Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 27, 2024
The
tumor
microenvironment
(TME)
is
a
complex
system
characterized
by
low
oxygen,
pH,
high
pressure,
and
numerous
growth
factors
protein
hydrolases
that
regulate
wide
range
of
biological
behaviors
in
the
have
profound
impact
on
cancer
progression.
Immunotherapy
an
innovative
approach
to
treatment
activates
immune
system,
resulting
spontaneous
killing
cells.
However,
therapeutic
efficacy
these
clinically
approved
immunotherapies
(e.g.,
checkpoint
blocker
(ICB)
therapies
chimeric
antigen
receptor
(CAR)
T-cell
therapies)
far
from
satisfactory
due
presence
immunosuppressive
TMEs
created
part
hypoxia,
acidity,
levels
reactive
oxygen
species
(ROS),
dense
extracellular
matrix
(ECM).
With
continuous
advances
materials
science
drug-delivery
technologies,
biomaterials
hold
considerable
potential
for
targeting
TME.
This
article
reviews
biomaterial-based
TME
advance
our
current
understanding
role
enhancing
immunity.
In
addition,
strategies
remodeling
offer
enticing
advantages;
however,
represent
double-edged
sword.
process
reshaping
TME,
risk
growth,
infiltration,
distant
metastasis
may
increase.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Sept. 2, 2023
Immunotherapy
has
recently
emerged
as
a
treatment
strategy
which
stimulates
the
human
immune
system
to
kill
tumor
cells.
Tumor
immunotherapy
is
based
on
editing,
enhances
antigenicity
of
cells
and
increases
tumoricidal
effect
It
also
suppresses
immunosuppressive
molecules,
activates
or
restores
function,
anti-tumor
responses,
inhibits
growth
f
cell.
This
offers
possibility
reducing
mortality
in
triple-negative
breast
cancer
(TNBC).Immunotherapy
approaches
for
TNBC
have
been
diversified
recent
years,
with
breakthroughs
this
entity.
Research
checkpoint
inhibitors
(ICIs)
made
it
possible
identify
different
molecular
subtypes
formulate
individualized
schedules.
review
highlights
unique
microenvironment
integrates
analyzes
advances
ICI
therapy.
discusses
strategies
combination
ICIs
chemotherapy,
radiation
therapy,
targeted
emerging
methods
such
nanotechnology,
ribonucleic
acid
vaccines,
gene
Currently,
numerous
ongoing
completed
clinical
trials
are
exploring
utilization
conjunction
existing
modalities
TNBC.
The
objective
these
investigations
assess
effectiveness
various
combined
determine
most
effective
regimens
patients
TNBC.This
provides
insights
into
used
overcome
drug
resistance
immunotherapy,
explores
directions
development
Journal of Hematology & Oncology,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: Aug. 28, 2023
Triple-negative
breast
cancer
(TNBC),
a
highly
aggressive
subtype
of
cancer,
negatively
expresses
estrogen
receptor,
progesterone
and
the
human
epidermal
growth
factor
receptor
2
(HER2).
Although
chemotherapy
is
main
form
treatment
for
patients
with
TNBC,
effectiveness
TNBC
still
limited.
The
search
more
effective
therapies
urgent.
Multiple
targeted
therapeutic
strategies
have
emerged
according
to
specific
molecules
signaling
pathways
expressed
in
TNBC.
These
include
PI3K/AKT/mTOR
inhibitors,
Notch
poly
ADP-ribose
polymerase
antibody-drug
conjugates.
Moreover,
immune
checkpoint
example,
pembrolizumab,
atezolizumab,
durvalumab,
are
widely
explored
clinic.
We
summarize
recent
advances
therapy
immunotherapy
aim
serving
as
reference
development
individualized
future.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
The
immune
system
interacts
with
cancer
cells
in
various
intricate
ways
that
can
protect
the
individual
from
overproliferation
of
cells;
however,
these
interactions
also
lead
to
malignancy.
There
has
been
a
dramatic
increase
application
immunotherapy
last
decade.
However,
low
immunogenicity,
poor
specificity,
weak
presentation
efficiency,
and
off-target
side
effects
still
limit
its
widespread
application.
Fortunately,
advanced
biomaterials
effectively
contribute
play
an
important
role
treatment,
making
it
research
hotspot
biomedical
field.
This
review
discusses
immunotherapies
development
related
for
first
summarizes
types
tumor
applicable
clinical
practice
as
well
their
underlying
mechanisms.
