NIR-II-Responsive Versatile Nanozyme Based on H2O2 Cycling and Disrupting Cellular Redox Homeostasis for Enhanced Synergistic Cancer Therapy DOI
Pinghua Ling,

Danjie Song,

Pei Yang

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(8), P. 5290 - 5299

Published: July 16, 2024

Disturbing cellular redox homeostasis within malignant cells, particularly improving reactive oxygen species (ROS), is one of the effective strategies for cancer therapy. The ROS generation based on nanozymes presents a promising strategy treatment. However, therapeutic efficacy limited due to insufficient catalytic activity or their high dependence hydrogen peroxide (H2O2) oxygen. Herein, we reported nanozyme (CSA) well-defined CuSe hollow nanocubes (CS) uniformly covered with Ag nanoparticles (AgNPs) disturb and catalyze cascade intracellular biochemical reactions produce synergistic therapy breast cancer. In this system, CSA could interact thioredoxin reductase (TrxR) deplete tumor microenvironment-activated glutathione (GSH), disrupting antioxidant defense system augmenting generation. Besides, possessed peroxidase-mimicking toward H2O2, leading various including hydroxyl radical (•OH), superoxide radicals (•O2-), singlet (1O2), facilitated by Cu(II)/Cu(I) H2O2 cycling, plentiful catalytically active metal sites. Additionally, absorption charge separation performance AgNPs, exhibited excellent photothermal in second near-infrared (NIR-II, 1064 nm) region enhanced photocatalytic level cells. Owing inhibition TrxR activity, GSH depletion, CSA, abundant generation, displays remarkable specific growth.

Language: Английский

Nanomaterials for bone metastasis DOI

Xinyan Hao,

Buchan Jiang,

Junyong Wu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 640 - 651

Published: Aug. 1, 2024

Language: Английский

Citations

36
Spatially Asymmetric Nanoparticles for Boosting Ferroptosis in Tumor Therapy DOI
Mengmeng Hou, Minchao Liu, Hongyue Yu

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(4), P. 1284 - 1293

Published: Jan. 17, 2024

Despite its effectiveness in eliminating cancer cells, ferroptosis is hindered by the high natural antioxidant glutathione (GSH) levels tumor microenvironment. Herein, we developed a spatially asymmetric nanoparticle, Fe3O4@DMS&PDA@MnO2-SRF, for enhanced ferroptosis. It consists of two subunits: Fe3O4 nanoparticles coated with dendritic mesoporous silica (DMS) and PDA@MnO2 (PDA: polydopamine) loaded sorafenib (SRF). The spatial isolation Fe3O4@DMS PDA@MnO2-SRF subunits enhances synergistic effect between GSH-scavengers ferroptosis-related components. First, increased exposure subunit Fenton reaction, leading to production reactive oxygen species. Furthermore, effectively depletes GSH, thereby inducing inactivation glutathione-dependent peroxidases 4. Moreover, SRF blocks Xc– transport augmenting GSH depletion capabilities. dual Fe3O4@DMS&PDA@MnO2-SRF significantly weakens antioxidative system, boosting chemodynamic performance cells.

Language: Английский

Citations

18
Three-Step Depletion Strategy of Glutathione: Tunable Metal–Organic-Framework-Engineered Nanozymes for Driving Oxidative/Nitrative Stress to Maximize Ferroptosis Therapy DOI
Wenting Li, Shikai Liu, Ding He

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(6), P. 2071 - 2080

Published: Feb. 2, 2024

Ferroptosis is a novel type of nonapoptotic programmed cell death involving the accumulation lipid peroxidation (LPO) to lethal threshold. Herein, we propose tunable zeolitic imidazolate framework (ZIFs)-engineered biodegradable nanozymes for ferroptosis mediated by both reactive oxygen species (ROS) and nitrogen (RNS). l-Arginine utilized as an exogenous nitric oxide donor loaded into hollow ZIFs@MnO2 artificial nanozymes, which are formed etching ZIFs with potassium permanganate simultaneously generating MnO2 shell in situ. The constructed multienzyme-like activities including peroxidase, oxidase, catalase can release satisfactory ROS RNS through cascade reaction, consequently promoting LPO. Furthermore, it improve efficiency three-step strategy glutathione (GSH) depletion; that is, outer layer consumes GSH under slightly acidic conditions downregulates SLC7A11 reductase, thus directly inhibiting biosynthesis indirectly preventing regeneration.

Language: Английский

Citations

15
Size Modulation of Conjugated Polymer Nanoparticles for Improved NIR-II Fluorescence Imaging and Photothermal Therapy DOI
Yu Liu, Qin‐Qin Xu, Xinyue Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(4), P. 4420 - 4429

Published: Jan. 19, 2024

Near-infrared-II fluorescence imaging (NIR-II FI) has become a powerful technique for disease diagnosis owing to its superiorities, including high sensitivity, spatial resolution, deep depth, and low background interference. Despite the widespread application of conjugated polymer nanoparticles (CPNs) NIR-II FI, most developed CPNs have quite quantum yields based on energy gap law, which makes high-sensitivity high-resolution toward lesions still huge challenge. This work proposes nanoengineering strategy modulate size aimed at optimizing their performance improved phototheranostics. By adjusting initial concentration synthesized polymer, series with different particle sizes are successfully prepared via nanoprecipitation approach. Results show that brightness gradually amplifies decreasing size, optimal CPNs, NP0.2, demonstrate up 2.05-fold enhancement compared counterpart nanoparticles. With merits reliable biocompatibility, photostability, efficient light-heat conversion, NP0.2 been employed FI-guided photothermal therapy both in vitro vivo. Our highlights an effective improve advancing development FI life sciences.

