Engineering Stimuli‐Responsive Materials for Precision Medicine DOI Creative Commons
Ruixuan Zheng, Yu Chang, Dan Yao

et al.

Small, Journal Year: 2024, Volume and Issue: 21(1)

Published: Oct. 23, 2024

Abstract Over the past decade, precision medicine has garnered increasing attention, making significant strides in discovering new therapeutic drugs and mechanisms, resulting notable achievements symptom alleviation, pain reduction, extended survival rates. However, limited target specificity of primary inter‐individual differences have often necessitated high‐dosage strategies, leading to challenges such as restricted deep tissue penetration rates systemic side effects. Material science advancements present a promising avenue for these issues. By leveraging distinct internal features diseased regions application specific external stimuli, responsive materials can be tailored achieve targeted delivery, controllable release, biochemical reactions. This review aims highlight latest stimuli‐responsive their potential medicine. Initially, we introduce disease‐related stimuli capable elucidating reaction principles functional groups. Subsequently, provide detailed analysis representative pre‐clinical across various clinical applications, including enhancements treatment cancers, injury diseases, inflammatory infection high‐throughput microfluidic biosensors. Finally, discuss some challenges, off‐target effects, long‐term impacts nano‐materials, ethical concerns, offer insights into future perspectives materials.

Language: Английский

Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells DOI Creative Commons

Yongxia Zhao,

Xiaochun Ye,

Zhifeng Xiong

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(7), P. 796 - 796

Published: June 27, 2023

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are recognized hallmark of cancer and an important aspect treatment research. Abnormally elevated ROS often attributable to alterations in cellular metabolic activities increased oxidative stress, which affects both the development maintenance cancer. Moderately high beneficial maintain tumor cell genesis development, while toxic have been shown be force destroying cells. has become anticancer target based on proapoptotic effect ROS. Therefore, this review summarizes role DNA damage apoptosis cells caused by changes metabolism, as well various therapies targeting generation, order provide references generation.

Language: Английский

Citations

81
Stimuli responsive nanosonosensitizers for sonodynamic therapy DOI

Zeyu Jiang,

Wen‐Jing Xiao, Qinrui Fu

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 547 - 567

Published: Aug. 15, 2023

Language: Английский

Citations

73
Dual‐Cascade Activatable Nanopotentiators Reshaping Adenosine Metabolism for Sono‐Chemodynamic‐Immunotherapy of Deep Tumors DOI Creative Commons
Meixiao Zhan,

Fengshuo Wang,

Yao Liu

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(10)

Published: Feb. 2, 2023

Immunotherapy is an attractive treatment strategy for cancer, while its efficiency and safety need to be improved. A dual-cascade activatable nanopotentiator sonodynamic therapy (SDT) chemodynamic (CDT)-cooperated immunotherapy of deep tumors via reshaping adenosine metabolism herein reported. This (NPMCA) constructed through crosslinking deaminase (ADA) with chlorin e6 (Ce6)-conjugated manganese dioxide (MnO2) nanoparticles a reactive oxygen species (ROS)-cleavable linker. In the tumor microenvironment ultrasound (US) irradiation, NPMCA mediates CDT SDT concurrently in covered 2-cm tissues produce abundant ROS, which results scissoring ROS-cleavable linkers activate ADA within NCMCA block metabolism. Moreover, immunogenic cell death (ICD) dying cells upregulation stimulator interferon genes (STING) triggered by generated ROS Mn2+ from NPMCA, respectively, leading activation antitumor immune response. The potency response further reinforced reducing accumulation activated ADA. As result, enables SDT-cooperated immunotherapy, showing obviously improved therapeutic efficacy inhibit growths bilateral tumors, primary are tissues.

Language: Английский

Citations

66
Oxygen‐carrying semiconducting polymer nanoprodrugs induce sono‐pyroptosis for deep‐tissue tumor treatment DOI Creative Commons

Fengshuo Wang,

Yongliang Fan,

Yue Liu

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 19, 2024

Abstract Sonodynamic therapy (SDT) has been explored for cancer therapy, especially deep tumors due to its low tissue penetration restriction. The therapeutic efficacy of SDT is limited the complicated tumor microenvironment. This study reports construction oxygen‐carrying semiconducting polymer nanoprodrugs (OSPN pro ) treatment via combining amplified with pyroptosis. An oxygen carrier perfluorohexane, sonodynamic as sonosensitizer, and reactive species (ROS)‐responsive prodrug are co‐loaded into a nanoparticle system, leading formation these nanoprodrugs. Such OSPN show an effective accumulation in tissues after systemic administration, which they deliver relieve hypoxia microenvironment thus mediate producing ROS under ultrasound (US) irradiation, even when covered 2‐cm chicken breast tissue. In addition, ROS‐responsive prodrugs activated by generated trigger pyroptosis cells. sono‐pyroptosis induces strong antitumor immunity obviously higher level infiltrations effector immune cells tumors. Therefore, ‐based combinational can greatly inhibit growth tissue‐covered suppress metastasis. offers nanoplatform strategy.

