Magnetic Hydrogel Micromachines with Active Release of Antibacterial Agent for Biofilm Eradication DOI Creative Commons
Bonan Sun, Mengmeng Sun, Zifeng Zhang

et al.

Advanced Intelligent Systems, Journal Year: 2023, Volume and Issue: 6(2)

Published: May 24, 2023

Bacterial biofilms are widely found in nature, and they can be a major factor many local chronic infections inside the human body. To date, effective elimination of is intractable for conventional antibiotic therapies due to existence bacteria‐protecting extracellular polymeric substances. For biofilm eradication tiny tubular structures, magnetic hydrogel micromachines (MHM) designed that capable performing mechanical disruption while releasing antibacterial agents controllable fashion. Two modes motion controlled by external fields, namely planar rotation wobbling modes, have been investigated drive interact destruct biofilms. In addition, presented composed thermosensitive PNIPAm load with agent (H 2 O ) release them upon heating. The Fe 3 4 nanoparticles embedded matrix act as catalysts Fenton reaction, generating bacteria‐killing free radicals. synergetic effect has experimentally demonstrated well plates small tubes. MHMs may provide new design treat biofilm‐related narrow confined spaces.

Language: Английский

Magnetically Actuated Continuum Medical Robots: A Review DOI Creative Commons
Zhengxin Yang, Haojin Yang, Yanfei Cao

et al.

Advanced Intelligent Systems, Journal Year: 2023, Volume and Issue: 5(6)

Published: March 1, 2023

The magnetic field has unique advantages in manipulating miniature robots working inside the human body, such as high transparency to biological tissue and good controllability for generation. Generally, actuated robot can be classified into two categories: tethered devices like intravascular microcatheters untethered helical swimmers. Among these, have a long history clinical application prospects, considering their high‐dose delivery easy removal after procedure. As an evolution of traditional continuum medical devices, integration with actuation provides them better scalability improved dexterity. Although rapidly developed last decades, requires further advancements terms design, fabrication, modeling, control, especially applications. Herein, recent progress magnetically is focused on, intending offer readers comprehensive survey state‐of‐the‐art technologies information collection future system design.

Language: Английский

Citations

74

Stimuli-Responsive Functional Micro-/Nanorobots: A Review DOI
Yan Zhou, Min Ye, Chengzhi Hu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15254 - 15276

Published: Aug. 3, 2023

Stimuli-responsive functional micro-/nanorobots (srFM/Ns) are a class of intelligent, efficient, and promising microrobots that can react to external stimuli (such as temperature, light, ultrasound, pH, ion, magnetic field) perform designated tasks. Through adaptive transformation into the corresponding forms, they perfectly match demands depending on different applications, which manifest extremely important roles in targeted therapy, biological detection, tissue engineering, other fields. Promising srFM/Ns be, few reviews have focused them. It is therefore necessary provide an overview current development these intelligent clear inspiration for further this field. Hence, review summarizes advances stimuli-responsive regarding their response mechanism, achieved functions, applications highlight pros cons stimuli. Finally, we emphasize existing challenges propose possible strategies help accelerate study field promote toward actual applications.

Language: Английский

Citations

48

Autonomous 3D positional control of a magnetic microrobot using reinforcement learning DOI
Sarmad Ahmad Abbasi, Awais Ahmed,

Seungmin Noh

et al.

Nature Machine Intelligence, Journal Year: 2024, Volume and Issue: 6(1), P. 92 - 105

Published: Jan. 10, 2024

Language: Английский

Citations

32

AI-enhanced biomedical micro/nanorobots in microfluidics DOI Open Access
Hui Dong, Jiawen Lin,

Yihui Tao

et al.

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1419 - 1440

Published: Jan. 1, 2024

Although developed independently at the beginning, AI, micro/nanorobots and microfluidics have become more intertwined in past few years which has greatly propelled cutting-edge development fields of biomedical sciences.

Language: Английский

Citations

18

Particle manipulation under X-force fields DOI
Chun‐Dong Xue,

Yifan Yin,

Xiaoyu Xu

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights recent technological advances for progress in particle manipulation under X-force fields, and forecasts the trajectory of future developments.

