Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 26, 2025
Abstract
Rectal
cancer
surgery
is
challenging
due
to
the
complex
anatomy,
making
it
difficult
achieve
clear
surgical
margins.
Radiotherapy
(RT)
plays
a
crucial
role,
especially
in
treating
locally
recurrent
rectal
and
preserving
anal
function.
However,
its
effectiveness
often
limited
by
tumor
hypoxia,
particularly
prevalent
hypoxic
regions
near
bowel
wall
colorectal
cancer.
Hypoxia
contributes
both
radiation
resistance
apoptosis
resistance,
compromising
RT
outcomes.
To
overcome
hypoxia‐driven
radiotherapy
this
work
designs
engineers
radiotherapy‐sensitizing
bioplatform
for
efficient
RT.
It
combines
lanthanum
oxide
nanoparticles
(La
2
O
3
NPs)
with
cyanobacteria,
which
produces
oxygen
through
photosynthesis.
This
uniquely
reduces
enhances
deposition,
improves
efficacy.
La
NPs
further
enhance
reactive
species
(ROS)
production
induced
radiation,
triggering
pyroptosis
via
ROS‐NLRP3‐GSDMD
pathway,
while
amplifies
GSDME,
circumventing
resistance.
The
integrated
thermosensitive
hydrogels
ensure
precise
localization
of
bioplatform,
reducing
systemic
toxicity
improving
therapeutic
specificity.
Compared
conventional
therapies,
dual‐action
system
addresses
more
effectively.
In
vivo
vitro
hypoxia
models
validate
potent
anti‐tumor
efficacy,
offering
valuable
insights
refining
clinical
treatment
paradigms.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(26)
Published: April 7, 2024
Abstract
Brain
disorders
represent
a
significant
challenge
in
medical
science
due
to
the
formidable
blood–brain
barrier
(BBB),
which
severely
limits
penetration
of
conventional
therapeutics,
hindering
effective
treatment
strategies.
This
review
delves
into
innovative
realm
biomimetic
nanodelivery
systems,
including
stem
cell‐derived
nanoghosts,
tumor
cell
membrane‐coated
nanoparticles,
and
erythrocyte
membrane‐based
carriers,
highlighting
their
potential
circumvent
BBB's
restrictions.
By
mimicking
native
properties,
these
nanocarriers
emerge
as
promising
solution
for
enhancing
drug
delivery
brain,
offering
strategic
advantage
overcoming
barrier's
selective
permeability.
The
unique
benefits
leveraging
membranes
from
various
sources
is
evaluated
advanced
technologies
fabricating
membrane‐encapsulated
nanoparticles
capable
masquerading
endogenous
cells
are
examined.
enables
targeted
broad
spectrum
therapeutic
agents,
ranging
small
molecule
drugs
proteins,
thereby
providing
an
approach
neurocare.
Further,
contrasts
capabilities
limitations
with
traditional
methods,
underlining
enable
targeted,
sustained,
minimally
invasive
modalities.
concluded
perspective
on
clinical
translation
underscoring
transformative
impact
landscape
intractable
brain
diseases.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Abstract
Nanomedicine
based
brain
targeting
strategies
have
emerged
as
a
promising
avenue
for
ischemic
stroke
(IS)
treatment.
However,
conventional
approaches
face
significant
challenges
in
manipulating
biodistribution
and
achieving
efficient
to
attain
adequate
therapeutic
effects.
Here,
this
limitation
is
overcame
by
developing
magnetic
field
driven,
mitochondria‐targeted
ceria
nanosystem
(MMTCe)
nanosystem.
By
anchoring
nanoparticles
the
cell
membrane,
targeted
delivery
of
achieved
through
use
an
external
field,
which
turn
targets
damaged
mitochondria
repairs
microenvironment.
MMTCe
exhibits
superior
accumulation
within
vitro
blood
barrier
(BBB)
model
rat
stroke.
This
mediates
mitochondrial
function,
thereby
inhibiting
oxidative
stress
aberrant
activation
microglial
cells,
ultimately
inducing
rebalancing
Complemented
favorable
biosafety
profile,
top‐down
fabrication
provides
general
strategy
diseases
informs
development
magnetically
driven
systems.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101457 - 101457
Published: Jan. 5, 2025
Central
nervous
system
(CNS)
diseases
are
a
major
cause
of
disability
and
death
worldwide.
Due
to
the
blood-brain
barrier
(BBB),
drug
delivery
for
CNS
is
extremely
challenging.
Nano-delivery
systems
can
overcome
limitations
BBB
deliver
drugs
CNS,
improve
ability
target
brain
provide
potential
therapeutic
methods
diseases.
At
same
time,
choice
different
(bypassing
or
crossing
BBB)
further
optimize
effect
nano-drug
system.
This
article
reviews
nano-delivery
way
enters
brain.
Different
kinds
nanoparticles
were
discussed
in
depth.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 15, 2024
Exploring
effective
antibacterial
approaches
for
targeted
treatment
of
pathogenic
bacterial
infections
with
reduced
drug
resistance
is
great
significance.
Combinational
modality
that
leverages
different
therapeutic
components
can
improve
the
overall
effectiveness
and
minimize
adverse
effects,
thus
displaying
considerable
potential
against
infections.
Herein,
red
blood
cell
membrane
fuses
macrophage
to
develop
hybrid
shell,
which
further
camouflages
around
drug-loaded
liposome
fabricate
biomimetic
(AB@LRM)
precise
therapy.
