Mn-single-atom nano-multizyme enabled NIR-II photoacoustically monitored, photothermally enhanced ROS storm for combined cancer therapy DOI Creative Commons
Xiaozhe Wang, Xiaofeng Ren, Jie Yang

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

To realize imaging-guided multi-modality cancer therapy with minimal side effects remains highly challenging. We devised a bioinspired hollow nitrogen-doped carbon sphere anchored individually dispersed Mn atoms (Mn/N-HCN) via oxidation polymerization triton micelle as soft template, followed by carbonization and annealing. Enzyme kinetic analysis optical properties were performed to evaluate the photothermally synergized nanocatalytic therapy. Simultaneously mimicking several natural enzymes, namely peroxidase (POD), catalase (CAT), oxidase (OXD), glutathione (GPx), this nano-multizyme is able produce cytotoxic hydroxyl radical (•OH) singlet oxygen (1O2) without external energy input through parallel series catalytic reactions suppress upregulated antioxidant (glutathione) in tumor. Furthermore, NIR-II absorbing Mn/N-HCN permits photothermal (PTT), enhancement of CAT activity, photoacoustic (PA) imaging monitor accumulation kinetics nanozyme process situ. Both vitro vivo experiments demonstrate that near-infrared-II (NIR-II) PA-imaging guided, enhanced efficient induce apoptosis cancerous cells eradicate tumor tissue. This study not only demonstrates new method for effective diagnosis but also provides insights into designing multi-functional nanozymes.

Language: Английский

Single Atom‐Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo‐Nanodynamic Therapy of Triple Negative Breast Cancer DOI Creative Commons
Qiqing Chen, Min Zhang, Hui Huang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(6)

Published: Jan. 16, 2023

Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce oxidative stress damage. However, mutant cancers, especially triple-negative cancer (TNBC), have evolved acquire specific antioxidant defense functions, significantly limiting killing efficiency SDT. Herein, authors engineered distinct single copper atom-doped titanium dioxide (Cu/TiO2 ) nanosonosensitizer with highly catalytic and sonosensitive activities synergistic chemodynamic sonodynamic treatment TNBC. The single-atom Cu is anchored most stable Ti vacancies hollow TiO2 sonosensitizers, not only substantially improved activity Cu-mediated Fenton-like reaction, but also considerably augmented by facilitating separation electrons (e- holes (h+ ). Both in vitro vivo studies demonstrate that nanosonosensitizers effectively achieved inhibitory effect TNBC, providing paradigm non-invasive safe tumor elimination through mutual process sono/chemo-nanodynamic based multifunctional nanosonosensitizers.

Language: Английский

Citations

59
Defect Engineering in Nanocatalysts: From Design and Synthesis to Applications DOI
Pir Muhammad, Amir Zada, Jamshaid Rashid

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: Feb. 13, 2024

Abstract Defect engineering is an emerging technology for tailoring nanomaterials' characteristics and catalytic performance in various applications. Recently, defect‐engineered nanoparticles have emerged as highly researched materials applications because of their exceptional redox reaction capabilities physicochemical optical properties. The properties nanomaterials can be readily adjusted by controlling the nature concentration defects within nanoparticles, avoiding need intricate design strategies. This review investigates defect nanocatalysts, including design, fabrication, Initially, categories strategies nanomaterial impacts on nanocatalysts' electronic surface properties, activity, selectivity, stability are summarized. Then, processes uses, gas sensing, hydrogen (H 2 ) evolutions, water splitting, reductions carbon dioxide (CO nitrogen to value‐aided products, pollutant degradation, biomedical (oncotherapy, antibacterial wound healing, biomolecular sensing) discussed. Finally, limitations prospective paths allowing logical optimization nanocatalytic long‐term efficient also examined. comprehensive gives unique insights into current state nanocatalysts inspires future research exploiting shortcomings improve customize performance.

