Immunogenic Cell Death and Metabolic Reprogramming in Cancer: Mechanisms, Synergies, and Innovative Therapeutic Strategies DOI Creative Commons
Jie Jiang, Ying Yan, Chunhui Yang

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 950 - 950

Published: April 12, 2025

Immunogenic cell death (ICD) is a promising cancer therapy where dying tumor cells release damage-associated molecular patterns (DAMPs) to activate immune responses. Recent research highlights the critical role of metabolic reprogramming in cells, including Warburg effect, oxidative stress, and lipid metabolism, modulating ICD shaping microenvironment. These changes enhance activation, making tumors more susceptible surveillance. This review explores mechanisms linking mitochondrial endoplasmic reticulum (ER) ferroptosis. It also discusses innovative therapeutic strategies, such as personalized combination therapies, inhibitors, targeted delivery systems, improve efficacy. The future immunotherapy lies integrating activation overcome evasion, with multi-omics approaches microbiome modulation offering new avenues for enhanced treatment outcomes.

Language: Английский

Preparation, characterization, bioactivity, and safety evaluation of PEI-modified PLGA nanoparticles loaded with polysaccharide from Cordyceps militaris DOI
Hongyan Pei, Jun Li, Jian Kuang

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 8(1)

Published: Dec. 29, 2024

Language: Английский

Citations

27
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

9
A mitochondria-interfering nanocomplex cooperates with photodynamic therapy to boost antitumor immunity DOI
Zhijie Zhang,

Qingfu Zhao,

Qingqing Xu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123094 - 123094

Published: Jan. 7, 2025

Language: Английский

Citations

2
Hydrogen‐Bonded Organic Framework Nanoscintillators for X‐Ray‐Induced Photodynamic Therapy in Hepatocellular Carcinoma DOI Open Access

Lihui Gu,

Han Wu, Xu Li

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract X‐ray induced photodynamic therapy (X‐PDT) leverages penetrating to generate singlet oxygen ( 1 O 2 ) for treating deep‐seated tumors. However, conventional X‐PDT typically relies on heavy metal inorganic scintillators and organic photosensitizers produce , which presents challenges related toxicity energy conversion efficiency. In this study, highly biocompatible phosphorescent nanoscintillators based hydrogen‐bonded frameworks (HOF) are designed engineered, termed BPT‐HOF@PEG, enhance in hepatocellular carcinoma (HCC) treatment. BPT‐HOF@PEG functions simultaneously as both scintillator photosensitizer, effectively absorbing transferring abundant . Both vitro vivo investigations demonstrate that internalized efficiently produces significant quantities of upon irradiation. Additionally, exposure directly inflicts DNA damage, the synergistic effects these mechanisms result pronounced cell death substantial tumor growth inhibition, with a inhibition rate up 90.4% assessments. RNA sequencing analyses reveal induces apoptosis Hepa1‐6 cells while inhibiting proliferation, culminating death. Therefore, work highlights considerable potential efficient HOF nanoscintillators‐based promising therapeutic approach HCC, providing effective alternative negligible patients unresectable

Language: Английский

Citations

2
Carrier-Free Nanodrugs: From Bench to Bedside DOI

Fang Fang,

Xiaoyuan Chen

ACS Nano, Journal Year: 2024, Volume and Issue: 18(35), P. 23827 - 23841

Published: Aug. 20, 2024

Carrier-free nanodrugs with extraordinary active pharmaceutical ingredient (API) loading (even 100%), avoidable carrier-induced toxicity, and simple synthetic procedures are considered as one of the most promising candidates for disease theranostics. Substantial studies commercial success "carrier-free" nanocrystals have demonstrated their strong clinical potential. However, practical translations remain challenging impeded by unpredictable assembly processes, insufficient delivery efficiency, an unclear in vivo fate. In this Perspective, we systematically outline contemporary emerging carrier-free based on diverse APIs, well highlight opportunities challenges translation. Looking ahead, further improvements design preparation, drug delivery, efficacy, safety nanomedicines essential to facilitate translation from bench bedside.

