BMJ Open,
Journal Year:
2024,
Volume and Issue:
14(1), P. e076043 - e076043
Published: Jan. 1, 2024
The
objective
of
this
study
is
to
delineate
disparities
between
patients
with
knee
osteoarthritis
(KOA)
based
on
obesity
status,
investigate
the
interplay
among
body
composition,
physical
activity
and
pain/function
in
KOA
conduct
subgroup
analyses
focusing
those
obesity.
Cross-sectional
study.
Residents
eight
communities
Shijiazhuang,
Hebei
Province,
China,
were
surveyed
from
March
2021
November
2021.
178
symptomatic
aged
40
years
or
older
included.
primary
outcome
measure
was
pain,
assessed
using
Western
Ontario
McMaster
Universities
Osteoarthritis
Index-pain
(WOMAC-P)
scale.
Secondary
measures
included
function,
evaluated
through
WOMAC-function
(WOMAC-F)
scale
Five-Time-Sit-to-Stand
Test
(FTSST).
Data
analysis
involved
t-tests,
Wilcoxon
rank-sum
tests,
χ2
linear
logistical
regression
analysis.
Participants
(n=178)
41-80
age
(median:
65,
P25-P75:
58-70),
82%
female.
Obese
(n=103)
had
worse
pain
self-reported
function
(p<0.05).
In
general
KOA,
fat
mass
positively
associated
bilateral
(β=1.21
(95%
CI
0.03
0.15)),
WOMAC-P
scores
(β=0.25
0.23
1.22)),
WOMAC-F
(β=0.28
0.35
1.29))
FTSST
(β=0.19
0.42)),
moderate-intensity
low-intensity
negatively
(β=-0.80
-0.10
-0.01))
Skeletal
Muscle
Index
(SMI)
(β=-0.16
-0.66
-0.03)).
obesity,
SMI
(β=-0.30
-3.94
-0.00)).
Patients
compared
non-obese
patients.
Greater
mass,
lower
muscle
increased
poor
function.
More
skeletal
improvement
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(11)
Published: Feb. 7, 2023
Osteoarthritis
(OA)
is
a
progressive
joint
disease
characterized
by
inflammation
and
cartilage
destruction,
its
progression
closely
related
to
imbalances
in
the
M1/M2
synovial
macrophages.
A
two-pronged
strategy
for
regulation
of
intracellular/extracellular
nitric
oxide
(NO)
hydrogen
protons
reprogramming
macrophages
proposed.
The
combination
carbonic
anhydrase
IX
(CA9)
siRNA
NO
scavenger
"two-in-one"
nanocarriers
(NAHA-CaP/siRNA
nanoparticles)
developed
OA
therapy
scavenging
inhibiting
CA9
expression
In
vitro
experiments
demonstrate
that
these
NPs
can
significantly
scavenge
intracellular
similar
levels
as
those
normal
group
downregulate
mRNA
(≈90%),
thereby
repolarizing
M1
into
M2
phenotype
increasing
pro-chondrogenic
TGF-β1
(≈1.3-fold),
chondrocyte
apoptosis.
Furthermore,
vivo
show
have
great
anti-inflammation,
protection
repair
effects,
effectively
alleviating
both
monoiodoacetic
acid-induced
early
late
mouse
models
surgical
destabilization
medial
meniscus-induced
rat
model.
Therefore,
siCA9
delivery
system
potential
efficient
treatment.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(13)
Published: Jan. 26, 2024
Abstract
Developing
nanozymes
with
effective
reactive
oxygen
species
(ROS)
scavenging
ability
is
a
promising
approach
for
osteoarthritis
(OA)
treatment.
Nonetheless,
numerous
lie
in
their
relatively
low
antioxidant
activity.
In
certain
circumstances,
some
of
these
may
even
instigate
ROS
production
to
cause
side
effects.
To
address
challenges,
copper‐based
metal–organic
framework
(Cu
MOF)
nanozyme
designed
and
applied
OA
Cu
MOF
exhibits
comprehensive
powerful
activities
(i.e.,
SOD‐like,
CAT‐like,
•OH
activities)
while
negligible
pro‐oxidant
(POD‐
OXD‐like
activities).
Collectively,
more
at
various
types
than
other
Cu‐based
antioxidants,
such
as
commercial
CuO
single‐atom
nanozyme.
