Nanomedicine Remodels Tumor Microenvironment for Solid Tumor Immunotherapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(15), P. 10217 - 10233

Published: April 2, 2024

Although immunotherapy is relatively effective in treating hematological malignancies, their efficacy against solid tumors still suboptimal or even noneffective presently. Compared to cancers, exhibit strikingly different immunosuppressive microenvironment, severely deteriorating the of immunotherapy: (1) chemical features such as hypoxia and mild acidity suppress activity immune cells, (2) pro-tumorigenic domestication cells microenvironment within further undermines effectiveness immunotherapy, (3) dense physical barrier tumor tissues prevents intratumoral infiltration contact killing active cells. Therefore, we believe that reversing are critical priority for tumors. Due unique morphologies, structures, compositions, nanomedicines have become powerful tools achieving this goal. In Perspective, will first briefly introduce then summarize most recent progresses nanomedicine-based by remodeling immune-microenvironment a comprehensive manner. It highly expected Perspective aid advancing tumors, optimistic on future development burgeoning field.

Language: Английский

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A Vacancy‐Engineering Ferroelectric Nanomedicine for Cuproptosis/Apoptosis Co‐Activated Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 4, 2024

Abstract Low efficacy of immunotherapy due to the poor immunogenicity most tumors and their insufficient infiltration by immune cells highlights importance inducing immunogenic cell death activating system for achieving better treatment outcomes. Herein, ferroelectric Bi 2 CuO 4 nanoparticles with rich copper vacancies (named BCO‐V Cu ) are rationally designed engineered ferroelectricity‐enhanced apoptosis, cuproptosis, subsequently evoked immunotherapy. In this structure, suppressed recombination electron–hole pairs band bending polarization lead high catalytic activity, triggering reactive oxygen species bursts apoptosis. The fragments produced apoptosis serve as antigens activate T cells. Moreover, generated charge catalysis, nanomedicine can act “a smart switch” open membrane, promote nanomaterial endocytosis, shut down + outflow pathway evoke thus a strong response is triggered reduced content adenosine triphosphate. Ribonucleic acid transcription tests reveal pathways related activation. Thus, study firstly demonstrates feasible strategy enhancing using single semiconductor‐induced cuproptosis.

Language: Английский

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Biomimetic piezoelectric nanomaterial-modified oral microrobots for targeted catalytic and immunotherapy of colorectal cancer

Science Advances, Journal Year: 2024, Volume and Issue: 10(19)

Published: May 8, 2024

Lactic acid (LA) accumulation in the tumor microenvironment poses notable challenges to effective immunotherapy. Here, an intelligent treatment microrobot based on unique physiological structure and metabolic characteristics of

Language: Английский

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Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 8, 2024

Although nanocatalytic medicine has demonstrated its advantages in tumor therapy, the outcomes heavily relie on substrate concentration and metabolic pathways are still indistinct. We discover that violet phosphorus quantum dots (VPQDs) can catalyze production of reactive oxygen species (ROS) without requiring external stimuli catalytic substrates confirmed to be (O2) hydrogen peroxide (H2O2) through computational simulation experiments. Considering short O2 H2O2 at site, we utilize calcium (CaO2) supply for VPQDs construct nanoparticles together with them, named VPCaNPs. VPCaNPs induce oxidative stress cells, particularly characterized by a significant increase hydroxyl radicals superoxide radicals, which cause substantial damage structure function ultimately leading cell apoptosis. Intriguingly, provided CaO2 degrade slowly, degradation product, phosphate, as well CaO2-generated ions, promote calcification. Antitumor immune activation less metastasis also observed administrated animals. In conclusion, our study unveils anti-tumor activity catalysts generating cytotoxic ROS products calcification, providing promising strategy treating tumors.

Language: Английский

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A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 29, 2024

Thermoelectric technology has recently emerged as a distinct therapeutic modality. However, its effectiveness is significantly limited by the restricted temperature gradient within living organisms. In this study, we introduce high-performance plasmonic-thermoelectric catalytic therapy utilizing urchin-like Cu

Language: Английский

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Tensile Strain‐Mediated Bimetallene Nanozyme for Enhanced Photothermal Tumor Catalytic Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(24)

Published: April 9, 2024

Abstract Nanozymes have demonstrated significant potential in combating malignant tumor proliferation through catalytic therapy. However, the therapeutic effect is often limited by insufficient performance. In this study, we propose utilization of strain engineering metallenes to fully expose active regions due their ultrathin nature. Here, present first report on a novel tensile strain‐mediated local amorphous RhRu (la‐RhRu) bimetallene with exceptional intrinsic photothermal and photo‐enhanced multiple enzyme‐like activities. Through geometric phase analysis, electron diffraction profile, X‐ray diffraction, it revealed that crystalline‐amorphous heterophase boundaries can generate approximately 2 % bimetallene. The structure in‐plane induce an amplified effect. Both experimental theoretical evidence support notion promotes Functioning as microenvironment (TME)‐responsive nanozyme, la‐RhRu exhibits remarkable efficacy both vitro vivo. This work highlights tremendous atomic‐scale strategy enhancing

