Cited by Global, regional, and national burden of early-onset colorectal cancer and projection to 2050: An analysis based on the Global Burden of Disease Study 2021

Parabacteroides johnsonii Inhibits the Onset and Progression of Colorectal Cancer by Modulating the Gut Microbiota DOI

Jing Liu, Yong Zhang, Li‐Yan Xu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Background Colorectal cancer (CRC) is the third most prevalent malignant tumor and second leading cause of cancer-related deaths globally. The genus Parabacteroides an important component gut microbiota. P. distasonis goldsteinii are reported probiotics, their roles in CRC have been investigated related studies. However, association between johnsonii remains unknown. Methods (10–42) Lactococcus formosensis (22–2) were isolated from healthy human feces. 25 mice that demonstrated normal feeding activity randomly assigned to four groups : control (NC group), model (IC (PJ L. (LO group). Colonic tissues IC, PJ, LO colon NC group then collected for HE staining immunohistochemical staining. Fecal samples during hyperproliferative adenoma phases Metagenomic sequencing metabolite analysis. Results intervention reduced number slowed growth colonic tumors, improved histological scores, decreased microenvironmental inflammation levels. composition intestinal flora with cancer, increased microbial species diversity, maintained microbiota stability. Furthermore, abundance Bifidobacterium pseudolongum Lactobacillus, which play a role ameliorating AOM/DSS-induced dysbiosis. affected metabolic pathways, including amino sugar degradation galactose metabolism, sphingolipid synthesis, acid polyphenol synthesis tryptophan metabolism pathway as primary being affected. Conclusion Our study profiled administration reduces tumors lower staging by modulating its metabolites at early stages.

Language: Английский

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Moxibustion regulates KDM4D expression and modulates lipid metabolism to inhibit tumor proliferation in CAC mice DOI

Guona Li,

Jindan Ma,

Luyi Wu

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 5, 2025

Language: Английский

Citations

Long-term trends in the burden of colorectal cancer in Europe over three decades: a joinpoint regression and age-period-cohort analysis DOI

Dan Long,

Chenhan Mao,

Zhensheng Zhang

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Dec. 5, 2023

Background The burden of colorectal cancer (CRC) in Europe is at a high level, but the epidemiological features have not yet been systematically studied. This study aimed to provide timely and reliable assessment trends CRC scientific basis for its prevention treatment. Methods We analyzed data on 44 European countries between 1990 2019 from Global Burden Disease (GBD) 2019. In addition, joinpoint regression model was applied reflect temporal trends. age-period-cohort constructed explore age, period, birth cohort effects that influence risk morbidity mortality. Results Europe, new cases, disability-adjusted life years (DALYs) deaths rose by 70.01%, 22.88% 38.04% 2019, respectively. age-standardized incidence rate (ASIR) has increased, while DALY mortality (ASMR) declined. found men experienced significantly higher than women. Age-period-cohort analysis showed increased with age time; it lower later-born earlier-born cohort. Conclusion ASIR generally trended upwards stabilizing recent still level. varied considerably different countries. There pronounced gender difference burden, middle-aged older should be priority population

Language: Английский

Citations

Third-Generation PacBio Sequencing to Explore Gut Bacteria and Gender in Colorectal Cancer DOI

Shengquan Yu,

Jian Chu,

Wu Yinhang

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 192, P. 106684 - 106684

Published: May 16, 2024

Language: Английский

Citations

OncoSexome: the landscape of sex-based differences in oncologic diseases DOI

Xinyi Shen, Yintao Zhang, Jiamin Li

et al.

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D1443 - D1459

Published: Nov. 13, 2024

The NIH policy on sex as biological variable (SABV) emphasized the importance of sex-based differences in precision oncology. Over 50% clinically actionable oncology genes are sex-biased, indicating drug efficacy. Research has identified non-reproductive cancers, highlighting need for comprehensive cancer data. We therefore developed OncoSexome, a multidimensional knowledge base describing (https://idrblab.org/OncoSexome/) across four key topics: antineoplastic drugs and responses (SDR), oncology-related biomarkers (SBM), risk factors (SRF) microbial landscape (SML). SDR covers 2051 anticancer drugs; SBM describes 12 551 sex-differential biomarkers; SRF illustrates 350 sex-dependent factors; SML demonstrates 1386 microbes with abundances associated development. OncoSexome is unique illuminating multifaceted influences cancer, providing both external endogenous contributors to development broadest oncological classes. Given increasing global research interest differences, expected impact future practices significantly.

Language: Английский

Citations

Genetically Predicted Causal Effects of Gut Microbiota and Gut Metabolites on Digestive Tract Cancer: A Two-Sample Mendelian Randomization Analysis DOI

Xu Jia Li,

Meng Gao,

Xu Xian Chen

et al.

