Janus particles: design, preparation, and biomedical applications

Materials Today Bio, Journal Year: 2019, Volume and Issue: 4, P. 100033 - 100033

Published: Sept. 1, 2019

Janus particles with an anisotropic structure have emerged as a focus of intensive research due to their diverse composition and surface chemistry, which show excellent performance in various fields, especially biomedical applications. In this review, we briefly introduce the structures, composition, properties particles, followed by summary Then review several design strategies including morphology, particle size, modification, that will affect particles. Subsequently, explore synthetic methodologies emphasis on most prevalent method (surface nucleation seeded growth). Following this, highlight applications, drug delivery, bio-imaging, bio-sensing. Finally, consider current challenges materials face perspectives future directions.

Language: Английский

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Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti‐Metastatic Immunotherapy

Advanced Science, Journal Year: 2019, Volume and Issue: 6(22)

Published: Sept. 12, 2019

Abstract Photodynamic therapy (PDT) is clinically promising in destructing primary tumors but ineffective against distant metastases. This study reports the use of immunogenic nanoparticles mediated combination PDT and magnetic hyperthermia to synergistically augment anti‐metastatic efficacy immunotherapy. Janus nanobullets integrating chlorine e6 (Ce6) loaded, disulfide‐bridged mesoporous organosilica bodies with heads (M‐MONs@Ce6) are tailored for redox/pH‐triggered photosensitizer release accompanying their matrix degradation. Cancer cell membrane cloaking enables favorable tumor‐targeted accumulation prolonged blood circulation time M‐MONs@Ce6. The has a strong synergy anticancer activity simultaneously elicits sequence death, resulting tumor‐specific immune responses. When combined anti‐CTLA‐4 antibody, biomimetic biodegradable nanoparticle notable eradication deeply metastatic low systematic toxicity, thus potentially advancing development hyperthermia, PDT, checkpoint blockade immunotherapy combat cancer metastasis.

Language: Английский

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Janus Nanoparticles: From Fabrication to (Bio)Applications

ACS Nano, Journal Year: 2021, Volume and Issue: 15(4), P. 6147 - 6191

Published: March 19, 2021

Janus nanoparticles (JNPs) refer to the integration of two or more chemically discrepant composites into one structure system. Studies JNPs have been significant interest due their interesting characteristics stemming from asymmetric structures, which can integrate different functional properties and perform synergetic functions simultaneously. Herein, we present recent progress particles, comprehensively detailing fabrication strategies applications. First, classification is divided three blocks, consisting polymeric composites, inorganic hybrid polymeric/inorganic composites. Then, are alternately summarized, examining self-assembly strategy, phase separation seed-mediated polymerization, microfluidic preparation nucleation growth methods, masking methods. Finally, various intriguing applications presented, including solid surfactants agents, micro/nanomotors, biomedical such as biosensing, controlled drug delivery, bioimaging, cancer therapy, combined theranostics. Furthermore, challenges future works in this field provided.

Language: Английский

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Biomimetic Diselenide‐Bridged Mesoporous Organosilica Nanoparticles as an X‐ray‐Responsive Biodegradable Carrier for Chemo‐Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(50)

Published: Nov. 9, 2020

Chemotherapy causes off-target toxicity and is often ineffective against solid tumors. Targeted on-demand release of chemotherapeutics remains a challenge. Here, cancer-cell-membrane-coated mesoporous organosilica nanoparticles (MONs) containing X-ray- reactive oxygen species (ROS)-responsive diselenide bonds for controlled doxorubicin (DOX) at tumor sites are developed. DOX-loaded MONs coated with 4T1 breast cancer cell membranes (CM@MON@DOX) show greater accumulation prolonged blood circulation time versus an uncoated control in mice bearing orthotopic mammary Under low-dose X-ray radiation, the exhibit carrier degradation-controlled via cleavage bonds, resulting DOX-mediated immunogenic death site. Combination PD-L1 checkpoint blockade further enhances inhibition growth metastasis low systemic toxicity. Together, findings promise these biomimetic, radiation-responsive diselenide-bond-bridged chemo-immunotherapy.

