Nanomaterials evoke pyroptosis boosting cancer immunotherapy DOI Creative Commons
Zhenhua Li,

Ziyue Xi,

Chuanyong Fan

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(2), P. 852 - 875

Published: Nov. 23, 2024

Cancer immunotherapy is currently a very promising therapeutic strategy for treating tumors. However, its effectiveness restricted by insufficient antigenicity and an immunosuppressive tumor microenvironment (ITME). Pyroptosis, unique form of programmed cell death (PCD), causes cells to swell rupture, releasing pro-inflammatory factors that can enhance immunogenicity remodel the ITME. Nanomaterials, with their distinct advantages different techniques, are increasingly popular, nanomaterial-based delivery systems demonstrate significant potential potentiate, enable, augment pyroptosis. This review summarizes discusses emerging field nanomaterials-induced pyroptosis, focusing on mechanisms pyroptosis pathways strategies activate or specific Additionally, we provide perspectives development this field, aiming accelerate further clinical transition.

Language: Английский

Metformin-based nanomedicines for reprogramming tumor immune microenvironment DOI
Jieyu Liu, Xiaoling Li, Yinggang Li

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(3), P. 993 - 1016

Published: Dec. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Language: Английский

Citations

34
Anti‐Tumor Strategies Targeting Nutritional Deprivation: Challenges and Opportunities DOI Open Access
Jinsheng Shi, Wei Han, Jie Wang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Higher and richer nutrient requirements are typical features that distinguish tumor cells from AU: cells, ensuring adequate substrates energy sources for cell proliferation migration. Therefore, deprivation strategies based on targeted technologies can induce impaired viability in which more sensitive than normal cells. In this review, nutrients required by related metabolic pathways introduced, anti-tumor developed to target described. addition the nutritional characteristics of other microenvironment (including macrophages, neutrophils, natural killer T cancer-associated fibroblasts) new also summarized. conclusion, recent advances targeting blockade reviewed, challenges prospects these discussed, theoretical significance optimizing clinical application nutrition strategies.

Language: Английский

Citations

0
Tailoring the dendronized structures of cyclodextrin-based supramolecular nanoassemblies for enhanced tumor paraptosis via disrupting endoplasmic reticulum homeostasis DOI
Jiecheng Ji, Jie Zhou, Xue Li

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
An Integrated Virtual Screening Platform to Identify Potent Co‐Assembled Nanodrugs for Cancer Treatment DOI
Bo Fang, Fei Pan, Tianyu Shan

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Co‐assembled nanodrugs provide significant advantages in cancer treatment and drug delivery, yet effective screening methods to identify molecular combinations for co‐assembly are lacking. This study presents a strategy integrating ligand‐based virtual (LBVS) density functional theory (DFT) calculations explore new with capabilities. The accuracy of this was validated by synthesizing various co‐assembled under mild conditions. Vinpocetine (Vin) lenvatinib (Len) representative that can directly co‐assemble into nanoparticles (NPs) through hydrogen bonding, van der Waals forces, π‐π interactions. These NPs were further functionalized polyethylene glycol (PEG), resulting PEG‐L/V exhibited enhanced stability biocompatibility. In addition, respond acidic conditions release Vin Len, working synergistically induce cell cycle arrest apoptosis tumor cells vitro while also inhibiting xenograft growth vivo. RNA sequencing (RNA‐seq) analysis revealed the mechanisms distinct from those single drugs. demonstrates feasibility utilizing computational approach combining LBVS DFT small molecules capabilities, leading innovative anticancer strategies.

Language: Английский

Citations

0
A Bacteria-Based Bioorthogonal Platform Disrupts the Flexible Lipid Homeostasis for Potent Metabolic Therapy DOI Creative Commons

Jiadai Yi,

Huan Wang, Qingqing Deng

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cancer cells exhibit altered metabolism and energetics, prominently reprogramming lipid to support tumor growth progression, making it a promising target for cancer therapy. However, traditional genetic pharmaceutical approaches disrupting face challenges due the adaptability of potential side effects on normal tissues. Here, we present bacteria-based bioorthogonal platform combining transition metal catalysts Lactobacillus disrupt flexible homeostasis in tumors. This activates glutamine transporter inhibitors situ, targeting synthesis hypoxic environments, while inhibits accumulation. By utilization, study proposes safe potent strategy therapy, with applications other metabolic diseases.

