ACS Chemical Neuroscience,
Journal Year:
2021,
Volume and Issue:
12(11), P. 1835 - 1853
Published: May 19, 2021
The
blood–brain
barrier
(BBB)
is
a
prime
focus
for
clinicians
to
maintain
the
homeostatic
function
in
health
and
deliver
theranostics
brain
cancer
number
of
neurological
diseases.
structural
hierarchy
situ
biochemical
signaling
BBB
neurovascular
unit
have
been
primary
targets
recapitulate
into
vitro
modules.
microengineered
perfusion
systems
development
3D
cellular
organoid
culture
given
major
thrust
research
neuropharmacology.
In
this
review,
we
on
revisiting
nanoparticles
based
bimolecular
engineering
enable
them
maneuver,
control,
target,
theranostic
payloads
across
as
nanorobots
or
nanobots.
Subsequently
provide
brief
outline
specific
case
studies
addressing
payload
delivery
tumor
disorders
(e.g.,
Alzheimer's
disease,
Parkinson's
multiple
sclerosis,
etc.).
addition,
also
address
opportunities
challenges
nanorobots'
design.
Finally,
how
computationally
powered
machine
learning
(ML)
tools
artificial
intelligence
(AI)
can
be
partnered
with
robotics
predict
design
next
generation
interact
without
causing
damage,
toxicity,
malfunctions.
content
review
could
references
multidisciplinary
science
clinicians,
roboticists,
chemists,
bioengineers
involved
cutting-edge
pharmaceutical
research.
Technological Forecasting and Social Change,
Journal Year:
2023,
Volume and Issue:
193, P. 122588 - 122588
Published: May 4, 2023
The
recent
devastating
pandemic
has
drastically
reminded
humanity
of
the
importance
constant
scientific
and
technological
progress.
A
strong
interdisciplinary
dialogue
between
academic
industrial
scientists
various
specialties,
entrepreneurs,
managers
public
is
paramount
in
triggering
new
breakthrough
ideas
which
often
emerge
at
interface
disciplines.
following
sections,
compiled
by
a
highly
diverse
group
authors,
are
summarizing
recently
achieved
game-changing
leaps
science
technology.
game-changers
range
from
paradigm
shifts
theories
to
make
impact
over
several
decades
that
have
potential
change
our
everyday
lives
tomorrow.
paper
an
relevance
for
thinkers,
large
corporations'
strategic
planners,
top
executives
alike;
it
provides
glimpse
into
what
further
breakthroughs
future
may
hold
thereby
intends
spark
with
its
readers.
Nano-Micro Letters,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: May 29, 2023
Abstract
Micro/nanorobots
can
propel
and
navigate
in
many
hard-to-reach
biological
environments,
thus
may
bring
revolutionary
changes
to
biomedical
research
applications.
However,
current
MNRs
lack
the
capability
collectively
perceive
report
physicochemical
unknown
microenvironments.
Here
we
propose
develop
swarming
responsive
photonic
nanorobots
that
map
local
conditions
on
fly
further
guide
localized
photothermal
treatment.
The
RPNRs
consist
of
a
nanochain
periodically-assembled
magnetic
Fe
3
O
4
nanoparticles
encapsulated
hydrogel
shell,
show
multiple
integrated
functions,
including
energetic
magnetically-driven
motions,
bright
stimuli-responsive
structural
colors,
conversion.
Thus,
they
actively
complex
environments
utilizing
their
controllable
then
visualize
targets
(e.g.,
tumor
lesion)
by
mapping
out
abnormal
pH,
temperature,
or
glucose
concentration)
via
external
light
irradiation
initiate
This
work
facilitates
development
intelligent
motile
nanosensors
versatile
multifunctional
nanotheranostics
for
cancer
inflammatory
diseases.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(14), P. 12971 - 12999
Published: July 11, 2023
Swarms,
which
stem
from
collective
behaviors
among
individual
elements,
are
commonly
seen
in
nature.
Since
two
decades
ago,
scientists
have
been
attempting
to
understand
the
principles
of
natural
swarms
and
leverage
them
for
creating
artificial
swarms.
To
date,
underlying
physics;
techniques
actuation,
navigation,
control;
field-generation
systems;
a
research
community
now
place.
This
Review
reviews
fundamental
applications
micro/nanorobotic
The
generation
mechanisms
emergent
micro/nanoagents
identified
over
past
elucidated.
advantages
drawbacks
different
techniques,
existing
control
systems,
major
challenges,
potential
prospects
discussed.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(22)
Published: March 9, 2024
Abstract
The
precise
targeted
delivery
of
therapeutic
agents
to
deep
regions
the
brain
is
crucial
for
effective
treatment
various
neurological
diseases.
However,
achieving
this
goal
challenging
due
presence
blood‒brain
barrier
(BBB)
and
complex
anatomy
brain.
Here,
a
biomimetic
self‐propelled
nanomotor
with
cascade
targeting
capacity
developed
inflammatory
nanomotors
are
designed
asymmetric
structures
mesoporous
SiO
2
head
multiple
MnO
tentacles.
Macrophage
membrane
modification
endows
BBB
penetration
abilities
catalyze
degradation
H
O
into
,
not
only
by
reducing
inflammation
but
also
providing
driving
force
penetration.