Language: Английский

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Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Advanced Science, Journal Year: 2021, Volume and Issue: 9(5)

Published: Dec. 19, 2021

Cancer immunotherapy has achieved promising clinical progress over the recent years for its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low patient response rates dose-limiting toxicity remain as major dilemmas immunotherapy. Stimuli-responsive nanoparticles (srNPs) combined with offer possibility amplify anti-tumor immune responses, where weak acidity, high concentration of glutathione, overexpressions enzymes, reactive oxygen species, external stimuli in act triggers controlled drug release. This review highlights design srNPs based on tumor microenvironment and/or combine different drugs, especially immunoregulatory agents, which eventually realize synergistic malignant primary or acquire a long-term memory prevent recurrence. The authors hope that this can provide theoretical guidance construction transformation smart delivery cancer

Language: Английский

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Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(23), P. 12682 - 12705

Published: July 16, 2020

Immunotherapy that harnesses the power of immune system to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune-related adverse events exist as two major issues immunotherapy. In parallel, a variety electromagnetic nanomaterials generate heat and/or reactive oxygen species triggered by energy have been applied magnetic hyperthermia therapy, sonodynamic photothermal photodynamic radiotherapy, which ability induce immunogenic cell death. This review summarizes recent development nanomedicines in combinational The mechanisms reprogramming immunosuppressive tumor microenvironment sensitizing tumors immunotherapy are highlighted. Furthermore, challenges perspectives discussed.

Language: Английский

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Polymeric Nanoparticles with ROS‐Responsive Prodrug and Platinum Nanozyme for Enhanced Chemophotodynamic Therapy of Colon Cancer

Advanced Science, Journal Year: 2020, Volume and Issue: 7(20)

Published: Sept. 6, 2020

Abstract The combination of chemotherapy and photodynamic therapy (PDT) has promising potential in the synergistic treatment cancer. However, are impeded by uncontrolled chemotherapeutics release behavior, targeting deficiencies, hypoxia‐associated poor PDT efficacy solid tumors. Here, a platinum nanozyme (PtNP) loaded reactive oxygen species (ROS)‐responsive prodrug nanoparticle (CPT‐TK‐HPPH/Pt NP) is created to overcome these limitations. ROS‐responsive consists thioketal bond linked with camptothecin (CPT) photosensitizer‐2‐(1‐hexyloxyethyl)‐2‐devinyl pyropheophorbide‐a (HPPH). PtNP CPT‐TK‐HPPH/Pt NP can efficiently catalyze decomposition hydrogen peroxide (H 2 O ) into relieve hypoxia. production satisfy consumption HPPH under 660 nm laser irradiation attain on‐demand CPT ensure enhanced therapy. As tumor diagnosis agent, results photoacoustic imaging fluorescence for exhibit desirable long circulation vivo targeting. NPs effectively inhibit proliferation growth vitro vivo. NP, its excellent drug behavior efficiency serve as new cancer theranostic will further promote research chemophotodynamic

Language: Английский

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Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Biomaterials, Journal Year: 2022, Volume and Issue: 282, P. 121433 - 121433

Published: Feb. 19, 2022

Language: Английский

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Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

Advanced Science, Journal Year: 2020, Volume and Issue: 8(1)

Published: Nov. 27, 2020

The impermeable barrier of solid tumors due to the complexity their components limits treatment effect nanomedicine and hinders its clinical translation. Several methods are available increase penetrability nanomedicine, yet they too complex be effective, operational, or practical. Surface modification employs characteristics direct contact between multiphase surfaces achieve most efficient penetration tumors. Furthermore, simple operation makes use feasible. In this review, latest surface strategies for into summarized classified "bulldozer strategies" "mouse strategies." Additionally, evaluation methods, existing problems, development prospects these technologies discussed.

Language: Английский

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Recent advances in innovative strategies for enhanced cancer photodynamic therapy

Theranostics, Journal Year: 2021, Volume and Issue: 11(7), P. 3278 - 3300

Published: Jan. 1, 2021

Photodynamic therapy (PDT), a non-invasive therapeutic modality, has received increasing attention owing to its high selectivity and limited side effects. Although significant clinical research progress been made in PDT, the breadth depth of application have not fully realized due limitations such as inadequate light penetration depth, non-targeting photosensitizers (PSs), tumor hypoxia. Consequently, numerous investigations put their emphasis on innovative strategies overcome aforementioned enhance effect PDT. Herein, up-to-date advances these methods for PDT are summarized by introducing design PS systems, working mechanisms examples. In addition, current challenges application, future perspectives further improvement also discussed.

Language: Английский

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