Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: March 22, 2023
Abstract
The
human
body
is
colonized
by
abundant
and
diverse
microorganisms,
collectively
known
as
the
microbiome.
oral
cavity
has
more
than
700
species
of
bacteria
consists
unique
microbiome
niches
on
mucosal
surfaces,
tooth
hard
tissue,
in
saliva.
homeostatic
balance
between
microbiota
immune
system
plays
an
indispensable
role
maintaining
well-being
health
status
host.
Growing
evidence
demonstrated
that
dysbiosis
actively
involved
regulating
initiation
progression
array
autoimmune
diseases.
Oral
driven
multiple
factors,
such
host
genetic
dietary
habits,
stress,
smoking,
administration
antibiotics,
tissue
injury
infection.
dysregulation
a
crucial
triggering
promoting
diseases
via
several
mechanisms,
including
microbial
translocation,
molecular
mimicry,
autoantigen
overproduction,
amplification
responses
cytokines.
Good
hygiene
behaviors,
low
carbohydrate
diets,
healthy
lifestyles,
usage
prebiotics,
probiotics
or
synbiotics,
transplantation
nanomedicine-based
therapeutics
are
promising
avenues
for
balanced
treating
microbiota-mediated
Thus,
comprehensive
understanding
relationship
critical
providing
novel
insights
into
development
microbiota-based
therapeutic
approaches
combating
these
refractory
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(15)
Published: June 10, 2021
Abstract
Cytokines
are
critical
mediators
that
oversee
and
regulate
immune
inflammatory
responses
via
complex
networks
serve
as
biomarkers
for
many
diseases.
Quantification
of
cytokines
has
significant
value
in
both
clinical
medicine
biology
the
levels
provide
insights
into
physiological
pathological
processes
can
be
used
to
aid
diagnosis
treatment.
their
significance
introduced
from
perspective
pro‐
anti‐inflammatory
effects.
Factors
affecting
quantification
biological
fluids,
native
different
body
sample
processing
storage
conditions,
sensitivity
freeze‐thaw,
soluble
cytokine
receptors
discussed.
In
addition,
recent
advances
vitro
vivo
assays,
biosensors
based
on
signal
outputs
intracellular
extracellular
protein
expression
summarized.
Various
platforms
high‐sensitivity
reliable
measurement
scenarios
discussed,
commercially
available
assays
compared.
A
discussion
challenges
development
advancement
technologies
aim
achieve
real‐time
multiplex
analysis
point‐of‐care
situations
applicable
biomedical
research
practice
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6518 - 6518
Published: March 30, 2023
Alzheimer’s
disease
is
one
of
the
most
commonly
diagnosed
cases
senile
dementia
in
world.
It
an
incurable
process,
often
leading
to
death.
This
multifactorial,
and
factor
this
inflammation.
Numerous
mediators
secreted
by
inflammatory
cells
can
cause
neuronal
degeneration.
Neuritis
may
coexist
with
other
mechanisms
disease,
contributing
progression,
also
directly
underlie
AD.
Although
much
has
been
established
about
processes
pathogenesis
AD,
many
aspects
remain
unexplained.
The
work
devoted
particular
pathomechanism
inflammation
its
role
diagnosis
treatment.
An
in-depth
detailed
understanding
neuroinflammation
help
development
diagnostic
methods
for
early
contribute
new
therapeutic
strategies
disease.
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
190, P. 106733 - 106733
Published: March 15, 2023
Natural
compounds
are
widely
used
to
prevent
and
treat
various
diseases
due
their
antioxidant
anti-inflammatory
effects.
As
a
kind
of
promising
natural
compound,
plant-derived
exosome-like
nanoparticles
(PELNs)
extracted
from
multivesicular
bodies
edible
plants,
including
vegetables,
foods,
fruits,
mainly
regulate
the
cellular
immune
response
pathogen
attacks.
Moreover,
PELNs
could
remarkably
interfere
with
dynamic
imbalance
between
pro-inflammatory
effects,
facilitating
maintain
homeostasis
microenvironment.
may
serve
as
better
alternative
animal-derived
exosomes
(ADEs)
owing
widespread
sources,
cost-effectiveness,
easy
accessibility.
can
mediate
interspecies
communication
by
transferring
cargoes
such
proteins,
lipids,
nucleic
acids
plant
cells
mammalian
cells.