Language: Английский

Citations

9
Mitochondrion‐Targeted Type I Photodynamic Therapy for Agonist Independent cGAS‐STING Activation DOI
Yin Xu,

Dongmin An,

Tian Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

CGAS-STING agonists generally lead to hyperimmunity and systemic toxicity, hindering their immunotherapeutic outcomes. Herein, a mitochondrion-targeted nanoagonist (termed HABH) containing boron dipyrromethene (BODIPY)-derived type I photosensitizer (BDP) Au nanoparticle-engineered hollow mesoporous silica (HMSN/AuNPs) has been fabricated for light-controlled mitochondrial stress-inducing agonist-independent cGAS-STING pathway activation. The HABH can actively target tumor tissues release the BDP. Under light illumination, BDP achieves photodynamic therapy (PDT) in mitochondria, generating massive hydroxyl radicals (•OH) inducing stress an oxygen-independent manner, promoting of DNA (mtDNA). Simultaneously, HMSN/AuNPs act as dual nanozymes derive cascade reactions •OH production, elevating intracellular oxidative state, together with BDP-induced stress, finally evoking facilitating interferon. In orthotopic breast models, achieved intratumoral immunoactivation eradicating primary tumors preventing metastasis tumors. Therefore, constructed enabled activation, providing paradigm photoimmunotherapy.

Language: Английский

Citations

1
Photoinduced Synergism of Ferroptosis/Pyroptosis/Oncosis by an O2-Independent Photocatalyst for Enhanced Tumor Immunotherapy DOI

Shankun Yao,

Fengwu Xu,

Ying Wang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Due to O2 dependence, hypoxia-induced apoptosis resistance, and immunosuppressive microenvironment, the effect of traditional photodynamic therapy toward hypoxic solid tumors is severely limited. Herein, we report an O2-independent photocatalyst (EBSe) for tumor immunotherapy potentiation via synergism near-infrared (NIR) light-induced ferroptosis/pyroptosis/oncosis. Simple Se ethyl modifications on methylene blue (MB) endow EBSe with a remarkable phototoxicity enhancement (>2500 folds) excellent index (PI > 32,000) 4T1 cells under hypoxia. exhibits self-adaptive processes that generate enhanced type I/II ROS normoxia elevate carbon radical production Interestingly, shows much higher cell uptake undergoes photoinduced lysosomal-to-nucleus translocation, which activates ferroptosis, pyroptosis, oncosis. The three nonapoptotic pathways potentiates antitumor immune responses in tumor-bearing mice. This work offers reliable strategy developing powerful PSs overcome resistance microenvironment tumors.

Language: Английский

Citations

1
“Mix‐and‐Match”: Self‐Sorting Assembly Governed Supramolecular Polymeric Nanomedicine for Boosting Combined Chemo/Phototherapy DOI

Yanggui Wu,

Ting Li,

Zeke Li

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.

Language: Английский

Citations

1
Nanocatalytic Medicine Enabled Next-Generation Therapeutics for Bacterial Infections DOI Creative Commons
Min Ge, Feng Jiang, Han Lin

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101255 - 101255

Published: Sept. 17, 2024

Language: Английский

Citations

5
Highly Stable Near-Infrared II Luminescent Diradicaloids for Cancer Phototheranostics DOI
Lina Feng,

Yanyan Tuo,

Zipeng Wu

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(47), P. 32582 - 32594

Published: Nov. 13, 2024

Near-infrared II (NIR-II) phototheranostic agents have become prominent for the early diagnosis and precise treatment of cancer. Organic open-shell diradicaloids with distinct structure narrow band gap are promising candidates phototherapeutic due to their strong spin-coupling effect NIR light-harvesting capacity. However, achieving stable efficient NIR-II luminescent is crucial yet rather challenging considering high chemical reactivity self-absorption. Herein, two highly diradicaloids, 2PhNVDPP PhNVDPP, were successfully fabricated by employing an acceptor planarization/π-conjugation extension donor rotation strategy. After encapsulation into water-dispersible nanoparticles (NPs), NPs exhibit luminescence, PCE 53%, improved photo/heat stability. In vivo experiments demonstrated clear visualization blood vessels tumors, as well successful imaging-guided photothermal ablation tumors. This study not only develops a pioneering diradicaloid agent luminescence but also provides unique perspective effectiveness multimodal anticancer therapy.

Language: Английский

Citations

5