Density
functional
theory
calculations
also
confirm
the
origin
its
outstanding
enzyme‐like
activities.
vitro
vivo
results
demonstrate
that
an
excellent
decrease
intracellular
levels
relieve
hypoxic
microenvironment
synovial
macrophages.
As
result,
can
modulate
polarization
macrophages
from
pro‐inflammatory
M1
anti‐inflammatory
M2
subtype,
inhibit
degradation
cartilage
matrix
efficient
The
biocompatibility
protective
properties
make
it
valuable
asset
treating
ROS‐related
ailments
beyond
OA.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 3, 2024
Abstract
Lymphatic
vessels,
comprising
the
secondary
circulatory
system
in
human
body,
play
a
multifaceted
role
maintaining
homeostasis
among
various
tissues
and
organs.
They
are
tasked
with
serious
of
responsibilities,
including
regulation
lymph
absorption
transport,
orchestration
immune
surveillance
responses.
vessel
development
undergoes
series
sophisticated
regulatory
signaling
pathways
governing
heterogeneous-origin
cell
populations
stepwise
to
assemble
into
highly
specialized
lymphatic
networks.
Lymphangiogenesis,
as
defined
by
new
vessels
sprouting
from
preexisting
vessels/embryonic
veins,
is
main
developmental
mechanism
underlying
formation
expansion
networks
an
embryo.
However,
abnormal
lymphangiogenesis
could
be
observed
many
pathological
conditions
has
close
relationship
progression
diseases.
Mechanistic
studies
have
revealed
set
lymphangiogenic
factors
cascades
that
may
serve
potential
targets
for
regulating
lymphangiogenesis,
further
modulate
Actually,
increasing
number
clinical
trials
demonstrated
promising
interventions
showed
feasibility
currently
available
treatments
future
translation.
Targeting
promoters
or
inhibitors
not
only
directly
regulates
but
improves
efficacy
diverse
treatments.
In
conclusion,
we
present
comprehensive
overview
physiological
functions,
describe
critical
involvement
multiple
Moreover,
summarize
targeting
therapeutic
values
providing
novel
perspectives
treatment
strategy
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(15), P. 10625 - 10641
Published: April 2, 2024
Development
of
nanomedicines
that
can
collaboratively
scavenge
reactive
oxygen
species
(ROS)
and
inhibit
inflammatory
cytokines,
along
with
osteogenesis
promotion,
is
essential
for
efficient
osteoarthritis
(OA)
treatment.
Herein,
we
report
the
design
a
ROS-responsive
nanomedicine
formulation
based
on
fibronectin
(FN)-coated
polymer
nanoparticles
(NPs)
loaded
azabisdimethylphoaphonate-terminated
phosphorus
dendrimers
(G4-TBP).
The
constructed
G4-TBP
NPs-FN
size
268
nm
are
stable
under
physiological
conditions,
be
specifically
taken
up
by
macrophages
through
FN-mediated
targeting,
dissociated
in
oxidative
microenvironment.
dendrimer
having
intrinsic
anti-inflammatory
property
FN
both
antioxidative
properties
display
integrated
functions
ROS
scavenging,
hypoxia
attenuation,
macrophage
M2
polarization,
thus
protecting
from
apoptosis
creating
designed
bone
immune
microenvironment
stem
cell
osteogenic
differentiation.
These
characteristics
lead
to
their
effective
treatment
an
OA
model
vivo
reduce
pathological
changes
joints
including
synovitis
inhibition
cartilage
matrix
degradation
simultaneously
promote
differentiation
repair.
developed
combining
advantages
bioactive
treat
may
immunomodulatory
therapy
different
diseases.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(46)
Published: July 9, 2023
Abstract
MicroRNAs
(miRNAs)
regulate
several
physiological
and
pathological
processes
involved
in
various
diseases,
including
osteoarthritis
(OA).
OA
is
the
most
common
global
musculoskeletal
disorder,
characterized
by
irreversible
progressive
destruction
of
articular
cartilage.
Supplementation
with
exogenous
miRNAs
may
represent
a
promising
therapeutic
treatment,
miRNA‐124
(miR‐124)
being
prime
candidate
for
its
anti‐inflammatory
ability;
however,
an
effective
drug
delivery
system
urgently
required
to
enhance
miR‐124
stability
capacity
enter
chondrocytes.
To
this
end,
tetrahedral
framework
nucleic
acids’
(tFNAs)
self‐assembled
3D
DNA
nanostructures
possess
superior
inherent
biocompatibility,
versatile
functionality,
unsurpassed
editability,
strong
cellular
internalization
ability.
