Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

Bioactive Materials, Journal Year: 2022, Volume and Issue: 22, P. 141 - 167

Published: Sept. 29, 2022

Currently, there are no clinical drugs available to treat acute kidney injury (AKI). Given the high prevalence and mortality rate of AKI, development effectively AKI is a huge unmet medical need research hotspot. Although existing evidence fully demonstrates that reactive oxygen nitrogen species (RONS) burst at site major contributor progression, heterogeneity, complexity, unique physiological structure make most antioxidant anti-inflammatory small molecule ineffective because lack targeting side effects. Recently, nanodrugs with intrinsic through control size, shape, surface properties have opened exciting prospects for treatment AKI. Many emerged address limitations current treatments. In this review, we systematically summarized first time about emerging exploit pathological features overcome traditional small-molecule achieve efficacy. First, analyzed structural characteristics main mechanism AKI: hypoxia, harmful substance accumulation-induced RONS renal despite multifactorial initiation heterogeneity Subsequently, introduced strategies used improve reviewed advances nano-RONS-sacrificial agents, nanozymes, nanocarriers antioxidants drugs. These demonstrated excellent therapeutic effects, such as greatly reducing oxidative stress damage, restoring function, low Finally, discussed challenges future directions translating into treatment.

Language: Английский

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Oral Metal‐Free Melanin Nanozymes for Natural and Durable Targeted Treatment of Inflammatory Bowel Disease (IBD)

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 9, 2023

Oral antioxidant nanozymes bring great promise for inflammatory bowel disease (IBD) treatment. To efficiently eliminate reactive oxygen species (ROS), various metal-based have been developed the treatment of IBD but their practical applications are seriously impaired by unstable ROS-eliminating properties and potential metal ion leakage in digestive tract. Here, authors first time propose metal-free melanin (MeNPs) with excellent gastrointestinal stability biocompatibility as a favorable therapy strategy IBD. Moreover, MeNPs extremely natural long-lasting characteristics targeting lesions. In view dominant role ROS IBD, further reveal that oral administration can greatly alleviate six major pathological features IBD: oxidative stress, endoplasmic reticulum apoptosis, inflammation, gut barrier disruption, dysbiosis. Overall, this highlights clinical application prospects via harnessing scavenging at lesions, offering paradigm nanozyme or other diseases.

Language: Английский

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State of the art advancements in sonodynamic therapy (SDT): Metal-Organic frameworks for SDT

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 449, P. 137889 - 137889

Published: July 4, 2022

Language: Английский

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Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(12), P. 1502 - 1514

Published: Oct. 26, 2023

Language: Английский

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Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 20, 2023

Abstract Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, efficient treatment has always been hot topic research medicine. In past decades, as a potential biomaterial, stimuli‐responsive hydrogels have focus attention for due their excellent biocompatibility and design flexibility. Recently, thanks rapid development nanotechnology material science, more efforts made develop safer, personal effective therapy some frequent but tough such sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, ulcerative colitis. Herein, from recent studies articles, conventional emerging delivery anti‐inflammatory drugs summarized. And prospects clinical translation future also discussed further detail.

Language: Английский

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Microenvironment-responsive nanocarriers for targeted bone disease therapy

Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101838 - 101838

Published: March 29, 2023

Language: Английский

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Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 15, 2024

Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.

Language: Английский

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pH-responsive size-adjustable liposomes induce apoptosis of fibroblasts and macrophages for rheumatoid arthritis treatment

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 179, P. 256 - 271

Published: March 12, 2024

Language: Английский

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Cell Membrane-derived Nanovesicles as Extracellular Vesicle-mimetics in Wound Healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101595 - 101595

Published: Feb. 19, 2025

Language: Английский

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Emerging early diagnostic methods for acute kidney injury

Theranostics, Journal Year: 2022, Volume and Issue: 12(6), P. 2963 - 2986

Published: Jan. 1, 2022

Many factors such as trauma and COVID-19 cause acute kidney injury (AKI).Late AKI have a very high incidence mortality rate.Early diagnosis of provides critical therapeutic time window for treatment to prevent progression chronic renal failure.However, the current clinical detection based on creatinine urine output isn't effective in diagnosing early AKI.In recent years, has made great progress with advancement information technology, nanotechnology, biomedicine.These emerging methods are mainly divided into two aspects: First, predicting through models construct by machine learning; Second, newly-discovered biomarkers.Currently, these shown potential become an attractive tool AKI.Therefore, it is important discuss summarize this review, we first systematically application learning prediction algorithms specific scenarios.In addition, introduce key role biomarkers AKI, then comprehensively technologies AKI.Finally, challenges prospects biomarker detection.The review expected provide new insights provided inspiration design other major diseases.

Language: Английский

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