Language: Английский

Citations

26
Endoplasmic Reticulum‐Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono‐Immunotherapy DOI
Xiaoyu Xu, Meixu Chen, Shan Jiang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 27, 2024

Abstract Reactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy. However, unsatisfactory activity and mediocre ER induction ability of sonosensitizers essentially restrict SDT efficacy ICD stimulation. Herein, a versatile ER‐targeting Iridium(III) nanosonosensitizer is developed as superior inducer boosted tumor An ingenious cholic acid (CA)‐functionalized sonosensitizer Ir‐CA well‐designed skillfully crosslinked with human serum albumin (HSA) to form HSA@Ir‐CA. With high stability, favorable tumor‐targeting ability, reduction‐responsiveness, HSA@Ir‐CA preferentially accumulates sites enhanced cellular uptake, followed by rapid disassembly responding intracellular reductive environment. The uncaged selectively accumulate precisely disrupt situ produced type I II ROS upon US irradiation high‐efficiency SDT. Moreover, the maximized eminently amplifies evoke robust systemic immunity, inhibiting growths primary/distant tumor, lung metastasis, recurrence. This combined immune checkpoint inhibitor (αPD‐L1) further achieves reinforced therapeutic outcome against immunologically “cold” tumor. study presents an effective paradigm optimize amplify ICD‐initiated responses

Language: Английский

Citations

19
Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation DOI Open Access

Wencong Jia,

Ye Wu, Yujie Xie

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.

Language: Английский

Citations

3
A biomimetic cuproptosis amplifier for targeted NIR-II fluorescence/photoacoustic imaging-guided synergistic NIR-II photothermal immunotherapy DOI

Yeneng Dai,

Lipeng Zhu, Xue Li

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122455 - 122455

Published: Dec. 27, 2023

Language: Английский

Citations

33
Photoacoustic‐Imaging‐Guided Photothermal Regulation of Calcium Influx for Enhanced Immunogenic Cell Death DOI
Mengxin Wang, Fengfeng Xue, Lu An

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(19)

Published: Jan. 15, 2024

Abstract Immunogenic cell death (ICD) induced by calcium ion (Ca 2+ ) overload has attracted significant attention owing to its ability activate the immune system and generate durable antitumor responses. However, slow release of Ca commonly used nanomodulators provides tumor cells with opportunity efficiently eliminate excess through channels, thus diminishing therapeutic efficacy. Consequently, it is crucial explore strategies for rapid release. To address this issue, a glutathione‐triggered Ca(IO 3 2 @starch‐based nanobomb presented. This not only enables accurate efficient delivery site but also exploits photoacoustic (PA) imaging‐guided photothermal precise control TRPV1 channel activation enhancing influx. Both in vitro vivo results confirm that photothermally regulated influx based on effectively promotes ICD stimulates infiltration tissues, ultimately leading effective inhibition growth metastasis. The developed presents potential strategy enhance overload, addressing challenges associated timely regulation offering prospects improved immunotherapy.

Language: Английский

Citations

15
Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy DOI

Fuhong Yang,

Jingqi Lv,

Wen Ma

et al.

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Language: Английский

Citations

11
PAD4 Inhibitor‐Functionalized Layered Double Hydroxide Nanosheets for Synergistic Sonodynamic Therapy/Immunotherapy Of Tumor Metastasis DOI Creative Commons
Di Zhu, Yu Lu,

Shuqing Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 6, 2024

Abstract Sonodynamic therapy (SDT) is demonstrated to trigger the systemic immune response of organism and facilitate treatment metastatic tumors. However, SDT‐mediated neutrophil extracellular traps (NETs) formation can promote tumor cell spread, thus weakening therapeutic effectiveness Herein, amorphous CoW‐layered double hydroxide (a‐CoW‐LDH) nanosheets are functionalized with a peptidyl arginine deiminase 4 (PAD4) inhibitor, i.e., YW3‐56, construct multifunctional nanoagent (a‐LDH@356) for synergistic SDT/immunotherapy. Specifically, a‐CoW‐LDH act as sonosensitizer generate abundant reactive oxygen species (ROS) under US irradiation. After loading a‐LDH@356 plus irradiation not only effectively induces ROS generation immunogenic death, but also inhibits elevation citrullinated histone H3 (H3cit) release NETs, enabling enhancement anti‐tumor metastasis effect. Using 4T1 model, it that combining YW3‐56 stimulates an by upregulating proportion immune‐activated cells inducing polarization M1 macrophages, escape downregulating expression PD‐1 on irradiation, which arrests primary progression inhibition rate 69.5% prevents least number lung nodules.

Language: Английский

Citations

10