Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(10), P. 4089 - 4101
Published: Jan. 1, 2024
Our work suggested that cuproptosis serves as a key toxic mechanism of CuO NPs, damaging mitochondria to induce ferroptosis by disrupting mitochondrial membrane lipid synthesis.
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(18)
Published: March 2, 2024
Abstract The induction of cuproptosis, a recently identified form copper‐dependent immunogenic cell death, is promising approach for antitumor therapy. However, sufficient accumulation intracellular copper ions (Cu 2+ ) in tumor cells essential inducing cuproptosis. Herein, an intelligent cuproptosis‐inducing nanosystem constructed by encapsulating oxide (CuO) nanoparticles with the ionophore elesclomol (ES). After uptake cells, ES@CuO degraded to release Cu and ES synergistically trigger thereby significantly inhibiting growth murine B16 melanoma cells. Moreover, further promoted cuproptosis‐mediated immune responses reprogrammed immunosuppressive microenvironment increasing number tumor‐infiltrating lymphocytes secreted inflammatory cytokines. Additionally, combining programmed death‐1 (PD‐1) immunotherapy substantially increased efficacy melanoma. Overall, findings this study can lead use novel strategy therapy, which may enhance checkpoint inhibitor
Language: Английский
Citations
65
Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107258 - 107258
Published: June 21, 2024
Several cardiovascular illnesses are associated with aberrant activation of cellular pyroptosis, ferroptosis, necroptosis, cuproptosis, disulfidptosis and macrophage polarisation as hallmarks contributing to vascular damage abnormal cardiac function. Meanwhile, these three novel forms dysfunction closely related mitochondrial homeostasis. Mitochondria the main organelles that supply energy maintain Mitochondrial stability is maintained through a series regulatory pathways, such fission, fusion mitophagy. Studies have shown (e.g., impaired dynamics mitophagy) promotes ROS production, leading oxidative stress, which induces M1 phenotypic polarisation. Therefore, an in-depth knowledge dynamic regulation mitochondria during necessary understand disease development. This paper systematically summarises impact changes in mitophagy on regulating dysfunctions promote understanding pathogenesis diseases provide corresponding theoretical references for treating diseases.
Language: Английский
Citations
22
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: Aug. 16, 2024
Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial tricarboxylic acid cycle and loss iron–sulfur cluster proteins, ultimately resulting in proteotoxic stress triggering death. Recently, has garnered significant interest tumor research due to its potential as crucial therapeutic strategy against cancer. In this review, we summarized cellular molecular mechanisms relationship other types Additionally, reviewed current drugs or strategies available induce cells, including Cu ionophores, small compounds, nanomedicine. Furthermore, targeted metabolism specific regulatory genes cancer therapy enhance sensitivity cuproptosis. Finally, discussed feasibility targeting overcome chemotherapy immunotherapy resistance suggested future directions. This study that could open new avenues for developing therapy.
Language: Английский
Citations
22
Cancer Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15
Published: Jan. 2, 2025
Artificial intelligence (AI) is significantly advancing precision medicine, particularly in the fields of immunogenomics, radiomics, and pathomics. In AI can process vast amounts genomic multi-omic data to identify biomarkers associated with immunotherapy responses disease prognosis, thus providing strong support for personalized treatments. analyze high-dimensional features from computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography/computed (PET/CT) images discover tumor heterogeneity, treatment response, progression, thereby enabling non-invasive, real-time assessments therapy. Pathomics leverages deep analysis digital pathology images, uncover subtle changes tissue microenvironments, cellular characteristics, morphological features, offer unique insights into response prediction biomarker discovery. These AI-driven technologies not only enhance speed, accuracy, robustness discovery but also improve precision, personalization, effectiveness clinical treatments, are driving a shift empirical medicine. Despite challenges such as quality, model interpretability, integration multi-modal data, privacy protection, ongoing advancements AI, coupled interdisciplinary collaboration, poised further AI’s roles prediction. improvements expected lead more accurate, strategies ultimately better patient outcomes, marking significant step forward evolution
Language: Английский
Citations
5
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 15, 2025
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.
Language: Английский
Citations
3
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Language: Английский
Citations
2
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 2, 2025
Radiotherapy is crucial in local cancer management and needs advancements. Tumor cells elevate intracellular copper levels to promote growth resist radiation; thus, targeted delivery mitochondria could enhance radiotherapy by inducing cuproptosis tumor cells. In this study, we engineered a multifunctional nanoliposome complex, termed Lipo-Ele@CuO2, which encapsulates both peroxide (CuO2) the chelator elesclomol, can Cu ions mitochondria. The Lipo-Ele@CuO2 complex induces mitochondria-mediated synergistically enhances efficacy of radiotherapy. CuO2 acts as donor exhibits inherent sensitivity acidic environments. Additionally, it depletes glutathione, thereby sensitizing cuproptosis. Leveraging its pH-responsive properties microenvironment, facilitate controlled release efficiently delivering at sites. combined vitro vivo studies demonstrate that Lipo-Ele@CuO2-based therapy significantly improves antitumor excellent safety profiles, effectively boosting effectiveness Furthermore, metabolomic transcriptomic analyses reveal combination precipitates significant alterations energy metabolism, notably repressing genes related iron-sulfur cluster assembly glycolysis, confirming induction This therapeutic strategy provides viable approach for addressing clinical resistance demonstrates translational potential.
Language: Английский
Citations
2
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 15, 2024
Normal life requires cell division to produce new cells, but death is necessary maintain balance. Dysregulation of can lead the survival and proliferation abnormal promoting tumor development. Unlike apoptosis, necrosis, autophagy, newly recognized forms regulated (RCD) cuproptosis, ferroptosis, PANoptosis provide novel therapeutic strategies for treatment. Increasing research indicates that immune cells mediated by these discovered regulate microenvironment (TME) influence effectiveness immunotherapy. This review primarily elucidates molecular mechanisms their complex effects on TME. also summarizes exploration nanoparticle applications in therapy based vivo vitro evidence derived from induction or inhibition RCD pathways.
Language: Английский
Citations
16
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(44), P. 30033 - 30045
Published: Oct. 28, 2024
Cuproptosis, a recently identified form of copper-dependent cell death, shows promising tumor suppressive effects with minimal drug resistance. However, its therapeutic efficacy is hampered by dependence on copper ions and the glutathione (GSH)-rich microenvironment in tumors. Here, we have developed polyvalent aptamer nanodrug conjugates (termed CuPEs@PApt) nucleosome-like structure to improve cuproptosis therapy exploiting mitochondrial overload GSH depletion. Polyvalent (PApt), comprising epithelial adhesion molecule aptamers for targeting repetitive PolyT sequences chelation, facilitates efficient loading targeted delivery peroxide-Elesclomol nanodots (CuPEs). Upon internalization cells, Elesclomol released from CuPEs@PApt accumulates mitochondria initiate cuproptosis, while lysosomal degradation CuP generates exogenous Cu2+ H2O2, triggering Fenton-like reaction depletion enhance cuproptosis. In vitro vivo experiments confirm this strategy inducing immunogenic latter contributing activation antitumor immune response synergistic growth inhibition.
Language: Английский
Citations
12
Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122723 - 122723
Published: July 31, 2024
Language: Английский
Citations
9