Space-Specific Mixing Excitation for High-SNR Spatial Encoding in Magnetic Particle Imaging DOI
Yanjun Liu, Guanghui Li, Jiaqian Li

et al.

IEEE Transactions on Biomedical Engineering, Journal Year: 2024, Volume and Issue: 71(10), P. 2889 - 2899

Published: May 13, 2024

Magnetic Particle Imaging (MPI) is a radiation-free tracer-based imaging technology that visualizes the spatial distribution of superparamagnetic iron oxide nanoparticles. Conventional encoding methods in MPI rely on gradient magnetic field with constant strength to generate field-free point or line for scanning. However, increasing can enhance theoretical resolution but also lead decrease Signal-to-Noise Ratio (SNR) and sensitivity system. This poses technical challenge balancing sensitivity, necessitating intricate hardware design.

Language: Английский

Unveiling Invisible Extracellular Vesicles: Cutting‐Edge Technologies for Their in Vivo Visualization DOI Creative Commons
Prakash Gangadaran, Fatima Khan, Ramya Lakshmi Rajendran

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(5)

Published: Sept. 1, 2024

ABSTRACT Extracellular vesicles (EVs), nanosized lipid bilayer released by nearly all types of cells, play pivotal roles as intercellular signaling mediators with diverse biological activities. Their adaptability has attracted interest in exploring their role disease biomarker theranostics. However, the vivo biodistribution and pharmacokinetic profiles EVs, particularly following administration into living subjects, remain unclear. Thus, imaging is vital to enhance our understanding homing retention patterns, blood tissue half‐life, excretion pathways exogenous thereby advancing real‐time monitoring within systems therapeutic applications. This review examines state‐of‐the‐art methods including EV labeling various agents, optical imaging, magnetic resonance nuclear imaging. The strengths weaknesses each technique are comprehensively explored, emphasizing clinical translation. Despite potential EVs cancer theranostics, achieving a thorough behavior challenging. highlights urgency addressing current questions biology applications EVs. It underscores need for continued research unravel complexities surrounding implications. By identifying these challenges, this contributes ongoing efforts optimize techniques use. Ultimately, bridging gap between advancements will facilitate integration EV‐based marking crucial step toward harnessing full medical practice.

Language: Английский

Citations

3
How Nanotherapeutic Platforms Play a Key Role in Glioma? A Comprehensive Review of Literature DOI Creative Commons

Yongqing Yang,

Nianlan Cheng,

Qiao Luo

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 3663 - 3694

Published: July 1, 2023

Abstract: Glioblastoma (GBM), a highly aggressive form of brain cancer, is considered one the deadliest cancers, and even with most advanced medical treatments, affected patients have poor prognosis. However, recent advances in nanotechnology offer promising avenues for development versatile therapeutic diagnostic nanoplatforms that can deliver drugs to tumor sites through blood-brain barrier (BBB). Despite these breakthroughs, use GBM therapy has been subject great controversy due concerns over biosafety nanoplatforms. In years, biomimetic gained unprecedented attention biomedical field. With advantages such as extended circulation times, improved immune evasion active targeting compared conventional nanosystems, bionanoparticles shown potential applications. this prospective article, we endeavor comprehensively review application bionanomaterials treatment glioma, focusing on rational design multifunctional facilitate BBB infiltration, promote efficient accumulation tumor, enable precise imaging, achieve remarkable suppression. Furthermore, discuss challenges future trends Through careful optimization nanoplatforms, researchers are paving way toward safer more effective therapies patients. The nanoplatform applications glioma avenue precision medicine, which could ultimately improve patient outcomes quality life. Graphical Keywords: nanomedicine, bionanotechnology, therapy, drug delivery system

Language: Английский

Citations

9
A Novel Local Magnetic Fluid Hyperthermia Based on High Gradient Field Guided by Magnetic Particle Imaging DOI
Siao Lei, Jie He, Xiazi Huang

et al.

IEEE Transactions on Biomedical Engineering, Journal Year: 2024, Volume and Issue: 71(8), P. 2528 - 2536

Published: March 18, 2024

Magnetic Particle Imaging (MPI)-guided Fluid Hyperthermia (MFH) has the potential for widespread utilization, as it allows prediction of magnetothermal dosage, real-time visualization thermal therapy process, and precise localization lesion area. However, existing MPI-guided MFH (MPI-MFH) method is insensitive to concentration gradients magnetic nanoparticles (MNPs) susceptible causing damage normal tissues with high MNP concentrations during treatment, while inadequately heating tumor lower concentrations. In this work, we established a relationship between efficiency through simulations phantom measurements, enabling optimal selection parameters guided by MPI. Based on these findings, developed high-gradient field MPI-MFH using fieldfree point (FFP) approach achieve local heating. Phantom experiments in vivo glioma model were conducted validate proposed method. The results demonstrated that MPIMFH can improve gradient sensitivity ±1 mg/ml, thereby more effective lesion-site without damaging tissues. This not only reduced size effectively but also holds promise application various other types cancers.

Language: Английский

Citations

2
Magnetic Field Strength Encoded Handheld Magnetic Particle Imaging System with Multi-Waveform Excitation DOI
Bo Zhang, Haoran Zhang, Pengli Gao

et al.

