Advanced Strategies for Strengthening the Immune Activation Effect of Traditional Antitumor Therapies DOI

Jingyi Ning,

Xinxin Lu,

Jianhui Dong

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(8), P. 4701 - 4715

Published: July 3, 2024

The utilization of traditional therapies (TTS), such as chemotherapy, reactive oxygen species-based therapy, and thermotherapy, to induce immunogenic cell death (ICD) in tumor cells has emerged a promising strategy for the activation antitumor immune response. However, limited effectiveness most TTS inducing ICD effect tumors hinders their applications combination with immunotherapy. To address this challenge, various intelligent strategies have been proposed strengthen these TTS, then achieve synergistic efficacy These primarily focus on augmenting or facilitating antigen (released by cells) presentation process during they are systematically summarized review. Finally, existing bottlenecks prospects application regulation also discussed.

Language: Английский

Recent advances in biomimetic cell membrane–camouflaged nanoparticles for cancer therapy DOI Creative Commons
Sajjad Alimohammadvand,

Masoumeh Kaveh Zenjanab,

Milad Mashinchian

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116951 - 116951

Published: June 19, 2024

The emerging strategy of biomimetic nanoparticles (NPs) via cellular membrane camouflage holds great promise in cancer therapy. This scholarly review explores the utilization membranes derived from diverse entities; blood cells, immune stem and bacterial cells as examples NP coatings. camouflaging endows NPs with nuanced tumor-targeting abilities such self-recognition, homotypic targeting, long-lasting circulation, thus also improving tumor therapy efficacy overall. comprehensive examination encompasses a variety cell camouflaged (CMCNPs), elucidating their underlying targeted mechanisms delineating strategies for anti-cancer applications. Furthermore, systematically presents synthesis source materials methodologies employed order to construct characterize these CMCNPs, specific emphasis on use treatment.

Language: Английский

Citations

13
Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death DOI
Jiahao Liang, Xiangge Tian, Meirong Zhou

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122608 - 122608

Published: May 9, 2024

Language: Английский

Citations

12
Biomimetic Tumor Cell Membrane‐Encapsulated Nanoparticles Combine NIR‐II Photothermal Therapy and Chemotherapy for Enhanced Immunotherapy in Triple‐Negative Breast Cancer DOI
Wei Xiong, Ziyi Cheng, Hongwei Chen

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Abstract To advance the understanding and potential treatment strategies for triple‐negative breast cancer (TNBC), particularly focusing on its high metastatic propensity uncertain molecular targets, a biomimetic tumor cell membrane‐encapsulated nanodelivery system is developed enhanced immunotherapy. This assembled with second near‐infrared (NIR‐II) photothermal agent, chemotherapeutic drug, programmed death‐ligand 1 (PD‐L1) inhibitors camouflaged by TNBC membranes. An NIR‐II Ag 2 S quantum dots (QDs) introduced not only realizing pronounced imaging‐guided therapy (PTT), but also co‐activating immunogenic death (ICD) chemotherapy. Homologous targeting camouflage properties endowed excellent biocompatibility efficient delivery ability to site, demonstrating synergistic therapeutic efficacy. The release of damage‐associated patterns (DAMP) marked induction ICD, crucial reshaping immune microenvironment. Further integration α‐PD‐L1 achieved 56.5% checkpoint inhibition rate, synergistically amplifying response ultimately activate key cytokines, thereby achieving anti‐tumor immunotherapy effects. Notably, this approach realized considerable reduction nodules 51.2% in lung metastasis model. proposed extended remission effectively reduced metastasis, paving way reliable promising

Language: Английский

Citations

11
Erythrocyte‐Membrane‐Camouflaged Magnetic Nanocapsules With Photothermal/Magnetothermal Effects for Thrombolysis DOI

Liqiong Zhu,

Weishuai Lian,

Nuo Yu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: May 1, 2024

Abstract Venous/arterial thrombosis poses significant threats to human health. However, drug‐enabled thrombolysis treatment often encounters challenges such as short half‐life and low bioavailability. To address these issues, the design of erythrocyte‐membrane (EM) camouflaged nanocapsules (USIO/UK@EM) incorporating ultra‐small iron oxide (USIO) urokinase (UK) drug, which exhibits remarkable photothermal/magnetothermal effects drug delivery ability for venous/arterial thrombolysis, is reported. USIO, UK, EM are coextruded fabricate USIO/UK@EM with average sizes 103.7 nm. As possesses wide photoabsorption good magnetic properties, its solution demonstrates a temperature increase 41.8–42.9 °C within 5 min when exposed an 808 nm laser (0.33 mW cm −2 ) or alternating field (AMF). Such effect along UK confers impressive thrombolytic rates 82.4% 74.2%, higher than that (≈15%) achieved by alone. Further, coating extends circulating ( t 1/2 = 3.28 h). When administered mice rabbits, tail vein thrombus in femoral artery rabbits can be dissolved synergetic thermothrombolysis UK. Therefore, this study not only offers insights into rational multifunctional biomimetic but also showcases promising strategy utilizing nanomedicine.

