Recent Progress on Tumor Microenvironment‐Activated NIR‐II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment DOI
Hao Xiao, Gui‐long Wu, Senyou Tan

et al.

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(4)

Published: Jan. 17, 2024

Abstract Malignant tumors seriously threaten human life and well‐being. Emerging Near‐infrared II (NIR‐II, 1000–1700 nm) phototheranostic nanotechnology integrates diagnostic treatment modalities, offering merits including improved tissue penetration enhanced spatiotemporal resolution. This remarkable progress has opened promising avenues for advancing tumor theranostic research. The microenvironment (TME) differs from normal tissues, exhibiting distinct attributes such as hypoxia, acidosis, overexpressed hydrogen peroxide, excess glutathione, other factors. Capitalizing on these attributes, researchers have developed TME‐activatable NIR‐II agents with therapeutic concurrently. Therefore, developing activation holds significant research importance. Currently, is still in its preliminary stages. review examines the recent advances dual‐functional activatable over past years. It systematically presents activated by various TME factors acidity (pH), peroxide (H 2 O ), glutathione (GSH), sulfide S), enzymes, their hybrid. encompasses fluorescence photoacoustic imaging diagnostics, along photothermal, photodynamic, chemodynamic, gas therapies triggered Lastly, difficulties opportunities confronting simultaneous diagnosis field are highlighted.

Language: Английский

Stimulus‐Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy DOI Creative Commons

Fuzhen Hu,

Jia Huang,

Tiejun Bing

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)

Published: Jan. 25, 2024

Abstract Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy cuproptosis remains limited by poor delivery efficiency copper ion carriers. Herein, complex nanoparticles (denoted as Cu(I) NP) are developed that can efficiently deliver into cells to induce cuproptosis. NP demonstrate stimulus‐responsive release complexes, which results mitochondrial dysfunction and promotes aggregation lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), leading Notably, not only cuproptosis, but also elicit robust immune responses suppress tumor growth. Overall, this study provides a promising strategy for cuproptosis‐based

Language: Английский

Citations

42
Nanomedomics DOI

Ganghao Liang,

Wanqing Cao, Dongsheng Tang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

Citations

36
Expanded ROS Generation and Hypoxia Reversal: Excipient‐free Self‐assembled Nanotheranostics for Enhanced Cancer Photodynamic Immunotherapy DOI

Jing Yang,

Bibo Ren,

Xuntao Yin

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 12, 2024

The efficacy of photodynamic therapy (PDT)-related cancer therapies is significantly restricted by two irreconcilable obstacles, i.e., low reactive oxygen species (ROS) generation capability and hypoxia which constrains the immune response. Herein, this work develops a self-assembled clinical photosensitizer indocyanine green (ICG) HSP90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) nanoparticles (ISDN) without any excipient. This discovers that hydrophobic interaction forces between ICG 17-DMAG promote photostability its intersystem crossing (ISC) process, thereby improving ROS quantum yield from 0.112 to 0.46. Augmented enhances PDT further immunogenic cell death (ICD) effects. inhibits HSP90/hypoxia-inducible factor 1α (HIF-1α) axis dramatically reverse immunosuppressive tumor microenvironment caused PDT-aggravated hypoxia. In mouse model pancreatic cancer, ISDN markedly improve cytotoxic T lymphocyte infiltration MHC I II activation, demonstrating superior ICD effects in situ powerful systematic antitumor immunity generation, eventually achieving vigorous recurrence resistance. study proposes an unsophisticated versatile strategy for enhancing systemic potentially extending it multiple cancers.

Language: Английский

Citations

36
Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica DOI Creative Commons
Yan Liu, Xiang Wang, Ben Wang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The combination of photosensitizers (PSs) and nanomaterials is a widely used strategy to enhance PS efficacy broaden their applicability. However, the current nanocarrier-based delivery strategies focus on conventional PSs, neglecting critical issue phototoxicity. In this study, DHUOCl-25, an activatable (aPS) activated by hypochlorous acid, synthesized combining silicon source structure activation unit. DHUOCl-25 functions as silica for synthesizing mesoporous nanostrctures (MSNs) using standardized protocol, enabling synthesis aPS-covalently modified MSNs variety biologic therapeutic applications. On one hand, resulting nano-aPS maintains aPS functionality antibacterial application achieving synergistic action via MB PDT retained cetyltrimethylammonium bromide (CTAB) (antibacterial agent) (DHU-MSNs-2). other exhibits MSN properties drug loading, facilitating integration photodynamic therapy with chemotherapy (DHU-MSNs-6) tumors demonstrating against spinal metastases lung cancer. These results validate developing novel aPSs expanding MSNs.

