Synergistic Gas Therapy and Targeted Interventional Ablation With Size‐Controllable Arsenic Sulfide (As2S3) Nanoparticles for Effective Elimination of Localized Cancer Pain DOI

Yu Tang,

Jiyun Zhang,

Yuan Yuan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract The elimination of localized cancer pain remains a globally neglected challenge. A potential solution lies in combining gas therapy with targeted interventional ablation therapy. In this study, HA‐As 2 S 3 nanoparticles controlled sizes are synthesized using different molecular weights sodium hyaluronate (HA) as supramolecular scaffold. Initially, HA co‐assembles arsenic ions (As 3+ ) via coordinate bonds, forming scaffold intermediates. These intermediates, varying size, then react sulfur to produce size‐controlled particles. This approach demonstrates that enable precise control over the particle size sulfide, offering straightforward and environmentally friendly method for synthesizing metal sulfide an acidic environment, release hydrogen sulfide(H S) As . released directly damage tumor mitochondria, leading substantial reactive oxygen species (ROS) production from mitochondria. Concurrently, H inhibits activity catalase (CAT) complex IV, preventing beneficial decomposition ROS disrupting electron transfer mitochondrial respiratory chain. Consequently, it is found significantly enhances induced by nanodrugs, effectively killing local tumors ultimately eliminating mice.

Language: Английский

Ternary inulin hydrogel with long-term intestinal retention for simultaneously reversing IBD and its fibrotic complication DOI Creative Commons

Xiangjing Cao,

Tao Shi, Weitao Wang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 28, 2024

Excessive accumulation of reactive oxygen and nitrogen species (RONS) dysbiosis intestinal microbiota are pivotal symptoms for inflammatory bowel disease (IBD) its associated complications, such as fibrosis. This research introduces a probiotic inulin hydrogel loaded with polypyrrole (PPy) nanozymes antifibrotic drug pirfenidone (PFD) (PPy/PFD@Inulin gel) designed the concurrent amelioration IBD fibrotic complication. Upon oral administration, gel matrix could extend gastrointestinal residence time PPy PFD, facilitating efficient reduction pro-inflammatory cytokine levels enhancement epithelial barrier repair well suppression fibrosis through sustained RONS scavenging, modulation gut attenuation TGF-β/Smad signaling pathway to inhibit fibroblast proliferation. Notably, PPy/PFD@Inulin demonstrated significant prophylactic therapeutic efficacy in acute chronic colitis induced by dextran sodium sulfate (DSS) mouse models. Thus, engineered ternary offered pioneered paradigm simultaneous reversal fibrosis, single regimen.

Language: Английский

Citations

19
Colon‐Targeted Ginseng Polysaccharides‐Based Microspheres for Improving Ulcerative Colitis via Anti‐Inflammation and Gut Microbiota Modulation DOI Open Access
Dongxue Huo,

Yanfei Li,

Lijun Song

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Natural plant‐derived polysaccharides exhibit substantial potential for treating ulcerative colitis (UC) owing to their anti‐inflammatory and antioxidant properties favorable safety profiles. However, practical application faces several challenges, including structural instability in gastric acid, imprecise targeting of inflamed regions, limited intestinal retention times. To address these limitations, pH‐responsive, colon‐targeting microspheres (pWGPAC MSs) are developed delivering phosphorylated wild ginseng (pWGP) alleviate UC. These pWGPAC MSs fabricated by incorporating pWGP into calcium‐crosslinked alginate with subsequent chitosan surface modification enhance mucosal adhesion. demonstrated exceptional stability under acidic conditions while enabling targeted release the colon. In a mouse model UC, effectively mitigated injury, attenuated inflammation, restored barrier function. Further mechanistic investigations revealed that modulated TLR4/MYD88 signaling pathway promoted M2 macrophage polarization. Integrated microbiome metabolome analyses regulated gut microbiota composition decreased pro‐inflammatory metabolite levels. addition, promising Collectively, findings establish as therapeutic strategy treatment UC provide solid foundation future clinical applications.

Language: Английский

Citations

2
Orally administered metal–organic framework nanocubes for sequence-targeted quercetin delivery in colitis alleviation DOI
Runan Zhao, Tao Chen, Shumeng Hu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160373 - 160373

Published: Feb. 1, 2025

Language: Английский

Citations

1
Inflammation-Targeted Delivery of Probiotics for Alleviation of Colitis and Associated Cognitive Disorders through Improved Vitality and Colonization DOI
Yi Chen,

Mingju Shui,

Hongyi Li

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123163 - 123163

Published: Feb. 1, 2025

Language: Английский

Citations

1
Probiotic Delivery for Editing of the Gut Microbiota to Mitigate Colitis and Maintain Hepatic Homeostasis Via Gut–Liver Axis DOI

Junwei Deng,

Yaoyu Hu, Pengfei Zhu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Inflammatory bowel disease (IBD) compromises the intestinal barrier and disrupts gut microbiota, impacting liver function via gut-liver axis, which in turn influences microbiota through lipid metabolites exacerbating IBD. This study introduced a probiotic-based treatment using Lactobacillus acidophilus encapsulated tungsten ion-loaded mesoporous polydopamine (LA@WMPDA) to ameliorate colitis balance enterohepatic homeostasis. After oral administration, encapsulation could protect acidophilus, scavenge reactive oxygen/nitrogen species, released ions would inhibit abnormal Enterobacteriaceae growth during colitis, consequently restoring regulating microbiota. Nontargeted metabolomics transcriptomics analyses showed increased short-chain fatty acids indole derivatives, decreased hepatic metabolism. Pathways associated with immune response, cell migration death, response bacterium significant down-regulation colon transcriptome analysis. Thus, this provided pioneered paradigm for IBD highlighted regulation of liver-related metabolic functions axis.

