Small, Journal Year: 2024, Volume and Issue: 20(33)
Published: April 25, 2024
The effect of immunoinflammation on bone repair during the recovery process defects needs to be further explored. It is reported that Mg
Language: Английский
Small Methods, Journal Year: 2024, Volume and Issue: 8(8)
Published: March 21, 2024
Bone tissue defects present a major challenge in orthopedic surgery. engineering using multiple versatile bioactive materials is potential strategy for bone-defect repair and regeneration. Due to their unique physicochemical mechanical properties, biofunctional can enhance cellular adhesion, proliferation, osteogenic differentiation, thereby supporting stimulating the formation of new bone tissue. 3D bioprinting physical stimuli-responsive strategies have been employed various studies on regeneration fabrication desired multifunctional biomaterials with integrated properties. In this review, applied engineering, emerging techniques, rational manufacturing novel therapeutic regenerative functions are summarized. Furthermore, impact differentiation stem cells pathways associated biomaterial-induced osteogenesis discussed.
Language: Английский
Citations
14
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(15), P. 18658 - 18670
Published: April 8, 2024
Three-dimensional (3D)-printed biodegradable polymer scaffolds are at the forefront of personalized constructs for bone tissue engineering. However, it remains challenging to create a biological microenvironment growth. Herein, we developed novel yet feasible approach facilitate biomimetic mineralization via self-adaptive nanotopography, which overcomes difficulties in surface biofunctionalization 3D-printed polycaprolactone (PCL) scaffolds. The building blocks nanotopography were PCL lamellae that formed on scaffold surface-directed epitaxial crystallization and acted as linker nucleate generate hydroxyapatite crystals. Accordingly, uniform robust mineralized layer was immobilized throughout scaffolds, strongly bound strands had no effect mechanical properties In vitro cell culture experiments revealed resulting biocompatible enhanced proliferation osteogenic differentiation mouse embryolous osteoblast cells. Furthermore, demonstrated showed strong capability accelerate vivo regeneration using rabbit defect model. This study provides valuable opportunities enhance application repair, paving way translation other orthopedic implants.
Language: Английский
Citations
14
Materials Science and Engineering R Reports, Journal Year: 2024, Volume and Issue: 159, P. 100801 - 100801
Published: May 3, 2024
Language: Английский
Citations
12
Biofabrication, Journal Year: 2024, Volume and Issue: 17(1), P. 012005 - 012005
Published: Nov. 8, 2024
Abstract Artificial bone graft stands out for avoiding limited source of autograft as well susceptibility to infection allograft, which makes it a current research hotspot in the field defect repair. However, traditional design and manufacturing method cannot fabricate scaffold that mimics complicated bone-like shape with interconnected porous structure multiple properties akin human natural bone. Additive manufacturing, can achieve implant’s tailored external contour controllable fabrication internal microporous structure, is able form almost any designed via layer-by-layer process. As additive promising building artificial scaffold, only combining excellent structural appropriate process produce ideal biological mechanical properties. In this article, we sum up analyze state art methods realize shape/properties collaborative intelligent manufacturing. Scaffold be mainly classified into based on unit cells whole while basic 3D bioprinting are recommended suitable fabrication. The challenges future perspectives manufactured also discussed.
Language: Английский
Citations
11
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(15)
Published: March 1, 2024
Abstract The rapid multiplication of residual tumor cells and poor reconstruction quality new bone are considered the major challenges in postoperative treatment osteosarcoma. It is a promising candidate for composite scaffold which combines photothermal therapy (PTT) regeneration induction local However, it inevitable to damage normal tissues around due hyperthermia PTT, while mild heat shows limited effect on antitumor as can be easily repaired by stress‐induced shock proteins (HSP). This study reports type single‐atom Cu nanozyme‐loaded scaffolds, exhibit exceptional conversion properties well peroxidase glutathione oxidase mimicking activities vitro experiments. leads lipid peroxidation (LPO) reactive oxygen species (ROS) upregulation, ultimately causing ferroptosis. accumulation LPO ROS also contributes HSP70 inactivation, maximizing PTT efficiency against tumors at an appropriate therapeutic temperature minimizing surrounding tissues. Further, promotes via continuous release bioactive ions (Ca 2+ , P 5+ Si 4+ ). results vivo experiments reveal that scaffolds inhibit growth promote repair.
Language: Английский
Citations
10
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12492 - 12492
Published: Aug. 6, 2023
The natural healing process of bone is impaired in the presence tumors, trauma, or inflammation, necessitating external assistance for regeneration. limitations autologous/allogeneic grafting are still being discovered as research progresses. Bone tissue engineering (BTE) now a crucial component treating injuries and actively works to promote vascularization, stage repair. A biomaterial with hydroxyapatite (HA), which resembles mineral makeup invertebrate bones teeth, has demonstrated high osteoconductivity, bioactivity, biocompatibility. However, due its brittleness porosity, restrict application, scientists have been prompted explore ways improve properties by mixing it other materials, modifying structural composition, improving fabrication techniques growth factor loading, co-cultivating regrowth cells stimulate vascularization. This review scrutinizes latest five-year on HA composite studies aimed at amplifying vascularization
Language: Английский
Citations
20
Advanced Science, Journal Year: 2023, Volume and Issue: 11(6)
Published: Dec. 8, 2023
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease featuring an abnormal immune microenvironment and resultant accumulation of hydrogen ions (H + ) produced by activated osteoclasts (OCs). Currently, clinic RA therapy can hardly achieve sustained or efficient therapeutic outcomes due to the failures in generating sufficient modulation manipulating H that deteriorates bone damage. Herein, highly effective modulatory nanocatalytic platform, nanoceria‐loaded magnesium aluminum layered double hydroxide (LDH‐CeO 2 ), proposed for enhanced based on acid neutralization metal ion inherent bioactivity. Specifically, mild alkaline LDH initiates significant M2 repolarization macrophages triggered elevated antioxidation effect CeO via neutralizing excessive microenvironment, thus resulting recruitment regulatory T cell (Treg) suppressions helper 17 (Th 17) plasma cells. Moreover, osteogenic activity stimulated Mg released from LDH, thereby promoting damaged healing. The encouraging adjuvant‐induced model mice demonstrate high feasibility such concept, which provides novel modality bone‐repairing effects inorganic material.
Language: Английский
Citations
20
Advanced Science, Journal Year: 2023, Volume and Issue: 10(22)
Published: May 25, 2023
Abstract The local application of drug‐loaded bioactive scaffold materials is one the important directions to solve clinical problem osteoporotic (OP) bone defects. This study retains advantages drug loading and mechanical properties natural 3D scaffolds. scaffolds are functionally modified through chemical self‐assembly approaches with polydopamine (PDA) nanoparticles parathyroid hormone‐related peptide‐1 (PTHrP‐1) for efficient loading. investigates effects novel on ossification, osteoclastogenesis, macrophage polarization. work elucidates in regulating osteoclastic activity new formation vitro. Further studies establishment repair OP defects small animals conducted, potential porous promote initially verified. preparation safe economical anti‐OP material provides a theoretical basis translational applications.
Language: Английский
Citations
18
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 151136 - 151136
Published: April 9, 2024
Language: Английский
Citations
9