Language: Английский

Citations

3
Nanotheranostics with Radionuclides for Cancer Diagnosis and Therapy DOI Open Access

Minhui Cui,

Mengmeng Zhu, Dongsheng Tang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Anti‐tumor theranostic radionuclide nanosystems have gained significant attention as an emerging therapeutic strategy. This review systematically elucidates the concept and recent advances of anti‐tumor nanotheranostic systems with radionuclides, a focus on design nanocarriers, precise selection their advantages limitations in clinical translation. also explores integration imaging various treatment modalities, including photodynamic therapy, photothermal sonodynamic immunotherapy. Furthermore, combination therapy fluorescence magnetic resonance technologies, which broadens application nanotheranostics, is discussed. Finally, outlooks future development nanotheranostics radionuclides proposes key research focus.

Language: Английский

Citations

3
Ultrabright NIR-II Nanoprobe for Image-Guided Accurate Resection of Tiny Metastatic Lesions DOI
Huihui Xu,

Lishan Yuan,

Qiankun Shi

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(4), P. 1367 - 1375

Published: Jan. 16, 2024

Fluorescence imaging is a vital way to delineate the tumor boundaries. Here, we achieve NIR-II aggregation-induced emission luminogen (AIEgen) with fluorescence quantum yield (QY) of 12.6% in water through straightforward alkyl side chain modification. After loading AIEgen into polystyrene (PS) nanospheres, thermal deactivation pathway extremely limited, thereby concentrating absorption excitation on emission. The intensity further enhanced by 5.4 times, QY increases 21.1%, and signal accordingly 8.7 surpassing conventional DSPE-PEG carriers. NIR-II@PS nanoprobe showcases superior resolution tissue penetration depth compared indocyanine green (ICG) short-range near-infrared AIEgens. In vivo investigations underscore its tumor-to-normal ratio (3.9) at 24 h post intravenous injection, enabling complete resection ≤1 mm metastases under bioimaging guidance. Additionally, PS carrier-nanoparticles exhibit low toxicity vivo, laying promising foundation for future design medical nanomaterials.

Language: Английский

Citations

16
Diverse interactions between AIEgens and biomolecules/organisms: Advancing from strategic design to precision theranostics DOI
Qihang Ding, Xiaoyu Xu, Yang Li

et al.

Chem, Journal Year: 2024, Volume and Issue: 10(7), P. 2031 - 2073

Published: July 1, 2024

Language: Английский

Citations

15
A hypoxia-activated and microenvironment-remodeling nanoplatform for multifunctional imaging and potentiated immunotherapy of cancer DOI Creative Commons
Jianwen Song, He Wang, Xue Meng

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 29, 2024

Language: Английский

Citations

15
Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment DOI
Min Zhang, Dandan Sun, Hui Huang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

Citations

14
Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy DOI Creative Commons
Yue Li, Jia Chen, Qi Xia

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 16, 2024

Photothermal therapy (PTT) is a promising non-invasive treatment that has shown great potential in eliminating tumors. It not only induces apoptosis of cancer cells but also triggers immunogenic cell death (ICD) which could activate the immune system against cancer. However, immunosuppressive tumor microenvironment (TIME) poses challenge to triggering strong responses with single treatment, thus limiting therapeutic effect immunotherapy. In this study, dual-targeted nano delivery (GOx@FeNPs) combined αPD-L1 checkpoint blocker inhibit colorectal (CRC) progression by mediating PTT, ferroptosis and anti-tumor response. Briefly, specific was achieved cyclic arginine glycyl aspartate (cRGD) peptide anisamide (AA) GOx@FeNPs had good photothermal realize PTT induce ICD, deplete glutathione (GSH) catalyze production reactive oxygen species (ROS) from endogenous H

Language: Английский

Citations

13