Additionally,
loaded
curcumin,
which
actively
regulates
macrophage
polarization
from
M1
M2
phenotype.
All
in
vitro
cell,
organoid
model,
vivo
animal
experiments
confirmed
effectiveness
targeting,
penetration,
anti‐inflammatory,
nervous
system
function
maintenance.
Therefore,
study
introduces
platform
ability
active
Nature Nanotechnology,
Journal Year:
2024,
Volume and Issue:
19(4), P. 494 - 503
Published: Jan. 3, 2024
Abstract
Microscale
organisms
and
specialized
motile
cells
use
protein-based
spring-like
responsive
structures
to
sense,
grasp
move.
Rendering
this
biomechanical
transduction
functionality
in
an
artificial
micromachine
for
applications
single-cell
manipulations
is
challenging
due
the
need
a
bio-applicable
nanoscale
spring
system
with
large
programmable
strain
response
piconewton-scale
forces.
Here
we
present
three-dimensional
nanofabrication
monolithic
integration,
based
on
acrylic
elastomer
photoresist,
of
magnetic
quantifiable
compliance
sensitive
0.5
pN,
constructed
customized
elasticity
magnetization
distributions
at
nanoscale.
We
demonstrate
effective
design
programmability
these
‘picospring’
ensembles
as
energy
mechanisms
integrated
construction
soft
micromachines,
onboard
sensing
actuation
functions
scale
microrobotic
grasping
locomotion.
The
integration
active
springs
into
offers
avenue
create
biocompatible
microrobots
non-disruptive
interactions
biological
entities.
Science Robotics,
Journal Year:
2024,
Volume and Issue:
9(87)
Published: Feb. 21, 2024
Micro/nanorobotic
swarms
consisting
of
numerous
tiny
building
blocks
show
great
potential
in
biomedical
applications
because
their
collective
active
delivery
ability,
enhanced
imaging
contrast,
and
environment-adaptive
capability.
However,
vivo
real-time
tracking
micro/nanorobotic
remain
a
challenge,
considering
the
limited
size
spatial-temporal
resolution
current
modalities.
Here,
we
propose
strategy
that
enables
navigation
microswarm
stagnant
flowing
blood
environments
by
using
laser
speckle
contrast
(LSCI),
featuring
full-field
imaging,
high
temporal-spatial
resolution,
noninvasiveness.
The
change
dynamic
convection
induced
can
be
quantitatively
investigated
analyzing
perfusion
unit
(PU)
distribution,
offering
an
alternative
approach
to
investigate
swarm
behavior
its
interaction
with
various
environments.
Both
surrounding
environment
were
monitored
imaged
LSCI
real
time,
images
further
analyzed
for
simultaneous
complex
vascular
system.
Moreover,
our
realized
vivo,
showing
promising
LSCI-guided
Cyborg and Bionic Systems,
Journal Year:
2024,
Volume and Issue:
5
Published: Jan. 1, 2024
Untethered
and
self-transformable
miniature
robots
are
capable
of
performing
reconfigurable
deformation
on-demand
locomotion,
which
aid
the
traversal
toward
various
lumens,
bring
revolutionary
changes
for
targeted
delivery
in
gastrointestinal
(GI)
tract.
However,
viscous
non-Newtonian
liquid
environment
plicae
gastricae
obstacles
severely
hamper
high-precision
actuation
payload
delivery.
Here,
we
developed
a
low-friction
soft
robot
by
assembly
densely
arranged
cone
structures
grafting
hydrophobic
monolayers.
The
magnetic
orientation
encoded
can
move
multiple
modes,
with
substantially
reduced
drag,
terrain
adaptability,
improved
motion
velocity
across
liquids.
Notably,
stiffness
be
reversibly
controlled
magnetically
induced
hardening,
enabling
on-site
scratching
destruction
antibiotic-ineradicable
polymeric
matrix
biofilms
low-frequency
field.
Furthermore,
magnetocaloric
effect
utilized
to
eradicate
bacteria
under
high-frequency
alternating
To
verify
potential
applications
inside
body,
clinical
imaging-guided
platforms
were
vision-based
control
robots.
show
their
high
perform
bacterial
infection
therapy
lumens
body.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 30, 2024
Wireless
capsule
endoscopy
(WCE)
offers
a
non-invasive
evaluation
of
the
digestive
system,
eliminating
need
for
sedation
and
risks
associated
with
conventional
endoscopic
procedures.
Its
significance
lies
in
diagnosing
gastrointestinal
tissue
irregularities,
especially
small
intestine.
However,
existing
commercial
WCE
devices
face
limitations,
such
as
absence
autonomous
lesion
detection
treatment
capabilities.
Recent
advancements
micro-electromechanical
fabrication
computational
methods
have
led
to
extensive
research
sophisticated
technology
integration
into
endoscopes,
intending
supersede
wired
endoscopes.
This
Review
discusses
future
requirements
intelligent
robots,
providing
comparative
various
methods'
merits
disadvantages,
highlighting
recent
developments
six
technologies
relevant
WCE.
These
include
near-field
wireless
power
transmission,
magnetic
field
active
drive,
ultra-wideband/intrabody
communication,
hybrid
localization,
AI-based
detection,
magnetic-controlled
diagnosis
treatment.
Moreover,
we
explore
feasibility
"capsule
surgeons".