IEEE Transactions on Instrumentation and Measurement, Journal Year: 2024, Volume and Issue: 73, P. 1 - 11

Published: Jan. 1, 2024

Language: Английский

Citations

2
Responsive Magnetic Particle Imaging Tracer: Overcoming “Always‐On” Limitation, Eliminating Interference, and Ensuring Safety in Adaptive Therapy DOI Open Access
Guoqiang Guan, Guangyuan Shi, Huiyi Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Magnetic particle imaging (MPI) has emerged as a novel technology utilizing superparamagnetic nanoparticles tracers, essential for disease diagnosis and treatment guidance in preclinical animal models. Unlike other modalities, MPI provides high sensitivity, deep tissue penetration, no signal attenuation. However, existing tracers suffer from “always‐on” signals, which complicate organ‐specific hinder accuracy. To overcome these challenges, we have developed responsive tracer using pH‐responsive PdFe alloy particles coated with gatekeeper polymer. This exhibits pH‐sensitive Fe release modulation of the signal, enabling selective higher signal‐to‐noise ratio intratumoral pH quantification. Notably, this facilitates subtraction‐enhanced imaging, effectively eliminating interference liver uptake expanding scope abdominal imaging. Additionally, employs dual‐function mechanism adaptive cancer therapy, combining pH‐switchable enzyme‐like catalysis dual‐key co‐activation ROS generation, Pd skeleton that scavenges free radicals to minimize Fe‐related toxicity. advancement promises significantly expand MPI's applicability diagnostics therapeutic monitoring, marking leap forward technology.

Language: Английский

Citations

2
An adaptive multi-frame parallel iterative method for accelerating real-time magnetic particle imaging reconstruction DOI
Yusong Shen, Liwen Zhang, Yaxin Shang

et al.

Physics in Medicine and Biology, Journal Year: 2023, Volume and Issue: 68(24), P. 245016 - 245016

Published: Oct. 27, 2023

Objective. Real-time reconstruction of magnetic particle imaging (MPI) shows promising clinical applications. However, prevalent methods are mainly based on serial iteration, which causes large delay in real-time reconstruction. In order to achieve lower latency MPI reconstruction, we propose a parallel method for accelerating the speed methods.Approach. The proposed method, named adaptive multi-frame iterative (AMPIM), enables processing signals images parallel. To facilitate computing, further an acceleration strategy computation improve computational efficiency our AMPIM.Main results. OpenMPIData was used evaluate AMPIM, and results show that AMPIM improves frame rate per second by two orders magnitude compared algorithms including Kaczmarz algorithm, conjugate gradient normal residual alternating direction multipliers algorithm. reconstructed image using has high contrast-to-noise with reducing artifacts.Significance. can parallelly optimize least squares problems multiple right-hand sides exploiting dimension side. great potential application rate.

Language: Английский

Citations

6
Adhesion molecule–targeted magnetic particle imaging nanoprobe for visualization of inflammation in acute lung injury DOI
Pengli Gao, Yu Liu, Xiaoli Wang

et al.

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2023, Volume and Issue: 51(5), P. 1233 - 1245

Published: Dec. 14, 2023

Language: Английский

Citations

6
Magnetic particle imaging deblurring with dual contrastive learning and adversarial framework DOI
Jiaxin Zhang, Zechen Wei, Xiangjun Wu

et al.

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 165, P. 107461 - 107461

Published: Sept. 9, 2023

Language: Английский

Citations

4
First Nonhuman Primate-Sized Magnetic Particle Imaging System Based on Digital-Scanned Focus Field DOI Creative Commons
Zechen Wei, Yanjun Liu, Sijia Liu

et al.

IEEE Transactions on Instrumentation and Measurement, Journal Year: 2024, Volume and Issue: 73, P. 1 - 11

Published: Jan. 1, 2024

Language: Английский

Citations

1
CXCR4-targeted sensitive magnetic particle imaging for abdominal aortic aneurysm early detection and prognosis evaluation by recognizing total inflammatory cells DOI Creative Commons
Genmao Cao, Ruijing Zhang,

Xiaohua Jia

et al.

Cardiovascular Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Abstract Aims The maximum aortic diameter remains the diagnostic criteria and indicator for prognosis prediction of abdominal aneurysms (AAAs). An additional imaging modality is currently needed to help evaluate AAA as well early detection formation. This study evaluated most effective inflammatory markers using single-cell sequencing and, from these, developed probes facilitate in vivo multimodal inflammation. Methods results Single-cell RNA (scRNAseq) human aneurysms, GSE155468 GSE166676 data sets, identified CXCR4 representative marker. Anti-CXCR4-PE antibody was conjugated superparamagnetic iron oxide nanoparticles synthesize Fe3O4-anti-CXCR4-PE probes. biocompatibility specificity were validated vitro. Magnetic particle (MPI) fluorescence (FLI) performed assess inflammation advanced mouse models. CXCR4-specific receptor inhibitor, AMD3100, used confirming an excellent target therapy. scRNAseq indicated that chemokine-related pathways upregulated chemokine marks all AAA-related immune cells vascular cells. effectively recognized cells, strong MPI FLI signals corresponded increased CXCR4, CD45, CD68 levels represented severity rupture risk. Importantly, can identify formation when ultrasound undiagnosable. Finally, AMD3100 treatment model inhibited expansion reduced wall by inhibiting accumulation haematopoietic stem Conclusion associated with a AAA. CXCR4-targeting MPI/FLI provides novel approach detection.

Language: Английский

Citations

1