Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 9, 2024
Lung
cancer
has
high
metastasis
and
drug
resistance.
The
prognosis
of
lung
patients
is
poor
the
patients’
survival
chances
are
easily
neglected.
Ferroptosis
a
programmed
cell
death
proposed
in
2012,
which
differs
from
apoptosis,
necrosis
autophagy.
novel
type
regulated
driven
by
iron-dependent
lipid
peroxidation
subsequent
plasma
membrane
ruptures.
It
broad
prospects
field
tumor
disease
treatment.
At
present,
multiple
studies
have
shown
that
biological
compounds
can
induce
ferroptosis
cells,
exhibits
significant
anti-cancer
effects,
they
advantages
safety,
minimal
side
less
possibility
to
In
this
review,
we
summarize
used
for
treatment
focusing
on
its
mechanism.
addition,
systematically
review
current
research
status
combining
nanotechnology
with
treatment,
shed
new
light
targeting
pathways
applying
compounds-based
therapies.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(29)
Published: Sept. 14, 2023
Abstract
The
combination
of
immunotherapy
and
molecular
targeted
therapy
exhibits
promising
therapeutic
efficacy
in
hepatocellular
carcinoma
(HCC),
but
the
underlying
mechanism
is
still
unclear.
Here,
phosphoglycerate
mutase
1
(PGAM1)
identified
as
a
novel
immunometabolic
target
by
using
bioinformatic
algorithm
based
on
multiple
HCC
datasets.
PGAM1
highly
expressed
associated
with
poor
prognosis
response
to
immunotherapy.
In
vitro
vivo
experiments
indicate
that
targeting
inhibited
cell
growth
promoted
infiltration
CD8
+
T‐cells
due
decreased
enzymatic
activity.
Mechanistically,
inhibition
promotes
ferroptosis
downregulating
Lipocalin
(LCN2)
inducing
energy
stress
ROS‐dependent
AKT
inhibition,
which
can
also
downregulate
Programmed
death
1‐ligand
(PD‐L1).
Moreover,
an
allosteric
inhibitor
(KH3)
good
antitumor
effects
patient‐derived
xenograft
(PDX)
models
enhanced
anti‐PD‐1
subcutaneous
orthotopic
models.
Taken
together,
findings
demonstrate
exerts
effect
promoting
T‐cell
synergize
HCC.
Targeting
be
new
strategy
“killing
two
birds
one
stone”
for
treatment.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 18, 2024
Immunotherapy
has
made
significant
strides
in
cancer
treatment,
particularly
through
immune
checkpoint
blockade
(ICB),
which
shown
notable
clinical
benefits
across
various
tumor
types.
Despite
the
transformative
impact
of
ICB
treatment
therapy,
only
a
minority
patients
exhibit
positive
response
to
it.
In
with
solid
tumors,
those
who
respond
well
typically
demonstrate
an
active
profile
referred
as
"hot"
(immune-inflamed)
phenotype.
On
other
hand,
non-responsive
may
distinct
"cold"
(immune-desert)
phenotype,
differing
from
features
tumors.
Additionally,
there
is
more
nuanced
"excluded"
positioned
between
and
categories,
known
type.
Effective
differentiation
understanding
intrinsic
factors,
characteristics,
TME,
external
factors
are
critical
for
predicting
results.
It
widely
accepted
that
therapy
exerts
profound
effect
on
limited
efficacy
against
or
"altered"
necessitating
combinations
therapeutic
modalities
enhance
cell
infiltration
into
tissue
convert
tumors
ones.
Therefore,
aligning
traits
this
review
systematically
delineates
respective
influencing
extensively
discusses
varied
approaches
drug
targets
based
assess
efficacy.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 18, 2024
The
global
challenge
posed
by
cancer,
marked
rising
incidence
and
mortality
rates,
underscores
the
urgency
for
innovative
therapeutic
approaches.
PI3K/Akt
signaling
pathway,
frequently
amplified
in
various
cancers,
is
central
regulating
essential
cellular
processes.
Its
dysregulation,
often
stemming
from
genetic
mutations,
significantly
contributes
to
cancer
initiation,
progression,
resistance
therapy.
Concurrently,
ferroptosis,
a
recently
discovered
form
of
regulated
cell
death
characterized
iron-dependent
processes
lipid
reactive
oxygen
species
buildup,
holds
implications
diseases,
including
cancer.
Exploring
interplay
between
dysregulated
pathway
ferroptosis
unveils
potential
insights
into
molecular
mechanisms
driving
or
inhibiting
ferroptotic
cells.
