy
exerted
antibacterial
anti-inflammatory
effects.
Furthermore,
Que@Gel-DA
NPs
significantly
alleviated
UC
symptoms
dextran
sodium
sulfate
(DSS)-induced
mouse
model.
evidenced
significant
increase
body
weight,
reduction
occult
blood
feces,
recovery
crypt
structure.
The
stained
results
indicated
that
inflammation
promoting
polarization
M2
macrophages
reduce
apoptosis
modulate
immunity.
Therefore,
NPs,
ROS-sensitive
nano-drug
delivery
system,
represent
novel
therapeutic
approach
clinical
intervention
Pharmacological Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107642 - 107642
Published: Feb. 1, 2025
Radiotherapy
is
a
method
of
treating
cancer
through
radiation
aimed
at
killing
cells
or
inhibiting
their
growth.
However,
radiotherapy
has
numerous
side
effects
because
it
kills
tumors
while
causing
damage
to
normal
tissues.
The
literature
shows
that
can
cause
heart
tissue.
This
study
found
engineered
yeast
produced
butyrate
maintain
small
intestinal
barrier
function
by
recovering
GPR109A
reduce
caused
abdominal
irradiation
in
mice.
We
unexpectedly
could
mitigate
irradiation-induced
via
the
gut-heart
axis.
Mechanistically,
enhanced
taurine
and
nicotinamide
metabolism
increasing
relative
abundance
Akkermansia
Lachnospiraceae_NK4A136;
then,
modulated
cardiac
activating
Sgcg
Nppa
genes
attenuate
induced
irradiation.
Finally,
we
confirmed
mitigated
total
body
irradiation,
which
protected
other
vital
organs
tract.
profound
impact
on
treatment,
emergence
will
alleviate
benefit
patients.