Functional Hydrogels as Wound Dressing to Enhance Wound Healing

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12687 - 12722

Published: Aug. 10, 2021

Hydrogels, due to their excellent biochemical and mechnical property, have shown attractive advantages in the field of wound dressings. However, a comprehensive review functional hydrogel as dressing is still lacking. This work first summarizes skin healing process relates evaluation parameters then reviews advanced functions dressings such antimicrobial adhesion hemostasis, anti-inflammatory anti-oxidation, substance delivery, self-healing, stimulus response, conductivity, recently emerged monitoring feature, strategies adopted achieve these are all classified discussed. Furthermore, applications for treatment different types wounds incisional excisional summarized. Chronic also mentioned, focus attention on infected wounds, burn diabetic Finally, future directions further proposed.

Language: Английский

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Smart wound dressings for wound healing

Nano Today, Journal Year: 2021, Volume and Issue: 41, P. 101290 - 101290

Published: Sept. 22, 2021

Language: Английский

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Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 14(1)

Published: Dec. 2, 2021

Abstract Conductive biomaterials based on conductive polymers, carbon nanomaterials, or inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity human skin, good antioxidant antibacterial activities, electrically controlled drug delivery, photothermal effect. However, a review highlights design application of for engineering is lacking. In this review, fabrication methods with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, acellular dermal matrix applications corresponding mechanism promoting process were summarized. The approaches that realize their value wounds via three main strategies (electrotherapy, dressing, assessment) reviewed. as dressing when facing different acute chronic (infected diabetic wound) monitoring discussed detail. challenges perspectives designing developing multifunctional are proposed well.

Language: Английский

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Wound Healing: From Passive to Smart Dressings

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(16)

Published: June 26, 2021

Abstract The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden on healthcare systems. Although, application traditional wound dressings contributes to an effective healing outcome, yet, complexity process remains major health challenge. Recent advances materials fabrication technologies have led that provide proper conditions for healing. 3D‐printed dressings, biomolecule‐loaded as well smart flexible bandages are among recent alternatives been developed accelerate Additionally, new generation contains variety microelectronic sensors real‐time monitoring environment is able apply required actions support progress. Moreover, manufacturing enable development next dressing substrates, known electronic skin, whole physiochemical markers single platform. current study reviews importance emerging strategy care management highlights different types promoting process.

Language: Английский

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Hydrogel‐Based Flexible Electronics

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(14)

Published: Aug. 29, 2022

Abstract Flexible electronics is an emerging field of research involving multiple disciplines, which include but not limited to physics, chemistry, materials science, electronic engineering, and biology. However, the broad applications flexible are still restricted due several limitations, including high Young's modulus, poor biocompatibility, responsiveness. Innovative aiming for overcoming these drawbacks boost its practical application highly desirable. Hydrogel a class 3D crosslinked hydrated polymer networks, exceptional material properties render it as promising candidate next generation electronics. Here, latest methods synthesizing advanced functional hydrogels state‐of‐art hydrogel‐based in various fields reviewed. More importantly, correlation between hydrogel device performance discussed here, have better understanding development by using environmentally responsive hydrogels. Last, perspectives on current challenges future directions multifunctional provided.

Language: Английский

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Smart Ti₃C₂T_x MXene Fabric with Fast Humidity Response and Joule Heating for Healthcare and Medical Therapy Applications

ACS Nano, Journal Year: 2020, Volume and Issue: 14(7), P. 8793 - 8805

Published: July 9, 2020

An increasing utilization of flexible healthcare electronics and biomedicine-related therapeutic materials urges the development multifunctional wearable/flexible smart fabrics for personal therapy health management. However, it is currently a challenge to fabricate on-body electronic devices with reliable mechanical flexibility, excellent breathability, self-controllable joule heating effects. Here, we MXene-based fabric by depositing 2D Ti3C2Tx nanosheets onto cellulose fiber nonwoven via special MXene–cellulose interactions. Such exhibit sensitive reversible humidity response upon H2O-induced swelling/contraction channels between MXene interlayers, enabling wearable respiration monitoring application. Besides, can also serve as low-voltage thermotherapy platform due its fast stable electro-thermal response. Interestingly, water molecular extraction induces electrical heating, i.e., functioning temperature alarm, which allows real-time without low-temperature burn risk. Furthermore, metal-like conductivity renders an Joule effect, moderately kill bacteria surrounding wound in bacteria-infected healing therapy. This work introduces suitable next-generation mobile medical