Evidence
suggests
that
may
sensitize
cells
induction,
offering
promising
strategy
overcome
drug
resistance.
This
review
aims
provide
comprehensive
exploration
this
interplay,
shedding
light
on
disrupting
enhance
as
an
alternative
route
inducing
improving
treatment
outcomes.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 16, 2024
Photothermal
therapy
(PTT)
is
a
promising
non-invasive
treatment
that
has
shown
great
potential
in
eliminating
tumors.
It
not
only
induces
apoptosis
of
cancer
cells
but
also
triggers
immunogenic
cell
death
(ICD)
which
could
activate
the
immune
system
against
cancer.
However,
immunosuppressive
tumor
microenvironment
(TIME)
poses
challenge
to
triggering
strong
responses
with
single
treatment,
thus
limiting
therapeutic
effect
immunotherapy.
In
this
study,
dual-targeted
nano
delivery
(GOx@FeNPs)
combined
αPD-L1
checkpoint
blocker
inhibit
colorectal
(CRC)
progression
by
mediating
PTT,
ferroptosis
and
anti-tumor
response.
Briefly,
specific
was
achieved
cyclic
arginine
glycyl
aspartate
(cRGD)
peptide
anisamide
(AA)
GOx@FeNPs
had
good
photothermal
realize
PTT
induce
ICD,
deplete
glutathione
(GSH)
catalyze
production
reactive
oxygen
species
(ROS)
from
endogenous
H
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(9), P. 3621 - 3637
Published: Jan. 1, 2024
Ferroptosis,
an
emerging
type
of
programmed
cell
death,
is
initiated
by
iron-dependent
and
excessive
ROS-mediated
lipid
peroxidation,
which
eventually
leads
to
plasma
membrane
rupture
death.
Many
canonical
signalling
pathways
biological
processes
are
involved
in
ferroptosis.
Furthermore,
cancer
cells
more
susceptible
ferroptosis
due
the
high
load
ROS
unique
metabolic
characteristics,
including
iron
requirements.
Recent
investigations
have
revealed
that
plays
a
crucial
role
progression
tumours,
especially
HCC.
Specifically,
induction
can
not
only
inhibit
growth
hepatoma
cells,
thereby
reversing
tumorigenesis,
but
also
improves
efficacy
immunotherapy
enhances
antitumour
immune
response.
Therefore,
triggering
has
become
new
therapeutic
strategy
for
therapy.
In
this
review,
we
summarize
characteristics
based
on
its
underlying
mechanism
HCC
provide
possible
applications.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Aug. 8, 2024
Hepatocellular
Carcinoma
(HCC),
the
most
common
primary
liver
cancer,
ranks
as
third
cause
of
cancer-related
deaths
globally.
A
deeper
understanding
cell
death
mechanisms
in
HCC
is
essential
for
developing
more
effective
treatment
strategies.
This
review
explores
programmed
(PCD)
pathways
involved
HCC,
including
apoptosis,
necroptosis,
pyroptosis,
ferroptosis,
and
immunogenic
(ICD).
These
trigger
specific
cascades
that
influence
development
progression
HCC.
Although
multiple
PCD
are
shared
cellular
factors
suggest
a
possible
interplay
between
different
forms
death.
However,
exact
roles
which
pathway
plays
major
role
remain
unclear.
also
highlights
how
disruptions
related
to
drug
resistance
cancer
therapy,
promoting
combined
approach
induction
anti-tumor
enhance
therapeutic
efficacy.
Further
research
required
unravel
complex
modalities
may
lead
innovative
breakthroughs.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(4), P. 100939 - 100939
Published: June 26, 2024
Ferroptosis
is
a
nonapoptotic
form
of
cell
death
characterized
by
iron
dependence
and
lipid
peroxidation.
involved
in
range
pathological
processes,
such
as
cancer.
Many
studies
have
confirmed
that
ferroptosis
plays
an
essential
role
inhibiting
cancer
proliferation.
In
addition,
series
small-molecule
compounds
been
developed,
including
erastin,
RSL3,
FIN56,
which
can
be
used
inducers.
The
combination
inducers
with
anticancer
drugs
produce
significant
synergistic
effect
treatment,
patients
treated
these
combinations
exhibit
better
prognosis
than
receiving
traditional
therapy.
Therefore,
thorough
understanding
the
roles
great
significance
for
treatment
This
review
mainly
elaborates
molecular
biological
characteristics
mechanism
ferroptosis,
summarizes
function
development
treatment,illustrates
application
patient's
prediction
drug
discovery,
discusses
prospects
targeting
ferroptosis.
