Abstract
The
electrical
microenvironment
is
considered
a
pivotal
determinant
in
various
pathophysiological
processes,
including
tissue
homeostasis
and
wound
healing.
Consequently,
extensive
research
endeavors
have
been
directed
toward
applying
electricity
to
cells
tissues
through
external
force
devices
or
biomaterial-based
platforms.
In
addition
situ
electroconductive
matrices,
new
class
of
electroactive
biomaterials
responsive
stimuli
has
emerged
as
focal
point
interest.
These
materials,
response
intrinsic
biochemical
(e.g.,
glucose)
physical
light,
magnetism,
stress),
hold
significant
potential
for
cell
stimulation
regeneration.
this
communication,
we
underscore
distinct
category
biomaterials,
discussing
the
currently
developed
biomaterial
platforms
their
biological
roles
stimulating
during
healing
regeneration
process.
We
also
critically
evaluate
inherent
limitations
challenges
these
while
offering
forward-looking
insights
into
promise
future
clinical
translations.
Graphical
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(3)
Published: Oct. 16, 2023
Abstract
Piezoelectric,
pyroelectric,
and
ferroelectric
materials
are
considered
unique
biomedical
due
to
their
dielectric
crystals
asymmetric
centers
that
allow
them
directly
convert
various
primary
forms
of
energy
in
the
environment,
such
as
sunlight,
mechanical
energy,
thermal
into
secondary
electricity
chemical
energy.
These
possess
exceptional
conversion
ability
excellent
catalytic
properties,
which
have
led
widespread
usage
within
fields.
Numerous
applications
demonstrated
great
potential
with
these
materials,
including
disease
treatment,
biosensors,
tissue
engineering.
For
example,
piezoelectric
used
stimulate
cell
growth
bone
regeneration,
while
pyroelectric
applied
skin
cancer
detection
imaging.
Ferroelectric
even
found
use
neural
implants
record
electrical
activity
brain.
This
paper
reviews
relationship
between
ferroelectric,
piezoelectric,
effects
fundamental
principles
different
reactions.
It
also
highlights
preparation
methods
three
significant
progress
made
applications.
The
review
concludes
by
presenting
key
challenges
future
prospects
for
efficient
catalysts
based
on
nanomaterials
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(9), P. 3325 - 3350
Published: Jan. 1, 2023
This
review
provides
a
brief
overview
of
the
recent
developments
in
hydrogel
systems
that
respond
dynamically
to
various
stimuli,
including
some
interesting
fabrication
strategies,
and
their
application
cardiac,
bone,
neural
tissue
regeneration.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 11, 2023
Bioprinting
has
attracted
much
attention
due
to
its
suitability
for
fabricating
biomedical
devices.
In
particular,
bioprinting
become
one
of
the
growing
centers
in
field
wound
healing,
with
various
types
bioprinted
devices
being
developed,
including
3D
scaffolds,
microneedle
patches,
and
flexible
electronics.
Bioprinted
can
be
designed
specific
biostructures
biofunctions
that
closely
match
shape
sites
accelerate
regeneration
skin
through
approaches.
Herein,
a
comprehensive
review
smart
dressings
is
presented,
emphasizing
crucial
effect
determining
biofunctions.
The
begins
an
overview
techniques
devices,
followed
in-depth
discussion
polymer-based
inks,
modification
strategies,
additive
ingredients,
properties,
applications.
strategies
are
divided
into
seven
categories,
chemical
synthesis
novel
physical
blending,
coaxial
bioprinting,
multimaterial
absorption,
immobilization,
hybridization
living
cells,
examples
presented.
Thereafter,
frontiers
4D
artificial
intelligence-assisted
situ
discussed
from
perspective
interdisciplinary
sciences.
Finally,
current
challenges
future
prospects
this
highlighted.
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: July 31, 2023
Most
bone-related
injuries
to
grassroots
troops
are
caused
by
training
or
accidental
injuries.
To
establish
preventive
measures
reduce
all
kinds
of
trauma
and
improve
the
combat
effectiveness
troops,
it
is
imperative
develop
new
strategies
scaffolds
promote
bone
regeneration.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8307 - 8472
Published: June 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(11), P. 13563 - 13572
Published: March 7, 2024
Antibacterial
hydrogels
have
emerged
as
a
promising
approach
for
effective
wound
treatment.
However,
despite
extensive
research
on
the
fabrication
of
antibacterial
hydrogels,
it
remains
challenging
to
develop
injectable,
biocompatible,
transparent,
and
mass-producible
with
properties.
In
this
study,
we
successfully
fabricated
an
drug-loaded
composite
hydrogel,
named
CC45/OKG40/HS,
through
Schiff
base
reaction
between
carboxymethyl
chitosan
(CC)
oxidized
konjac
glucomannan
(OKG),
followed
by
encapsulation
stevioside-stabilized
honokiol
(HS)
micelles.
The
CC45/OKG40/HS
hydrogel
exhibited
several
favorable
properties,
including
short
gel
time
(<10
min),
high
water
content
(>92%),
injectability,
good
adhesiveness,
self-healing
ability,
transparency.
vitro
experiments
confirmed
its
excellent
antioxidant
activities,
biocompatibility
(no
cytotoxicity,
hemolysis
ratio
<5%).
Furthermore,
in
vivo
evaluation
demonstrated
that
CC45/OKG40/HS0.5
accelerated
healing
relieving
inflammatory
responses
enhancing
re-epithelization.
Given
feasibility
mass
production,
findings
showed
has
potential
advanced
dressing
commercial
use.
