Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection DOI Creative Commons
Ehsan Mohammadifar, Matteo Gasbarri,

Mathias Dimde

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 37(3)

Published: Sept. 30, 2024

In Nature, most known objects can perform their functions only when in supramolecular self-assembled from, e.g. protein complexes and cell membranes. Here, a dendritic polymer is presented that inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with an irreversible (virucidal) mechanism into Two-dimmensional (2D-SupraPol). Monomeric analogs of the inhibit SARS-CoV-2 reversibly, thus allowing for virus to regain infectivity after dilution. Upon assembly, 2D-SupraPol shows remarkable half-inhibitory concentration (IC50 30 nM) vitro vivo Syrian Hamster model has good efficacy. Using cryo-TEM, it shown controllable lateral size be tuned by adjusting pH use small angle X-ray neutron scattering unveil architecture assembly. This functional 2D-SupraPol, its are proposed, as prophylaxis nasal spray interaction tract.

Language: Английский

Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective DOI Creative Commons
Jieyu Liu, Yinan Bai, Yinggang Li

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 107, P. 105301 - 105301

Published: Aug. 23, 2024

Increasing evidence indicates that immunotherapy is hindered by a hostile tumor microenvironment (TME) featured with deprivation of critical nutrients and pooling immunosuppressive metabolites. Tumor cells outcompete immune effector for essential nutrients. Meanwhile, wide range cell-derived toxic metabolites exerts negative impacts on anti-tumor response, diminishing the efficacy immunotherapy. Nanomedicine excellent targetability offers novel approach to improving cancer via metabolically reprogramming TME. Herein, we review recent strategies enhancing immunotherapeutic effects through rewiring metabolism nanomedicine. Attention drawn immunometabolic tactics stromal in TME Additionally, discuss future directions developing metabolism-regulating nanomedicine precise efficacious

Language: Английский

Citations

75
Metformin-based nanomedicines for reprogramming tumor immune microenvironment DOI
Jieyu Liu, Xiaoling Li, Yinggang Li

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(3), P. 993 - 1016

Published: Dec. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Language: Английский

Citations

28
Tumor microenvironment targeted nano-drug delivery systems for multidrug resistant tumor therapy DOI Creative Commons

Xinyue Shao,

Xiaoling Zhao, Binghao Wang

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1689 - 1714

Published: Jan. 2, 2025

In recent years, nano-drug delivery systems (Nano-DDS) that target the tumor microenvironment (TME) to overcome multidrug resistance (MDR) have become a research hotspot in field of cancer therapy. By precisely targeting TME and regulating its unique pathological features, such as hypoxia, weakly acidic pH, abnormally expressed proteins, etc., these Nano-DDS enable effective therapeutic agents reversal MDR. This scientific community is increasing investment development diversified exploring their anti-drug potential. Therefore, it particularly important conduct comprehensive review progress TME-targeted years. After brief introduction MDR, design principle structure liposomes, polymer micelles inorganic nanocarriers are focused on, characteristics described. It also demonstrates how break through MDR treatment various mechanisms, discusses synthetic innovation, results overcoming mechanisms. The was concluded with deliberations on key challenges future outlooks

Language: Английский

Citations

2
Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts DOI Creative Commons

Zhongsong Zhang,

Long Chen

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

Citations

2
Breast Cancer: Extracellular Matrix and Microbiome Interactions DOI Open Access
Lourdes Herrera‐Quintana, Héctor Vázquez‐Lorente, Julio Plaza‐Díaz

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7226 - 7226

Published: June 30, 2024

Breast cancer represents the most prevalent form of and leading cause cancer-related mortality among females worldwide. It has been reported that several risk factors contribute to appearance progression this disease. Despite advancements in breast treatment, a significant portion patients with distant metastases still experiences no cure. The extracellular matrix potential target for enhanced serum biomarkers cancer. Furthermore, degradation epithelial–mesenchymal transition constitute primary stages local invasion during tumorigenesis. Additionally, microbiome influence on diverse physiological processes. is emerging microbial dysbiosis element development various cancers, including Thus, better understanding interactions could provide novel alternatives treatment management. In review, we summarize current evidence regarding intricate relationship between microbiome. We discuss arising associations future perspectives field.

Language: Английский

Citations

9
Effectiveness and safety of transarterial chemoembolization combined with PD-1 inhibitors and lenvatinib for unresectable intrahepatic cholangiocarcinoma DOI Creative Commons

Jintao Huang,

Di Hu,

Xin Hong

et al.

