Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

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A Molybdenum Disulfide Nanozyme with Charge‐Enhanced Activity for Ultrasound‐Mediated Cascade‐Catalytic Tumor Ferroptosis

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(11)

Published: Dec. 31, 2022

Abstract The deficient catalytic activity of nanozymes and insufficient endogenous H 2 O in the tumor microenvironment (TME) are major obstacles for nanozyme‐mediated therapy. Since electron transfer is basic essence catalysis‐mediated redox reactions, we explored contributing factors enzymatic based on positive negative charges, which experimentally theoretically demonstrated to enhance peroxidase (POD)‐like a MoS nanozyme. Hence, an acidic microenvironment‐responsive ultrasound‐mediated cascade nanocatalyst (BTO/MoS @CA) presented that made from few‐layer nanosheets grown surface piezoelectric tetragonal barium titanate (T‐BTO) modified with pH‐responsive cinnamaldehyde (CA). integration CA‐mediated self‐supply, charge‐enhanced activity, glutathione (GSH) depletion enables out‐of‐balance homeostasis, leading effective ferroptosis minimal side effects.

Language: Английский

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Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 1, 2023

The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy use tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome stromal barrier for management triple-negative breast cancer (TNBC). SnSNPs possess narrow bandgap (1.18 eV), allowing efficient electron (e-)-hole (h+) pair separation to generate reactive oxygen species under US activation. More importantly, display mild photothermal properties in situ denature collagen facilitate deep into mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by boosts immunity. In mouse models malignant TNBC hepatocellular carcinoma (HCC), combination robust SDT enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. study presents an innovative enhance immunity using strategy, offering potential combined sono-immunotherapy nanomedicine field.

Language: Английский

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Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet‐Based Sonosensitizers Via Crystalline‐to‐Amorphous Phase Transformation

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(17)

Published: Feb. 13, 2023

Abstract Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other strategies. However, the current sonosensitizers used SDT normally exhibit low activity ultrasound (US)‐induced reactive oxygen species (ROS) generation. Herein, crystalline‐to‐amorphous phase transformation is reported as simple but powerful strategy to engineer ultrathin 2D CoW‐LDH and NiW‐LDH nanosheets highly efficient SDT. The from polycrystalline amorphous ones achieved through acid etching treatment. Importantly, one, (a‐CoW‐LDH) possess higher ROS generation under US irradiation, which ≈17 times commercial TiO 2 sonosensitizer. results suggest that enhanced performance a‐CoW‐LDH US‐induced may be attributed transformation‐induced defect electronic structure changes. After polyethylene glycol modification, can serve high‐efficiency sonosensitizer achieve cell death in vitro tumor eradication vivo irradiation.

Language: Английский

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Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: July 12, 2023

Piezocatalytic therapy, which generates reactive oxygen species (ROS) under mechanical force, has garnered extensive attention for its use in cancer therapy owing to deep tissue penetration depth and less O2 -dependence. However, the piezocatalytic therapeutic efficiency is limited poor piezoresponse, low separation of electron-hole pairs, complicated tumor microenvironment (TME). Herein, a biodegradable, porous Mn-doped ZnO (Mn-ZnO) nanocluster with enhanced piezoelectric effect constructed via doping engineering. Mn-doping not only induces lattice distortion increase polarization but also creates rich vacancies (OV ) suppressing recombination leading high-efficiency generation ROS ultrasound irradiation. Moreover, shows TME-responsive multienzyme-mimicking activity glutathione (GSH) depletion ability mixed valence Mn (II/III), further aggravating oxidative stress. Density functional theory calculations show that can improve performance enzyme Mn-ZnO due presence OV . Benefiting from boosting GSH ability, significantly accelerate accumulation lipid peroxide inactivate peroxidase 4 (GPX4) induce ferroptosis. The work may provide new guidance exploring novel sonosensitizers therapy.

Language: Английский

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Stimuli responsive nanosonosensitizers for sonodynamic therapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 547 - 567

Published: Aug. 15, 2023

Language: Английский

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Oxygen‐Deficient Molybdenum Oxide Nanosensitizers for Ultrasound‐Enhanced Cancer Metalloimmunotherapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(9)

Published: Jan. 2, 2023

Oxygen-deficient molybdenum oxide (MoOX ) nanomaterials are prepared as novel nanosensitizers and TME-stimulants for ultrasound (US)-enhanced cancer metalloimmunotherapy. After PEGylation, MoOX -PEG exhibits efficient capability US-triggered reactive oxygen species (ROS) generation glutathione (GSH) depletion. Under US irradiation, generates a massive amount of ROS to induce cell damage immunogenic death (ICD), which can effectively suppress tumor growth. More importantly, itself further stimulates the maturation dendritic cells (DCs) triggeres activation cGAS-STING pathway enhance immunological effect. Due robust ICD induced by SDT DC stimulated -PEG, combination treatment -triggered aCTLA-4 amplifies antitumor therapy, inhibits metastases, elicits immune responses defeat abscopal tumors.

