Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
The
complicated
environment
of
the
oral
cavity
presents
significant
challenges
to
traditional
antibacterial
approaches,
which
has
driven
exploration
novel
therapeutic
strategies.
Metal-based
nanomaterials
(MNMs),
with
diverse
mechanisms
(e.g.,
membrane
disruption,
oxidative
stress)
and
evolution
from
empirical
theory-guided
design,
exhibit
immense
potential.
This
review
introduces
pioneering
Hierarchical
Response
Strategy
Framework,
systematically
classifying
MNM
systems
into
three
progressive
levels:
Primary
category,
comprising
MNMs
that
exert
spontaneous
effects
based
on
inherent
physicochemical
properties
ion
release);
Secondary
including
precisely
controlled
actions
by
microenvironmental
or
stimulus-responsive
light-induced
ROS);
Tertiary
encompassing
integrate
regenerative
functions
for
multidimensional
therapy
remineralization).
Through
this
framework,
authors
elucidate
MNMs'
transition
single-function
precision-controlled,
multifunctional
synergy,
analyze
impact
metal
elements
structural
design
efficacy,
summarize
their
applications
in
dental
caries,
endodontic
infections,
periodontal
disease,
etc.
framework
offers
a
perspective
existing
research
theoretical
foundation
rational
next-generation
precise,
smart,
comprehensive
anti-infective
materials.
Acta Biomaterialia,
Journal Year:
2024,
Volume and Issue:
180, P. 183 - 196
Published: April 10, 2024
The
utilization
of
biodegradable
magnesium
(Mg)
alloys
in
the
fabrication
temporary
non-vascular
stents
is
an
innovative
trend
biomedical
engineering.
However,
heterogeneous
degradation
profiles
these
biomaterials,
together
with
potential
bacterial
colonization
that
could
precipitate
infectious
or
stenotic
complications,
are
critical
obstacles
precluding
their
widespread
clinical
application.
In
pursuit
overcoming
limitations,
this
study
applies
principles
biomimicry,
particularly
hydrophobic
and
anti-fouling
characteristics
lotus
leaves,
to
pioneer
creation
nanocomposite
coatings.
These
coatings
integrate
poly-trimethylene
carbonate
(PTMC)
covalent
organic
frameworks
(COFs),
modify
stent's
surface
property.
strategic
design
coating's
topography,
porosity,
self-polishing
capabilities
collectively
aims
decelerate
processes
minimize
biological
adhesion.
protective
qualities
were
substantiated
through
rigorous
testing
both
vitro
dynamic
bile
tests
vivo
New
Zealand
rabbit
choledochal
models.
Empirical
findings
from
trials
confirmed
implementation
COF-based
robustly
fortifies
Mg
implantations,
conferring
heightened
resistance
biocorrosion
biofouling
as
well
improved
biocompatibility
within
bodily
environments.
outcomes
research
elucidate
a
comprehensive
framework
for
multifaceted
strategies
against
stent
corrosion
fouling,
thereby
charting
visionary
pathway
toward
systematic
conception
new
class
reliable
COF-derived
modifications
poised
amplify
efficacy
Mg-based
stents.
STATEMENT
OF
SIGNIFICANCE:
Biodegradable
widely
utilized
stents,
though
rapid
susceptibility
infection
pose
significant
challenges.
Our
has
developed
coating
inspired
by
lotus,
integrating
(COF).
achieved
property
optimal
energy
on
substrate,
which
decelerates
reduces
biofilm
formation.
Comprehensive
evaluations
utilizing
simulations
implantation
models
reveal
improves
durability
longevity
stent.
implications
suggest
alloy
treatments
leap
forward
advancing
performance
endurance
applications.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 5, 2024
Abstract
Osteoporosis
is
the
most
common
bone
metabolic
disease
that
affects
health
of
middle-aged
and
elderly
people,
which
hallmarked
by
imbalanced
remodeling
a
deteriorating
immune
microenvironment.