This
review
summarizes
biogenesis,
composition,
classification
exosomes;
common
separation,
purification,
characterization
methods
PELNs,
potential
advantages
over
ADEs;
immunomodulatory
functions
in
colitis,
cancer,
inflammation-associated
metabolic
diseases.
Additionally,
future
perspectives
challenges
associated
clinical
application
discussed.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
24, P. 96 - 111
Published: Dec. 14, 2022
Wound
healing
has
become
one
of
the
basic
issues
faced
by
medical
community
because
susceptibility
skin
wounds
to
bacterial
infection.
As
such,
it
is
highly
desired
design
a
nanocomposite
hydrogel
with
excellent
antibacterial
activity
achieve
high
wound
closure
effectiveness.
Here,
based
on
ultrasound-triggered
piezocatalytic
therapy,
multifunctional
designed
promote
bacteria-infected
healing.
Under
ultrasonic
vibration,
surface
barium
titanate
(BaTiO3,
BT)
nanoparticles
embedded
in
rapidly
generate
reactive
oxygen
species
(ROS)
owing
established
strong
built-in
electric
field,
endowing
superior
efficacy.
This
modality
shows
intriguing
advantages
over
conventional
photodynamic
such
as
prominent
soft
tissue
penetration
ability
and
avoidance
serious
phototoxicity
after
systemic
administration
photosensitizers.
Moreover,
N-[tris(hydroxymethyl)methyl]acrylamide
(THM),
N-(3-aminopropyl)methacrylamide
hydrochloride
(APMH)
oxidized
hyaluronic
acid
(OHA)
exhibits
outstanding
self-healing
bioadhesive
properties
able
accelerate
full-thickness
Notably,
compared
widely
reported
mussel-inspired
adhesive
hydrogels,
OHA/THM-APMH
due
multiple
hydrogen
bonds
from
unique
tri-hydroxyl
structure
overcomes
shortage
that
catechol
groups
are
easily
oxidized,
giving
long-term
repeatable
adhesion
performance.
Importantly,
this
hybrid
confines
BT
area
locally
induced
piezoelectric
catalysis
under
ultrasound
eradicate
bacteria,
markedly
improving
therapeutic
biosafety
great
potential
for
harmless
treatment
tissues.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 22, 2024
Abstract
Cytokines
are
critical
in
regulating
immune
responses
and
cellular
behavior,
playing
dual
roles
both
normal
physiology
the
pathology
of
diseases
such
as
cancer.
These
molecules,
including
interleukins,
interferons,
tumor
necrosis
factors,
chemokines,
growth
factors
like
TGF-β,
VEGF,
EGF,
can
promote
or
inhibit
growth,
influence
microenvironment,
impact
efficacy
cancer
treatments.
Recent
advances
targeting
these
pathways
have
shown
promising
therapeutic
potential,
offering
new
strategies
to
modulate
system,
progression,
overcome
resistance
conventional
therapies.
In
this
review,
we
summarized
current
understanding
implications
cytokine
chemokine
signaling
By
exploring
molecules
biology
response,
highlighted
development
novel
agents
aimed
at
modulating
combat
The
review
elaborated
on
nature
cytokines
promoters
suppressors
tumorigenesis,
depending
context,
discussed
challenges
opportunities
presents
for
intervention.
We
also
examined
latest
advancements
targeted
therapies,
monoclonal
antibodies,
bispecific
receptor
inhibitors,
fusion
proteins,
engineered
variants,
their
metastasis,
microenvironment.
Additionally,
evaluated
potential
combining
therapies
with
other
treatment
modalities
improve
patient
outcomes.
Besides,
focused
ongoing
research
clinical
trials
that
pivotal
advancing
our
application
cytokine-
chemokine-targeted
patients.
Small,
Journal Year:
2024,
Volume and Issue:
20(35)
Published: May 1, 2024
Abstract
Cancer
nanovaccines
represent
a
promising
frontier
in
cancer
immunotherapy,
utilizing
nanotechnology
to
augment
traditional
vaccine
efficacy.