Language: Английский

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Advanced Hydrogels as Wound Dressings

Biomolecules, Journal Year: 2020, Volume and Issue: 10(8), P. 1169 - 1169

Published: Aug. 11, 2020

Skin is the largest organ of human body, protecting it against external environment. Despite high self-regeneration potential, severe skin defects will not heal spontaneously and need to be covered by substitutes. Tremendous progress has been made in field tissue engineering, recent years, develop new Among them, hydrogels are one candidates with most potential mimic native microenvironment, due their porous hydrated molecular structure. They can applied as a permanent or temporary dressing for different wounds support regeneration healing injured epidermis, dermis, both. Based on material used fabrication, subdivided into two main groups-natural synthetic. Moreover, reinforced incorporating nanoparticles obtain "in situ" hybrid hydrogels, showing superior properties tailored functionality. In addition, sensors embedded hydrogel wound dressings provide real-time information about This review focuses developments hydrogel-based substitutes replacement. particular, we discuss synthesis, biomedical application novel "smart" hydrogels.

Language: Английский

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Smart Flexible Electronics‐Integrated Wound Dressing for Real‐Time Monitoring and On‐Demand Treatment of Infected Wounds

Advanced Science, Journal Year: 2020, Volume and Issue: 7(6)

Published: Jan. 10, 2020

Abstract As the most frequent wound complication, infection has become a major clinical challenge in management. To overcome “Black Box” status of wound‐healing process, next‐generation dressings with abilities real‐time monitoring, diagnosis during early stages, and on‐demand therapy attracted considerable attention. Here, by combining emerging development bioelectronics, smart flexible electronics‐integrated dressing double‐layer structure, upper layer which is polydimethylsiloxane‐encapsulated electronics integrated temperature sensor ultraviolet (UV) light‐emitting diodes, lower UV‐responsive antibacterial hydrogel, designed. This expected to provide via wound‐temperature monitoring treatment release antibiotics from hydrogel situ UV irradiation. The system possesses good flexibility, excellent compatibility, high sensitivity durability. Animal experiment results demonstrate that capable real time, detecting bacterial providing effective on basis need. proof‐of‐concept research holds great promise developing new strategies significantly improve management other pathological diagnoses treatments.

Language: Английский

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A Macroporous Hydrogel Dressing with Enhanced Antibacterial and Anti‐Inflammatory Capabilities for Accelerated Wound Healing

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(21)

Published: April 6, 2020

Abstract Here, a novel macroporous hydrogel dressing is presented that can accelerate wound healing and guard against bacteria‐associated infection. Carboxymethyl agarose (CMA) successfully prepared from agarose. The CMA molecular chains are cross‐linked by hydrogen bonding to form supramolecular hydrogel, the hydroxy groups in molecules complex with Ag + promote formation. This composite exhibits pH‐responsiveness temperature‐responsiveness releases , an antibacterial agent, over prolonged period of time. Moreover, this outstanding cytocompatibility hemocompatibility. In vitro vivo investigations demonstrate has enhanced anti‐inflammatory capabilities significantly skin tissue regeneration closure. Astonishingly, cause inflammation process occur earlier for shorter amount time than normal process. Given its excellent antibacterial, anti‐inflammatory, physicochemical properties, broad application management anticipated.

Language: Английский

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Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 1708 - 1733

Published: Jan. 20, 2022

Wound dressings based on nanomaterials play a crucial role in wound treatment and are widely used whole range of medical settings, from minor to life-threatening tissue injuries. This article presents an educational review the accumulating knowledge this multidisciplinary area lay out challenges opportunities that lie ahead ignite further faster development clinically valuable technologies. The analyzes functional advantages nanomaterial-based gauzes hydrogels as well hybrid structures thereof. On basis, state-of-the-art advances transfer (semi)blind approaches evaluation state smart enable real-time monitoring diagnostic functions could help during healing. explores translation related aspects into real-world use. ongoing future associated with clinical decisions presented reviewed.

Language: Английский

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