Language: Английский

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Defect-Rich Glassy IrTe₂ with Dual Enzyme-Mimic Activities for Sono-Photosynergistic-Enhanced Oncotherapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 3952 - 3960

Published: Feb. 9, 2023

The complexity, diversity, and heterogeneity of malignant tumors pose a formidable challenge for antitumor therapy. To achieve the goal significantly enhancing effect, nanomedicine-based synergistic therapy is one important strategies. Herein, we innovatively report defect-rich glassy IrTe2 (G-IrTe2) with weak Ir–Te bond strength sonodynamic (SDT), chemodynamic (CDT), mild photothermal (PTT). G-IrTe2 sonosensitizer under ultrasound (US) stimuli exhibits excellent reactive oxygen species (ROS) production performance. Besides, catalase (CAT)-like activity can provide abundant to enhance SDT effect. Then, theoretical calculation verifies that US easily make irregular be broken in amorphous free electrons will released combine further form singlet (1O2). Meanwhile, peroxidase (POD)-like also catalyze endogenous H2O2 produce more ROS which conducive better tumor ablation. Furthermore, produced by sono-/chemodynamic processes cause mitochondrial dysfunction give rise heat shock protein (HSP) downregulated expression, maximizing efficiency PTT. Therefore, such rich defect could involved oncotherapy then effectively outstanding efficacy. This study provides new research idea expanding application inorganic nanomaterials promoting therapeutic effect tumors.

Language: Английский

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Near-Infrared-II-Activatable Self-Assembled Manganese Porphyrin-Gold Heterostructures for Photoacoustic Imaging-Guided Sonodynamic-Augmented Photothermal/Photodynamic Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 18(1), P. 713 - 727

Published: Dec. 20, 2023

Porphyrins and their derivatives are widely used as photosensitizers sonosensitizers in tumor treatment. Nevertheless, poor water solubility low chemical stability reduce singlet oxygen (1O2) yield and, consequently, photodynamic therapy (PDT) sonodynamic (SDT) efficiency. Although strategies for porphyrin molecule assembly have been developed to augment 1O2 generation, there is scope further improving PDT SDT efficiencies. Herein, we synthesized ordered manganese (SM) nanoparticles with well-defined self-assembled metalloporphyrin networks that enabled efficient energy transfer enhanced photocatalytic sonocatalytic activity production. Subsequently, Au were grown situ on the SM surface by anchoring terminal alkynyl of form plasmonic SMA heterostructures, which showed excellent near-infrared-II (NIR-II) region absorption photothermal properties, facilitated electron–hole pair separation transfer. With modification hyaluronic acid (HA), SMAH heterostructure nanocomposites exhibited good actively targeted cancer cells. Under NIR-II light ultrasound (US) irradiation, generates hyperthermia, a large amount 1O2, inducing cell damage. Both vitro vivo studies confirmed effectively suppressed growth decreasing GSH levels SDT-augmented PDT/PTT. Moreover, utilizing strong window, can achieve photoacoustic imaging-guided combined This work provides paradigm enhancing metalloporphyrins improve synergistic therapeutic effect SDT/PDT/PTT.

Language: Английский

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Titanium‐Based Nanoarchitectures for Sonodynamic Therapy‐Involved Multimodal Treatments

Small, Journal Year: 2023, Volume and Issue: 19(12)

Published: Jan. 15, 2023

Sonodynamic therapy (SDT) has considerably revolutionized the healthcare sector as a viable noninvasive therapeutic procedure. It employs combination of low-intensity ultrasound and chemical entities, known sonosensitizer, to produce cytotoxic reactive oxygen species (ROS) for cancer antimicrobial therapies. With nanotechnology, several unique nanoplatforms are introduced sonosensitizers, including, titanium-based nanomaterials, thanks their high biocompatibility, catalytic efficiency, customizable physicochemical features. Additionally, developing sonosensitizers facilitates integration SDT with other treatment modalities (for example, chemotherapy, chemodynamic therapy, photodynamic photothermal immunotherapy), hence increasing overall results. This review summarizes most recent developments in tissue engineering using titanium mediated SDT. The synthesis strategies biosafety aspects Titanium-based also discussed. Finally, various challenges prospects its further development potential clinical translation highlighted.

Language: Английский

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