Engineered Regeneration,
Journal Year:
2022,
Volume and Issue:
3(2), P. 182 - 200
Published: April 26, 2022
Chronic
skin
wounds
affect
more
than
40
million
patients
globally
and
represent
a
severe
growing
burden
for
the
healthcare
systems,
with
annual
costs
expected
to
exceed
$15
billions
by
2022.
To
satisfy
huge
demand
effective
wound
care
products,
different
types
of
dressings
have
been
introduced
on
market
during
last
decades.
Based
“the
moist
healing
theory”
postulated
Prof
Winter
in
1962,
bandages
were
initially
designed
recreate
optimal
environment
favor
process.
Then,
thanks
advancements
achieved
biomaterial
design
processing,
biotechnology,
imaging
electronic
fields,
great
effort
has
devoted
development
formulations
able
actively
participate
tissue
healing.
Indeed,
both
literature
report
medicated
dressings,
i.e.,
products
releasing
anti-microbial
agents,
anti-inflammatory
drugs,
or
bioactive
molecules.
In
this
scenario,
review
aims
at
critically
describing
currently
available
highlighting
their
proved
effectiveness
management.
Moreover,
an
overview
main
strategies
exploited
personalized
reported.
Lastly,
concerns
regulatory
affairs
practical
issues
limiting
clinical
translation
advanced
research
platforms
also
discussed.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(8), P. 12687 - 12722
Published: Aug. 10, 2021
Hydrogels,
due
to
their
excellent
biochemical
and
mechnical
property,
have
shown
attractive
advantages
in
the
field
of
wound
dressings.
However,
a
comprehensive
review
functional
hydrogel
as
dressing
is
still
lacking.
This
work
first
summarizes
skin
healing
process
relates
evaluation
parameters
then
reviews
advanced
functions
dressings
such
antimicrobial
adhesion
hemostasis,
anti-inflammatory
anti-oxidation,
substance
delivery,
self-healing,
stimulus
response,
conductivity,
recently
emerged
monitoring
feature,
strategies
adopted
achieve
these
are
all
classified
discussed.
Furthermore,
applications
for
treatment
different
types
wounds
incisional
excisional
summarized.
Chronic
also
mentioned,
focus
attention
on
infected
wounds,
burn
diabetic
Finally,
future
directions
further
proposed.
Nano-Micro Letters,
Journal Year:
2021,
Volume and Issue:
14(1)
Published: Dec. 2, 2021
Abstract
Conductive
biomaterials
based
on
conductive
polymers,
carbon
nanomaterials,
or
inorganic
nanomaterials
demonstrate
great
potential
in
wound
healing
and
skin
tissue
engineering,
owing
to
the
similar
conductivity
human
skin,
good
antioxidant
antibacterial
activities,
electrically
controlled
drug
delivery,
photothermal
effect.
However,
a
review
highlights
design
application
of
for
engineering
is
lacking.
In
this
review,
fabrication
methods
with
various
structural
forms
including
film,
nanofiber,
membrane,
hydrogel,
sponge,
foam,
acellular
dermal
matrix
applications
corresponding
mechanism
promoting
process
were
summarized.
The
approaches
that
realize
their
value
wounds
via
three
main
strategies
(electrotherapy,
dressing,
assessment)
reviewed.
as
dressing
when
facing
different
acute
chronic
(infected
diabetic
wound)
monitoring
discussed
detail.
challenges
perspectives
designing
developing
multifunctional
are
proposed
well.
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
10(16)
Published: June 26, 2021
Abstract
The
universal
increase
in
the
number
of
patients
with
nonhealing
skin
wounds
imposes
a
huge
social
and
economic
burden
on
healthcare
systems.
Although,
application
traditional
wound
dressings
contributes
to
an
effective
healing
outcome,
yet,
complexity
process
remains
major
health
challenge.
Recent
advances
materials
fabrication
technologies
have
led
that
provide
proper
conditions
for
healing.
3D‐printed
dressings,
biomolecule‐loaded
as
well
smart
flexible
bandages
are
among
recent
alternatives
been
developed
accelerate
Additionally,
new
generation
contains
variety
microelectronic
sensors
real‐time
monitoring
environment
is
able
apply
required
actions
support
progress.
Moreover,
manufacturing
enable
development
next
dressing
substrates,
known
electronic
skin,
whole
physiochemical
markers
single
platform.
current
study
reviews
importance
emerging
strategy
care
management
highlights
different
types
promoting
process.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(14)
Published: Aug. 29, 2022
Abstract
Flexible
electronics
is
an
emerging
field
of
research
involving
multiple
disciplines,
which
include
but
not
limited
to
physics,
chemistry,
materials
science,
electronic
engineering,
and
biology.
However,
the
broad
applications
flexible
are
still
restricted
due
several
limitations,
including
high
Young's
modulus,
poor
biocompatibility,
responsiveness.
Innovative
aiming
for
overcoming
these
drawbacks
boost
its
practical
application
highly
desirable.
Hydrogel
a
class
3D
crosslinked
hydrated
polymer
networks,
exceptional
material
properties
render
it
as
promising
candidate
next
generation
electronics.
Here,
latest
methods
synthesizing
advanced
functional
hydrogels
state‐of‐art
hydrogel‐based
in
various
fields
reviewed.
More
importantly,
correlation
between
hydrogel
device
performance
discussed
here,
have
better
understanding
development
by
using
environmentally
responsive
hydrogels.
Last,
perspectives
on
current
challenges
future
directions
multifunctional
provided.
ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(7), P. 8793 - 8805
Published: July 9, 2020
An
increasing
utilization
of
flexible
healthcare
electronics
and
biomedicine-related
therapeutic
materials
urges
the
development
multifunctional
wearable/flexible
smart
fabrics
for
personal
therapy
health
management.