European Radiology Experimental, Journal Year: 2025, Volume and Issue: 9(1)

Published: Feb. 18, 2025

The objective of this study was to evaluate the therapeutic effectiveness and safety transarterial chemoembolization (TACE) combined with programmed cell death-1 (PD-1) inhibitors lenvatinib in treatment unresectable intrahepatic cholangiocarcinoma (uICC). This multicenter retrospective screened patients uICC who underwent TACE combination PD-1 between January 2019 June 2023. Tislelizumab or camrelizumab (200 mg) intravenously administered every three weeks. daily dose 8 mg for weighing < 60 kg 12 those ≥ kg. In cases disease progression, strategy adjusted based on clinical condition individual patient's preferences. Options included transitioning standard supportive care continuing lenvatinib. primary outcomes were overall survival (OS) progression-free (PFS), while secondary response rate (ORR), control (DCR), incidence adverse events (AEs). A total 59 included. Over a median follow-up period 32.3 months, OS PFS 25.8 months (95% confidence interval [CI]: 17.9-33.7) 9.5 CI: 7.9-11.0), respectively. ORR 55.9%, DCR 96.6%. Grade 3 four AEs observed 15 (25.4%). demonstrated promising potential manageable profile uICC. TACE, inhibitors, represents novel option plus represent manageable. improved compared prior standard-of-care treatments.

Language: Английский

Citations

1
Robust Acid-Responsive AILE Luminescence Effect Nanoparticle for Drug Release Monitoring and Induction of Apoptosis in Cancer Cells DOI

Chang Cao,

Wen Wang,

Shuo Zhu

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Through the PFOEP-SO3(−) + multidrug molecules constructed nanoparticle (NP) experiments and validated by molecular simulation docking experiments, we propose a interaction principle for inducing aggregation-induced locally excited emission (AILE) luminescence from fluorenone (FO)-based conjugated polymers (CPs). Based on this mechanism, NP built π–π stacking. The NPs demonstrate facile synthesis, robust stability, high drug-loading efficiency, enabling tumor-specific drug release in acidic lysosomal environments (pH 3.8–4.7) to minimize off-target toxicity. Concurrently, PFOEPA exhibit pH-dependent fluorescence enhancement: incorporation induces structural reorganization into "sandwich" configuration, amplifying with blue shift under neutral/alkaline conditions, while acidic-triggered protonation collapse disrupts NPs. Moreover, it can be used as an indicator monitoring release, is accompanied changes during process. This possesses multiple functions expected serve effective pH-responsive delivery system.

Language: Английский

Citations

0
Tumor-Targeting Theranostic Polymers DOI
Ying Wei, Mingfeng Wang

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Theranostic polymers have emerged as a versatile platform in cancer nanomedicine, integrating therapeutic and imaging functionalities to overcome challenges oncology. Featuring diverse architectures such linear polymers, dendrimers, star-like bottle-brush these systems enable tumor-targeted drug delivery, real-time imaging, controlled release. Recent advances stimuli-responsive designs biomimetic strategies improved their specificity, stability, adaptability, outperforming conventional nanocarriers. This review summarizes the design, synthesis, biomedical applications of theranostic focusing on potential address tumor heterogeneity biological barriers. The biocompatibility, immunogenicity, clinical translation are discussed, with perspective toward future developments precision medicine imaging-guided therapy.

Language: Английский

Citations

0
Rhein and hesperidin nanoparticles remodel tumor immune microenvironment by reducing CAFs and CCL2 secreted by CAAs for efficient triple-negative breast cancer therapy DOI
Jingyi Huang, Hongyan Zhang, Lisha Ma

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 113001 - 113001

Published: Aug. 25, 2024

Language: Английский

Citations

4
A Slimming/Excavating Strategy for Enhanced Intratumoral Penetration of Acid‐Disassemblable NO‐Releasing Nanomedicines DOI Open Access
Lingdong Jiang,

An‐Bang Wu,

Lingting Zeng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Poor tumor penetration is the major predicament of nanomedicines that limits their anticancer efficacy. The dense extracellular matrix (ECM) in one barriers against deep nanomedicines. In this work, a slimming/excavating strategy proposed for enhanced intratumoral based on an acid‐disassemblable nanomicelles‐assembled nanomedicine and NO‐mediated degradation ECM. constructed by cross‐linking nanomicelles, which are self‐assembled with two kinds dendrimers containing phenylboronic acid lactobionic acid, through borate esterification. acidic microenvironment, pH‐sensitive ester bonds among nanomicelles hydrolyzed, triggering disassembly (≈150 nm) into small (≈25 nm). response to over‐expressed glutathione (GSH), NO donor loaded produces NO, mediates expression metalloproteinases ECM tumor. By collaboration disassembling behavior ECM, designed can penetrate long distance tumors. will provide inspiration overcoming challenge penetration.

Language: Английский

Citations

0