Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Abstract
Sonodynamic
therapy
(SDT)
holds
great
promise
as
a
therapeutic
approach
for
treating
atherosclerotic
plaque.
However,
the
efficacy
of
SDT
is
hindered
by
restricted
tissue
penetration
depth
and
insufficient
generation
reactive
oxygen
species
(ROS)
associated
with
conventional
sonosensitizers.
Furthermore,
determining
optimal
timing
ultrasound
(US)
irradiation
after
administration
sonosensitizers
presents
significant
technical
challenge.
Addressing
these
issues
crucial
enhancing
effectiveness
SDT.
Herein,
hyaluronic
acid‐modified
US‐propelled
Janus
mesoporous
SiO
2
partially
coated
gold
nanorods
loaded
2,2‐azobis[2‐(2‐imidazolin‐2‐yl)
propane]
dihydrochloride
(AIPH)
developed,
along
functionalized
Ag/Ag
S
nanoparticles
(HA‐JASAA),
near‐infrared‐II
(NIR‐II)
fluorescence
imaging‐guided
Following
intravenous
HA‐JASAA,
acid
modification
enables
specific
targeting
proinflammatory
macrophages
within
plaques.
Subsequently,
upon
reacting
H
O
in
microenvironment,
it
turns
on
NIR‐II
signal.
US
applied
when
intensity
signal
reaches
its
peak;
AIPH
HA‐JASAA
undergoes
conversion
into
nitrogen
propelling
toward
deep
plaque
tissue.
under
activation,
two
sonosensitizers,
Ag
S,
generate
oxygen‐independent
oxygen‐dependent
ROS
respectively
to
induce
apoptosis
lesional
macrophages,
thereby
significantly
inhibiting
progression
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(11), P. 7106 - 7164
Published: May 17, 2024
The
identification
and
detection
of
disease-related
biomarkers
is
essential
for
early
clinical
diagnosis,
evaluating
disease
progression,
the
development
therapeutics.
Possessing
advantages
high
sensitivity
selectivity,
fluorescent
probes
have
become
effective
tools
monitoring
active
molecules
at
cellular
level
in
vivo.
In
this
review,
we
describe
current
designed
quantification
key
bioactive
associated
with
common
diseases,
such
as
organ
damage,
inflammation,
cancers,
cardiovascular
brain
disorders.
We
emphasize
strategies
behind
design
capable
biomarker
diagnosis
cover
some
aspects
combined
diagnostic/therapeutic
based
on
regulating
molecules.
This
review
concludes
a
discussion
challenges
outlook
probes,
highlighting
future
avenues
research
that
should
enable
these
to
achieve
accurate
biomedical
applications.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(32), P. 17881 - 17891
Published: Aug. 2, 2023
Atherosclerotic
plaque
rupture
is
a
significant
cause
of
acute
cardiovascular
events
such
as
heart
attack
and
stroke,
triggered
by
the
decomposition
fiber
caps
induced
cysteine
cathepsin.
However,
accurate
measurement
cathepsin
B
(CTB)
activity
in
plaques
challenging
due
to
low
specificity
insufficient
penetration
depth
available
atherosclerosis-associated
fluorescent
probes,
hampering
reliable
assessment
vulnerability.
To
address
these
limitations,
we
added
both
lipophilic
alkyl
chain
hydrophilic
CTB
substrate
hemicyanine
scaffold
develop
lipid-unlocked
responsive
probe
(L-CRP)
that
uses
lipids
two
keys
unlock
photoacoustic
(PA)
signals
for
measuring
environments.
Such
properties
allow
L-CRP
imaging
specific
activities
foam
cells
atherosclerotic
while
keeping
silence
toward
lipid-deficient
environments,
M1-type
macrophages
LPS-induced
inflammatory
lesions.
Moreover,
activatable
PA
exhibit
deeper
tissue
ability
(>1.0
cm)
than
current
probes
based
on
near-infrared
(∼0.3
cm),
suitable
atherosclerosis
living
mice.
In
mice,
dynamically
reports
intraplaque
levels,
which
well-correlated
with
vulnerability
characteristics
cap
thickness,
macrophage
recruitment,
necrotic
core
size,
thus
enabling
risk
stratification
mice
complicated
pneumonia.
successfully
identifies
excised
human
artery
tissues,
promising
auxiliary
diagnosis
clinical
application.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(45)
Published: Sept. 17, 2023
To
improve
the
magnetic
resonance
imaging
(MRI)
efficiency
and
ferroptosis
therapy
efficacy
of
exceedingly
small
iron
oxide
nanoparticles
(IO,
<5
nm)
for
tumors
via
enhancing
sensitivity
tumor
microenvironment
(TME)
responsiveness,
inspired
by
molecular
logic
gates,
a
self-assembled
IO
with
an
AND
gate
function
is
designed
constructed.
Typically,
cystamine
(CA)
conjugated
onto
end
poly(2-methylthio-ethanol
methacrylate)
(PMEMA)
to
generate
PMEMA-CA.
The
PMEMA-CA
grafted
surface
brequinar
(BQR)-loaded
form
IO-BQR@PMEMA.
