Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153103 - 153103
Published: June 13, 2024
Language: Английский
MedComm, Journal Year: 2024, Volume and Issue: 5(7)
Published: June 22, 2024
Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, potentially highly efficient method of phototherapy. The three components PDT primarily include photosensitizers, oxygen, light. employs specific wavelengths light to active photosensitizers at the tumor site, generating reactive oxygen species that are fatal cells. Nevertheless, traditional have disadvantages such as poor water solubility, severe oxygen-dependency, low targetability, difficult penetrate deep tissue, which remains toughest task in application clinic. Here, we systematically summarize development molecular mechanisms challenges management, highlighting advantages nanocarriers-based against cancer. third generation has opened up new horizons PDT, cooperation between nanocarriers attained satisfactory achievements. Finally, clinical studies discussed. Overall, present an overview our perspective field believe this work will provide insight into tumor-based PDT.
Language: Английский
Citations
26
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122
Published: Aug. 6, 2024
Language: Английский
Citations
20
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Photodynamic therapy (PDT) holds promise as a cancer treatment modality due to its potential for enhanced precision and safety. To enhance deep tissue penetration minimize adsorption phototoxicity, developing photosensitizers activated by second near-infrared window (NIR-II) light shows significant potential. However, the efficacy of PDT is often impeded tumor microenvironment hypoxia, primarily caused irregular vasculature. Fortunately, stimulator interferon genes (STING) pathway, known immune activation, has been linked vasculature normalization. In this study, we developed nanoplatform (Fe-THBQ/SR) loading STING agonist (SR-717) into an iron-tetrahydroxy-1,4-benzoquinone (Fe-THBQ) metal–organic framework. Fe-THBQ was proven be effective NIR-II photosensitizer, generating numerous reactive oxygen species (ROS) under 1064 nm laser irradiation. These ROS downregulated heat shock protein expression, consequently promoting mild-photothermal (mild-PTT), facilitated ferroptosis depleting glutathione (GSH)/glutathione peroxidase 4. Moreover, Fe-THBQ/SR released SR-717 upon GSH stimulation, synergizing with ROS-mediated double-stranded DNA leakage activation. This process contributed normalization hypoxia alleviation, thereby enhancing efficacy. Overall, presented versatile single-laser-triggered mild-PTT simultaneously coupled it activation form reinforcing cycle. synergistic enhancements increased immunogenicity cells, remodeled immunosuppressive microenvironment, T lymphocyte infiltration, improved therapeutic outcomes.
Language: Английский
Citations
1
Advanced Science, Journal Year: 2023, Volume and Issue: 10(35)
Published: Nov. 8, 2023
Abstract Photodynamic therapy (PDT) has been widely employed in tumor treatment due to its effectiveness. However, the hypoxic microenvironment which is caused by abnormal vasculature severely limits efficacy of PDT. Furthermore, implicated failure immunotherapy. In this study, a novel nanoparticle denoted as Combo‐NP introduced, composed biodegradable NIR II fluorescent pseudo‐conjugate polymer featuring disulfide bonds within main chain, designated TPA‐BD, and vascular inhibitor Lenvatinib. exhibits dual functionality not only inducing cytotoxic reactive oxygen species (ROS) directly eliminate cells but also eliciting immunogenic cell death (ICD). This ICD response, turn, initiates robust cascade immune reactions, thereby augmenting generation T lymphocytes (CTLs). addition, addresses issue hypoxia normalizing vasculature. normalization process enhances PDT while concurrently fostering increased CTLs infiltration microenvironment. These synergistic effects synergize potentiate photodynamic‐immunotherapeutic properties nanoparticles. when combined with anti‐programmed death‐ligand 1 (PD‐L1), they showcase notable inhibitory on metastasis. The findings study introduce an innovative nanomedicine strategy aimed at triggering systemic anti‐tumor responses for Uveal melanoma.
Language: Английский
Citations
22
Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)
Published: June 18, 2024
Abstract In the treatment of uveal melanoma (UVM), histone deacetylase inhibitors (HDACi) have emerged as a promising epigenetic therapy. However, their clinical efficacy is hindered by suboptimal pharmacokinetics and strong self‐rescue tumor cells. To overcome these limitations, reactive oxygen species (ROS)‐responsive nanoparticles (NPs) are designed that encapsulate HDACi MS‐275 glutamine metabolism inhibitor V‐9302. Upon reaching microenvironment, NPs can disintegrate, thereby releasing to increase level ROS V‐9302 reduce production glutathione (GSH) related self‐rescue. These synergistic effects lead lethal storm induce cell pyroptosis. When combined with programmed death protein 1 monoclonal antibodies ( α ‐PD‐1), facilitate immune infiltration, improving anti‐tumor immunity, converting “immune‐cold” tumors into “immune‐hot” tumors, enhancing memory in mice. The findings present nano‐delivery strategy for co‐delivery therapeutics metabolic inhibitors, which induces pyroptosis cells improves effectiveness chemotherapy immunotherapy.
