Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 8, 2024
Abstract
Growing
evidences
have
proved
that
tumors
evade
recognition
and
attack
by
the
immune
system
through
escape
mechanisms,
PDL1/Pbrm1
genes
a
strong
correlation
with
poor
response
or
resistance
to
checkpoint
blockade
(ICB)
therapy.
Herein,
multifunctional
biomimetic
nanocarrier
(siRNA‐CaP@PD1‐NVs)
is
developed,
which
can
not
only
enhance
cytotoxic
activity
of
cells
blocking
PD1/PDL1
axis,
but
also
reduce
tumor
via
Pbrm1/PDL1
gene
silencing,
leading
significant
improvement
in
immunosuppressive
microenvironment.
Consequently,
promotes
DC
cell
maturation,
enhances
infiltration
CD8+
T
cells,
forms
long‐term
memory,
effectively
inhibit
growth
even
eliminate
tumors,
prevent
recurrence
metastasis.
Overall,
this
study
presents
powerful
strategy
for
co‐delivery
siRNA
drugs,
adjuvant,
inhibitors,
holds
great
promise
improving
effectiveness
safety
current
immunotherapy
regimens.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(11)
Published: Feb. 10, 2022
Abstract
Hepatocellular
carcinoma
(HCC)
commonly
emerges
in
an
immunologically
“cold”
state,
thereafter
protects
it
away
from
cytolytic
attack
by
tumor‐infiltrating
lymphocytes,
resulting
poor
response
to
immunotherapy.
Herein,
acidic/photo‐sensitive
dendritic
cell
(DCs)‐based
neoantigen
nano‐vaccine
has
been
explored
convert
tumor
immune
state
into
“hot”,
and
remodel
tumor‐associated
neutrophils
potentiate
anticancer
for
enhancing
immunotherapy
efficiency.
The
is
constructed
SiPCCl
2
‐hybridized
mesoporous
silica
with
coordination
of
Fe(III)‐captopril,
coating
exfoliated
membrane
matured
DCs
H22‐specific
stimulation.
nano‐vaccines
actively
target
H22
tumors
induce
immunological
death
boost
antigen
release
the
generation
excess
1
O
through
photodynamic
therapy,
which
act
as
situ
vaccination
strengthen
antitumor
T‐cell
against
primary
growth.
Interestingly,
are
also
home
lymph
nodes
directly
activation
proliferation
neoantigen‐specific
T
cells
suppress
primary/distal
Moreover,
acidic‐triggered
captopril
microenvironment
can
polarize
protumoral
N2
phenotype
N1
improving
effects
achieve
complete
regression
(83%)
H22‐bearing
mice
prolong
survival
time.
This
work
provides
alternative
approach
developing
novel
HCC
strategies.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(19)
Published: Feb. 7, 2024
Neutrophils
are
the
most
abundant
white
blood
cells
in
circulation
and
act
as
first
line
of
defense
against
infections.
Increasing
evidence
suggests
that
neutrophils
possess
heterogeneous
phenotypes
functional
plasticity
human
health
diseases,
including
cancer.
play
multifaceted
roles
cancer
development
progression,
an
N1/N2
paradigm
is
proposed,
where
N1
exert
anti-tumor
properties
while
N2
display
tumor-supportive
immune-suppressive
functions.
Selective
activation
beneficial
neutrophil
population
targeted
inhibition
or
re-polarization
tumor-promoting
has
shown
important
potential
tumor
therapy.
In
addition,
due
to
natural
inflammation-responsive
physical
barrier-crossing
abilities,
their
derivatives
(membranes
extracellular
vesicles
(EVs))
regarded
advanced
drug
delivery
carriers
for
enhanced
targeting
improved
therapeutic
efficacy.
this
review,
recent
advances
engineering
remodeling
microenvironment
(TME)
comprehensively
presented.
This
review
will
provide
a
broad
understanding
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 531 - 531
Published: April 12, 2024
Nanoparticle-based
drug
delivery
systems
hold
promise
for
cancer
treatment
by
enhancing
the
solubility
and
stability
of
anti-tumor
drugs.
Nonetheless,
challenges
inadequate
targeting
limited
biocompatibility
persist.
In
recent
years,
cell
membrane
nano-biomimetic
have
emerged
as
a
focal
point
research
development,
due
to
their
exceptional
traits,
including
precise
targeting,
low
toxicity,
good
biocompatibility.