Language: Английский

Citations

1
Hydrogel microrobots for biomedical applications DOI Creative Commons
Wenping Song,

Leike Li,

Xuejia Liu

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: May 22, 2024

Recent years have witnessed a surge in the application of microrobots within medical sector, with hydrogel standing out due to their distinctive advantages. These microrobots, characterized by exceptional biocompatibility, adjustable physico-mechanical attributes, and acute sensitivity biological environments, emerged as pivotal tools advancing applications such targeted drug delivery, wound healing enhancement, bio-imaging, precise surgical interventions. The capability navigate perform tasks complex systems significantly enhances precision, efficiency, safety therapeutic procedures. Firstly, this paper delves into material classification properties compares advantages different materials. Furthermore, it offers comprehensive review principal categories recent innovations synthesis, actuation mechanisms, biomedical hydrogel-based microrobots. Finally, manuscript identifies prevailing obstacles future directions microrobot research, aiming furnish insights that could propel advancements field.

Language: Английский

Citations

5
Polyoxometalates emerging as multifunctional powerhouses in the battle against cancer DOI
Xiaotong Xu, Yunfei Guo,

Bole Li

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216210 - 216210

Published: Sept. 16, 2024

Language: Английский

Citations

3
Intestinal nanoparticle delivery and cellular response: a review of the bidirectional nanoparticle-cell interplay in mucosa based on physiochemical properties DOI Creative Commons
Yu Wang,

Y Mo,

Yingwei Sun

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 1, 2024

Orally administered nanocarriers play an important role in improving druggability, promoting intestinal absorption, and enhancing therapeutic applications for the treatment of local systemic diseases. However, delivering efficiency cell response mucosa to orally is affected by physiological environment barriers gastrointestinal tract, physicochemical properties nanocarriers, their bidirectional interactions. Goblet cells secrete form extracellular mucus, which hinders movement nanoparticles. Meanwhile, epithelial may absorb NPs, allowing transcytosis or degradation. Conversely, nanoparticle-induced toxicity occur as a biological nanoparticle exposure. Additionally, immune functions secretions such mucin, peptide, cytokines also be altered. In this review, we discuss interactions between nanoparticles focusing on enterocytes goblet cells, M according essential crosstalk with cells. Furthermore, recent advances how physiochemical influence interplay, delivery, fate mucosa. Understanding different from perspective interaction provides support development, rational design, potency maximation, application advanced oral nanocarrier delivery systems.

Language: Английский

Citations

3
Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice DOI Creative Commons
Yang Bai, Danling Jiang, Boda Wu

et al.

APL Materials, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Ulcerative colitis (UC) is an intestinal condition, involving inflammatory response, apoptosis, and associated processes. As one of the traditional Chinese medicine treatments for UC, quercetin has received attention because it can attenuate inflammation. However, oral administration does not perform well in therapy. In this study, reactive oxygen species (ROS)-sensitive nanoparticles (Que@Gel-DA NPs) prepared by self-assembly polymerization were proposed treatment UC. Quercetin was encapsulated within a shell layer gelatin, followed dopamine on gelatin surface. Relative to free form quercetin, dual-layer encapsulation enhanced solubility bioavailability achieved intragastric protection, extended resident time gastrointestinal tract. Upon reaching colon lesion, underwent degradation response ROS, served enhance biocompatibility mitigate burst release. This resulted controlled release which enabled precise therapy exerted antibacterial anti-inflammatory effects. Furthermore, Que@Gel-DA NPs significantly alleviated UC symptoms dextran sodium sulfate (DSS)-induced mouse model. evidenced significant increase body weight, reduction occult blood feces, recovery crypt structure. The stained results indicated that inflammation promoting polarization M2 macrophages reduce apoptosis modulate immunity. Therefore, NPs, ROS-sensitive nano-drug delivery system, represent novel therapeutic approach clinical intervention

Language: Английский

Citations

0
Butyrate-engineered yeast activates Nppa and Sgcg genes and reduces radiation-induced heart damage via the gut-heart axis DOI Creative Commons
Jiahao Wu, Kaihua Ji, Guangbo Kang

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107642 - 107642

Published: Feb. 1, 2025

Radiotherapy is a method of treating cancer through radiation aimed at killing cells or inhibiting their growth. However, radiotherapy has numerous side effects because it kills tumors while causing damage to normal tissues. The literature shows that can cause heart tissue. This study found engineered yeast produced butyrate maintain small intestinal barrier function by recovering GPR109A reduce caused abdominal irradiation in mice. We unexpectedly could mitigate irradiation-induced via the gut-heart axis. Mechanistically, enhanced taurine and nicotinamide metabolism increasing relative abundance Akkermansia Lachnospiraceae_NK4A136; then, modulated cardiac activating Sgcg Nppa genes attenuate induced irradiation. Finally, we confirmed mitigated total body irradiation, which protected other vital organs tract. profound impact on treatment, emergence will alleviate benefit patients.

Language: Английский

Citations

0