A Systematic Review of Nanoparticle-Mediated Ferroptosis in Glioma Therapy DOI Creative Commons
Jing Lin,

Wenguang Xiao,

Zhenlin Hu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 5779 - 5797

Published: May 1, 2025

Glioma, a highly malignant central nervous system tumor, exhibits aggressive invasiveness, extensive infiltration, and poor prognosis. Conventional treatments such as surgery, radiotherapy, chemotherapy are hindered by limitations including the inability to overcome blood-brain barrier (BBB), drug resistance, high recurrence rates. Ferroptosis induced nanoparticle-based systems offers an innovative strategy for glioma therapy efficiently traversing BBB, precisely delivering ferroptosis inducers, enhancing tumor accumulation, enabling stimuli-responsive release. These features collectively improve induction efficiency of in cells. Various nanoplatforms, inorganic nanoparticles, biomimetic carriers, polymer-based systems, have demonstrated potential crossing inducing ferroptosis, suppressing progression. enhance reactive oxygen species generation, deplete glutathione, disrupt microenvironment defense mechanisms, achieving synergistic therapeutic effects. The integration with nanotechnology is emerging promising, non-invasive treatment gliomas, offering substantial potential.

Language: Английский

Carrier‐Free Self‐Assembly Nano‐Sonosensitizers for Sonodynamic‐Amplified Cuproptosis‐Ferroptosis in Glioblastoma Therapy DOI Creative Commons
Yang Zhu,

Xuegang Niu,

Chengyu Ding

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(23)

Published: April 6, 2024

Abstract Cuproptosis is a newly discovered form of programmed cell death significantly depending on the transport efficacy copper (Cu) ionophores. However, existing Cu ionophores, primarily small molecules with short blood half‐life, face challenges in transporting enough amounts ions into tumor cells. This work describes construction carrier‐free nanoparticles (Ce6@Cu NPs), which self‐assembled by coordination 2+ sonosensitizer chlorin e6 (Ce6), facilitating sonodynamic‐triggered combination cuproptosis and ferroptosis. Ce6@Cu NPs internalized U87MG cells induce sonodynamic effect glutathione (GSH) depletion capability, promoting lipid peroxidation eventually inducing Furthermore, + concentration increases as reacts reductive GSH, resulting downregulation ferredoxin‐1 lipoyl synthase. induces oligomerization lipoylated dihydrolipoamide S‐acetyltransferase, causing proteotoxic stress irreversible cuproptosis. possess satisfactory ability to penetrate blood‐brain barrier, significant accumulation orthotopic U87MG‐Luc glioblastoma. The ferroptosis evidenced both vitro vivo minimal side effects. represents promising therapeutic strategy combining cuproptosis, potentially inspiring further research developing logical effective cancer therapies based

Language: Английский

Citations

42
Immunological nanomaterials to combat cancer metastasis DOI

Yuanbo Pan,

Junjie Cheng, Yang Zhu

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6399 - 6444

Published: Jan. 1, 2024

This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.

Language: Английский

Citations

24
Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications DOI Creative Commons
Yongxin Zheng, Junlu Sun,

Zhiting Luo

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)

Published: Nov. 26, 2024

Abstract Regulated cell death (RCD) refers to the form of that can be regulated by various biomacromolecules. Each modalities have their distinct morphological changes and molecular mechanisms. However, intense evidences suggest lipid peroxidation common feature initiates propagates death. Excessive alters property membrane further damage proteins nucleic acids, which is implicated in human pathologies. Here, we firstly review classical chain process peroxidation, clarify current understanding myriad roles mechanisms RCD types. We also discuss how involves diseases such intimate association between peroxidation-driven leveraged develop rational therapeutic strategies.

Language: Английский

Citations

18
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

7
Copper-Based Biomaterials for Anti-Tumor Therapy: Recent Advances and Perspectives DOI
Shufang Zhang, Shuping Peng

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment DOI Creative Commons
Mengyao Yang, Xin Wang,

Mengke Peng

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Language: Английский

Citations

2
Navigating the Brain: Harnessing Endogenous Cellular Hitchhiking for Targeting Neoplastic and Neuroinflammatory Diseases DOI Creative Commons

Suraj Wagh,

Paras Famta,

Saurabh Shah

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101040 - 101040

Published: Feb. 1, 2025

Language: Английский

Citations

2
Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy DOI

Fuhong Yang,

Jingqi Lv,

Wen Ma

et al.

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Language: Английский

Citations

14
Three‐Level Nanoparticle Rocket Strategy for Colorectal Cancer Therapeutics in Photothermal Therapy, Inflammation Modulation, and Cuproptosis Induction DOI Open Access
Wenting Shang,

Xueer Xia,

Yuting Zhu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Disturbances in intracellular copper (Cu) homeostasis can trigger cuproptosis, a new form of cell death, which, when combined with photothermal therapy (PTT), offers promising solution to the persistent challenges colorectal cancer (CRC) treatment. In this study, “three‐level nanoparticle rocket” strategy is developed by engineering Cu 5.4 O, multifunctional Cu‐based nanoenzyme that and has electron transfer properties antioxidant efficiency. O effectively remodels inflammatory environment scavenging reactive oxygen species, thereby overcoming traditional limitations PTT. Concurrently, releases substantial amounts + into malignant cells, disrupting homeostasis, inducing ultimately inhibiting tumor progression. vivo vitro experiments demonstrate operates through multiple successive interlocking stages significantly eradicate tumors, prevent relapse, prolong survival. This study provides profound insights synergistic effects PTT, regulation, cuproptosis within complex microenvironment, presenting innovative approaches for future CRC therapy.

Language: Английский

Citations

1
Flexible Morphological Regulation of Photothermal Nanodrugs: Understanding the Relationship between the Structure, Photothermal Effect, and Tumoral Biodistribution DOI Creative Commons
Shukun Li, Yudong Li, Guizhi Shen

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

The morphology of nanodrugs is utmost importance in photothermal therapy because it directly influences their physicochemical behavior and biological responses. However, clarifying the inherent relationship between resultant properties remains challenging, mainly due to limitations flexible morphological regulation nanodrugs. Herein, we created a range morphologically controlled nanoassemblies based on poly(ethylene glycol)-block-poly(d,l-lactide) (PEG–PLA) block copolymer building blocks, which model photosensitizer phthalocyanine was incorporated. Four different topologies were compared, namely, spherical vesicles, bowl-shaped rodlike micelles, vesicular tubes. vivo tumoral biodistribution investigated, revealing with particle morphology. Finally, tumor ablation capability optimized demonstrated. This study represents systematic discrete nanodrugs, highlighting customization supramolecular toward clinical antitumor therapy.

Language: Английский

Citations

1