Language: Английский

Citations

2

Collective Reconfiguration and Propulsion Behaviors of Chlorella-Based Biohybrid Magnetic Microrobot Swarm DOI
De Gong, Jun Cai,

Bo Gu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Magnetic microrobots hold great promise for applications in drug delivery and environmental remediation, but achieving collective reconfiguration effective propulsion dense, motile magnetic remains a significant challenge. In this research, we have fabricated Chlorella-based biohybrid bulk using facile biotemplating process studied their superior performance. Our results show that the dispersed superparamagnetic individuals can self-organize into swarm of chain-like multimers, via rolling or tumbling modes. The near-bound locomotion demonstrates pseudochiral periodic reciprocation properties, detailed morphological analysis has been conducted. Furthermore, form vortices realize spinning mode. These findings indicate spheroidal exhibit high maneuverability programmable self-assembly, reconfiguration, based on dynamic interactions. summary, research provides feasible method constructing reconfigurable explores an applicable paradigm flexible control cooperation. advances implications practical various fields.

Language: Английский

Citations

2

Ultrasound Microrobots with Reinforcement Learning DOI Creative Commons

Matthijs Schrage,

Mahmoud Medany, Daniel Ahmed

et al.

Advanced Materials Technologies, Journal Year: 2023, Volume and Issue: 8(10)

Published: March 2, 2023

Powered by acoustics, existing therapeutic and diagnostic procedures will become less invasive new methods available that have never been before. Acoustically driven microrobot navigation based on microbubbles is a promising approach for targeted drug delivery. Previous studies used acoustic techniques to manipulate in vitro vivo the delivery of drugs using minimally procedures. Even though many advanced capabilities sophisticated control achieved acoustically powered microrobots, there remain challenges be solved. In order develop next generation intelligent micro/nanorobots, it highly desirable conduct accurate identification micro-nanorobots their dynamic motion autonomously. Here we use reinforcement learning strategies learn dynamics them through forces. The result demonstrated first time autonomous microfluidic environment. Taking advantage benefit second radiation force, swarm form large swarm, which then along desired trajectory. More than 100 thousand images were training study unexpected microbubbles. As this work, microrobots are validated controlled, illustrating good level robustness providing computational intelligence enables navigate independently an unstructured environment without requiring outside assistance.

Language: Английский

Citations

30

Ultrasonic Steering Wheels: Turning Micromotors by Localized Acoustic Microstreaming DOI
Qiang Gao,

Zhou Yang,

Ruitong Zhu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4729 - 4739

Published: Feb. 23, 2023

The ability to steer micromotors in specific directions and at precise speeds is highly desired for their use complex environments. However, a generic steering strategy that can be applied of all types surface coatings yet developed. Here, we report ultrasound ∼100 kHz spin spherical micromotor so it turns left or right when moving forward, moves full circles. direction angular spinning the radii circular trajectories are precisely tunable by varying voltages frequencies, as well particle properties such its radius, materials, coating thickness. Such hypothesized originate from microstreaming flows localized around solid microsphere vibrating ultrasound. In addition causing spin, streaming also helped release cargos during capture-transport-release mission. Localized does not depend on interference with propulsion mechanism wide variety micromotors. This work suggests used microrobots complex, biologically relevant environments microorganisms cells.

Language: Английский

Citations

25

Roadmap for Clinical Translation of Mobile Microrobotics DOI Creative Commons
Ugur Bozuyuk, Paul Wrede, Erdost Yıldız

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 21, 2024

Medical microrobotics is an emerging field to revolutionize clinical applications in diagnostics and therapeutics of various diseases. On the other hand, mobile has important obstacles pass before translation. This article focuses on these challenges provides a roadmap medical microrobots enable their use. From concept "magic bullet" physicochemical interactions complex biological environments applications, there are several translational steps consider. Clinical translation only possible with close collaboration between experts researchers address technical microfabrication, safety, imaging. The application potential can be materialized by designing that solve current main challenges, such as actuation limitations, material stability, imaging constraints. strengths weaknesses progress discussed for near future outlined.

Language: Английский

Citations

14

Metareview: a survey of active matter reviews DOI Creative Commons
Michael te Vrugt, Raphael Wittkowski

The European Physical Journal E, Journal Year: 2025, Volume and Issue: 48(2)

Published: Feb. 1, 2025

In the past years, amount of research on active matter has grown extremely rapidly, a fact that is reflected in particular by existence more than 1000 reviews this topic. Moreover, field become very diverse, ranging from theoretical studies statistical mechanics particles to applied work medical applications microrobots and biological systems artificial swimmers. This makes it difficult get an overview over as whole. Here, we provide such form metareview article surveys existing review articles books matter. Thereby, provides useful starting point for finding literature about specific

Language: Английский

Citations

2