Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Abstract
Sonodynamic
therapy
(SDT)
holds
great
promise
as
a
therapeutic
approach
for
treating
atherosclerotic
plaque.
However,
the
efficacy
of
SDT
is
hindered
by
restricted
tissue
penetration
depth
and
insufficient
generation
reactive
oxygen
species
(ROS)
associated
with
conventional
sonosensitizers.
Furthermore,
determining
optimal
timing
ultrasound
(US)
irradiation
after
administration
sonosensitizers
presents
significant
technical
challenge.
Addressing
these
issues
crucial
enhancing
effectiveness
SDT.
Herein,
hyaluronic
acid‐modified
US‐propelled
Janus
mesoporous
SiO
2
partially
coated
gold
nanorods
loaded
2,2‐azobis[2‐(2‐imidazolin‐2‐yl)
propane]
dihydrochloride
(AIPH)
developed,
along
functionalized
Ag/Ag
S
nanoparticles
(HA‐JASAA),
near‐infrared‐II
(NIR‐II)
fluorescence
imaging‐guided
Following
intravenous
HA‐JASAA,
acid
modification
enables
specific
targeting
proinflammatory
macrophages
within
plaques.
Subsequently,
upon
reacting
H
O
in
microenvironment,
it
turns
on
NIR‐II
signal.
US
applied
when
intensity
signal
reaches
its
peak;
AIPH
HA‐JASAA
undergoes
conversion
into
nitrogen
propelling
toward
deep
plaque
tissue.
under
activation,
two
sonosensitizers,
Ag
S,
generate
oxygen‐independent
oxygen‐dependent
ROS
respectively
to
induce
apoptosis
lesional
macrophages,
thereby
significantly
inhibiting
progression
European journal of medical research,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: March 4, 2024
Type
2
diabetes
mellitus
(T2DM)
poses
a
significant
global
health
burden.
This
is
particularly
due
to
its
macrovascular
complications,
such
as
coronary
artery
disease,
peripheral
vascular
and
cerebrovascular
which
have
emerged
leading
contributors
morbidity
mortality.
review
comprehensively
explores
the
pathophysiological
mechanisms
underlying
these
protective
strategies,
both
existing
emerging
secondary
preventive
measures.
Furthermore,
we
delve
into
applications
of
experimental
models
methodologies
in
foundational
research
while
also
highlighting
current
limitations
future
directions.
Specifically,
focus
on
literature
published
post-2020
concerning
prevention
complications
patients
with
T2DM
by
conducting
targeted
studies
supported
robust
evidence
offer
holistic
perspective.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(32), P. 13260 - 13269
Published: Aug. 1, 2024
The
occurrence
and
development
of
diseases
are
accompanied
by
abnormal
activity
or
concentration
biomarkers
in
cells,
tissues,
blood.
However,
the
insufficient
sensitivity
accuracy
available
fluorescence
probes
hinder
precise
monitoring
associated
indexes
biological
systems,
which
is
generally
due
to
high
probe
intrinsic
false-negative
signal
caused
reactive
oxygen
species
(ROS)-induced
decomposition.
To
resolve
these
problems,
we
have
engineered
a
ROS-stable,
meso-carboxylate
boron
dipyrromethene
(BODIPY)-based
fluorescent
probe,
displays
quite
low
background
doubly
quenched
combined
strategy
photoinduced
electron
transfer
(PET)
effect
"ester-to-carboxylate"
conversion.
achieved
S/N
ratio
with
ultrasensitivity
good
selectivity
toward
biothiols,
endowing
its
fast
detection
capability
biothiol
level
200×-diluted
plasma
samples.
Using
this
remarkable
distinguishing
liver
injury
from
normal
even
at
80×
dilution.
Moreover,
owing
stability
ROS,
was
successfully
employed
for
high-fidelity
imaging
negative
fluctuation
nonsmall-cell
lung
cancer
(NSCLC)
during
dihydroartemisinin-induced
ferroptosis.
This
delicate
design
suppressing
reveals
insights
into
enhancing
diseases.
Nanoscale Horizons,
Journal Year:
2024,
Volume and Issue:
9(9), P. 1390 - 1416
Published: Jan. 1, 2024
Molecular
disassembly
is
pioneering
a
new
route
to
refined
diagnostic
and
therapeutic
solutions.
This
approach
breaks
down
self-assembled
molecules,
offering
enhanced
precision
efficiency
in
various
bio-oriented
applications.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(40), P. 47381 - 47393
Published: Sept. 28, 2023
The
formation
of
atherosclerosis
is
the
root
cause
various
cardiovascular
diseases
(CVDs).
Therefore,
effective
CVD
interventions
call
for
precise
identification
plaques
to
aid
in
clinical
treatment
such
diseases.
Herein,
a
reactive
oxygen
species
(ROS)-responsive
sequentially
targeted
fluorescent
probe
developed
atherosclerotic
plaque
recognition.
An
aggregation-induced
emission
active
fluorophore
linked
maleimide
(polyethylene
glycol)
hydroxyl
with
ROS-responsive
cleavable
bond,
which
further
functionalized
CLIKKPF
peptide
(TPAMCF)
specifically
binding
phosphatidylserine
foam
cells.
After
being
assembled
aqueous
medium,
TPAMCF
nanoparticles
can
efficiently
accumulate
through
high
affinity
externalized
Activated
by
locally
accumulated
ROS
cells,
are
interrupted,
and
then
TPA
be
released
subsequently
identify
lipid
droplets
inside
cells
achieve
fluorescence
imaging
plaques.
Such
nanoprobes
have
favorable
response
performance
exhibit
special
target
vitro.
In
addition,
nanoprobe-based
permitted
high-contrast
detection
specimens
ex
vivo.
as
promising
probe,
capable
potential
candidate
plaque.