Further,
focuses
on
applied
metal
nanomaterials,
silicon
nanoparticles,
carbon
nanotubes,
polymer
cell
membrane
nanocarriers.
Moreover,
we
introduce
preparation
processing
technologies
(liposomes,
microspheres,
microneedles,
hydrogels)
summarize
mechanisms
when
immunotherapy.
Finally,
discuss
future
advancements
shortcomings
Research
biomaterial-based
is
booming;
several
challenges
remain
be
overcome
transition
experimental
Biomaterials
have
optimized
continuously
nanotechnology
achieved
continuous
progression,
ensuring
more
efficient
biomaterials,
thereby
providing
platform
opportunity
breakthroughs
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(21)
Published: Feb. 16, 2024
Immunotherapy
represents
a
revolutionary
paradigm
in
cancer
management,
showcasing
its
potential
to
impede
tumor
metastasis
and
recurrence.
Nonetheless,
challenges
including
limited
therapeutic
efficacy
severe
immune-related
side
effects
are
frequently
encountered,
especially
solid
tumors.
Hydrogels,
class
of
versatile
materials
featuring
well-hydrated
structures
widely
used
biomedicine,
offer
promising
platform
for
encapsulating
releasing
small
molecule
drugs,
biomacromolecules,
cells
controlled
manner.
Immunomodulatory
hydrogels
present
unique
capability
augmenting
immune
activation
mitigating
systemic
toxicity
through
encapsulation
multiple
components
localized
administration.
Notably,
based
on
biopolymers
have
gained
significant
interest
owing
their
biocompatibility,
environmental
friendliness,
ease
production.
This
review
delves
into
the
recent
advances
bio-based
immunotherapy
synergistic
combinatorial
approaches,
highlighting
diverse
applications.
It
is
anticipated
that
this
will
guide
rational
design
field
immunotherapy,
fostering
clinical
translation
ultimately
benefiting
patients.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(5), P. 1151 - 1170
Published: Jan. 1, 2024
This
review
summarizes
composition
and
preparation
methodologies
of
injectable
hydrogels
highlights
the
delivery
mechanisms
drugs
for
tumor
therapy,
along
with
discussion
on
optimal
therapeutic
efficiency
provides
perspective
challenges
solutions
in
applications.
Science Advances,
Journal Year:
2022,
Volume and Issue:
8(47)
Published: Nov. 23, 2022
Cancer
vaccines
have
attracted
widespread
interest
in
tumor
therapy
because
of
the
potential
to
induce
an
effective
antitumor
immune
response.
However,
many
challenges
including
weak
immunogenicity,
off-target
effects,
and
immunosuppressive
microenvironments
prevented
their
broad
clinical
translation.
To
overcome
these
difficulties,
delivery
systems
been
designed
for
cancer
vaccines.
As
carriers
vaccine
systems,
hydrogels
gained
substantial
attention
they
can
encapsulate
a
variety
antigens/immunomodulators
protect
them
from
degradation.
This
enables
simultaneously
reverse
immunosuppression
stimulate
Meanwhile,
controlled
release
properties
allow
precise
temporal
spatial
loads
situ
further
enhance
response
Therefore,
this
review
summarizes
classification
vaccines,
highlights
strategies
hydrogel-based
provides
some
insights
into
future
development
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: July 27, 2023
Abstract
Postoperative
tumor
recurrence
and
metastases
often
lead
to
cancer
treatment
failure.
Here,
we
develop
a
local
embedded
photodynamic
immunomodulatory
DNA
hydrogel
for
early
warning
inhibition
of
postoperative
recurrence.
The
contains
PDL1
aptamers
that
capture
enrich
in
situ
relapsed
cells,
increasing
ATP
concentration
provide
timely
signal.
When
positive
signal
is
detected,
laser
irradiation
performed
trigger
therapy
kill
captured
cells
release
tumor-associated
antigens
(TAA).
In
addition,
reactive
oxygen
species
break
strands
the
encoded
aptamer
CpG,
which
together
with
TAA
promote
sufficient
systemic
antitumor
immunotherapy.
murine
model
where
are
injected
at
surgical
site
mimic
recurrence,
find
system
enables
detection
by
enriching
increase
concentrations.
As
result,
significant
inhibitory
effect
approximately
88.1%
on
recurrent
tumors
effectively
suppressing
metastasis,
offering
promising
avenue
effective