IO-BQR@PMEMA
(SA-IO-BQR@PMEMA)
obtained
due
hydrophobicity
PMEMA.
carbon-sulfur
single
bond
can
be
oxidized
reactive
oxygen
species
(ROS)
in
TME
thio-oxygen
double
bond,
resulting
conversion
from
being
hydrophobic
hydrophilic.
disulfide
broken
glutathione
(GSH)
TME,
leading
shedding
PMEMA
surface.
Under
dual
actions
ROS
GSH
(i.e.,
gate),
SA-IO-BQR@PMEMA
disassembled
release
IO,
Fe2+/3+
,
BQR.
In
vitro
vivo
results
demonstrate
mechanism,
high
T1
MRI
performance
exceptional
tumors,
excellent
biosafety
SA-IO-BQR@PMEMA.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(12)
Published: Feb. 19, 2023
Developing
activatable
fluorescent
probes
with
superlative
fluorescence
enhancement
factor
(F/F0
)
to
improve
the
signal-to-noise
(S/N)
ratio
is
still
an
urgent
issue.
"AND"
molecular
logic
gates
are
emerging
as
a
useful
tool
for
enhanced
selectivity
and
accuracy.
Here,
gate
developed
super-enhancers
designing
huge
F/F0
S/N
ratio.
It
utilizes
lipid-droplets
(LDs)
controllable
background
input
sets
target
analyte
variable
input.
The
tremendously
quenching
due
double
locking,
thus
extreme
of
obtained.
Importantly,
this
probe
can
transfer
LDs
after
response
occurs.
be
directly
visualized
through
spatial
location
without
control
group.
Accordingly,
peroxynitrite
(ONOO-
(CNP2-B)
de
novo
designed.
CNP2-B
achieves
2600
reacting
ONOO-
.
Furthermore,
from
mitochondria
lipid
droplets
being
activated.
higher
obtained
than
commercial
3'-(p-hydroxyphenyl)
fluorescein
(HPFin
vitro
in
vivo.
Therefore,
atherosclerotic
plaques
at
mouse
models
delineated
clearly
administration
situ
gel.
Such
envisioned
execute
more
imaging
tasks.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(14)
Published: Jan. 4, 2024
Abstract
In
vivo
optical
imaging
of
trace
biomarkers
in
residual
microtumors
holds
significant
promise
for
cancer
prognosis
but
poses
a
formidable
challenge.
Here,
novel
hydrogel
sensor
is
designed
ultrasensitive
and
specific
the
elusive
biomarker.
This
seamlessly
integrates
molecular
beacon
nanoprobe
with
fibroblasts,
offering
both
high
tissue
retention
capability
an
impressive
signal‐to‐noise
ratio
imaging.
Signal
amplification
accomplished
through
exonuclease
I‐mediated
biomarker
recycling.
The
resulting
sensitively
detects
carcinoembryonic
antigen
detection
limit
1.8
pg
mL
−1
test
tubes.
Moreover,
it
successfully
identifies
nodules
median
diameter
less
than
2
mm
mice
bearing
partially
removed
primary
triple‐negative
breast
carcinomas
(4T1).
Notably,
this
proven
effective
sensitive
diagnosis
invasive
tumors
post‐surgical
infiltrating
4T1
cells,
leveraging
role
fibroblasts
locally
enriching
tumor
cells.
Furthermore,
microtumor
rapidly
photothermal
ablation
by
polydopamine‐based
under
guidance
visualization,
achieving
≈100%
suppression
recurrence
lung
metastasis.
work
offers
promising
alternative
strategy
visually
detecting
microtumors,
potentially
enhancing
patients
following
surgical
interventions.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(16)
Published: Feb. 27, 2024
Abnormal
physiological
processes
and
diseases
can
lead
to
content
or
activity
fluctuations
of
biocomponents
in
organelles
whole
blood.
However,
precise
monitoring
these
abnormalities
remains
extremely
challenging
due
the
insufficient
sensitivity
accuracy
available
fluorescence
probes,
which
be
attributed
background
arising
from
two
sources,
1)
biocomponent
autofluorescence
(BCAF)
2)
probe
intrinsic
(PIF).
To
overcome
obstacles,
we
have
re-engineered
far-red
NIR
II
rhodol
derivatives
that
possess
weak
BCAF
interference.
And
a
series
"zero"
PIF
sensing-platforms
were
created
by
systematically
regulating
open-loop/spirocyclic
forms.
Leveraging
advancements,
devised
various
ultra-sensitive
indicators,
achieving
substantial
boosts
(190
1300-fold).
Among
8-LAP
demonstrated
accurate
tracking
quantifying
leucine
aminopeptidase
(LAP)
blood
at
stages
tumor
metastasis.
Furthermore,
coupling
with
an
endoplasmic
reticulum-targeting
element
enabled
detection
ERAP1
HCT116
cells
p53
abnormalities.
This
delicate
design
eliminating
provides
insights
into
enhancing
existing
probes
toward
imaging
abnormal
diseases.