This
review
outlines
categorization
advantages
bionic
nano-delivery
systems,
provides
an
introduction
preparation
methods,
assesses
applications
in
treatment,
chemotherapy,
gene
therapy,
immunotherapy,
photodynamic
photothermal
combination
therapy.
Notably,
delves
into
application
various
identifies
opportunities
future
advancement.
Embracing
membrane-coated
biomimetic
nanoparticles
presents
novel
unparalleled
avenue
personalized
tumor
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(7), P. 3224 - 3252
Published: Jan. 1, 2024
Neoantigens
play
a
pivotal
role
in
the
field
of
tumour
therapy,
encompassing
stimulation
anti-tumour
immune
response
and
enhancement
targeting
capability.
Nonetheless,
numerous
factors
directly
influence
effectiveness
neoantigens
bolstering
responses,
including
neoantigen
quantity
specificity,
uptake
rates
by
antigen-presenting
cells
(APCs),
residence
duration
within
microenvironment
(TME),
their
ability
to
facilitate
maturation
APCs
for
activation.
Nanotechnology
assumes
significant
several
aspects,
facilitating
release,
promoting
delivery
cells,
augmenting
dendritic
shielding
from
protease
degradation,
optimizing
interactions
between
system.
Consequently,
development
nanotechnology
synergistically
enhances
efficacy
cancer
theranostics.
In
this
review,
we
provide
an
overview
sources,
mechanisms
neoantigen-induced
evolution
precision
neoantigen-based
nanomedicine.
This
encompasses
various
therapeutic
modalities,
such
as
immunotherapy,
phototherapy,
radiotherapy,
chemotherapy,
chemodynamic
other
strategies
tailored
augment
therapeutics.
We
also
discuss
current
challenges
prospects
application
nanomedicine,
aiming
expedite
its
clinical
translation.
Nanoscale Horizons,
Journal Year:
2022,
Volume and Issue:
7(7), P. 682 - 714
Published: Jan. 1, 2022
Engineered
EVs
containing
an
intelligent
core
have
been
designed
to
interact
with
a
living
host
environment
and
function
in
ideal
situation.
This
review
provides
new
insight
into
design
of
next-generation
EV-based
theranostic
platforms.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Sept. 7, 2023
Abstract
Neutrophils,
the
most
prevalent
innate
immune
cells
in
humans,
have
garnered
significant
attention
recent
years
due
to
their
involvement
cancer
progression.
This
comprehensive
review
aimed
elucidate
important
roles
and
underlying
mechanisms
of
neutrophils
from
perspective
whole
life
cycle,
tracking
them
development
bone
marrow
circulation
finally
tumor
microenvironment
(TME).
Based
on
an
understanding
heterogeneity,
we
described
relationship
between
abnormal
clinical
manifestations
cancer.
Specifically,
explored
function,
origin,
polarization
within
TME.
Furthermore,
also
undertook
extensive
analysis
intricate
management,
including
neutrophil-based
treatment
strategies.
In
conclusion,
firmly
assert
that
directing
future
research
endeavors
towards
comprehending
remarkable
heterogeneity
exhibited
by
is
paramount
importance.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(29)
Published: April 5, 2024
Abstract
Rapid
advances
in
nanotechnology
have
made
it
possible
to
combine
photothermal
therapy
(PTT)
with
immunotherapy,
enabling
activate
an
situ
vaccine
effect.
However,
this
effect
is
severely
impeded
by
low
antigen
presentation
level
and
highly
suppressive
tumor
immune
microenvironment
(immune
“cold”
tumors).
To
overcome
the
obstacles,
multifunctional
carrier‐free
nanoparticles
(FCDP‐NPs)
assembled
from
Fe
2+
,
toll‐like
receptor
9
agonist
(CpG),
cationic
lipid
(DOTAP)
agent
polydopamine
are
developed.
After
intratumoral
injection,
FCDP‐NPs
carrying
positive
charge
exposed
under
laser
irradiation,
which
can
capture
tumor‐associated
antigens
(TAAs)
generated
upon
post‐PTT
form
nanovaccines
(FCD‐NPs@TAAs).
The
further
promote
cross‐presentation
of
TAAs,
stimulate
adaptive
responses,
shape
“hot”
tumors.
As
a
result,
improve
survival
rates
elicit
durable
memory
that
remarkedly
prevents
metastasis,
illustrating
useful
platform
for
PTT
synergized
immunotherapy.