Language: Английский

Citations

9
Rationally designed NIR-II excitable and endoplasmic reticulum-targeted molecular phototheranostics for imaging-guided enhanced photoimmunotherapy of triple-negative breast cancer DOI Creative Commons
Fen Liu, Qiang Kang, Hao Xiao

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 22, 2025

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of characterized by an extremely poor prognosis. Photoimmunotherapy has emerged as promising strategy for the treatment TNBC. This approach works selectively destroying tumor cells, releasing tumor-associated antigens, activating immune system, and effectively inhibiting proliferation metastasis. However, majority current phototheranostic approaches are hindered limited tissue penetration in first near-infrared (NIR-I) ultraviolet–visible (UV–Vis) regions. Additionally, due to lack specific subcellular targets, it may be difficult treat deep-seated lesions with ambiguous extensive boundaries caused TNBC metastases. Consequently, development effective, deep-penetrating, organelle-targeted phototheranostics essential enhancing outcomes work proposes novel molecular design NIR-II realize planar rigid conjugation alkyl chain functionalization. The di-hexaalkyl chains vertical configuration on donor (4H-cyclopenta[2,1-b:3,4-b'] dithiophene) shielding units (fluorene) introduced construct S-D-A-D-S type (IR-FCD). structure IR-FCD exhibits robust intramolecular charge transfer capability, lower band gap, enhanced photon absorption properties, significant steric hindrance from vertically arranged minimize non-radiative energy loss. By incorporating N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide at terminus elongated chain, followed self-assembly into DSPE-S-S-PEG2000, excitable (IR-FCD-Ts NPs) endoplasmic reticulum (ER) targeting capability were successfully synthesized imaging-guided photoimmunotherapy IR-FCD-Ts NPs demonstrate exceptional optical characteristics, maximum 1068 nm (extending 1300 nm) emission 1273 1700 nm), along high molar coefficient 2.76*104 L/mol·c 1064 aqueous solution. Under exposure laser irradiation, exhibit superior photothermal properties have potential photodynamic therapy. ER, thereby inducing ER stress significantly immunogenic cell death (ICD) triggers strong antitumor response inhibits metastasis

Language: Английский

Citations

1
Nanoparticle-mediated immunogenic cell death for cancer immunotherapy DOI

Haolong Qi,

Yuan Li,

Yingjie Geng

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 656, P. 124045 - 124045

Published: March 30, 2024

Language: Английский

Citations

7
Inhibitory Impact Of Cinobufagin In Triple-Negative Breast Cancer Metastasis: Involvements Of Macrophage Reprogramming Through Upregulated MME and Inactivated FAK/STAT3 Signaling DOI
Zhaohui Zhu, Hanlu Wang, Qian Xu

et al.

Clinical Breast Cancer, Journal Year: 2024, Volume and Issue: 24(4), P. e244 - e257.e1

Published: Jan. 26, 2024

Language: Английский

Citations

4
Paclitaxel Prodrug Enables Glutathione Depletion to Boost Cancer Treatment DOI

Biyou Zhang,

Shiyu Zhou,

Shaojin Lu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(39), P. 26690 - 26703

Published: Sept. 20, 2024

Herein, we constructed a paclitaxel (PTX) prodrug (PA) by conjugating PTX with acrylic acid as cysteine-depleting agent. The as-synthesized PA can assemble diacylphosphatidylethanolamine-PEG

Language: Английский

Citations

4
Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy DOI Creative Commons

Yonghua Cai,

Heng Xiao, Shuaishuai Xue

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: Feb. 3, 2025

Glioma, particularly glioblastoma (GBM), is a highly aggressive tumor with limited responsiveness to immunotherapy. PANoptosis, form of programmed cell death merging pyroptosis, apoptosis, and necroptosis, plays an important role in reshaping the microenvironment (TME) enhancing immunotherapy effectiveness. This study investigates PANoptosis dynamics glioma explores therapeutic potential its activation, through natural compounds such as cinobufagin. We comprehensively analyzed PANoptosis-related genes (PANoRGs) multiple cohorts, identifying different patterns constructing enrichment score (PANoScore) evaluate relationship patient prognosis immune activity. Cinobufagin, identified activator, was evaluated for ability induce enhance anti-tumor responses both vitro vivo GBM models. Our findings indicate that high PANoScore gliomas showed increased infiltration, effector T cells, enhanced sensitivity immunotherapies. Cinobufagin effectively induced leading immunogenic death, facilitated tumor-associated microglia/macrophages (TAMs) polarization towards M1-like phenotype while augmenting CD4+/CD8 + infiltration activation. Importantly, cinobufagin combined anti-PD-1 therapy exhibited significant synergistic effects prolonged survival These highlight PANoptosis-targeting agents, cinobufagin, combination immunotherapy, offering promising approach convert "cold" tumors into "hot" ones improving treatment outcomes.

Language: Английский

Citations

0
Dimethylcurcumin and Copper Sulfate-Loaded Silk Nanoparticles for Synergistic Therapy against Breast Cancer DOI
Bo Zhang, Yonghong Deng, Defeng Xu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Dimethylcurcumin (ASC-J9) is an organic active pharmaceutical ingredient with anti-inflammatory, antioxidant, and antitumor effects. However, its application has been significantly hindered by poor solubility in aqueous solutions, a short vivo half-life, low bioavailability after oral administration, limited accumulation absorption target areas. Nano-drug delivery systems can serve as drug carriers to enhance delivery, addressing these challenges improved efficacy reduced adverse In this study, microfluidic swirl mixer used prepare silk fibroin composite nanoparticles containing ASC-J9 copper sulfate (CuS), the effects of different process parameters on (SNPs) were explored optimized. The synthesized ASC-J9-CuS@SNPs exhibited mean particle diameter 180 ± 10 nm PDI 0.20 0.03. Two-dimensional/three-dimensional (2D/3D) cell experiments showed that nanomaterials have excellent biocompatibility activity noticeable cancer specificity. effectively controlled tumor growth without causing damage blood cells vital organs. Both vitro demonstrated anticancer effect was enhanced photo thermotherapy. current study provides promising strategy for using nanocarriers breast therapy.

Language: Английский

Citations

0