Language: Английский
Citations
8
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(23), P. 29672 - 29685
Published: May 30, 2024
Metastasis and recurrence are notable contributors to mortality associated with breast cancer. Although immunotherapy has shown promise in mitigating these risks after conventional treatments, its effectiveness remains constrained by significant challenges, such as impaired antigen presentation dendritic cells (DCs) inadequate T cell infiltration into tumor tissues. To address limitations, we developed a multifunctional nanoparticle platform, termed GM@P, which consisted of hydrophobic shell encapsulating the photosensitizer MHI148 hydrophilic core containing STING agonist 2'3'-cGAMP. This design elicited robust type I interferon responses activate antitumor immunity. The GM@P nanoparticles loaded specifically targeted cancer cells. Upon exposure 808 nm laser irradiation, MHI148-loaded produced toxic reactive oxygen species (ROS) eradicate through photodynamic therapy (PDT). Notably, PDT stimulated immunogenic death (ICD) foster potency immune responses. Furthermore, superior photoacoustic imaging (PAI) capabilities enabled simultaneous visualization diagnostic therapeutic procedures. Collectively, our findings uncovered that combination activation facilitated more conducive microenvironment, characterized enhanced DC maturation, CD8+ cells, proinflammatory cytokine release. strategy local augment systemic effects, offering promising approach suppress growth, inhibit metastasis, prevent recurrence.
Language: Английский
Citations
7
Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(2), P. 35 - 35
Published: Jan. 30, 2024
Multifunctional nanoparticles are of significant importance for synergistic multimodal antitumor activity. Herein, zinc oxide (ZnO) was used as pH-sensitive loading the chemotherapy agent doxorubicin (DOX) and photosensitizer indocyanine green (ICG), biocompatible low-molecular-weight heparin (LMHP) gatekeepers photothermal therapy/photodynamic therapy/chemotherapy/immunotherapy. ZnO decomposed into cytotoxic Zn2+ ions, leading to a tumor-specific release ICG DOX. simultaneously produced oxygen (O2) reactive species (ROS) photodynamic therapy (PDT). The released under laser irradiation ROS PDT raised tumor temperature (PTT). DOX directly caused cell death chemotherapy. Both also induced immunogenic (ICD) immunotherapy. in vivo vitro results presented superior inhibition progression, metastasis recurrence. Therefore, this study could provide an efficient approach designing multifunctional therapy.
Language: Английский
Citations
6
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 10129 - 10144
Published: Oct. 1, 2024
Immunotherapy is a promising cancer treatment because of its ability to sustainably enhance the natural immune response. However, effects multiple immunotherapies, including ICIs, are limited by resistance these agents, immune-related adverse events, and lack reasonable therapeutic targets available at right time place. The tumor microenvironment (TME), which features tumor-associated macrophages (TAMs), plays significant role in owing hypoxic blood vessels, resulting evasion. To immunotherapy, photodynamic therapy (PDT) can increase innate adaptive responses through immunogenic cell death (ICD) improve TME. Traditional photosensitizers (PSs) also include novel nanomedicines precisely target cells or TAMs. Here, we reviewed summarized current strategies possible influencing factors for photoimmunotherapy.
Language: Английский
Citations
4
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Sonodynamic therapy, a treatment modality recently widely used, is capable of disrupting the tumor microenvironment by inducing immunogenic cell death (ICD) and enhancing antitumor immunity during immunotherapy. Erdafitinib, an inhibitor fibroblast growth factor receptor, has demonstrated potential benefits for treating bladder cancer. However, Erdafitinib shows effectiveness in only small number patients, majority patients responding positively to medication have "immune-cold" tumors. To increase therapeutic efficacy we herein developed biodegradable pseudoconjugate polymer (PSP) with sonodynamic capabilities. could be efficiently encapsulated nanoparticles (NP-PE) prepared through self-assembly PSP oxidation-sensitive (P1). Under ultrasound conditions, NP-PE effectively induced cytotoxicity producing reactive oxygen species further triggering ICD. Compared inhibited expression FGFR3 higher extent. In animal models cancer, growth, stimulated immunity, synergized antiprogrammed death-ligand 1 (aPD-L1), offering novel approach
Language: Английский
Citations
0
Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
ABSTRACT Recently, there has been a surge in scholarly interest regarding the application of sophisticated materials technology to expedite wound healing, particularly through integration nanocomposites endowed with multifaceted functionalities augment efficacy care products. In order propose an external power‐free healing dressing electrical stimulation function, polyvinylidene fluoride (PVDF) nanofibers incorporating graphene oxide (GO) at varying concentrations were fabricated via electrospinning technique. Scanning electron microscopy (SEM) was employed reveal morphology composite nanofibers. Fourier transform infrared (FTIR) spectroscopy and X‐ray diffraction (XRD) analyses confirmed transition PVDF from α phase β phase. The antibacterial PVDF/GO against Staphylococcus aureus rigorously examined. Results indicated marked enhancement correlation increasing content GO. Moreover, piezoelectric property assessments, cytotoxicity, hemolysis tests meticulously performed. outcomes suggested that containing 0.5 w/w% GO (PVDF/GO‐0.5) demonstrated superior performance across all evaluated metrics, terms mechanical properties, characteristics, efficacy. These findings imply PVDF/GO‐0.5 possess capability mimic endogenous electric field, which is beneficial boost cellular migration proliferation, thereby accelerating process. Overall, innovative proposed this study can be considered highly promising candidate field tissue engineering.
Language: Английский
Citations
0