Cellulose nanofibers embedded chitosan/tannin hydrogel with high antibacterial activity and hemostatic ability for drug-resistant bacterial infected wound healing

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 329, P. 121687 - 121687

Published: Dec. 12, 2023

Language: Английский

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Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics

Polymers, Journal Year: 2023, Volume and Issue: 15(15), P. 3305 - 3305

Published: Aug. 4, 2023

Hydrogels have a three-dimensional network structure and high-water content, are similar in to the extracellular matrix, often used as wound dressings. Natural polymers excellent biocompatibility biodegradability commonly utilized prepare hydrogels. Natural-polymer-based hydrogels can antibacterial bioactive properties by loading agents or being combined with therapeutics such phototherapy, which has great advantages field of treatment microbial infections. In published reviews infectious wounds, common classification criteria include function, source properties, type agent, etc. However, there few on based raw materials, description natural-polymer-based is not comprehensive detailed. this paper, principle material classification, characteristics seven types natural that be discussed, respectively, application wounds described detail. Finally, research status, limitations, prospects briefly discussed.

Language: Английский

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Multifunctional Microneedle Patch Based on Metal-Phenolic Network with Photothermal Antimicrobial, ROS Scavenging, Immunomodulatory, and Angiogenesis for Programmed Treatment of Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(26), P. 33205 - 33222

Published: June 25, 2024

In diabetic patients with skin injuries, bacterial proliferation, accumulation of reactive oxygen species (ROS) in the tissues, and impaired angiogenesis make wound healing difficult. Therefore, eliminating bacteria, removing ROS, promoting are necessary for treating acute wounds. this study, benefiting from ability polyphenols to form a metal-phenolic network (MPN) metal ions, TA-Eu MPN nanoparticles (TM NPs) were synthesized. The prepared photothermal agent CuS NPs TM then loaded onto supporting base needle tips PVA/HA (PH) microneedles, respectively, obtain PH/CuS/TM microneedles. Antibacterial experiments showed that microneedles could remove bacteria by effect. vitro effectively scavenge inhibit macrophage polarization M1 type, induce M2 type as well have promote vascular endothelial cell migration angiogenesis. Furthermore, vivo accelerated inhibiting pro-inflammatory cytokines rat model. efficient antibacterial, ROS scavenging, anti-inflammatory, immunomodulatory, angiogenic abilities hold promise dressings

Language: Английский

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Recent advances on thermosensitive hydrogels-mediated precision therapy

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(3), P. 100911 - 100911

Published: April 14, 2024

Precision therapy has become the preferred choice attributed to optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse effects. Over past few years, sprayable or injectable thermosensitive hydrogels have exhibited high potential. These can be applied as cell-growing scaffolds drug-releasing reservoirs by simply mixing a free-flowing sol phase at room temperature. Inspired their unique properties, been widely delivery treatment platforms for precision medicine. In this review, state-of-the-art developments are investigated, which covers from thermo-gelling mechanisms main components biomedical applications, including wound healing, anti-tumor activity, osteogenesis, periodontal, sinonasal ophthalmic diseases. The most promising applications trends of also discussed light features.

Language: Английский

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Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

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Electron Spin Polarization Engineering in Ferromagnetic Bioheterojunction for Sonotherapy of Osteomyelitis

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(34)

Published: April 1, 2024

Abstract Electron spinning polarization has garnered increased attention for its potential to enhance device properties. However, application in life health, specifically anti‐infection and tissue repair, remains under‐explored. In this study, a ferromagnetic heterojunction CF (Fe 3 O 4 /TiO 2 ) is constructed with spin‐polarized electrons, demonstrating efficient antibiosis performance ultrasound (US) assistance. The antibacterial mechanism elucidated as follows: metallic states of Fe induce an asymmetric distribution the electron spin state TiO , increasing density electrons near Fermi level CF. Under US treatment, built‐in electric field synergistically suppress recombination sono‐activated carriers, promoting reactive oxygen species (ROS) production. Simultaneously, bacterial membrane influenced by micromagnetic induced causing severe disturbance respiratory chain. combined damage from ROS disturbed chain results death. Fortunately, built activates specific mechanosensitive ion channels, including TREK1, Piezo1, related pathways, enhancing osteoblast differentiation. Sonotherapy using exhibits excellent therapeutic effect treating osteomyelitis. This study provides novel insights into manipulating applications health.

Language: Английский

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Glucose and pH dual-responsive hydrogels with antibacterial, reactive oxygen species scavenging, and angiogenesis properties for promoting the healing of infected diabetic foot ulcers

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Black phosphorus thermosensitive hydrogels loaded with bone marrow mesenchymal stem cell-derived exosomes synergistically promote bone tissue defect repair

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(20), P. 4396 - 4407

Published: Jan. 1, 2023

BP nanosheets were irradiated with NIR light to control the swelling/deswelling phase transition of hydrogels and constructed an light-responsive exosome controlled-release platform for bone regeneration.

Language: Английский

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Photodynamic patterning of living bacterial biofilms with high resolutions for information encryption and antibiotic screening

Aggregate, Journal Year: 2024, Volume and Issue: 5(4)

Published: March 1, 2024

Abstract Controlling the growth of bacterial biofilms in a specific pattern greatly enhances study cell‐to‐cell interactions and paves way for expanding their biological applications. However, development simple, cost‐effective, highly resolved biopatterning approaches remains persistent challenge. Herein, pioneering photodynamic technique creation living with customized geometries at high resolutions is presented. First all, an outstanding aggregation‐induced emission photosensitizer synthesized to enable efficient killing low concentration. By combining custom‐designed photomasks featuring both opaque transparent patterns, viability photosensitizer‐coated bacteria successfully manipulated by controlling degree light transmittance. This process leads formation patterns replicated from photomask. Such innovative strategy can be employed generate composed either mono‐ or multispecies, spatial resolution approximately 24 µm. Furthermore, its potential applications information storage/encryption antibiotic screening are explored. provides alternative understand investigate intricate among within 3D biofilms, holding great promise controlled fabrication dynamic systems advanced

Language: Английский

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A comprehensive review on the inherent and enhanced antifouling mechanisms of hydrogels and their applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130994 - 130994

Published: March 21, 2024

Language: Английский

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