This
review
comprehensively
examines
the
current
state‐of‐the‐art
nanovaccine
development,
elucidating
innovative
strategies
and
technologies
employed
their
design.
It
explores
both
preclinical
clinical
advancements,
emphasizing
key
studies
demonstrating
potential
elicit
robust
anti‐tumor
immune
responses.
The
study
encompasses
various
facets,
including
integrating
biomaterial‐based
nanocarriers
for
antigen
delivery,
adjuvant
selection,
impact
of
nanoscale
properties
on
performance.
Detailed
insights
into
complex
interplay
between
tumor
microenvironment
responses
are
provided,
highlighting
challenges
opportunities
optimizing
therapeutic
outcomes.
Additionally,
presents
thorough
analysis
ongoing
trials,
presenting
snapshot
landscape.
By
curating
latest
scientific
findings
developments,
this
aims
serve
as
comprehensive
resource
researchers
clinicians
engaged
advancing
immunotherapy.
Integrating
design
holds
immense
promise
revolutionizing
treatment
paradigms,
provides
timely
update
evolving
landscape
nanovaccines.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 26, 2024
Chronic
inflammatory
processes
in
the
oral
mucosa
and
periodontitis
are
common
disorders
caused
by
microflora
microbial
biofilms.
These
factors
activate
both
innate
adaptive
immune
systems,
leading
to
production
of
pro-inflammatory
cytokines.
Cytokines
known
play
a
crucial
role
pathogenesis
gingivitis
have
been
proposed
as
biomarkers
for
diagnosis
follow-up
these
diseases.
They
can
stromal
cells,
local
inflammation
tissue
damage.
This
damage
include
destruction
periodontal
ligaments,
gingiva,
alveolar
bone.
Studies
reported
increased
levels
cytokines,
such
interleukin-1beta
(IL-1beta),
tumor
necrosis
factor
(TNF),
IL-6,
IL-17,
IL-23,
patients
with
periodontitis.
In
experimental
models
periodontitis,
TNF
IL-23/IL-17
axis
pivotal
disease
pathogenesis.
Inactivation
pathways
through
neutralizing
antibodies,
genetic
engineering
or
IL-10
function
has
demonstrated
reduce
activity.
review
discusses
cytokines
particular
emphasis
on
their
mediating
destruction.
It
also
explores
new
therapeutic
interventions
that
offer
potential
research
clinical
therapy
chronic
Toxicology,
Journal Year:
2024,
Volume and Issue:
503, P. 153771 - 153771
Published: March 1, 2024
Lead
(Pb2+)
is
a
hazardous
heavy
metal
that
pervasive
in
the
human
environment
as
result
of
anthropogenic
activity,
and
poses
serious
health
risks,
particularly
children.
Due
to
its
innumerable
unique
physical
chemical
properties,
it
has
various
applications;
therefore,
become
common
environmental
pollutant.
may
cause
oxidative
stress,
accumulating
evidence
indicates
stress
influences
pathophysiology
lead
poisoning,
also
called
plumbism.
The
immune
system
continually
exposed
pathogens
xenobiotics,
including
metals
such
lead,
appears
be
one
most
vulnerable
targets.
After
being
cells
are
subjected
reactive
oxygen
species
(ROS)
production.
When
generation
consumption
ROS
out
equilibrium,
cell
structures,
phospholipids
disrupted
leading
lipid
peroxidation.
Various
inflammatory
signalling
pathways
activated
consequence,
along
with
reduced
disease
resistance,
inflammation,
autoimmunity,
sensitization
disruption
cell-mediated
humoral
systems.
negatively
affects
metabolism
cytokines,
interleukins
IL-2,
IL-1b,
IL-6,
IL-4,
IL-8,
tumor
necrosis
factor-alpha
(TNF-α),
interferon-gamma
(IFN),
well
expression
functioning
enzymes
cyclooxygenases.
However,
toxicity
depends
on
kind
dosage,
route
entry,
exposure
period,
age,
host
genetic
predisposition.