In
study,
tFNAs
carrying
one
or
three
(T‐miR1
T‐miR3)
are
successfully
synthesized.
T‐miR3
largely
absorbed
via
induced
inflammatory
chondrocytes
IL‐1β.
With
reactive
oxygen
species’
scavenging
ability
inflammation‐suppressive
release
behavior,
efficiently
protects
against
IL‐1β
injury
vitro.
Additionally,
effectively
prevents
progression
inhibiting
chondrocyte
apoptosis,
smoothing
cartilage
surfaces,
suppressing
extracellular
matrix
degradation,
increasing
synovial
thickness,
protecting
vivo
cartilage,
illustrating
treatment.
This
study
provides
experimental
evidence
novel
strategies
treatment
clinical
setting.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(51)
Published: Aug. 11, 2023
Abstract
The
high
density
structure
of
cartilage
matrix
negative
charge
seriously
hinders
the
penetration
and
enrichment
drugs/genes
into
tissue.
In
this
study,
hexachlorocyclotriphosphonitrile
is
used
as
core
to
prepare
self‐polymerized
phosphorus
dendrimers
with
inflammatory
reaction
through
substitution
condensation
reaction.
vector
can
achieve
efficient
damaged
articular
(slightly
acidic
condition)
effective
anchoring
(normal
physiological
size
effect
under
response.
Meanwhile,
a
gene
“delivery
library,”
G1‐NC5.HCl@siRNA
gradually
released
microspheres
degrading;
long‐term
silencing
specific
genes
realized.
Further,
loaded
hydrogel
by
ionic
bond
coordination
microfluidic
techniques
improve
residency
in
joint
cavity.
results
vitro
vivo
e
xperiments
show
that
complex
has
better
at
pH
=
6.6,
decreases
7.6,
which
effectively
anchor
site
for
continuous
drug
delivery.
composite
significantly
degeneration
osteoarthritis
(OA)
promote
regeneration.
Therefore,
microsphere
delivery
system
response
promising
penetrant/anchoring
carrier
OA
treatment.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 16, 2024
Nanotechnology-based
approaches
are
promising
for
the
treatment
of
musculoskeletal
(MSK)
disorders,
which
present
significant
clinical
burdens
and
challenges,
but
their
translation
requires
a
deep
understanding
complex
interplay
between
nanotechnology
MSK
biology.
Organ-on-a-chip
(OoC)
systems
have
emerged
as
an
innovative
versatile
microphysiological
platform
to
replicate
dynamics
tissue
microenvironment
studying
nanotechnology-biology
interactions.
This
review
first
covers
recent
advances
applications
OoCs
ability
mimic
biophysical
biochemical
stimuli
encountered
by
tissues.
Next,
integrating
into
OoCs,
cellular
responses
behaviors
may
be
investigated
precisely
controlling
manipulating
nanoscale
environment.
Analysis
disease
mechanisms,
particularly
bone,
joint,
muscle
degeneration,
drug
screening
development
personalized
medicine
greatly
facilitated
using
OoCs.
Finally,
future
challenges
directions
outlined
field,
including
advanced
sensing
technologies,
integration
immune-active
components,
enhancement
biomimetic
functionality.
By
highlighting
emerging
this
aims
advance
intricate
nanotechnology-MSK
biology
interface
its
significance
in
management,
therapeutic
interventional
strategies.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 923 - 923
Published: April 22, 2024
This
review
critically
evaluates
advancements
in
multifunctional
hydrogels,
particularly
focusing
on
their
applications
osteoarthritis
(OA)
therapy.
As
research
evolves
from
traditional
natural
materials,
there
is
a
significant
shift
towards
synthetic
and
composite
known
for
superior
mechanical
properties
enhanced
biodegradability.
spotlights
novel
such
as
injectable
microneedle
technology,
responsive
which
have
revolutionized
OA
treatment
through
targeted
efficient
therapeutic
delivery.
Moreover,
it
discusses
innovative
hydrogel
including
protein-based
superlubricating
potential
to
reduce
joint
friction
inflammation.
The
integration
of
bioactive
compounds
within
hydrogels
augment
efficacy
also
examined.
Furthermore,
the
anticipates
continued
technological
deeper
understanding
hydrogel-based
therapies.
It
emphasizes
provide
tailored,
minimally
invasive
treatments,
thus
highlighting
critical
role
advancing
dynamic
field
biomaterial
science
management.