Language: Английский

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A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous H2O2- and O2-independent ROS generation

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 20, 2025

Language: Английский

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A metal-organic framework (MOF) built on surface-modified Cu nanoparticles eliminates tumors via multiple cascading synergistic therapeutic effects

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 662, P. 298 - 312

Published: Feb. 9, 2024

Language: Английский

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Phase Engineered Cu_xS–Ag₂S with Photothermoelectric Activity for Enhanced Multienzyme Activity and Dynamic Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: Feb. 28, 2024

Abstract The insufficient exposure sites and active site competition of multienzyme are the two main factors to hinder its therapeutic effect. Here, a phase‐junction nanomaterial (amorphous‐crystalline Cu x S–Ag 2 S) is designed prepared through simple room temperature ion‐exchange process. A small amount Ag + added into 7 S 4 nanocrystals, which transforms amorphous phased produces crystalline simultaneously. In this structure, overhanging bonds on surface provide abundant for optimizing activity. Meanwhile, state enhances photothermal effect non‐radiative relaxation, due low thermal resistance, forms significant gradient unlock optimized thermo‐electrodynamic therapy. Furthermore, benefiting from high asymmetry state, material spin‐polarized that can effectively inhibit electron–hole recombination. way, thermoelectric facilitate enzyme‐catalyzed cycle by providing electrons holes, enabling an enhanced coupling therapy with activity, induces excellent anti‐tumor performance. More importantly, catalytic process simulated density‐functional theory proves alleviates burden favorable adsorption O prevents competition.

Language: Английский

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Catalytic Biomaterials

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(3), P. 271 - 285

Published: Feb. 16, 2024

ConspectusCatalytic biomaterials, an emerging frontier in biomaterials research, offer tremendous potential to circumvent the limitations of traditional treatment approaches, such as low specificity and adverse effects. By harnessing intrinsic physicochemical properties materials, catalytic especially nanoscale (termed nanomedicine), can directly engage with a range biogenic substrates initiate various chemical or biochemical reactions vivo. Chemically designed nanozymes emulate endogenous enzymes regulating intracellular redox homeostasis, offering distinct advantages over their natural counterparts, design flexibility, adjustable functionalities, robust stability harsh conditions, cost-effective production. The extensively investigated mimicked by include peroxidases, oxidases, superoxide dismutases, catalase, glutathione peroxidase. To improve enzyme-mimicking activities properties, composition, size, morphology, exposed crystal facets, surface chemistry, are finely tuned for reactive oxygen species (ROS)-producing pro-oxidative ROS-eliminating antioxidative applications. As interdisciplinary research catalysis biomedicine deepens, cutting-edge concepts catalysis, including single-atom photocatalysis, electrocatalysis, piezoelectric thermoelectric have gradually merged biomaterials. resultant be activated spatiotemporally light, ultrasound, magnetic fields, heat, etc., beyond scope aforementioned endogenously responsive nanozymes. Given semiconductor nature these externally defect engineering heterojunction strategies utilized enhance separation suppress recombination electron–hole pairs modulating bandgap structures. Consequently, efficacy rationally engineered generating scavenging ROS profoundly improved. Apart from ROS-centered applications, content has also been extended transformation substrates, depletion, glucose/lactate consumption, gas production inorganic nanocatalysts. Collectively, which purposefully influence cellular homeostasis regulate cell signaling pathways, assumed play pivotal role addressing spectrum pathophysiological disorders associated oxidative stress dysfunctions, cancer, inflammation, immunomodulation, neurodegeneration, cardiovascular diseases. connections among nanomedicine, nanozymes, we present our insights here clarify distinctions. Catalytic broader scope, spanning nanoscale, microscale, macroscale that possess specific activities. involved encompass both enzyme-mimetic well endogenously/exogenously initiated nanomedicine emphasizes integration nanotechnology therapeutic Nanozymes specifically focus on nanomaterials. Thus, utilize term "catalytic biomaterials" describe this fast-evolving field anticipate will motivate deeper between materials science, medicine.In Account, provide concise introduction fundamental understanding categorizing them into three groups based action mechanisms. Then, highlight group's work fabrication diverse biomedical cancer therapy, antibacterial, anti-inflammation, tissue engineering, regenerative medicine Our primary is deliberate tailor-made application sophisticated scenarios. biological effects arising elucidated. Furthermore, perspectives clinical translation discussed. We envision rapid development could spur evolution highly effective therapeutic/regenerative approaches minimal toxicity wide medical conditions.

Language: Английский

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