Magnesium
calcium
are
pivotal
matrix
components
participate
in
formation
process,
especially
microenvironment
regulation
stages.
Nevertheless,
how
to
potently
deliver
magnesium
tissue
remains
challenge.
Here,
we
have
constructed
multifunctional
nanoplatform
composed
calcium-based
upconversion
nanoparticles
organic
frameworks
(CM-NH
2
-PAA-Ald,
denoted
as
CMPA),
features
bone-targeting
pH-responsive
properties,
effectively
regulating
inflammatory
promoting
coordination
osteogenic
functions
for
treating
osteoporosis.
The
can
efficaciously
target
gradually
degrade
response
acidic
osteoporosis
release
ions.
This
study
validates
CMPA
possessing
favorable
biocompatibility
suppress
inflammation
facilitate
osteogenesis
treat
Importantly,
high-throughput
sequencing
results
demonstrate
exerts
good
effect
through
inhibition
nuclear
factor
kappa-B
signaling
pathway,
thereby
normalizing
osteoporotic
collaborative
therapeutic
strategy
focuses
on
improving
provides
new
insight
treatment
diseases
such
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 30, 2024
Abstract
Abnormal
osteogenic
and
remodeling
microenvironment
due
to
osteoblast
apoptosis
are
the
primary
causes
of
delayed
fracture
healing
in
osteoporotic
patients.
Magnesium
(Mg)
alloys
exhibit
biodegradability
appropriate
elastic
moduli
for
bone
defects
osteoporosis,
but
effect
on
local
disorder
is
still
insufficient.
Inspired
by
“honeycomb,”
layered
double
hydroxide
(LDH)
with
regular
traps
graphene
oxide
quantum
dots
(GOQDs)
inlayed
constructed
pulsed
electrodeposition
generate
GOQD/LDH
composite
nanocoatings
surfaces
Mg
alloy
substrates.
The
honeycomb
bionic
multi‐layer
stereoscopic
structure
shows
good
regulation
degradation
support
time
required
defect.
Within
its
lattice,
conducive
osteogenesis
provided
both
rescue
GOQD
LDH.
rescued
activation
mitophagy
clear
dysfunctional
mitochondria,
where
upregulation
BNIP3
phosphorylation
played
a
key
role.
rat
model
femoral
confirmed
improvement
regeneration
osseointegration
coating.
In
summary,
controllable
excellent
pro‐osteogenic
performance
demonstrated
promising
design
strategy
implants
therapy
defects.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(2), P. 1062 - 1076
Published: Jan. 21, 2024
Magnesium
is
a
revolutionary
biomaterial
for
orthopedic
implants,
owing
to
its
eminent
mechanical
properties
and
biocompatibility.
However,
uncontrolled
degradation
rate
remains
severe
challenge
potential
applications.
In
this
study,
we
developed
self-healing
micro
arc
oxidation
(MAO)
dicalcium
phosphate
dihydrate
(DCPD)
double-passivated
coating
on
magnesium
membrane
(Mg-MAO/DCPD)
investigated
bone-defect
healing.
The
Mg-MAO/DCPD
possessed
feasible
self-repairing
ability
good
cytocompatibility.
vitro
experiments
showed
that
the
Mg
contents
surface
were
0.3,
3.8,
4.1,
6.1,
7.9%
when
times
0,
1,
2,
3,
4
weeks,
respectively,
exhibiting
available
corrosion
resistance.
slow
sustained
release
of
Mg2+
during
process
activated
extracellular
matrix
proteins
bone
regeneration,
accelerating
osteogenic
differentiation
human
marrow
mesenchymal
stem
cells
(hBMSCs).
extract
solutions
considerably
promoted
activation
Wnt
PI3K/AKT
signaling
pathways.
Furthermore,
evaluation
rat
skull
defect
model
manifested
outstanding
bone-healing
efficiency
membrane.
Taken
together,
demonstrates
an
optimized
excellent
bioactivity
believed
have
great
application
prospects
in
tissue
engineering.