Language: Английский

Citations

44
Synergistic Interaction between Metal Single‐Atoms and Defective WO3−x Nanosheets for Enhanced Sonodynamic Cancer Therapy DOI Creative Commons
Zhan Zhou, Tao Wang, Tingting Hu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 27, 2024

Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of SAs on oxygen vacancy (OV)‐rich WO 3− x nanosheets generate a synergistic effect efficient SDT is reported. Crystalline 3 OV‐rich first prepared by simple calcination ·H 2 O under an air N atmosphere, respectively. Pt, Cu, Fe, Co, Ni then deposited obtain SA‐decorated nanocomposites (M‐WO ). Importantly, Cu‐WO sonosensitizer exhibits much higher activity ultrasound (US)‐induced production reactive species than that Cu , which also M‐WO nanosheets. Both experimental theoretical results suggest excellent performance should be attributed between OVs. Therefore, after polyethylene glycol modification, can quickly kill cancer cells in vitro effectively eradicate tumors vivo US irradiation. Transcriptome sequencing analysis further molecular validation ‐mediated SDT‐activated apoptosis TNF signaling pathways potential drivers tumor induction.

Language: Английский

Citations

44
A Multifunctional Bimetallic Nanoplatform for Synergic Local Hyperthermia and Chemotherapy Targeting HER2‐Positive Breast Cancer DOI Creative Commons
Li Zhao, Fei Chang, Yao Tong

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Anti-HER2 (human epidermal growth factor receptor 2) therapies significantly increase the overall survival of patients with HER2-positive breast cancer. Unfortunately, a large fraction may develop primary or acquired resistance. Further, multidrug combination used to prevent this in clinic places significant burden on patients. To address issue, work develops nanotherapeutic platform that incorporates bimetallic gold-silver hollow nanoshells (AuAg HNSs) exceptional near-infrared (NIR) absorption capability, small-molecule tyrosine kinase inhibitor pyrotinib (PYR), and Herceptin (HCT). This realizes targeted delivery multiple therapeutic effects, including chemo-and photothermal activities, oxidative stress, immune response. In vitro assays reveal HCT-modified nanoparticles exhibit specific recognition ability effective internalization by cells. The released PYR inhibit cell proliferation downregulating HER2 its associated pathways. NIR laser application induces effect tumor apoptosis, whereas an intracellular reactive oxygen species burst amplifies stress triggers cancer ferroptosis. Importantly, multimodal therapy also promotes upregulation genes related TNF NF-κB signaling pathways, enhancing activation immunogenic death. vivo studies confirm reduction volume after treatment, substantiating potential effectiveness these nanocarriers.

Language: Английский

Citations

16
Applications and Enhancement Strategies of ROS-based Non-invasive Therapies in Cancer Treatment DOI Creative Commons
Qiuyan Guo,

Yingnan Tang,

Shengmei Wang

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515

Published: Jan. 1, 2025

Language: Английский

Citations

2
Defect Engineering in Biomedical Sciences DOI Open Access
Meng Yuan, Mehraneh Kermanian, Tarun Agarwal

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: June 4, 2023

Abstract With the promotion of nanochemistry research, large numbers nanomaterials have been applied in vivo to produce desirable cytotoxic substances response endogenous or exogenous stimuli for achieving disease‐specific therapy. However, performance is a critical issue that difficult improve and optimize under biological conditions. Defect‐engineered nanoparticles become most researched hot materials biomedical applications recently due their excellent physicochemical properties, such as optical properties redox reaction capabilities. Importantly, can be easily adjusted by regulating type concentration defects without requiring other complex designs. Therefore, this tutorial review focuses on defect engineering briefly discusses classification, introduction strategies, characterization techniques. Several representative defective are especially discussed order reveal relationship between properties. A series disease treatment strategies based engineered summarized. By summarizing design application nanomaterials, simple but effective methodology provided researchers therapeutic effects nanomaterial‐based platforms from science perspective.

Language: Английский

Citations

39
2D Piezoelectric BiVO4 Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy DOI
Ruoxi Zhao,

Haixia Zhu,

Lili Feng

et al.

Small, Journal Year: 2023, Volume and Issue: 19(36)

Published: May 1, 2023

Increasing the yield of reactive oxygen species (ROS) to enhance oxidative stress in cells is an eternal goal cancer therapy. In this study, BiVO4 artificial nanozyme developed with adjustable vanadium vacancy for ultrasound (US) enhanced piezoelectric/sonodynamic Under US excitation, vacancy-rich nanosheets (abbreviated Vv -r NSs) facilitate generation a large number electrons improve ROS yield. Meanwhile, mechanical strain imposed by irradiation makes NSs display typical piezoelectric response, which tilts conduction band be more negative and valance positive than redox potentials O2 /O2•- H2 O/·OH, boosting efficiency generation. Both density functional theory calculations experiments confirm that introduction cationic can sonodynamic effect. As expected, have better peroxidase enzyme catalytic glutathione depletion activities, resulting increased intracellular stress. This triple amplification strategy induced substantially inhibits growth cells. The work may open avenue achieve synergetic therapy introducing vacancy, broadening biomedical use materials.

