Multifaceted Carbonized Metal–Organic Frameworks Synergize with Immune Checkpoint Inhibitors for Precision and Augmented Cuproptosis Cancer Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(27), P. 17852 - 17868

Published: June 28, 2024

The discovery of cuproptosis, a copper-dependent mechanism programmed cell death, has provided way for cancer treatment. However, cuproptosis inherent limitations, including potential cellular harm, the lack targeting, and insufficient efficacy as standalone Therefore, exogenously controlled combination treatments have emerged key strategies cuproptosis-based oncotherapy. In this study, Cu2–xSe@cMOF nanoplatform was constructed combined sonodynamic/cuproptosis/gas therapy. This platform enabled precise cotreatment, with external control allowing selective induction in cells. approach effectively prevented metastasis recurrence. Furthermore, antiprogrammed death protein ligand-1 antibody (aPD-L1), maximized advantages immune checkpoint Additionally, under ultrasound irradiation, H2Se gas generated from induced cytotoxicity Further, it reactive oxygen species, which hindered survival proliferation. study reports an externally system that combines carbonized metal–organic framework aPD-L1 to enhance precision reinforced therapy could be valuable effective therapeutic agent reduce mortality morbidity future.

Language: Английский

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Single Atom Catalysts Remodel Tumor Microenvironment for Augmented Sonodynamic Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 16, 2024

The immunosuppressive tumor microenvironment (TME) is a huge hurdle in immunotherapy. Sono-immunotherapy new treatment modality that can reverse TME, but the sonodynamic effects are compromised by overexpressed glutathione (GSH) and hypoxia TME. Herein, this work reports sono-immunotherapy strategy using Pd

Language: Английский

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Gradient‐Tuned VO₄ Vacancies in BiVO₄ Photoanode for Boosting Bulk Hole Transport and Oxygen Evolution Reaction Performance

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)

Published: Feb. 29, 2024

Abstract Although bismuth vanadate (BiVO 4 ) photoanode has been widely used, the solar‐driven oxygen evolution reaction (OER) performance is constrained due to substantial bulk recombination and poor mobility of charge carriers. Herein, a facile solvothermal post‐treatment approach that employs N,N‐dimethylformamide (DMF) developed induce VO vacancy gradient from surface BiVO film, which not only improves diffusion but also establishes an advantageous upward band promote hole transport. Under Air Mass 1.5 Global (AM1.5G) simulated solar illumination, optimized with (denoted as B(VO) 1‐δ exhibits excellent OER separation efficiency 74.4% at 1.23 V versus reversible hydrogen electrode (RHE) incident‐photon‐to‐current conversion 30.7% 445 nm, 1.2 1.4 times higher than pristine , respectively. After loading nickel‐iron hydroxyl oxide (NiFeOOH) cocatalyst, photocurrent density escalates 5.92 mA cm −2 in scavenger (Na 2 SO 3 solution 5.07 potassium borate buffer RHE, far superior . This work highlights gradient‐tuned vacancies can effectively modulate structure transfer photoanode, providing new strategy for boosting water splitting performance.

Language: Английский

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An Enzyme‐Engineered Coppery Nanozyme for High‐Efficiency Mild Photothermal/Chemodynamic/Starvation Therapy Through Self‐Reinforcing Cancer Energy Metabolism Regulation

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Feb. 5, 2024

Abstract Photothermal therapy (PTT) has a great prospect in further improving tumor therapeutic outcomes, whereas its efficiency is restrained by low light penetration, excessive heat damage to normal tissues, up‐regulated shock proteins (HSPs), and limited effect of single treatment. Herein, an enzyme‐engineered coppery nanozyme based on dendritic mesoporous carbon nanosphere as the cornerstone load with glucose oxidase (GOx) followed modification hyaluronic acid constructed. Density functional theory calculations indicate that obtained exhibits peroxidase glutathione mimicking activities improve hydroxyl radicals (•OH) production. Furthermore, both generation •OH production GOx‐induced energy supply blockade can reduce HSPs expression enhance mild PTT (η = 34.9 %) upon irradiation 1064 nm laser, turn, accelerate catalytic processes for more •OH. Last but not least, introduction copper induce lipoylated protein dihydrolipoamide S‐acetyltransferase aggregation cause cellular cuproptosis. Due synergy multiple therapies, inhibition rate reach 93.4%. Overall, this work provides effective strategy potential treatment basis synergistic therapies.

Language: Английский

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Single-Atom-Based Nanoenzyme in Tissue Repair

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

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Piezoelectrical Hydrogel Containing Cationic Vacancies Bismuth Sulfide with Enhanced Sonodynamic/Nanozyme Activity for Synergistic Killing Bacteria and Boosting Osteoblast Differentiation

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: 13(10), P. 3420 - 3436

Published: Jan. 1, 2025

A piezoelectric nanozyme is a novel biomaterial with the integration of piezoelectricity and activity that has capability killing bacteria promoting cell responses under mechanical stimulus exhibits great prospects in tissue regeneration. Herein, bismuth sulfide (BS) cationic vacancies (VBS) was synthesized, which enhanced activities compared BS. Moreover, hydrogel VBS phenylboronic acid grafted sodium alginate-arginine (VBS-PSA) prepared. Triggered by ultrasound (US) high power (>0.5 W cm-2), VBS-PSA produces large amount reactive oxygen species (ROS) through both piezoelectricity-enhanced sonodynamic efficiency peroxidase-like (POD-like) activity, thereby displaying powerful antibacterial capability. However, low-power US (≤0.5 effect generates electrical signals significantly stimulate osteoblast (proliferation differentiation) enhance catalase-like (CAT-like) for scavengers ROS generation oxygen, creating favorable microenvironment growth. Our study presents strategy to apply hydrogels enhancing synergistically kill responses. The would have potential repair infected bone defects.

Language: Английский

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Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

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Piezoelectric Effect Modulates Nanozyme Activity: Underlying Mechanism and Practical Application

Small, Journal Year: 2023, Volume and Issue: 19(52)

Published: Aug. 27, 2023

Abstract Nanozyme activity relies on surface electron transfer processes. Notably, the piezoelectric effect plays a vital role in influencing nanozyme by generating positive and negative charges materials' surfaces. This article comprehensively reviews potential mechanisms practical applications of regulating through effect. The first elucidates how enables nanozymes to exhibit catalytic activity. It is highlighted that produced this directly participate redox reactions, leading conversion materials from an inactive active state. Moreover, field generated can enhance accelerating rates or reducing binding energy between substrates. Practical are explored subsequent section, including water pollutant degradation, bacterial disinfection, biological detection, tumor therapy, which demonstrate versatile potentials applications. review concludes emphasizing need for further research into nanozymes, suggesting expanding scope types exploring new application areas. Furthermore, promising direction synergistic therapy discussed as inspiring avenue future research.

Language: Английский

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Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Language: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

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