Language: Английский

Citations

8
Dual-enzyme decorated semiconducting polymer nanoagents for second near-infrared photoactivatable ferroptosis-immunotherapy DOI
Yue Liu, Renjie Lu, Meng Li

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(10), P. 2406 - 2419

Published: Jan. 1, 2024

Enzymes provide a class of potential options to treat cancer, while the precise regulation enzyme activities for effective and safe therapeutic actions has been poorly reported. Dual-enzyme decorated semiconducting polymer nanoagents second near-infrared (NIR-II) photoactivatable ferroptosis-immunotherapy are reported in this study. Such (termed SPHGA) consist hemoglobin (Hb)-based (SP@Hb), adenosine deaminase (ADA) glucose oxidase (GOx) with loadings thermal-responsive nanoparticle shell. NIR-II photoactivation SPHGA results generation heat trigger on-demand releases two enzymes (ADA GOx) via destroying shells. In tumor microenvironment, GOx oxidizes form hydrogen peroxide (H2O2), which promotes Fenton reaction iron SP@Hb, resulting an enhanced ferroptosis effect immunogenic cell death (ICD). addition, ADA degrades high-level reverse immunosuppressive thus amplifying antitumor immune responses. Via ferroptosis-immunotherapy, shows improved absolutely remove bilateral tumors effectively suppress metastases subcutaneous 4T1 breast cancer models. This study presents dual-enzyme-based nanoagent controllable therapy.

Language: Английский

Citations

7
Semiconducting polymer nanoprodrugs enable tumor-specific therapy via sono-activatable ferroptosis DOI

Fengshuo Wang,

Zhiting Wu,

Yijing Zhang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122722 - 122722

Published: July 29, 2024

Language: Английский

Citations

4
Heterogeneous Piezo-self-Fenton material design: intersecting solution for pollutant degradation and tumor therapy DOI
Jiahui Cai, Jiaying Xiao,

Gaoxiang Du

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The commonalities and differences of EPSF catalysts in organic pollutant degradation tumor-targeted therapy are summarized, focusing on catalytic mechanisms, material systems, performance enhancement strategies, catalyst design.

Language: Английский

Citations

0
Advances in Sonodynamic Therapy: Focus on Ferroptosis DOI

Wen‐Qing Su,

Hao Wang,

Juhong Pan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Ferroptosis is a nonapoptotic form of cell death discovered in 2012. Noninvasive treatments regulating ferroptosis are important for wide range diseases. Among the noninvasive treatments, sonodynamic therapy (SDT) has become promising due to its strong tissue penetration and few side effects. In recent years, targeted drug delivery platforms constructed on basis SDT have provided an efficient mode regulation ferroptosis. Based latest research reports, this Perspective introduces basic mechanism influencing factors therapeutic effects, elucidates significance ferroptosis-targeted SDT, summarizes studies through different pathways. We also present innovative composite ultrasound-responsive platforms. Finally, brief summary outlook based current presented.

Language: Английский

Citations

0
Bifunctional bone substitute materials for bone defect treatment after bone tumor resection DOI Creative Commons
Zhule Wang, Ingrid C.M. van der Geest, Sander C.G. Leeuwenburgh

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100889 - 100889

Published: Dec. 1, 2023

Aggressive benign, malignant and metastatic bone tumors can greatly decrease the quality of patients' lives even lead to substantial mortality. Several clinical therapeutic strategies have been developed treat tumors, including preoperative chemotherapy, surgical resection tumor tissue, subsequent systemic chemo- or radiotherapy. However, those are associated with inevitable drawbacks, such as severe side effects, local recurrence, difficult-to-treat defects after resection. To overcome these shortcomings achieve satisfactory outcomes, advanced bifunctional biomaterials which simultaneously promote regeneration combat growth increasingly advocated. These substitute materials fill following subsequently exert anticancer effects. Here we describe various types most prevalent provide an overview common treatment options. Subsequently, review current progress regarding development combining osteogenic efficacy. this end, categorize based on their mechanism deriving from i) intrinsic biomaterial properties, ii) drug release agents, iii) oxidative stress-inducing iv) hyperthermia-inducing biomaterials. Consequently, offers researchers, surgeons oncologists up-to-date our knowledge options, design strong potential for application in oncological orthopedics.

Language: Английский

Citations

10
Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds DOI Creative Commons

Qiuran Liang,

Yuehui Wang,

Yili Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Lung cancer has high metastasis and drug resistance. The prognosis of lung patients is poor the patients’ survival chances are easily neglected. Ferroptosis a programmed cell death proposed in 2012, which differs from apoptosis, necrosis autophagy. novel type regulated driven by iron-dependent lipid peroxidation subsequent plasma membrane ruptures. It broad prospects field tumor disease treatment. At present, multiple studies have shown that biological compounds can induce ferroptosis cells, exhibits significant anti-cancer effects, they advantages safety, minimal side less possibility to In this review, we summarize used for treatment focusing on its mechanism. addition, systematically review current research status combining nanotechnology with treatment, shed new light targeting pathways applying compounds-based therapies.

Language: Английский

Citations

3