Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 3, 2022

Limited substrates content is a major hurdle dampening the antitumor effect of catalytic therapy. Herein, two-dimensional interplanar heterojunction (FeOCl/FeOOH NSs) with ·OH generation under ultrasound irradiation fabricated and utilized for cancer This prepared through replacing chlorine from iron oxychloride hydroxyl. Benefiting longer hydroxyl bond length enhanced affinity water, alkali replacement treatment integrates synthesis exfoliation in one step. In particular, build-in electric field facilitated Z-scheme formed due to aligning Fermi levels. The holes on valence band FeOCl have great ability catalyze O

Language: Английский

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Heterojunction Nanomedicine

Advanced Science, Journal Year: 2022, Volume and Issue: 9(11)

Published: Feb. 17, 2022

Exogenous stimulation catalytic therapy has received enormous attention as it holds great promise to address global medical issues. However, the therapeutic effect of is seriously restricted by fast charge recombination and limited utilization exogenous catalysts. In past few decades, many strategies have been developed overcome above serious drawbacks, among which heterojunctions are most widely used promising strategy. This review attempts summarize recent progress in rational design fabrication heterojunction nanomedicine, such semiconductor-semiconductor (including type I, II, III, PN, Z-scheme junctions) semiconductor-metal Schottky, Ohmic, localized surface plasmon resonance-mediated junctions). The mechanisms properties junction systems also discussed relation biomedical applications, especially cancer treatment sterilization. concludes with a summary challenges some perspectives on future directions this exciting still evolving field research.

Language: Английский

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Conferring BiVO₄ Nanorods with Oxygen Vacancies to Realize Enhanced Sonodynamic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(44)

Published: Sept. 9, 2022

Abstract Owing to the high depth of tissue penetration, non‐invasiveness, and controllability, ultrasound (US)‐mediated sonodynamic therapy (SDT) has shown broad application prospects for tumor treatment. However, electron‐hole separation inefficiency sonosensitizers hypoxia remain two major challenges limiting effect SDT. Here, ultrafine photoetched bismuth vanadate (BiVO 4 ) nanorods modified with DSPE‐PEG 2000 (PEBVO@PEG NRs) were fabricated achieve in situ self‐supply oxygen (O 2 reactive species (ROS) hypoxic therapy. The photoetching approach could enhance charge by inducing enriched vacancies on surface BiVO , thereby improving generation efficiency ROS O . PEBVO@PEG overcome main obstacles traditional SDT process show promising therapeutic effects, thus providing new strategies performance sonosensitizer elimination.

Language: Английский

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Engineered Bio‐Heterojunction Confers Extra‐ and Intracellular Bacterial Ferroptosis and Hunger‐Triggered Cell Protection for Diabetic Wound Repair

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(9)

Published: Aug. 1, 2023

Abstract Nanomaterial‐mediated ferroptosis has garnered considerable interest in the antibacterial field, as it invokes disequilibrium of ion homeostasis and boosts lipid peroxidation extra‐ intracellular bacteria. However, current ferroptosis‐associated strategies indiscriminately pose damage to healthy cells, ultimately compromising their biocompatibility. To address this daunting issue, work designed a precise bio‐heterojunction (F‐bio‐HJ) consisting Fe 2 O 3 , Ti C ‐MXene, glucose oxidase (GOx) induce extra‐intracellular bacteria‐targeted for infected diabetic cutaneous regeneration. /Ti ‐MXene@GOx (FMG) catalytically generates amount ROS which assaults membrane extracellular bacteria, facilitating permeation synchronously generated 2+ /Fe 3+ into bacteria under near‐infrared (NIR) irradiation, causing planktonic bacterial death via ferroptosis, overload, peroxidation. Additionally, FMG facilitates by transporting inward ferroportin (FPN). With GOx consuming glucose, creates hunger protection helps macrophages escape cell activating adenosine 5’‐monophosphate (AMP) activated protein kinase (AMPK) pathway. In vivo results authenticate that infectious regeneration without triggering normal cells. As envisaged, proposed tactic provides promising approach combat intractable infections precisely terminating infection steerable thereby markedly elevating biocompatibility therapeutic ferroptosis‐mediated strategies.