Language: Английский

Citations

33
Lattice Strain Engineering of Ti3C2 Narrows Band Gap for Realizing Extraordinary Sonocatalytic Bacterial Killing DOI

Minyue Ku,

Congyang Mao, Shuilin Wu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14840 - 14851

Published: July 26, 2023

The rapid development of sonodynamic therapy (SDT) provides a promising strategy for treating deep-seated multidrug-resistant (MDR) bacterial infection. However, the extreme scarcity biologically functional and highly efficient sonosensitizers severely limits further clinical practice SDT. Herein, lattice-strain-rich Ti3C2 (LS-Ti3C2) with greatly improved sonosensitizing effect is one-step synthesized using meso-tetra(4-carboxyphenyl)porphine (TCPP) by solvothermal method realizing extraordinary intervention TCPP causes all Ti–O chemical bonds most Ti–F on surface layer to break down. amino groups are then recombined these exposed Ti atoms perturb order atoms, resulting in displacement final lattice structural distortion Ti3C2. inherent strain narrows band gap Ti3C2, which mainly facilitates electron–hole pair separation electron transfer under ultrasound irradiation, thereby US-mediated reactive oxygen species (ROS) production subsequent robust bactericidal capability (99.77 ± 0.16%) against methicillin-resistant Staphylococcus aureus (MRSA). Overall, this research offers perspective into Ti-familial toward SDT practice.

Language: Английский

Citations

23
Designing Efficient Single Metal Atom Biocatalysts at the Atomic Structure Level DOI
Yang Liu,

Huan Zhao,

Yanli Zhao

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(13)

Published: Jan. 11, 2024

Various nanomaterials as biocatalysts could be custom-designed and modified to precisely match the specific microenvironment of diseases, showing a promise in achieving effective therapy outcomes. Compared conventional biocatalysts, single metal atom catalysts (SMACs) with maximized utilization through well-defined structures offer enhanced catalytic activity selectivity. Currently, there is still gap comprehensive overview connection between biocatalytic mechanisms SMACs. Therefore, it crucial deeply investigate role SMACs biocatalysis from atomic structure level elucidate their potential processes. In this minireview, we summarize catalysis regulation methods at level, focusing on optimization active sites, coordination environment, site-support interactions, briefly discuss for biomedical applications.

Language: Английский

Citations

14
Sulfur-Vacancy-Engineered Two-Dimensional Cu@SnS2–x Nanosheets Constructed via Heterovalent Substitution for High-Efficiency Piezocatalytic Tumor Therapy DOI
Xinyu Ma, Binbin Ding,

Zhuang Yang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(31), P. 21496 - 21508

Published: July 29, 2024

Ultrasound (US)-mediated piezocatalytic tumor therapy has attracted much attention due to its notable tissue-penetration capabilities, noninvasiveness, and low oxygen dependency. Nevertheless, the efficiency of is limited an inadequate piezoelectric response, separation electron–hole (e––h+) pairs, complex microenvironment (TME). Herein, ultrathin two-dimensional (2D) sulfur-vacancy-engineered (Sv-engineered) Cu@SnS2–x nanosheet (NS) with enhanced effect was constructed via heterovalent substitution strategy Sn4+ by Cu2+. The introduction Cu2+ ion not only causes changes in crystal structure increase polarization but also generates rich Sv decrease band gap from 2.16 1.62 eV inhibit e––h+ pairs recombination, collectively leading highly efficient generation reactive species under US irradiation. Moreover, shows US-enhanced TME-responsive Fenton-like catalytic activity glutathione depletion ability, further aggravating oxidative stress. Both vitro vivo results prove that Sv-engineered NSs can significantly kill cells achieve high-efficiency a biocompatible manner. Overall, this study provides new avenue for sonocatalytic broadens application 2D materials.

Language: Английский

Citations

13