However,
it
is
currently
a
challenge
to
fabricate
on-body
electronic
devices
with
reliable
mechanical
flexibility,
excellent
breathability,
self-controllable
joule
heating
effects.
Here,
we
MXene-based
fabric
by
depositing
2D
Ti3C2Tx
nanosheets
onto
cellulose
fiber
nonwoven
via
special
MXene–cellulose
interactions.
Such
exhibit
sensitive
reversible
humidity
response
upon
H2O-induced
swelling/contraction
channels
between
MXene
interlayers,
enabling
wearable
respiration
monitoring
application.
Besides,
can
also
serve
as
low-voltage
thermotherapy
platform
due
its
fast
stable
electro-thermal
response.
Interestingly,
water
molecular
extraction
induces
electrical
heating,
i.e.,
functioning
temperature
alarm,
which
allows
real-time
without
low-temperature
burn
risk.
Furthermore,
metal-like
conductivity
renders
an
Joule
effect,
moderately
kill
bacteria
surrounding
wound
in
bacteria-infected
healing
therapy.
This
work
introduces
suitable
next-generation
mobile
medical
Biomolecules,
Journal Year:
2020,
Volume and Issue:
10(8), P. 1169 - 1169
Published: Aug. 11, 2020
Skin
is
the
largest
organ
of
human
body,
protecting
it
against
external
environment.
Despite
high
self-regeneration
potential,
severe
skin
defects
will
not
heal
spontaneously
and
need
to
be
covered
by
substitutes.
Tremendous
progress
has
been
made
in
field
tissue
engineering,
recent
years,
develop
new
Among
them,
hydrogels
are
one
candidates
with
most
potential
mimic
native
microenvironment,
due
their
porous
hydrated
molecular
structure.
They
can
applied
as
a
permanent
or
temporary
dressing
for
different
wounds
support
regeneration
healing
injured
epidermis,
dermis,
both.
Based
on
material
used
fabrication,
subdivided
into
two
main
groups-natural
synthetic.
Moreover,
reinforced
incorporating
nanoparticles
obtain
"in
situ"
hybrid
hydrogels,
showing
superior
properties
tailored
functionality.
In
addition,
sensors
embedded
hydrogel
wound
dressings
provide
real-time
information
about
This
review
focuses
developments
hydrogel-based
substitutes
replacement.
particular,
we
discuss
synthesis,
biomedical
application
novel
"smart"
hydrogels.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(6)
Published: Jan. 10, 2020
Abstract
As
the
most
frequent
wound
complication,
infection
has
become
a
major
clinical
challenge
in
management.
To
overcome
“Black
Box”
status
of
wound‐healing
process,
next‐generation
dressings
with
abilities
real‐time
monitoring,
diagnosis
during
early
stages,
and
on‐demand
therapy
attracted
considerable
attention.
Here,
by
combining
emerging
development
bioelectronics,
smart
flexible
electronics‐integrated
dressing
double‐layer
structure,
upper
layer
which
is
polydimethylsiloxane‐encapsulated
electronics
integrated
temperature
sensor
ultraviolet
(UV)
light‐emitting
diodes,
lower
UV‐responsive
antibacterial
hydrogel,
designed.
This
expected
to
provide
via
wound‐temperature
monitoring
treatment
release
antibiotics
from
hydrogel
situ
UV
irradiation.
The
system
possesses
good
flexibility,
excellent
compatibility,
high
sensitivity
durability.
Animal
experiment
results
demonstrate
that
capable
real
time,
detecting
bacterial
providing
effective
on
basis
need.
proof‐of‐concept
research
holds
great
promise
developing
new
strategies
significantly
improve
management
other
pathological
diagnoses
treatments.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(21)
Published: April 6, 2020
Abstract
Here,
a
novel
macroporous
hydrogel
dressing
is
presented
that
can
accelerate
wound
healing
and
guard
against
bacteria‐associated
infection.
Carboxymethyl
agarose
(CMA)
successfully
prepared
from
agarose.
The
CMA
molecular
chains
are
cross‐linked
by
hydrogen
bonding
to
form
supramolecular
hydrogel,
the
hydroxy
groups
in
molecules
complex
with
Ag
+
promote
formation.
This
composite
exhibits
pH‐responsiveness
temperature‐responsiveness
releases
,
an
antibacterial
agent,
over
prolonged
period
of
time.
Moreover,
this
outstanding
cytocompatibility
hemocompatibility.
In
vitro
vivo
investigations
demonstrate
has
enhanced
anti‐inflammatory
capabilities
significantly
skin
tissue
regeneration
closure.
Astonishingly,
cause
inflammation
process
occur
earlier
for
shorter
amount
time
than
normal
process.
Given
its
excellent
antibacterial,
anti‐inflammatory,
physicochemical
properties,
broad
application
management
anticipated.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(2), P. 1708 - 1733
Published: Jan. 20, 2022
Wound
dressings
based
on
nanomaterials
play
a
crucial
role
in
wound
treatment
and
are
widely
used
whole
range
of
medical
settings,
from
minor
to
life-threatening
tissue
injuries.
This
article
presents
an
educational
review
the
accumulating
knowledge
this
multidisciplinary
area
lay
out
challenges
opportunities
that
lie
ahead
ignite
further
faster
development
clinically
valuable
technologies.
The
analyzes
functional
advantages
nanomaterial-based
gauzes
hydrogels
as
well
hybrid
structures
thereof.
On
basis,
state-of-the-art
advances
transfer
(semi)blind
approaches
evaluation
state
smart
enable
real-time
monitoring
diagnostic
functions
could
help
during
healing.
explores
translation
related
aspects
into
real-world
use.
ongoing
future
associated
with
clinical
decisions
presented
reviewed.