Language: Английский

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BiOCl Heterojunction photocatalyst: Construction, photocatalytic performance, and applications

Chemosphere, Journal Year: 2023, Volume and Issue: 317, P. 137823 - 137823

Published: Jan. 14, 2023

Language: Английский

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Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 23, 2023

The exogenous excitation requirement and electron-hole recombination are the key elements limiting application of catalytic therapies. Here a tumor microenvironment (TME)-specific self-triggered thermoelectric nanoheterojunction (Bi0.5Sb1.5Te3/CaO2 nanosheets, BST/CaO2 NSs) with self-built-in electric field facilitated charge separation is fabricated. Upon exposure to TME, CaO2 coating undergoes rapid hydrolysis, releasing Ca2+, H2O2, heat. resulting temperature difference on BST NSs initiates effect, driving reactive oxygen species production. H2O2 not only serves as substrate supplement for ROS generation but also dysregulates Ca2+ channels, preventing efflux. This further exacerbates calcium overload-mediated therapy. Additionally, promotes DC maturation antigen presentation, facilitating immunotherapy. It worth noting that NP hydrolyzes very slowly in normal cells, O2 without causing any adverse effects. Tumor-specific combined therapy, ion interference immunotherapy exhibit excellent antitumor performance female mice.

Language: Английский

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Development of ABO₄‐type photoanodes for photoelectrochemical water splitting

EcoEnergy, Journal Year: 2023, Volume and Issue: 1(1), P. 108 - 153

Published: Sept. 1, 2023

Abstract Photoelectrochemical (PEC) water splitting with zero carbon emissions is a promising technology to solve the global issues of energy shortage and environmental pollution. However, current development PEC systems facing bottleneck low solar‐to‐hydrogen (STH) efficiency (<10%), which cannot meet demand large‐scale H 2 production. The low‐cost, highly active, stable photoanode materials crucial for high STH splitting. recent BiVO 4 as has been great success, ABO ‐type ternary metal oxides similar structure have potential efficient photoanodes high‐performance design are critically reviewed special emphasis on modification strategies performance improvement mechanisms each semiconductor. comprehensive analysis in this review provides guidelines insights exploration new high‐efficiency solar fuel

Language: Английский

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Friends against the Foe: Synergistic Photothermal and Photodynamic Therapy against Bacterial Infections

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1116 - 1116

Published: March 31, 2023

Multidrug-resistant (MDR) bacteria are rapidly emerging, coupled with the failure of current antibiotic therapy; thus, new alternatives for effectively treating infections caused by MDR required. Hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic (PDT) have attracted extensive attention as antibacterial therapies owing to advantages such low invasiveness, toxicity, likelihood causing bacterial resistance. However, both strategies notable drawbacks, including high temperature requirements PTT weak ability PDT-derived ROS penetrate target cells. To overcome these limitations, a combination PDT has been used against bacteria. In this review, we discuss unique benefits limitations The mechanisms underlying synergistic effects PTT–PDT also discussed. Furthermore, introduced advancements in methods using nano-based agents treat Finally, highlight existing challenges future perspectives We believe that review will encourage PTT- PDT-based research can be referenced clinical applications.

Language: Английский

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Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2643 - 2692

Published: Jan. 1, 2024

This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.

Language: Английский

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Narrow Bandgap Schottky Heterojunction Sonosensitizer with High Electron–Hole Separation Boosted Sonodynamic Therapy in Bladder Cancer

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: March 29, 2024

Abstract Sonodynamic therapy (SDT) is applied to bladder cancer (BC) given its advantages of high depth tissue penetration and nontoxicity due the unique anatomical location near abdominal surface. However, low electron–hole separation efficiency wide bandgap sonosensitizers limit effectiveness SDT. This study aims develop a TiO 2 ‐Ru‐PEG Schottky heterojunction sonosensitizer with narrow for SDT in BC. Density functional theory (DFT) calculations experiments collectively demonstrate that reduced characteristic crystalline‐amorphous interface formed by deposition ruthenium (Ru) within shell layer . Thanks enhancement oxygen adsorption efficient pairs, promotes generation reactive species (ROS) under ultrasound (US) irradiation, resulting cell cycle arrest apoptosis tumor cells. The vivo results prove boosted subcutaneous orthotopic models while exhibiting good safety. adopts complex optimizing sonosensitizers, contributing progress improvement strategies presenting paradigm BC therapy.

Language: Английский

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