Language: Английский

Citations

0
Nanomedicines Targeting Metabolic Pathways in the Tumor Microenvironment: Future Perspectives and the Role of AI DOI Creative Commons

Shuai Fan,

Wenyu Wang,

Wieqi Che

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 201 - 201

Published: March 13, 2025

Background: Tumor cells engage in continuous self-replication by utilizing a large number of resources and capabilities, typically within an aberrant metabolic regulatory network to meet their own demands. This dysregulation leads the formation tumor microenvironment (TME) most solid tumors. Nanomedicines, due unique physicochemical properties, can achieve passive targeting certain tumors through enhanced permeability retention (EPR) effect, or active deliberate design optimization, resulting accumulation TME. The use nanomedicines target critical pathways holds significant promise. However, requires careful selection relevant drugs materials, taking into account multiple factors. traditional trial-and-error process is relatively inefficient. Artificial intelligence (AI) integrate big data evaluate delivery efficiency nanomedicines, thereby assisting nanodrugs. Methods: We have conducted detailed review key papers from databases, such as ScienceDirect, Scopus, Wiley, Web Science, PubMed, focusing on reprogramming, mechanisms action development metabolism, application AI empowering nanomedicines. integrated content present current status research metabolism potential future directions this field. Results: Nanomedicines possess excellent TME which be utilized disrupt cells, including glycolysis, lipid amino acid nucleotide metabolism. disruption selective killing disturbance Extensive has demonstrated that AI-driven methodologies revolutionized nanomedicine development, while concurrently enabling precise identification molecular regulators involved oncogenic reprogramming pathways, catalyzing transformative innovations targeted cancer therapeutics. Conclusions: great Additionally, will accelerate discovery metabolism-related targets, empower optimization help minimize toxicity, providing new paradigm for development.

Language: Английский

Citations

0
Harnessing and Mimicking Bacterial Features to Combat Cancer: From Living Entities to Artificial Mimicking Systems DOI
Peng Gao, Zhenyu Duan, Gang Xu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: Aug. 1, 2024

Bacterial-derived micro-/nanomedicine has garnered considerable attention in anticancer therapy, owing to the unique natural features of bacteria, including specific targeting ability, immunogenic benefits, physicochemical modifiability, and biotechnological editability. Besides, bacterial components have also been explored as promising drug delivery vehicles. Harnessing these features, cutting-edge biotechnologies applied attenuated tumor-targeting bacteria with properties or functions for potent effective cancer treatment, strategies gene-editing genetic circuits. Further, advent bacteria-inspired micro-/nanorobots mimicking artificial systems furnished fresh perspectives formulating developing highly efficient systems. Focusing on advantages this review delves into advances bacteria-derived treatment recent years, which experienced a process from living entities Meanwhile, summary relative clinical trials is provided primary challenges impeding their application are discussed. Furthermore, future directions suggested combat cancer.

Language: Английский

Citations

2
Targeting lipid metabolism via nanomedicine: a prospective strategy for cancer therapy DOI

Xing Huang,

Shengzhong Hou,

Yinggang Li

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123022 - 123022

Published: Dec. 15, 2024

Language: Английский

Citations

2
Enhanced confinements to modulate efficient reversible isomerization of donor-acceptor Stenhouse adducts in water through cooperative crowding in thermoresponsive dendronized nanogels DOI
Jiaxing Zhang,

Zibo Yan,

Qingyun Zhao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158518 - 158518

Published: Dec. 10, 2024

Language: Английский

Citations

1
Nanomaterials evoke pyroptosis boosting cancer immunotherapy DOI Creative Commons
Zhenhua Li,

Ziyue Xi,

Chuanyong Fan

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(2), P. 852 - 875

Published: Nov. 23, 2024

Cancer immunotherapy is currently a very promising therapeutic strategy for treating tumors. However, its effectiveness restricted by insufficient antigenicity and an immunosuppressive tumor microenvironment (ITME). Pyroptosis, unique form of programmed cell death (PCD), causes cells to swell rupture, releasing pro-inflammatory factors that can enhance immunogenicity remodel the ITME. Nanomaterials, with their distinct advantages different techniques, are increasingly popular, nanomaterial-based delivery systems demonstrate significant potential potentiate, enable, augment pyroptosis. This review summarizes discusses emerging field nanomaterials-induced pyroptosis, focusing on mechanisms pyroptosis pathways strategies activate or specific Additionally, we provide perspectives development this field, aiming accelerate further clinical transition.

Language: Английский

Citations

0