Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy

Theranostics, Journal Year: 2020, Volume and Issue: 10(8), P. 3793 - 3815

Published: Jan. 1, 2020

Magnetic hyperthermia (MH) has been introduced clinically as an alternative approach for the focal treatment of tumors.MH utilizes heat generated by magnetic nanoparticles (MNPs) when subjected to alternating field (AMF).It become important topic in nanomedical due their multitudes advantages towards effective antitumor therapy such high biosafety, deep tissue penetration, and targeted selective tumor killing.However, order MH progress realize its paramount potential choice cancer treatment, tremendous challenges have be overcome.Thus, efficiency needs enhancement.In recent 60-year history, focused primarily on heating using MNPs therapeutic applications.Increasing thermal conversion is fundamental strategy improving efficacy.Recently, emerging experimental evidence indicates that MNPs-MH produces nano-scale effects without macroscopic temperature rise.A understanding effect this localized induction destruction subcellular/cellular structures further supports efficacy therapy.In review, currently available strategies will discussed.Firstly, advancements engineering MNP size, composition, shape, surface significantly improve energy dissipation rates explored.Secondly, latest studies depicting local selectively disrupting cells/intracellular examined.Thirdly, enhance therapeutics combining with chemotherapy, radiotherapy, immunotherapy, photothermal/photodynamic (PDT), gene reviewed.Lastly, prospect significant MH-based discussed.This review provide a comprehensive efficacy, which would utmost benefit guiding users future development successful application medicine.

Language: Английский

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Targeting drugs to tumours using cell membrane-coated nanoparticles

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 20(1), P. 33 - 48

Published: Oct. 28, 2022

Language: Английский

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Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(23)

Published: April 21, 2020

Abstract Mesoporous silica nanoparticles (MSNs), one of the important porous materials, have garnered interest owing to their highly attractive physicochemical features and advantageous morphological attributes. They are particular importance for use in diverse fields including, but not limited to, adsorption, catalysis, medicine. Despite intrinsic stable siliceous frameworks, excellent mechanical strength, optimal attributes, pristine MSNs suffer from poor drug loading efficiency, as well compatibility degradability issues therapeutic, diagnostic, tissue engineering purposes. Collectively, desirable beneficial properties been harnessed by modifying surface frameworks through incorporating supramolecular assemblies various metal species, species conjugates. Substantial advancements these innovative colloidal inorganic nanocontainers drive researchers promoting them toward applications like stimuli (light/ultrasound/magnetic)‐responsive delivery‐associated therapies with exceptional performance vivo. Here, a brief overview fabrication along discussions on significant advances MSNs, is provided. The scope advancement terms structural attributes effects biomedical focus recent studies emphasized. Finally, interesting perspectives recapitulated, clinical translation.

Language: Английский

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Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(3)

Published: Jan. 5, 2021

Phototherapy such as photothermal therapy and photodynamic in cancer treatment has been developed quickly over the past few years for its noninvasive nature high efficiency. However, there are still many drawbacks phototherapy that prevent it from clinical applications. Thus, scientists have designed different systems to overcome issues associated with phototherapy, including enhancing targeting ability of low-temperature therapy, replacing near-infrared light other excitation sources, so on. This article discusses problems shortcomings encountered development highlights possible solutions address them may become a useful approach practice. aims give brief summary about current research advancements provides quick guideline toward future developments field.

Language: Английский

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Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Journal for ImmunoTherapy of Cancer, Journal Year: 2021, Volume and Issue: 9(1), P. e001926 - e001926

Published: Jan. 1, 2021

The past decade has witnessed major breakthroughs in cancer immunotherapy. This development been largely motivated by cell evasion of immunological control and consequent tumor resistance to conventional therapies. Immunogenic death (ICD) is considered one the most promising ways achieve total elimination. It activates T-cell adaptive immune response results formation long-term memory. ICD can be triggered many anticancer treatment modalities, including photodynamic therapy (PDT). In this review, we first discuss role PDT based on several classes photosensitizers, porphyrins non-porphyrins, critically evaluate their potential induction. We emphasize emerging trend induction combination with nanotechnology, which represents third-generation photosensitizers involves targeted PDT. However, also some limitations, reduced efficiency hypoxic microenvironment. Therefore, strategies for overcoming limitation, essential increasing efficiency. final part, suggest areas future research personalized immunotherapy, oxygen-boosted nanoparticles. conclusion, insights from last years increasingly support idea that a powerful strategy inducing experimental therapy. studies have focused mouse models, but it necessary validate clinical settings, will challenging area future.