Specifically,
photoactive
agent
black
phosphorus
quantum
dots
(BPQDs)
classical
antibiotics
amikacin
(AM)
are
loaded
in
AB@LRM
accurately
target
inflammatory
sites
through
guidance
long
residence
capability
membrane,
eventually
exerting
efficacious
activities.
Besides,
due
excellent
photothermal
photodynamic
properties,
BPQDs
act
as
an
efficient
when
exposed
near-infrared
laser
irradiation,
dramatically
increasing
sensitivity
bacteria
antibiotics.
Consequently,
synergistic
sterilizing
effect
produced
by
restricts
resistance.
Upon
shows
superior
anti-inflammatory
properties
models
P.
aeruginosa-infected
pneumonia
wounds.
Hence,
this
light-activatable
nanoplatform
good
biocompatibility
presents
advance
clinical
development
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(50)
Published: Nov. 6, 2024
Abstract
Oxidative
stress,
predominantly
from
neuronal
mitochondrial
damage
and
the
resultant
cytokine
storm,
is
central
to
cerebral
ischemia‐reperfusion
injury
(CIRI).
However,
delivering
drugs
mitochondria
remains
challenging
due
blood‐brain
barrier
(BBB),
which
impedes
drug
entry
into
affected
brain
tissues.
This
study
introduces
an
innovative
tannic
acid
(TA)
melanin‐modified
heteropolyacid
nanomedicine
(MHT),
highly
specifically
eliminates
reactive
oxygen
radicals
burst
efficiently
reduce
through
a
strategically
designed
sequential
targeting
strategy
tissue
mitochondria.
TA
endows
MHT
with
ability
by
binding
matrix
proteins
exposed
damaged
BBB
outer
membrane
of
neurons,
while
melanin
significantly
enhances
antioxidant
capacity
MHT.
Consequently,
effectively
inhibits
apoptosis
protecting
reversing
inflammatory
immune
environment
deactivation
cyclic
GMP‐AMP
synthase–stimulator
interferon
genes
(cGAS‐STING)
pathway.
demonstrated
strong
therapeutic
effect
on
CIRI,
ultralow
dose
(2
mg
kg
−1
)
proving
effective
in
condition.
work
not
only
new
avenue
CIRI
therapy
but
also
offers
paradigm
for
treating
other
diseases.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(7), P. 849 - 849
Published: June 22, 2024
The
state
of
well-being
and
health
our
body
is
regulated
by
the
fine
osmotic
biochemical
balance
established
between
cells
different
tissues,
organs,
systems.
Specific
districts
human
are
defined,
kept
in
correct
functioning,
and,
therefore,
protected
from
exogenous
or
endogenous
insults
both
mechanical,
physical,
biological
nature
presence
barrier
In
addition
to
placental
barrier,
which
even
acts
as
a
linker
two
organisms,
mother
fetus,
all
barriers,
including
blood-brain
(BBB),
blood-retinal
blood-nerve
blood-lymph
blood-cerebrospinal
fluid
operate
maintain
physiological
homeostasis
within
tissues
organs.
From
pharmaceutical
point
view,
most
challenging
undoubtedly
BBB,
since
its
notably
complicates
treatment
brain
disorders.
BBB
action
can
impair
delivery
chemical
drugs
biopharmaceuticals
into
brain,
reducing
their
therapeutic
efficacy
and/or
increasing
unwanted
bioaccumulation
surrounding
healthy
tissues.
Recent
nanotechnological
innovation
provides
advanced
biomaterials
ad
hoc
customized
engineering
functionalization
methods
able
assist
brain-targeted
drug
delivery.
this
context,
lipid
nanocarriers,
synthetic
(liposomes,
solid
nanoparticles,
nanoemulsions,
nanostructured
carriers,
niosomes,
proniosomes,
cubosomes)
cell-derived
ones
(extracellular
vesicles
cell
membrane-derived
nanocarriers),
considered
one
successful
systems
due
reasonable
biocompatibility
ability
cross
BBB.
This
review
aims
provide
complete
up-to-date
view
on
varied
whether
FDA-approved,
involved
clinical
trials,
used
vitro
vivo
studies,
for
inflammatory,
cancerous,
infectious
diseases.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Abstract
Excessive
fat
accumulation
and
chronic
inflammation
are
two
typical
characteristics
of
obesity.
AMP‐activated
protein
kinase
(AMPK),
a
master
regulator
energy
metabolism,
is
involved
in
adipogenesis,
lipogenesis,
modulation
adipose
tissue
(AT).
Thus,
effective
lipid
reduction
anti‐inflammation
through
AMPK
regulation
play
vital
roles
treating
Herein,
an
anti‐obesity
nanosandwich
fabricated
attaching
polymetformin
(PolyMet)
onto
photothermal
agent
black
phosphorus
nanosheets
(BP).
PolyMet
activates
to
inhibit
promote
browning,
mitigate
AT
by
decreasing
macrophage
infiltration,
repolarizing
phenotype,
downregulating
pro‐inflammatory
cytokines.
Additionally,
BP
induces
lipolysis
apoptosis
adipocytes
macrophages
effect.
By
further
functionalization
using
hyaluronic
acid
(HA)
MMP2
substrate‐linking
P3
peptide‐modified
HA
(P3‐HA),
enhanced
effect
obtained
dual‐targeting
HA,
HA‐mediated
CD44
poly‐clustering
after
cleavage.
Upon
laser
irradiation,
the
designed
(P3‐HA/PM@BP)
effectively
inhibits
obesity
development
obese
mice,
increases
M2/M1
ratio
AT,
reduces
serum
levels
cholesterol/triglyceride
improves
insulin
sensitivity,
exhibiting
promising
research
potential
facilitate
clinical
modern
therapies.
