Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 470, P. 134216 - 134216
Published: April 4, 2024
Language: Английский
Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 222, P. 114955 - 114955
Published: Nov. 25, 2022
Language: Английский
Citations
74
Small, Journal Year: 2023, Volume and Issue: 19(51)
Published: March 22, 2023
The rapid development of wearable biosensing calls for next-generation devices that allow continuous, real-time, and painless monitoring health status along with responsive medical treatment. Microneedles have exhibited great potential the direct access dermal interstitial fluid (ISF) in a minimally invasive manner. Recent studies microneedle-based evolved from conventional off-line detection to multiplexed, wireless, integrated sensing. In this review, classification fabrication techniques microneedles are first introduced, then representative examples transdermal different sensing modalities summarized. State-of-the-art advances therapeutic closed-loop systems presented formulate guidelines healthcare platforms. challenges prospects discussed pave new avenue toward pragmatic applications real world.
Language: Английский
Citations
61
ACS Nano, Journal Year: 2023, Volume and Issue: 18(1), P. 14 - 27
Published: Dec. 28, 2023
Memristors, promising nanoelectronic devices with in-memory resistive switching behavior that is assembled a physically integrated core processing unit (CPU) and memory even possesses highly possible multistate electrical behavior, could avoid the von Neumann bottleneck of traditional computing show efficient ability parallel computation high information storage. These advantages position them as potential candidates for future data-centric requirements add remarkable vigor to research next-generation artificial intelligence (AI) systems, particularly those involve brain-like applications. This work provides an overview evolution memristor-based devices, from their initial use in creating synapses neural networks application developing advanced AI systems chips. It offers broad perspective key device primitives enabling special applications view materials, nanostructure, mechanism models. We highlight these demonstrations have field AI, point out existing challenges nanodevices toward chips, propose guiding principle outlook promotion system optimization biomedical field.
Language: Английский
Citations
53
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)
Published: Sept. 15, 2023
Dermal interstitial fluid (ISF) is emerging as a rich source of biomarkers that complements conventional biofluids such blood and urine. However, the impact ISF sampling in clinical applications has been limited owing to challenges associated with extraction. The implementation microneedle-based wearable devices can extract dermal pain-free easy-to-use manner attracted growing attention recent years. Here, fully integrated touch-activated device based on laser-drilled hollow microneedle (HMN) patch for continuous sensing introduced. developed platform produce maintain required vacuum pressure (as low ≈ -53 kPa) collect adequate volumes (≈2 µL needle
Language: Английский
Citations
44
Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)
Published: Jan. 15, 2024
Abstract Point‐of‐care (POC) has the capacity to support low‐cost, accurate and real‐time actionable diagnostic data. Microneedle sensors have received considerable attention as an emerging technique evolve blood‐based diagnostics owing their direct painless access a rich source of biomarkers from interstitial fluid. This review systematically summarizes recent innovations in microneedle with particular focus on utility POC personalized medicine. The integration various sensing techniques, mostly electrochemical optical sensing, been established diverse architectures “lab‐on‐a‐microneedle” platforms. tailored geometries, mechanical flexibility, biocompatibility are constructed variety materials fabrication methods. Microneedles categorized into four types: metals, inorganics, polymers, hydrogels, elaborated state‐of‐the‐art bioengineering strategies for minimally invasive, continuous, multiplexed sensing. employed detect wide range electrolytes, metabolites, polysaccharides, nucleic acids, proteins drugs. Insightful perspectives outlined biofluid, microneedles, biosensors, devices, theragnostic instruments, which depict bright future upcoming intelligent health management.
Language: Английский
Citations
39
Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 222 - 241
Published: Oct. 12, 2023
Microneedles (MNs) is an emerging technology that employs needles ranging from 10 to 1000 μm in height, as a minimally invasive technique for various procedures such therapeutics, disease monitoring and diagnostics. The commonly used method of fabrication, micromolding, has the advantage scalability, however, micromolding unable achieve rapid customizability dimensions, geometries architectures, which are pivotal factors determining functionality efficacy MNs. 3D printing offers promising alternative by enabling MN fabrication with high dimensional accuracy required precise applications, leading improved performance. Furthermore, enabled its one-step process, there propitious potential growth 3D-printed MNs especially field personalized on-demand medical devices. This review provides overview considerations key parameters designing MNs, introduction on 3D-printing techniques fabricating this new generation well highlighting advancements biomedical applications facilitated Lastly, we offer some insights into future prospects specifically progress towards translation entry market.
Language: Английский
Citations
43
Advanced Science, Journal Year: 2023, Volume and Issue: 10(7)
Published: Jan. 16, 2023
Continuous monitoring of glucose allows diabetic patients to better maintain blood level by altering insulin dosage or diet according prevailing values and thus prevent potential hyperglycemia hypoglycemia. However, current continuous (CGM) relies mostly on enzyme electrodes micro-dialysis probes, which suffer from insufficient stability, susceptibility corrosion electrodes, weak inconsistent correlation, inevitable interference. A fluorescence-based sensor in the skin will likely be more stable, have improved sensitivity, can resolve issues electrochemical interference tissue. This study develops a fluorescent nanodiamond boronic hydrogel system porous microneedles for CGM. Fluorescent is one most photostable fluorophores with superior biocompatibility. When surface functionalized, integrate polymer form hydrogel, produce signals response environmental concentration. In this proof-of-concept study, strategy building miniatured device developed. The demonstrates remarkable long-term photo signal stability vivo both small large animal models. presents new fluorescence based CGM toward treatment control diabetes.
Language: Английский
Citations
32
Small, Journal Year: 2024, Volume and Issue: 20(26)
Published: Feb. 22, 2024
Abstract Microneedles (MNs) have maintained their popularity in therapeutic and diagnostic medical applications throughout the past decade. MNs are originally designed to gently puncture stratum corneum layer of skin lately evolved into intelligent devices with functions including bodily fluid extraction, biosensing, drug administration. offer limited invasiveness, ease application, minimal discomfort. Initially manufactured solely from metals, now available polymer‐based varieties. can be used create systems that deliver drugs chemicals uniformly, collect fluids, stimulus‐sensitive. Although these advancements favorable terms biocompatibility production costs, they insufficient for use MNs. This is first comprehensive review discusses individual MN toward evolution development smart multifunctional a variety novel impactful future applications. The study examines fabrication techniques, application purposes, experimental details constructs perform multiple concurrently, sensing, drug‐molecule release, sampling, remote communication capabilities. It highly likely near future, MN‐based will useful important component standard practice different
Language: Английский
Citations
16
TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 180, P. 117891 - 117891
Published: July 31, 2024
Language: Английский
Citations
15
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)
Published: Feb. 11, 2024
Abstract Wearable epidermal electronics with non‐ or minimally‐invasive characteristics can collect, transduce, communicate, and interact accessible physicochemical health indicators on the skin. However, due to stratum corneum layer, rich information about body is buried under skin for example, in interstitial fluid. Microneedle patches are typically designed arrays of special microsized needles length within 1000 µm. Such potentially enable access sample biomolecules give therapeutical treatment painlessly transdermally. Integrating microneedle various allows highly efficient transdermal bioelectronics, showing their great promise biomedical healthcare applications. This comprehensive review summarizes highlights recent progress integrated bioelectronics based patches. The design criteria state‐of‐the‐art fabrication techniques such devices initially discussed. Next, different functions, including but not limited monitoring, drug delivery, treatment, highlighted detail. Finally, key issues associated current technologies future opportunities elaborated sort out state research, point potential bottlenecks, provide research directions.
Language: Английский
Citations
9