Language: Английский

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Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Language: Английский

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Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(20), P. 11614 - 11667

Published: Jan. 1, 2021

Magnetic hyperthermia (MHT) is a therapeutic modality for the treatment of solid tumors that has now accumulated more than 30 years experience. In ongoing MHT clinical trials brain and prostate tumors, iron oxide nanoparticles are employed as intra-tumoral agents under patient-safe 100 kHz alternating magnetic field (AMF) applicator. Although currently approved by FDA imaging purposes anemia, (MNPs) designed efficient must respond to specific physical-chemical properties in terms magneto-energy conversion, heat dose production, surface chemistry aggregation state. Accordingly, past few decades, these requirements have boosted development new generation MNPs specifically aimed MHT. this review, we present an overview on their assemblies produced via different synthetic routes, focusing which MNP features allowed unprecedented heating efficiency levels be achieved highlighting nanoplatforms prevent loss intracellular environment. Moreover, review advances MNP-based embrace concept multimodal therapy, aims combine with chemotherapy, radiotherapy, immunotherapy, photodynamic or phototherapy. Next, better control temperature at tumor, focus studies optimized maintain gold-standard performance also tackling aim quantitatively assess amount tumor site regulate conditions. To conclude, future perspectives guidance how advance therapy will provided.

Language: Английский

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Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 163-164, P. 65 - 83

Published: Jan. 1, 2020

Significant research and preclinical investment in cancer nanomedicine has produced several products, which have improved care. Nevertheless, there exists a perception that 'has not lived up to its promise' because the number of approved products their clinical performance are modest. Many these analyses do consider long history many developed from iron oxide nanoparticles. Iron nanoparticles enjoyed use for about nine decades demonstrating safety, considerable utility versatility. FDA-approved applications include diagnosis, hyperthermia therapy, deficiency anemia. For nanomedicine, this wealth experience is invaluable provide key lessons highlight pitfalls pursuit nanotechnology-based therapeutics. We review with systemic liposomal drug delivery parenteral therapy anemia (IDA) note success injectable exploits inherent interaction between (innate) immune system, designers seek avoid. Magnetic fluid hyperthermia, harnesses magnetic hysteresis heating treating humans only Despite successful demonstration enhance overall survival trials, thermal medicine struggles establish presence. physical biological attributes approach, suggest reasons barriers acceptance. Finally, despite extensive new exciting points surprising immune-modulating potential. Recent data demonstrate interactions cells can induce anti-tumor responses. These present opportunities explore additional venerable technology. Clinical poignant case studies opportunities, complexities, challenges nanomedicine. They also illustrate need revised paradigms multidisciplinary approaches develop translate nanomedicines into

Language: Английский

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Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Theranostics, Journal Year: 2021, Volume and Issue: 12(1), P. 434 - 458

Published: Dec. 15, 2021

Cancer immunotherapy has made tremendous clinical progress in advanced-stage malignancies. However, patients with various tumors exhibit a low response rate to because of powerful immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity tumors. Photodynamic therapy (PDT) can not only directly kill cells, but also elicit immunogenic cell death (ICD), providing antitumor immunity. Unfortunately, limitations from the inherent nature complex TME significantly reduce efficiency PDT. Recently, smart nanomedicine-based strategies could subtly modulate pharmacokinetics therapeutic compounds optimize both PDT immunotherapy, resulting an improved effect. Here, emerging nanomedicines for PDT-driven cancer are reviewed, including hypoxia-reversed nanomedicines, nanosized metal-organic frameworks, subcellular targeted nanoparticles (NPs). Moreover, we highlight synergistic nanotherapeutics used amplify immune responses combined against Lastly, challenges future expectations field discussed.

Language: Английский

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Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 4996 - 5041

Published: Jan. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Language: Английский

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