World Journal of Oncology, Journal Year: 2023, Volume and Issue: 14(6), P. 558 - 569

Published: Nov. 18, 2023

Evidence from numerous observational studies and clinical trials has linked gut microbiota metabolites to digestive tract cancer. However, the causal effect between these factors remains uncertain.Data for this study were obtained MiBioGen, TwinsUK Registry, FinnGen (version R8). Two-sample Mendelian randomization analysis with inverse variance weighting method was primarily used, results validated by heterogeneity analysis, pleiotropy test, sensitivity analysis.At P < 5 × 10-8, our identified four microbiotas as risk cancer six colorectal Conversely, one exhibited protection against bile duct cancer, two showed protective effects stomach At 1 10-5, investigation revealed five, six, three, eight, eight esophageal, stomach, duct, liver, pancreatic, cancers, respectively. In contrast, four, two, five cancers. Additionally, GABA, a metabolite of microbiota, displayed significant cancer.In conclusion, specific play roles or relationship them been established, offering novel insights into microbiota-mediated development.

Language: Английский

Citations

A decade-long study on pathological distinctions of resectable early versus late onset colorectal cancer and optimal screening age determination DOI

Jiawei Song,

Tenghui Han,

Qian Lei

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 9, 2024

The incidence of Early-Onset Colorectal Cancer (EOCRC) is increasing. However, the prognosis EOCRC compared to Late-Onset (LOCRC), and ideal age for initial colorectal cancer (CRC) screening are not clear. In this study, we identified pathological differences between groups determined optimal CRC patients. We included 10,172 patients diagnosed with from January 2011 December 2021 in study. Survival were by plotting Kaplan-Meier survival curves conducting landmark analysis. Additionally, diagnostic was analyzed using cumulative curves. Compared LOCRC patients, had a higher proportion deficient mismatch repair (dMMR) more advanced TNM staging (P < 0.05). five-year significantly better than that Laparoscopic surgery improved long-term Proficient (pMMR) favored rate at stages I II same curve showed substantial increase number 40 years. especially among those pMMR, I-II, who undergo laparoscopic surgery. For people high risk cancer, such as family history poor lifestyle habits, starting should be

Language: Английский

Citations

Comprehensive Analysis of the Function and Prognostic Value of TAS2Rs Family-Related Genes in Colon Cancer DOI

Suzhen Bi, Jie Zhu, Liting Huang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6849 - 6849

Published: June 21, 2024

In the realm of colon carcinoma, significant genetic and epigenetic diversity is observed, underscoring necessity for tailored prognostic features that can guide personalized therapeutic strategies. this study, we explored association between type 2 bitter taste receptor (TAS2Rs) family-related genes cancer using RNA-sequencing clinical datasets from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). Our preliminary analysis identified seven TAS2Rs associated with survival univariate Cox regression analysis, all which were observed to be overexpressed in cancer. Subsequently, based on these genes, two molecular subtypes (Cluster A Cluster B) defined. These exhibited distinct immune characteristics, characterized by low cell infiltration less favorable outcomes, while B was high better prognosis. Finally, developed a robust scoring system gradient boosting machine (GBM) approach, integrated gene-pairing method, predict prognosis patients. This learning model could improve our predictive accuracy its value precision oncology framework.

Language: Английский

Citations

Direct and indirect effects of estrogens, androgens and intestinal microbiota on colorectal cancer DOI

Zihong Wu, Yi Sun,

Wenbo Huang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 26, 2024

Sex differences in colorectal cancer (CRC) has received considerable research attention recently, particularly regarding the influence of sex hormones and intestinal microbiota. Estrogen, at genetic epigenetic levels, directly inhibits CRC cell proliferation by enhancing DNA mismatch repair, regulating miRNAs, blocking cycle, modulating ion channels. However, estradiol's activation GPER promotes oncogene expression. Conversely, androgen contributes to dysregulation progression via nuclear receptors while inducing apoptosis through membrane receptors. Specific gut microorganisms produce genotoxins oncogenic metabolites that damage colonic contribute induction. Regarding tumor microenvironment, estrogen mitigates inflammation, reverses immunosuppression, increases microbiome diversity commensal bacteria abundance, decreases pathogen enrichment. On contrary, disrupts microecology, diminish immunotherapy efficacy, exacerbate inflammation growth. The impact is closely tied their receptor status, elucidating dual roles pathogenesis. This review comprehensively discusses direct indirect effects microbiota on CRC, considering environmental factors such as diet lifestyle propose novel prevention treatment strategies.

Language: Английский

Citations

A comprehensive study of Ephedra sinica Stapf-Schisandra chinensis (Turcz.) Baill herb pair on airway protection in asthma DOI

Zushun Zhuo, Jianhua Nie,

Bin Xie

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 322, P. 117614 - 117614

Published: Dec. 17, 2023

Language: Английский

Citations