Nano Today, Journal Year: 2021, Volume and Issue: 42, P. 101358 - 101358
Published: Dec. 28, 2021
Language: Английский
Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100032 - 100032
Published: Jan. 29, 2024
Nanozymes exhibit immense potential and promising prospects in the realm of diagnostic imaging tumor therapy, owing to their inherent physicochemical properties enzymatic activities. With further development application nanotechnology, nanozymes are expected become an important tool field medicine, providing new solutions for disease diagnosis treatment. This review provides overview recent studies over past five years on capable responding microenvironment (TME) multimodal imaging, with a focus hypoxia, acid pH, excess GSH ROS. In addition, we present current status several common related contrast agents, such as MRI/CT, MRI/PET, MRI/SPECT, PET/CT. Moreover, some thoughts challenges, future development, clinical translation microenvironment-responsive shared. aims provide up-to-date theranostic nanomedicine reference those who fields, promote progress this interdisciplinary subject, accelerate translation.
Language: Английский
Citations
20
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)
Published: Aug. 3, 2024
Abstract Complex microenvironments with bacterial infection, persistent inflammation, and impaired angiogenesis are the major challenges in chronic refractory diabetic ulcers. To address this challenge, a comprehensive strategy highly effective integrated antimicrobial, anti‐inflammatory, accelerated will offer new pathway to rapid healing of infected Here, inspired by tunable reactive oxygen species (ROS) regulation properties natural peroxisomes, work reports design infectious inflammatory self‐adaptive artificial peroxisomes synergetic Co‐Ru pair centers (APCR) for programmed ulcer therapy. Benefiting from synergistic Co Ru atoms, APCR can simultaneously achieve ROS production metabolic inhibition sterilization microenvironment. After disinfection, also eliminate alleviate oxidative stress microenvironment promote wound regeneration. The data demonstrate that combines antibacterial, provascular regeneration capabilities, making it an efficient safe nanomedicine treating foot ulcers via treatment pathway. This expects synthesizing bifunctional enzyme‐like provide promising path construct catalytic materials complex ulcers, trauma, or other infection‐caused diseases.
Language: Английский
Citations
18
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 15, 2024
With increasing proportion of the elderly in population, age-related diseases (ARD) lead to a considerable healthcare burden society. Prevention and treatment ARD can decrease negative impact aging disease. The rate is closely associated with production high levels reactive oxygen species (ROS). ROS-mediated oxidative stress triggers aging-related changes through lipid peroxidation, protein oxidation, DNA oxidation. Antioxidants control autoxidation by scavenging free radicals or inhibiting their formation, thereby reducing stress. Benefiting from significant advances nanotechnology, large number nanomaterials ROS-scavenging capabilities have been developed. be divided into two categories: as carriers for delivering drugs, themselves activity. This study summarizes current prevention ARD, highlights potential mechanisms used discusses challenges prospects applications.
Language: Английский
Citations
17
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 382 - 395
Published: Jan. 17, 2025
Language: Английский
Citations
3
Nano Today, Journal Year: 2021, Volume and Issue: 42, P. 101358 - 101358
Published: Dec. 28, 2021
Language: Английский
Citations
103